The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
Metabolic effects of resveratrol: addressing the controversies
Open accessAbstract
Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol.
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“PDE regulate the signaling of pancreatic β-cell within which they modulate the Ca2+ levels and, consequently, the secretion of insulin [16].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [16]
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“Among these, numerous pieces of evidence suggest that resveratrol activates AMPK [13,16].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [16]
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“The increase of cAMP levels activates protein kinase A (PKA) and exchange protein activated by cAMP (EPAC), inducing the activation of AMPK e consequently of SIRT-1 [16].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [16]
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Items 201–216 of 216
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Cited by
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Resveratrol (RV): A pharmacological review and call for further research
Zhang, L., Li, C., Kakar, M. U., Khan, M. S., Wu, P.-F., Amir, R. M., Dai, D., Naveed, M., Li, Q., Saeed, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112164 · Cited by 580
Resveratrol and Its Effects on the Vascular System
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An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes
Ota, A., & Ulrih, N. P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00436 · Cited by 236
Therapeutic Versatility of Resveratrol Derivatives
Nawaz, W., Zhou, Z.-Q., Deng, S., Ma, X., Ma, X., Li, C., & Shu, X. H. (2017) · Nutrients · doi:10.3390/nu9111188 · Cited by 180
Metadata
- Authors
- Bitterman, J. L., & Chung, J. H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chung, Jay H.
- ORCID
- Chung, Jay H.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2014-12-30
- Volume
- 72
- Issue
- 8
- Pages
- 1473-1488
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC6324849
- OpenAlex
- W1981445076
- Cited by
- 109
- References
- 216
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 14 · 2018: 9 · 2017: 15 · 2016: 18 · 2015: 4
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (Z01HL002243)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, polyphenols, metabolic effects, mitochondrial function, obesity, type 2 diabetes, inflammation, cancer cell growth, cardiovascular dysfunction, clinical trials, treatment development
- MeSH terms
- Resveratrol, Animals, Antioxidants, Diabetes Mellitus, Type 2, Humans, Longevity, Obesity, Stilbenes, Signal Transduction, Neuroprotective Agents, Cyclic Nucleotide Phosphodiesterases, Type 4, AMP-Activated Protein Kinases, Sirtuin 1
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