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Cited by 362

The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

Open access
Donadi, Eduardo A., Castelli, Erick C., Arnaiz-Villena, Antonio, Roger, Michel, Rey, Diego, Moreau, Philippe·2011·Cellular and Molecular Life Sciences

Abstract

The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3' untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes.

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Metadata

Authors
Donadi, E. A., Castelli, E. C., Arnaiz-Villena, A., Roger, M., Rey, D., & Moreau, P.
Venue
Cellular and Molecular Life Sciences
Published
2010-11-24
Volume
68
Issue
3
Pages
369-395
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2016249920
Cited by
362
References
118
FWCI
7.38
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. https://app.cochat.ai/papers/10.1007/s00018-010-0580-7
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Donadi, E. A., Castelli, E. C., Arnaiz-Villena, A., Roger, M., Rey, D., & Moreau, P. (2011). Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-010-0580-7

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