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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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Protein secondary structure prediction based on position-specific scoring matrices.

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Tumour-cell invasion and migration: diversity and escape mechanisms

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Genes that mediate breast cancer metastasis to lung

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CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

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A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.

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Identification of a set of genes with developmentally down-regulated expression in the mouse brain

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Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

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Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

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Evaluating conformational free energies: The colony energy and its application to the problem of loop prediction

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p130Cas: a versatile scaffold in signaling networks

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Integrin signalling: a new Cas(t) of characters enters the stage

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Gene expression and the myth of the average cell

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The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

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Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.Preprint

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Human Enhancer of Filamentation 1, a Novel p130cas-Like Docking Protein, Associates with Focal Adhesion Kinase and Induces Pseudohyphal Growth in Saccharomyces cerevisiae

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HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells

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Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

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Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase

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Requirements for Localization of p130cas to Focal Adhesions

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BCAR1, a Human Homologue of the Adapter Protein p130Cas, and Antiestrogen Resistance in Breast Cancer Cells

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Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle

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Bcar1/p130Cas Protein and Primary Breast Cancer: Prognosis and Response to Tamoxifen Treatment

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A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9

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Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.

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Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10/ mice and Rag-2/ mice reconstituted with CD4+CD45RBhigh T cells

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Dissection of HEF1-dependent functions in motility and transcriptional regulation

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The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites

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Proteolysis of the Docking Protein HEF1 and Implications for Focal Adhesion Dynamics

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Deregulation of HEF1 Impairs M-Phase Progression by Disrupting the RhoA Activation Cycle

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MollDE: a homology modeling framework you can click with

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Detection of Peptides, Proteins, and Drugs That Selectively Interact With Protein TargetsPreprint

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The Serine-rich Domain from Crk-associated Substrate (p130 ) Is a Four-helix Bundle

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Identification of two focal adhesion targeting sequences in the adapter molecule p130Cas

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CellCircuits: a database of protein network models

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The 1.1Å Resolution Crystal Structure of the p130cas SH3 Domain and Ramifications for Ligand Selectivity

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Inferring steady state single-cell gene expression distributions from analysis of mesoscopic samples

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Genes associated with Alzheimer's disease: an overview and current status

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Integrin signalling adaptors: not only figurants in the cancer story

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Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics

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CAS proteins in normal and pathological cell growth control

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Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated Pathways

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NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development

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Netrin-1 Attracts Axons through FAK-Dependent Mechanotransduction

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NEDD9 and BCAR1 Negatively Regulate E-Cadherin Membrane Localization, and Promote E-Cadherin Degradation

Tikhmyanova, N., & Golemis, E. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022102 · Cited by 77 · see citing works

Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent

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Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression

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Aurora A kinase activity influences calcium signaling in kidney cells

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Dynamics and Mechanism of p130Cas Localization to Focal Adhesions

Donato, D. M., Ryzhova, L., Meenderink, L. M., Kaverina, I., & Hanks, S. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091207 · Cited by 63 · see citing works

Association and interaction effects of Alzheimer’s disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population

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CAS proteins in health and disease: An update

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Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease

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Consortium-based genome-wide meta-analysis for childhood dental caries traits

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Genetic Biomarkers on Age-Related Cognitive Decline

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Roles for Crk in Cancer Metastasis and Invasion

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Development of a unique epigenetic signature during in vivo Th17 differentiation

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MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization

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Genetic risk factors for Alzheimer disease: emerging roles of microglia in disease pathomechanisms

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Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members

Deneka, A., Korben, V. A., & Golemis, E. A. (2015) · Gene · doi:10.1016/j.gene.2015.06.062 · Cited by 33 · see citing works

Nedd9 restrains renal cystogenesis in Pkd1 −/− mice

Nikonova, A. S., Plotnikova, O. V., Serzhanova, V., Efimov, A., Bogush, I. V., Cai, K. Q., Hensley, H. H., Egleston, B. L., Klein–Szanto, A. J., Seeger‐Nukpezah, T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405362111 · Cited by 31 · see citing works

Human brain vascular multi-omics elucidates disease-risk associations

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FCGR1A Serves as a Novel Biomarker and Correlates With Immune Infiltration in Four Cancer Types

Xu, J.-L., & Guo, Y. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.581615 · Cited by 28 · see citing works

P130cas-FAK interaction is essential for YAP-mediated radioresistance of non-small cell lung cancer

