Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members

Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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SH2 domains recognize specific phosphopeptide sequences

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

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Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

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Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

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HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium

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A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.

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Differential regulation of cell motility and invasion by FAK

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Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

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p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

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Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

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Integrin signalling: a new Cas(t) of characters enters the stage

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Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

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The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

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Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

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A phosphotyrosine displacement mechanism for activation of Src by PTPα

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Receptor protein tyrosine phosphatase alpha activates pp60c‐src and is involved in neuronal differentiation.

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Positive and negative selection invoke distinct signaling pathways.

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Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.Preprint

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Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

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Human Enhancer of Filamentation 1, a Novel p130cas-Like Docking Protein, Associates with Focal Adhesion Kinase and Induces Pseudohyphal Growth in Saccharomyces cerevisiae

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Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

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CAS proteins in normal and pathological cell growth control

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A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy

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Charting the molecular network of the drug target Bcr-Abl

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Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

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Phosphoproteome of Resting Human Platelets

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Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase

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Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition

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Hypermethylation of Genes for Diagnosis and Risk Stratification of Prostate Cancer

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The Chediak-Higashi Protein Interacts with SNARE Complex and Signal Transduction Proteins

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CIZ, a Zinc Finger Protein That Interacts with p130 cas and Activates the Expression of Matrix Metalloproteinases

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Protein tyrosine phosphatase 1B negatively regulates integrin signaling

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The Related Adhesion Focal Tyrosine Kinase Differentially Phosphorylates p130Cas and the Cas-like Protein, p105HEF1

Astier, A., Manié, S. N., Avraham, H. K., Hirai, H., Law, S. F., Zhang, Y., Golemis, E. A., Fu, Y., Druker, B. J., Haghayeghi, N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19719 · Cited by 125 · see citing works

Processive Phosphorylation of p130Cas by Src Depends on SH3-Polyproline Interactions

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Bypass Mechanisms of the Androgen Receptor Pathway in Therapy-Resistant Prostate Cancer Cell Models

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PTP‐PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates

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Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.

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Crohn disease: A current perspective on genetics, autophagy and immunity

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Relevance of Breast Cancer Antiestrogen Resistance Genes in Human Breast Cancer Progression and Tamoxifen Resistance

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Combination of Gene Targeting and Substrate Trapping to Identify Substrates of Protein Tyrosine Phosphatases Using PTP-PEST as a Model

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Follow-up of loci from the International Genomics of Alzheimer’s Disease Project identifies TRIP4 as a novel susceptibility gene

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Dissection of HEF1-dependent functions in motility and transcriptional regulation

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Direct Binding of p130Cas to the Guanine Nucleotide Exchange Factor C3G

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p130Cas: A key signalling node in health and disease

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Systematic identification of SH3 domain‐mediated human protein–protein interactions by peptide array target screening

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New signaling pathways govern the host response to C. albicans infection in various nichesPreprint

Liu, Y., Shetty, A. C., Schwartz, J. A. J., Bradford, L. L., Xu, W., Phan, Q. T., Kumari, P., Mahurkar, A., Mitchell, A. P., Ravel, J., et al. (2015) · Genome Research · doi:10.1101/gr.187427.114 · Cited by 86 · see citing works

Physical and Functional Interactions between Receptor-like Protein-tyrosine Phosphatase α and p59

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A novel Cas family member, HEPL, regulates FAK and cell spreading

Singh, M. K., Dadke, D., Nicolas, E., Serebriiskii, I. G., Apostolou, S., Canutescu, A., Egleston, B. L., & Golemis, E. A. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0953 · Cited by 74 · see citing works

Identification of Genes Expressed by Human Airway Eosinophils after an In Vivo Allergen Challenge

Esnault, S. J., KELLY, E. A. B., Schwantes, E. A., Liu, L. Y., Delain, L. P., Hauer, J. A., Bochkov, Y. A., Denlinger, L. C., Malter, J. S., Mathur, S. K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067560 · Cited by 74 · see citing works

Genetic Determinants of Disease Progression in Alzheimer's Disease

Wang, X., López, O. L., Sweet, R. A., Becker, J. T., DeKosky, S. T., Barmada, M. M., Demirci, F. Y., & Kamboh, M. I. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140729 · Cited by 68 · see citing works

Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake

Bruce-Staskal, P. J., Weidow, C. L., Gibson, J. J., & Bouton, A. H. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.13.2689 · Cited by 64 · see citing works

CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells

Weidow, C. L., Black, D. S., Bliska, J. B., & Bouton, A. H. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00079.x · Cited by 64 · see citing works

Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology

Vital, A. L., Tabernero, M. D., Castrillo, A., Rebelo, O., Tão, H., Gomes, F. C., Librero, A. B. N., Oliveira, C. R., Lopes, M. C., & Órfão, A. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq050 · Cited by 56 · see citing works

Dimerization of the Docking/Adaptor Protein HEF1 via a Carboxy-Terminal Helix-Loop-Helix Domain

Law, S. F., Zhang, Y., Fashena, S. J., Toby, G. G., Estojak, J., & Golemis, E. A. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4609 · Cited by 54 · see citing works

CAS proteins in health and disease: An update

Nikonova, A. S., Gaponova, A. V., Kudinov, A. E., & Golemis, E. A. (2014) · IUBMB Life · doi:10.1002/iub.1282 · Cited by 53 · see citing works

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease

Beck, T. N., Nicolas, E., Kopp, M. C., & Golemis, E. A. (2014) · Oncoscience · doi:10.18632/oncoscience.64 · Cited by 50 · see citing works

c-Src Signaling Induced by the Adapters Sin and Cas Is Mediated by Rap1 GTPase

Xing, L., Ge, C., Zeltser, R., Maskevitch, G., Mayer, B. J., & Alexandropoulos, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7363-7377.2000 · Cited by 50 · see citing works

c-SRC Mediates Neurite Outgrowth through Recruitment of Crk to the Scaffolding Protein Sin/Efs without Altering the Kinetics of ERK Activation

Yang, L., Alexandropoulos, K., & Sap, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111902200 · Cited by 50 · see citing works

Invasion of Host Cells by Salmonella typhimurium Requires Focal Adhesion Kinase and p130Cas

Shi, J., & Casanova, J. E. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0492 · Cited by 49 · see citing works

Quantitative Proteomics with siRNA Screening Identifies Novel Mechanisms of Trastuzumab Resistance in HER2 Amplified Breast Cancers

Boyer, A. P., Collier, T. S., Vidavsky, I., & Bose, R. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.020115 · Cited by 48 · see citing works

Characterization, partial purification, and peptide sequencing of p130,the main phosphoprotein associated with v-Crk oncoprotein

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The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics

Aquino, J. B., Lallemend, F., Marmigère, F., Adameyko, I. I., Golemis, E. A., & Ernfors, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.035 · Cited by 46 · see citing works

p130Cas, Crk-Associated Substrate, Plays Important Roles in Osteoclastic Bone Resorption

Nagai, Y., Osawa, K., Fukushima, H., Tamura, Y., Aoki, K., Ohya, K., Yasuda, H., Hikiji, H., Takahashi, M., Seta, Y., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1936 · Cited by 45 · see citing works

Connecting the Dots: Potential of Data Integration to Identify Regulatory SNPs in Late-Onset Alzheimer's Disease GWAS Findings

Rosenthal, S. L., Barmada, M. M., Wang, X., Demirci, F. Y., & Kamboh, M. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095152 · Cited by 45 · see citing works

Cas Mediates Transcriptional Activation of the Serum Response Element by Src

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Progesterone regulation of implantation-related genes: new insights into the role of oestrogen

Dassen, H. H. N. M., Punyadeera, C., Kamps, R., Klomp, J. P. G., Dunselman, G. A. J., Dijcks, F. A., de Goeij, A. F. P. M., EDERVEEN, A. G. H., & Groothuis, P. G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6553-9 · Cited by 44 · see citing works

EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

Neumann, L. C., Weinhäusel, A., Thomas, S., Horsthemke, B., Lohmann, D. R., & Zeschnigk, M. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-380 · Cited by 40 · see citing works

Phosphoproteomic Analysis of Platelets Activated by Pro-Thrombotic Oxidized Phospholipids and Thrombin

Zimman, A., Titz, B., Komisopoulou, E., Biswas, S., Graeber, T. G., & Podrez, E. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084488 · Cited by 38 · see citing works

