Resveratrol and obesity: can resveratrol relieve metabolic disturbances?
Open accessAbstract
There is an increasing need for novel preventive and therapeutic strategies to combat obesity and related metabolic disorders. In this respect, the natural polyphenol resveratrol has attracted significant interest. Animal studies indicate that resveratrol mimics the effects of calorie restriction via activation of sirtuin 1 (SIRT1). SIRT1 is an important player in the regulation of cellular energy homeostasis and mitochondrial biogenesis. Rodent studies have shown beneficial effects of resveratrol supplementation on mitochondrial function, glucose metabolism, body composition and liver fat accumulation. However, confirmation of these beneficial effects in humans by placebo-controlled clinical trials remains relatively limited. This review will give an overview of pre-clinical and clinical studies examining the effects of resveratrol on obesity-induced negative health outcomes. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
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Resveratrol is a potent activator of mitochondrial biogenesis in skeletal muscle.
“numerous reports have identified resveratrol as a potent activator of mitochondrial biogenesis in skeletal muscle (Figure 1)”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [173]
Resveratrol protects skeletal muscle from the deleterious effects of high fat feeding in mice.
“in addition to protecting skeletal muscle from the deleterious effects of high fat feeding in mice [173].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [173]
Variation in duration and dose of resveratrol may explain the diverse outcomes of these studies.
“Variation in duration and dose of resveratrol may explain the diverse outcomes of these studies (247).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [247]
Resveratrol is a plant-derived polyphenol that activates AMPK and, via SIRT1, increases PGC1α, PGC1α deacetylation, mitochondrial size and density, and mtDNA content in skeletal muscle.
“Resveratrol (3,5,4′-trihydroxystilbene) is a plant-derived polyphenol that activates AMPK and, via SIRT1, increases PGC1α, PGC1α deacetylation, mitochondrial size and density, and mtDNA content in skeletal muscle [reviewed in de Ligt et al. (247)].”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [247]
In the context of insulin-controlled metabolic flexibility, rodent studies largely show improved insulin sensitivity and glucose tolerance in models of obesity, diabetes, and metabolic dysfunction.
“In the context of insulin-controlled metabolic flexibility, rodent studies largely show improved insulin sensitivity and glucose tolerance in models of obesity, diabetes, and metabolic dysfunction [reviewed in de Ligt et al. (247)].”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [247]
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Resveratrol Suppresses T0901317-Induced Hepatic Fat Accumulation in Mice
Gao, M., & Liu, D. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9473-7 · Cited by 33 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- WGO, Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, global guideline, WGO Global Guidelines, 2012, pp. 1-29.
Cited by
Sorted by citations
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works
Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
Hesselink, M. K. C., Schrauwen-Hinderling, V., & Schrauwen, P. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.104 · Cited by 242 · see citing works
Self-citationNew strategies in sport nutrition to increase exercise performance
Close, G. L., Hamilton, D. L., Philp, A., Burke, L. M., & Morton, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.016 · Cited by 221 · see citing works
Sung, M. M., Kim, T. T., Denou, E., Soltys, C.-L. M., Hamza, S. M., Byrne, N. J., Masson, G., Park, H., Wishart, D. S., Madsen, K. L., et al. (2017) · Diabetes · doi:10.2337/db16-0680 · Cited by 204 · see citing works
Heebøll, S., Kreuzfeldt, M., Hamilton-Dutoit, S., Kjær Poulsen, M., Stødkilde-Jørgensen, H., Møller, H. J., Jessen, N., Thorsen, K., Kristina Hellberg, Y., Bønløkke Pedersen, S., et al. (2016) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1107620 · Cited by 154 · see citing works
Kantartzis, K., Fritsche, L., Bombrich, M., Machann, J., Schick, F., Staiger, H., Kunz, I., Schoop, R., Lehn‐Stefan, A., Heni, M., et al. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13268 · Cited by 87 · see citing works
de Ligt, M., Bruls, Y. M. H., Hansen, J., Habets, M.-F., Havekes, B., Nascimento, E. B. M., Moonen-Kornips, E., Schaart, G., Schrauwen-Hinderling, V. B., van Marken Lichtenbelt, W., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.004 · Cited by 79 · see citing works
Self-citationChristenson, J., Whitby, S. J., Mellor, D., Thomas, J., McKune, A., Roach, P. D., & Naumovski, N. (2016) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0035 · Cited by 47 · see citing works
- Authors
- de Ligt, M., Timmers, S., & Schrauwen, P.
- Affiliations
- Maastricht University Medical Centre (NL)
- Corresponding author
- Schrauwen, Patrick
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 1852
- Issue
- 6
- Pages
- 1137-1144
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2003504981
- Cited by
- 135
- References
- 82
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 17 · 2017: 17 · 2016: 19 · 2015: 12 · 2014: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Dutch Diabetes Foundation (2012.00.1525)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, obesity, SIRT1, mitochondrial biogenesis, energy homeostasis, glucose metabolism, hepatic lipid accumulation, body composition, polyphenols, metabolic disorders, clinical trials
- MeSH terms
- Resveratrol, Animals, Adipose Tissue, Brown, Humans, Mitochondria, Obesity, Stilbenes, Sirtuins, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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