Metabolic effects of resveratrol: addressing the controversies

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Therapeutic potential of resveratrol: the in vivo evidence

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Type 2 diabetes as an inflammatory disease

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Wine, alcohol, platelets, and the French paradox for coronary heart disease

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Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

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Pharmacology, physiology, and mechanisms of incretin hormone action.

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Molecular inflammation: Underpinnings of aging and age-related diseases

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

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ATM Activation by Oxidative Stress

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Mechanism of Human SIRT1 Activation by Resveratrol

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Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor

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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

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Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

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Inhibition of human LDL oxidation by resveratrol

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SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase

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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

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AMP‐activated protein kinase phosphorylation of endothelial NO synthase

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent

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SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

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Sirt1 protects against high-fat diet-induced metabolic damage

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Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

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Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Substrate-specific activation of sirtuins by resveratrol

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Resveratrol stimulates AMP kinase activity in neurons

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

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Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

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Calorie restriction and aging: review of the literature and implications for studies in humans

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Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

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Absorption of three wine-related polyphenols in three different matrices by healthy subjects

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Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

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Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice

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Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase

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AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

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SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

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Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

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Small molecule SIRT1 activators for the treatment of aging and age-related diseases

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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators

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FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2

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Resveratrol: A multitargeted agent for age-associated chronic diseases

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Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes

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Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β*

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Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 495

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., III, J. L. W., Goodyear, L. J., & Tong, Q. (2009) · Aging · doi:10.18632/aging.100075 · Cited by 487

Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1

Dioum, E. M., Chen, R., Alexander, M. S., Zhang, Q., Hogg, R. T., Gerard, R. D., & Garcia, J. A. (2009) · Science · doi:10.1126/science.1169956 · Cited by 478

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

Bhatt, J. K., Thomas, S., & Nanjan, M. J. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.003 · Cited by 475

Resveratrol induces mitochondrial biogenesis in endothelial cells

Csiszár, A., Labinskyy, N., Pinto, J. T., Ballabh, P., Zhang, H., Losonczy, G., Pearson, K. J., de Cabo, R., Pacher, P., Zhang, C., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2009 · Cited by 459

High-Dose Resveratrol Supplementation in Obese Men

Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455

Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals

Zheng, J., & Ramirez, V. D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703397 · Cited by 453

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020296 · Cited by 441

Pharmacokinetic and safety profile oftrans‐resveratrol in a rising multiple‐dose study in healthy volunteers

Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427

Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade

Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426

Are sirtuins viable targets for improving healthspan and lifespan?

Baur, J. A., Ungvari, Z. I., Minor, R. K., Couteur, D. G. L., & de Cabo, R. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3738 · Cited by 393

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 389

Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols

Gledhill, J. R., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706290104 · Cited by 386

LKB1/STRAD Promotes Axon Initiation During Neuronal Polarization

Shelly, M., Cancedda, L., Heilshorn, S. C., Sumbre, G., & Poo, M. (2007) · Cell · doi:10.1016/j.cell.2007.04.012 · Cited by 368

Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease

Magyar, K., Halmosi, R., Pálfi, A., Fehér, G., Czopf, L., Fulop, A., Battyány, I., Sümegi, B., Tóth, K., & Szabados, E. (2012) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1424 · Cited by 364

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

Tanno, M., Kuno, A., Yano, T., Miura, T., Hisahara, S., Ishikawa, S., Shimamoto, K., & Horio, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090266 · Cited by 358

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

Ungvari, Z. I., Labinskyy, N., Mukhopadhyay, P., Pinto, J. T., Bagi, Z. A., Ballabh, P., Zhang, C., Pacher, P., & Csiszár, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00375.2009 · Cited by 348

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Cerutti, R., Pirinen, E., Lamperti, C., Marchet, S., Sauve, A. A., Li, W., Leoni, V., Schon, E. A., Dantzer, F., Auwerx, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.001 · Cited by 343

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

Gerhart‐Hines, Z., Dominy, J. E., Blättler, S. M., Jedrychowski, M. P., Banks, A. S., Lim, J.-H., Chim, H., Gygi, S. P., & Puigserver, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.12.005 · Cited by 336

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

Chow, H. ‐. S., Garland, L. L., Hsu, C., Vining, D. R., Chew, W. M., Miller, J. A., Perloff, M., Crowell, J. A., & Alberts, D. S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0155 · Cited by 333

SRT1720 improves survival and healthspan of obese mice

Minor, R. K., Baur, J. A., Gomes, A. P., Ward, T. M., Csiszár, A., Mercken, E. M., Abdelmohsen, K., Shin, Y., Cantó, C., Scheibye‐Knudsen, M., et al. (2011) · Scientific Reports · doi:10.1038/srep00070 · Cited by 306

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

Mudò, G., Mäkelä, J., Liberto, V. D., Tselykh, T. V., Olivieri, M., Piepponen, P. T., Eriksson, O., Mälkiä, A., Bonomo, A., Kairisalo, M., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0850-z · Cited by 305