A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction

Ogden, K. K., Thompson, J., Hickner, Z. J., Huang, T., Tang, D. D., & Watts, S. W. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00229.2006 · Cited by 32 · see citing works

Plasmodium falciparum ‐induced CD36 clustering rapidly strengthens cytoadherence via p130CAS‐mediated actin cytoskeletal rearrangement

Davis, S. P., Amrein, M., Gillrie, M. R., Lee, K., Muruve, D. A., & Ho, M. (2011) · The FASEB Journal · doi:10.1096/fj.11-196923 · Cited by 31 · see citing works

Genome-Wide High-Resolution aCGH Analysis of Gestational Choriocarcinomas

Poaty, H., Coullin, P., Peko, J. F., Dessen, P., Diatta, A. L., Valent, A., Leguern, É., Prevot, S., Gombé-Mbalawa, C., Candelier, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029426 · Cited by 31 · see citing works

Differential Inhibition of Ex-Vivo Tumor Kinase Activity by Vemurafenib in BRAF(V600E) and BRAF Wild-Type Metastatic Malignant Melanoma

Tahiri, A., Redalen, K. R., Ree, A. H., de Wijn, R., Risberg, K., Busch, C., Lønning, P. E., Kristensen, V. N., & Geisler, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072692 · Cited by 31 · see citing works

Nedd9 restrains renal cystogenesis in Pkd1 −/− mice

Nikonova, A. S., Plotnikova, O. V., Serzhanova, V., Efimov, A., Bogush, I. V., Cai, K. Q., Hensley, H. H., Egleston, B. L., Klein–Szanto, A. J., Seeger‐Nukpezah, T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405362111 · Cited by 31 · see citing works

Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells.

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Genomic Characterization of Human and Rat Prolactinomas

Tong, Y., Zheng, Y., Zhou, J. R., Oyesiku, N. M., Koeffler, H. P., & Melmed, S. K. (2012) · Endocrinology · doi:10.1210/en.2012-1056 · Cited by 29 · see citing works

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin

Danzl, N., Donlin, L. T., & Alexandropoulos, K. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092384 · Cited by 27 · see citing works

Cas proteins: dodgy scaffolding in breast cancer

Tornillo, G., Defilippi, P., & Cabodi, S. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0443-5 · Cited by 27 · see citing works

Sin: good or bad? A T lymphocyte perspective

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Dcas Supports Cell Polarization and Cell-Cell Adhesion Complexes in Development

Tikhmyanova, N., Tulin, A., Roegiers, F., & Golemis, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012369 · Cited by 21 · see citing works

Susceptibility to Acute Rheumatic Fever Based on Differential Expression of Genes Involved in Cytotoxicity, Chemotaxis, and Apoptosis

Bryant, P. A., Smyth, G. K., Gooding, T. M., Oshlack, A., Harrington, Z., Currie, B. J., Carapetis, J. R., Robins-Browne, R. M., & Curtis, N. C. (2013) · Infection and Immunity · doi:10.1128/iai.01152-13 · Cited by 20 · see citing works

Microsatellite Stable Colorectal Cancers Stratified by the BRAF V600E Mutation Show Distinct Patterns of Chromosomal Instability

Bond, C., Nancarrow, D. J., Wockner, L. F., Wallace, L. M., Montgomery, G. W., Leggett, B., & Whitehall, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091739 · Cited by 19 · see citing works

Decreased expression of EFS is correlated with the advanced prostate cancer

Sertkaya, S., Hamid, S. M., Dilsiz, N., & Varışlı, L. (2014) · Tumor Biology · doi:10.1007/s13277-014-2703-5 · Cited by 18 · see citing works

Deficiency in Expression of the Signaling Protein Sin/Efs Leads to T-Lymphocyte Activation and Mucosal Inflammation

Donlin, L. T., Danzl, N. M., Wanjalla, C. N., & Alexandropoulos, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11035-11046.2005 · Cited by 17 · see citing works

NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer

Wallez, Y., Mace, P. D., Pasquale, E. B., & Riedl, S. J. (2012) · Genes & Cancer · doi:10.1177/1947601912460050 · Cited by 17 · see citing works

Oligodendroglial p130Cas Is a Target of Fyn Kinase Involved in Process Formation, Cell Migration and Survival

