The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association
Open accessAbstract
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3' untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes.
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Carosella, E. D., Rouas-Freiss, N., Roux, D. T.-L., Moreau, P., & LeMaoult, J. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395
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The role of immune checkpoints in antitumor response: a potential antitumor immunotherapy
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Guerini, F. R., Bolognesi, E., Chiappedi, M., Ghezzo, A., Canevini, M. P., Mensi, M. M., Vignoli, A., Agliardi, C., Zanette, M., & Clerici, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.10.002 · Cited by 39
Bylińska, A., Wilczyńska, K., Malejczyk, J., Milewski, Ł., Wagner, M., Jasek, M., Niepiekło-Miniewska, W., Wiśniewski, A., Płoski, R., Barcz, E., et al. (2018) · Molecular Genetics and Genomics · doi:10.1007/s00438-017-1404-3 · Cited by 38
Metadata
- Authors
- Donadi, E. A., Castelli, E. C., Arnaiz-Villena, A., Roger, M., Rey, D., & Moreau, P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2010-11-24
- Volume
- 68
- Issue
- 3
- Pages
- 369-395
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2016249920
- Cited by
- 362
- References
- 118
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Donadi, E. A., Castelli, E. C., Arnaiz-Villena, A., Roger, M., Rey, D., & Moreau, P. (2011). Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-010-0580-7
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