Li, J., Zhang, X., Hou, Z., Cai, S., Guo, Y., Sun, L., Li, A., Li, Q., Wang, E., & Miao, Y. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05224-7 · Cited by 27 · see citing works

p130 Crk-Associated Substrate (CAS) in Vascular Smooth Muscle

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Protective Variants in Alzheimer’s Disease

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Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion

Sciortino, M., Leal, M. D. P. C., Orso, F., Grassi, E., Costamagna, A., Provero, P., Tam, W., Turco, E., Defilippi, P., Taverna, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01332-z · Cited by 25 · see citing works

Regulation of p130Cas/BCAR1 Expression in Tamoxifen-Sensitive and Tamoxifen-Resistant Breast Cancer Cells by EGR1 and NAB2

Kumbrink, J., & Kirsch, K. H. (2012) · Neoplasia · doi:10.1593/neo.111760 · Cited by 23 · see citing works

Proteomics of Non-human Primate Plasma after Partial-body Radiation with Minimal Bone Marrow Sparing

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Identification of Key Genes in Lung Adenocarcinoma and Establishment of Prognostic Mode

Jiawei, Z., Mu, M., Xing, Y., Zhang, X., Li, D., Yafeng, L., Jun, X., Wangfa, H., Lijun, Z., Wu, J., et al. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.561456 · Cited by 22 · see citing works

Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer

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Dcas Supports Cell Polarization and Cell-Cell Adhesion Complexes in Development

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The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells

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Decreased expression of EFS is correlated with the advanced prostate cancer

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Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment

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NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer

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PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9

Bradbury, P., Mahmassani, M., Zhong, J., Turner, K., Paul, A., Verrills, N. M., & O’Neill, G. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.10.011 · Cited by 17 · see citing works

Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer’s disease by evaluating protein interactions through molecular docking and dynamic simulations

Hassan, M., Shahzadi, S., Alashwal, H., Zaki, N., Seo, S., & Moustafa, A. A. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3430-2 · Cited by 17 · see citing works

Estradiol stabilizes the 105-kDa phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells

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Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial

Wade, R. L., Bernardo, M. C. D., Richards, S. M., Rossi, D., Crowther-Swanepoel, D., Gaïdano, G., Oscier, D., Catovsky, D., & Houlston, R. S. (2011) · Haematologica · doi:10.3324/haematol.2011.043471 · Cited by 16 · see citing works

The focal adhesion targeting domain of p130Cas confers a mechanosensing function

Bradbury, P., Turner, K., Mitchell, C. B., Griffin, K. R., Middlemiss, S., Lau, L. M. S., Dagg, R. A., Taran, E., Cooper-White, J. J., Fabry, B., et al. (2017) · Journal of Cell Science · doi:10.1242/jcs.192930 · Cited by 14 · see citing works

Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics

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Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

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Association of the top 20 Alzheimer's disease risk genes with [18F]flortaucipir PET

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Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction–associated steatohepatitis

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Tyrosine Y189 in the Substrate Domain of the Adhesion Docking Protein NEDD9 Is Conserved with p130Cas Y253 and Regulates NEDD9-Mediated Migration and Focal Adhesion Dynamics

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NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway

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Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer

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The Genetic Basis of Alzheimer's Disease

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A novel large regulator RNA, B2, partially overlaps the HEF1/NEDD9/Cas-L gene

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Effects of lentivirus-mediated RNAi knockdown of NEDD9 on human lung adenocarcinoma cells in vitro and in vivo

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NEDD9 Restrains dsDNA Damage Response during Non-Small Cell Lung Cancer (NSCLC) Progression

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Targeting Cas Family Proteins as a Novel Treatment for Breast Cancer

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Alzheimer's disease: the large gene instability hypothesisPreprint

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Nedd9 Regulates Metastasis of Non-Small Cell Lung Cancer through Activation of Epithelial-Mesenchymal Transition and Tumor Cells Migration

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An Amyloid Agnostic Reformulation of the Alzheimer’s Disease: The Long Gene Vulnerability HypothesisPreprint

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DCAS supports cell polarization and cell-cell adhesion complexes in development

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Data from NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development

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Functional role for Cas cytoplasmic adaptor proteins during cortical axon pathfinding

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Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis

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Dissection of HEF1-dependent functions in motility and transcriptional regulation

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CAS proteins in health and disease: An update

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Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle

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CAS proteins in normal and pathological cell growth control

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