Gonsior, C., Binamé, F., Frühbeis, C., Bauer, N., Hoch-Kraft, P., Luhmann, H. J., Trotter, J., & White, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089423 · Cited by 16 · see citing works

Hypoxic Tumor Kinase Signaling Mediated by STAT5A in Development of Castration-Resistant Prostate Cancer

Redalen, K. R., Bratland, Å., Vlatkovic, L., Ragnum, H. B., Sælen, M. G., Olsen, D. R., Marignol, L. H., & Ree, A. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063723 · Cited by 15 · see citing works

Dot Far-Western Blot Analysis of Relative Binding Affinities of the Src Homology 3 Domains of Efs and Its Related Proteins

Ohba, T., Ishino, M., Aoto, H., & Sasaki, T. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2772 · Cited by 14 · see citing works

p130Cas, Crk-Associated Substrate Plays Essential Roles in Liver Development by Regulating Sinusoidal Endothelial Cell Fenestration†

Tazaki, T., Sasaki, T., Uto, K., Yamasaki, N., Tashiro, S., Sakai, R., Tanaka, M., Oda, H., Honda, Z., & Honda, H. (2010) · Hepatology · doi:10.1002/hep.23767 · Cited by 13 · see citing works

Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs

Ishino, M., Ohba, T., Inazawa, J., Sasaki, H., Ariyama, Y., & Sasaki, T. (1997) · Oncogene · doi:10.1038/sj.onc.1201346 · Cited by 13 · see citing works

p130Cas Scaffolds the Signalosome To Direct Adaptor-Effector Cross Talk during Kaposi's Sarcoma-Associated Herpesvirus Trafficking in Human Microvascular Dermal Endothelial Cells

Bandyopadhyay, C., Veettil, M. V., Dutta, S., & Chandran, B. (2014) · Journal of Virology · doi:10.1128/jvi.01674-14 · Cited by 12 · see citing works

Defective Thymocyte Maturation by Transgenic Expression of a Truncated Form of the T Lymphocyte Adapter Molecule and Fyn Substrate, Sin

Donlin, L. T., Roman, C. A. J., Adlam, M., Regelmann, A. G., & Alexandropoulos, K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6900 · Cited by 10 · see citing works

Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer

Miao, Y., Wang, L., Liu, Y., Li, A., Liu, S., Cao, H., Zhang, X., Jiang, G., Liu, D., & Wang, E. (2012) · Tumor Biology · doi:10.1007/s13277-012-0517-x · Cited by 9 · see citing works

The Adapter Molecule Sin Regulates T-Cell-Receptor-Mediated Signal Transduction by Modulating Signaling Substrate Availability

Xing, L., Donlin, L. T., Miller, R. H., & Alexandropoulos, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4581-4592.2004 · Cited by 9 · see citing works

The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases

de Pins, B., Mendes, T., Giralt, A., & Girault, J. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.749001 · Cited by 59 · see citing works

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis

Ando, K., Houben, S., Homa, M., de Fisenne, M.-A., Potier, M., Erneux, C., Brion, J., & Leroy, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.583755 · Cited by 39 · see citing works

Positional Effects Revealed in Illumina Methylation Array and The Impact on Analysis

Jiao, C., Zhang, C., Dai, R., Xia, Y., Wang, K., Giase, G. M., Chen, C., & Liu, C. (2018) · Epigenomics · doi:10.2217/epi-2017-0105 · Cited by 37 · see citing works

Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review

Vogrinc, D., Goričar, K., & Dolžan, V. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646901 · Cited by 32 · see citing works

A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer

Pathak, H. B., Zhou, Y., Sethi, G., Hirst, J. J., Schilder, R. J., Golemis, E. A., & Godwin, A. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144126 · Cited by 30 · see citing works

PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells

Chen, Z., Morales, J. E., Guerrero, P. A., Sun, H., & McCarty, J. H. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0085 · Cited by 30 · see citing works

A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade

Izquierdo, I., Barrachina, M. N., Hermida‐Nogueira, L., Casas, V., Morán, L. A., Lacerenza, S., Pinto-Llorente, R., Eble, J. A., Rı́os, V. D. L., Domínguez, E., et al. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0039-3400295 · Cited by 28 · see citing works

Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial

Edlund, K., Madjar, K., Lebrecht, A., Aktas, B., Pilch, H., Hoffmann, G., Hofmann, M., Kolberg, H.-C., Boehm, D., Battista, M., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2662 · Cited by 24 · see citing works

Identifying Blood Transcriptome Biomarkers of Alzheimer’s Disease Using Transgenic Mice

Ochi, S., Iga, J., Funahashi, Y., Yoshino, Y., Yamazaki, K., Kumon, H., Mori, H., Ozaki, Y., Mori, T., & Ueno, S. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02058-2 · Cited by 23 · see citing works

Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer

Deneka, A. Y., Kopp, M. C., Nikonova, A. S., Gaponova, A. V., Kiseleva, A. A., Hensley, H. H., Flieder, D. B., Serebriiskii, I. G., & Golemis, E. A. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3626 · Cited by 23 · see citing works

Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration

Sengupta, P., Das, R., Majumder, P., & Mukhopadhyay, D. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00033 · Cited by 18 · see citing works

Genome-Wide Methylation Mapping Using Nanopore Sequencing Technology Identifies Novel Tumor Suppressor Genes in Hepatocellular Carcinoma

Davenport, C., Scheithauer, T., Dunst, A., Bahr, F. S., Dorda, M., Wiehlmann, L., & Tran, D. D. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083937 · Cited by 18 · see citing works

NEDD9 sustains hexokinase expression to promote glycolysis

Deneka, A. Y., Nikonova, A. S., Lee, H., Kruger, W. D., & Golemis, E. A. (2022) · Oncogenesis · doi:10.1038/s41389-022-00391-w · Cited by 17 · see citing works

Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer’s disease by evaluating protein interactions through molecular docking and dynamic simulations

Hassan, M., Shahzadi, S., Alashwal, H., Zaki, N., Seo, S., & Moustafa, A. A. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3430-2 · Cited by 17 · see citing works

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial‐like head and neck carcinoma subtypes

Pavón, M. Á., Arroyo‐Solera, I., León, X., Tellez-Gabriel, M., Porcuna, D. V., Gallardo, A., Céspedes, M. V., Casanova, I., Pousa, A. L., Barnadas, A., et al. (2019) · Head & Neck · doi:10.1002/hed.25623 · Cited by 14 · see citing works

DNA Methylation and Uveal Melanoma

Yang, Z., Yang, J., Xu, Z.-Z., & Yu, W. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.228229 · Cited by 13 · see citing works

Overexpression of CASS4 promotes invasion in non-small cell lung cancer by activating the AKT signaling pathway and inhibiting E-cadherin expression

Li, A., Zhang, W., Xia, H., Miao, Y., Zhou, H., Zhang, X., Dong, Q., Li, Q., Qiu, X., & Wang, E. (2016) · Tumor Biology · doi:10.1007/s13277-016-5411-5 · Cited by 11 · see citing works

Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing

Berger, A. H., Bratland, E., Sjøgren, T., Heimli, M., Tyssedal, T., Bruserud, Ø., Johansson, S., Husebye, E. S., Oftedal, B. E., & Wolff, A. S. B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.722860 · Cited by 10 · see citing works

An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold

Wong, W., Estep, J. A., Treptow, A. M., Rajabli, N., Jahncke, J. N., Ubina, T., Wright, K. M., & Riccomagno, M. M. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002212 · Cited by 8 · see citing works

Genetic and functional analysis of unproductive splicing using LeafCutter2Preprint

Najar, C. F. B. A., Feng, R., Dai, C., Fair, B. J., Hauck, Q., Li, J., Cao, X., Dey, K. K., Jager, P. L. D., Bennett, D. A. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.06.646893 · Cited by 8 · see citing works

Kinome profiling analysis identified Src pathway as a novel therapeutic target in combination with histone deacetylase inhibitors for cutaneous T-cell lymphoma

Jimura, N., Fujii, K., Qiao, Z., Tsuchiya, R., Yoshimatsu, Y., Kondo, T., & Kanekura, T. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2021.01.004 · Cited by 7 · see citing works

Comprehensive transcriptome, miRNA and kinome profiling identifies new treatment options for personalized lung cancer therapy

