Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
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A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
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SIRT1 protects against ageing-associated metabolic diseases such as glucose intolerance and cancer.
“As such, SIRT1 confers protection against ageing-associated metabolic diseases such as glucose intolerance and cancer (Herranz et al., 2010; Pearson et al., 2008; Rutanen et al., 2010).”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Pearson et al., 2008
Resveratrol is a natural compound that influences energy metabolism and mitochondrial function and acts as a calorie restriction mimetic in animal obesity models.
“resveratrol treatment in mice fed a high calorie diet consistently improved various health parameters including glucose homeostasis, endurance and survival (Baur et al., 2006; Lagouge et al., 2006; Pearson et al., 2008; Sun et al., 2007), and has therefore been suggested to act as a calorie restriction mimetic.”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Pearson et al., 2008
Mammalian SIRT1 plays a context-dependent role in health span regulation, including mediating effects in metabolic stress such as high-fat diet-induced obesity.
“What is clear, however, is that mammalian SIRT1 plays a context-dependent role in health span regulation, for instance by mediating effects in metabolic stress situations, such as high-fat diet-induced obesity (Baur et al., 2006; Lagouge et al., 2006; Pearson et al., 2008).”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Pearson et al., 2008
Resveratrol treatment in mice on a high-calorie diet consistently improved health parameters including glucose homeostasis, endurance, and survival.
“Regardless of the mode of activation, resveratrol treatment in mice fed a high calorie diet consistently improved various health parameters including glucose homeostasis, endurance and survival (Baur et al., 2006; Lagouge et al., 2006; Pearson et al., 2008; Sun et al., 2007)”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Pearson et al., 2008
Because resveratrol's benefits resemble calorie restriction, these studies support PGC-1α activation as a central mechanism of CR.
“Since many of the beneficial effects of resveratrol are similar to those that would be expected from a calorie-restricted diet [151], these studies support the concept that activation of PGC-1α may be one of the central mechanisms of action of CR.”
From PGC-1α in aging and anti-aging interventions (2009) · cites this paper as [151]
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- Authors
- Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., Jamieson, H. A., Zhang, Y., Dunn, S. R., Sharma, K., Pleshko, N., Woollett, L. A., Csiszar, A., Ikeno, Y., Le Couteur, D., Elliott, P. J., Becker, K. G., Navas, P., Ingram, D. K., Wolf, N. S., Ungvari, Z., Sinclair, D. A., & de Cabo, R.
- Affiliations
- National Institutes of Health (US)
- Harvard University (US)
- New York Medical College (US)
- University of Michigan (US)
- The University of Sydney (AU)
- Johns Hopkins University (US)
- University of California San Diego (US)
- Hospital for Special Surgery (US)
- University of Cincinnati Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- GlaxoSmithKline (United Kingdom) (GB)
- Pennington Biomedical Research Center (US)
- University of Washington (US)
- Corresponding author
- Sinclair, David A.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 8
- Issue
- 2
- Pages
- 157-168
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2538685
- OpenAlex
- W2122073743
- Cited by
- 1,162
- References
- 88
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 31 · 2023: 33 · 2022: 32 · 2021: 57 · 2020: 46 · 2019: 67 · 2018: 59 · 2017: 58 · 2016: 65 · 2015: 91 · 2014: 94 · 2013: 104 · 2012: 91
- FWCI
- 39.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG19972, R01AG028730, R01AG019719, Z01AG000368, AG19719, R01AG019972)
- National Heart, Lung, and Blood Institute (R01HL077256, HL077256)
- National Eye Institute (R01EY011733)
- National Institute of General Medical Sciences (R01GM068072)
- National Institute of Diabetes and Digestive and Kidney Diseases (SP30 DK072437)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR046121)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R56HD034089, R01HD034089, HD034089)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, aging, longevity, age-related diseases, gene expression, albuminuria, inflammation, vascular endothelium, aortic elasticity, motor coordination, cataract, bone mineral density
- MeSH terms
- Resveratrol, Age Factors, Aging, Animals, Antioxidants, Energy Intake, Cardiovascular System, Food Deprivation, Food, Formulated, Gene Expression Regulation, Inflammation, Longevity, Male, Mice, Inbred C57BL, Osteoporosis, Stilbenes, Transcription, Genetic, Treatment Outcome, Apoptosis, Caloric Restriction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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