Zhong, S., Boergeling, Y., Zardo, P., Jonigk, D. D., & Borlak, J. T. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70177 · Cited by 5 · see citing works

Common Variation in Cytoskeletal Genes Is Associated with Conotruncal Heart Defects

Musfee, F. I., Agopian, A. J., Goldmuntz, E., Hakonarson, H. H., Morrow, B. E., Taylor, D. M., Tristani‐Firouzi, M., Watkins, W. S., Yandell, M. D., & Mitchell, L. E. (2021) · Genes · doi:10.3390/genes12050655 · Cited by 4 · see citing works

Proteogenomic Analysis of Coronary Artery Calcification in Human Populations

El-Sabawi, B. R., Huang, X., Lin, P., Anwar, M. Y., Betti, M. J., Kim, N., Perry, A., Perera, B. L. A., Gajjar, P., Colangelo, L. A., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.324171 · Cited by 1 · see citing works

An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling

Selicharová, I., Kirk, N. S., Kertisová, A., Lubos, M., Mitrová, K., Ticháčková, T., Žáková, L., Chrudinová, M., Březinová, J., Harant, K., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeb7558 · Cited by 1 · see citing works

Data from Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer

Deneka, A. Y., Kopp, M. C., Nikonova, A. S., Gaponova, A. V., Kiseleva, A. A., Hensley, H. H., Flieder, D. B., Serebriiskii, I. G., & Golemis, E. A. (2023) · doi:10.1158/0008-5472.c.6512911.v1

Data from Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial

Edlund, K., Madjar, K., Lebrecht, A., Aktas, B., Pilch, H., Hoffmann, G., Hofmann, M., Kolberg, H., Boehm, D. U., Battista, M. J., et al. (2023) · doi:10.1158/1078-0432.c.6531146

Ecological Adaptation of Phoxinus Minnows: Divergence in Phenotype, Genetics, and EvolutionPreprint

Zheng, H., Zhang, Z., Xiao, M., Ma, B., Xiong, D., Wei, K.-J., Ma, X., & Xie, P. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4815829

Molecular architecture of human atherosclerosis revealed through integrative human geneticsPreprint

El-Sabawi, B. R., Betti, M. J., Lin, P. C., Huang, X., Kim, N., Anwar, M. Y., Perry, A., Perera, B. L. A., Gajjar, P., Colangelo, L. A., et al. (2025) · medRxiv · doi:10.1101/2025.03.06.25323506

Functional role for Cas cytoplasmic adaptor proteins during cortical axon pathfinding

Estep, J. A., Treptow, A. M., Rao, P. A., Williamson, P., Wong, W., & Riccomagno, M. M. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011941

ANALYSIS OF GWAS-IDENTIFIED VARIANTS ASSOCIATED WITH ALZHEIMER’S DISEASE RISK IN CASS4, TREM2, CD2AP, AND MS4A4E GENES

Almeida, J. F. F., Thiebaut, A. S. C., dos Santos, L. R., de Oliveira, L. H. G., Pimassoni, L. H. S., Trancozo, M., Portela, P. M., Morelato, R. L., & Paula, F. (2026) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v7i6.8066

Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis

Walsh, A. E., Davis, B. A., Samuels, J. D., Mills, W. A., Thanos, J. M., Johnson, A. M., Moore, K. A., Puchalski, M. A., Steacy, E. J., Wendell, B. W., et al. (2026) · Journal of Experimental Medicine · doi:10.1084/jem.20260104

Cas phosphorylation regulates focal adhesion assembly

Kumar, S., Stainer, A., Dubrulle, J., Simpkins, C., & Cooper, J. A. (2023) · eLife · doi:10.7554/elife.90234 · Cited by 13 · see citing works

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

Harte, M. T., Hildebrand, J. D., Burnham, M. R., Bouton, A. H., & Parsons, J. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13649 · Cited by 361 · see citing works

"Cas"ting New Light on Integrin Signaling

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Integrin signalling: a new Cas(t) of characters enters the stage

O’Neill, G. M., Fashena, S. J., & Golemis, E. A. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01714-6 · Cited by 298 · see citing works

Induction of p130 cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

Vuori, K., Hirai, H., Aizawa, S., & Ruoslahti, E. I. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2606 · Cited by 421 · see citing works