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

Chachay, V., Macdonald, G. A., Martin, J. H., Whitehead, J. P., O'Moore‐Sullivan, T. M., Lee, P., Franklin, M. E., Klein, K., Taylor, P. J., Ferguson, M. L., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.024 · Cited by 296

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

Spanier, G., Xu, H., Xia, N., Tobias, S., Deng, S., Wojnowski, L., Förstermann, U., & Li, H. (2009) · PubMed · Cited by 288

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

Gertz, M., Nguyen, G. T. T., Fischer, F. F., Suenkel, B., Schlicker, C., Fränzel, B., Tomaschewski, J., Aladini, F., Becker, C., Wolters, D. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049761 · Cited by 286

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

Djouder, N., Tuerk, R. D., Suter, M., Chiabotti, P. S., Thali, R. F., Scholz, R., Vaahtomeri, K., Auchli, Y., Rechsteiner, H., Brunisholz, R., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.339 · Cited by 285

Urinary and Plasma Levels of Resveratrol and Quercetin in Humans, Mice, and Rats after Ingestion of Pure Compounds and Grape Juice

Meng, X., Maliakal, P. P., Lu, H., Lee, M., & Yang, C. S. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030582e · Cited by 281

Pilot study of resveratrol in older adults with impaired glucose tolerance

Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr235 · Cited by 281

Effects of stilbenes on arachidonate metabolism in leukocytes

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Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO

Wang, Y., & Tissenbaum, H. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.005 · Cited by 269

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.03.030 · Cited by 260

Effects of resveratrol on the rat brain respiratory chain.

Zini, R., Morin, C., Bertelli, A., Bertelli, A., & Tillement, J. P. (1999) · PubMed · Cited by 252

Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

Jiménez, Y., Mattison, J. A., Pearson, K. J., Martín‐Montalvo, A., Palacios, H. H., Sossong, A. M., Ward, T. M., Younts, C. M., Lewis, K. N., Allard, J. S., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.004 · Cited by 247

Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6427-8 · Cited by 244

Resveratrol increases vascular oxidative stress resistance

Ungvari, Z. I., Orosz, Z. Z., Rivera, A., Labinskyy, N., Xiangmin, Z., Olson, S. C., Podlutsky, A. J., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01258.2006 · Cited by 243

Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

Ferretta, A., Gaballo, A., Tanzarella, P., Piccoli, C., Capitanio, N., Nico, B., Annese, T., Paola, M. D., Dell’Aquila, C., Mari, M. D., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.010 · Cited by 243

Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

Park, C.-E., Kim, M., Lee, J. H., Min, B.-I., Bae, H., Choe, W., Kim, S. S., & Ha, J. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.25 · Cited by 242

An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol

Ghanim, H., Sia, C. L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., & Dandona, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0482 · Cited by 241

Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2

Szewczuk, L. M., Forti, L., Stivala, L. A., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314302200 · Cited by 240

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

Dolinsky, V. W., Chan, A. Y. M., Frayne, I. R., Light, P. E., Rosiers, C. D., & Dyck, J. R. B. (2009) · Circulation · doi:10.1161/circulationaha.108.787440 · Cited by 237

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

Higashida, K., Kim, S. H., Jung, S. R., Asaka, M., Holloszy, J. O., & Han, D.-H. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001603 · Cited by 237

Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD

Culpitt, S. V. (2003) · Thorax · doi:10.1136/thorax.58.11.942 · Cited by 227

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., & Sunagawa, K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.166991 · Cited by 221

SIRT1 Activation by Small Molecules

Dai, H., Kustigian, L. M., Carney, D. P., Case, A. W., Considine, T., Hubbard, B. P., Perni, R. B., Riera, T. V., Szczepankiewicz, B. G., Vlasuk, G. P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133892 · Cited by 215

Resveratrol Improves Endothelial Function

Zhang, H., Zhang, J., Ungvari, Z. I., & Zhang, C. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.187146 · Cited by 215

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., et al. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls070 · Cited by 212

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

Csiszár, A., Labinskyy, N., Olson, S. C., Pinto, J. T., Gupte, S. A., WU, J. M., Hu, F., Ballabh, P., Podlutsky, A. J., Losonczy, G., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133397 · Cited by 210

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

Dolinsky, V. W., Chakrabarti, S., Pereira, T. J., Oka, T., Levasseur, J. L., Beker, D. L., Zordoky, B. N. M., Morton, J. S., Nagendran, J., Lopaschuk, G. D., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.018 · Cited by 209

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S. R., An, S. S., Santhanam, L., Martin, B., Faulkner, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.018 · Cited by 206

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 204

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase

Tóth, P., Tarantini, S., Tucsek, Z., Ashpole, N. M., Sosnowska, D., Gautam, T., Ballabh, P., Koller, Á., Sonntag, W. E., Csiszár, A., et al. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00744.2013 · Cited by 197

Resveratrol as a calorie restriction mimetic: therapeutic implications

Chung, J. H., Manganiello, V., & Dyck, J. R. B. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.004 · Cited by 192

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice

Choi, Y. H., Park, S., Hockman, S. C., Zmuda‐Trzebiatowska, E., Svennelid, F., Haluzı́k, M., Gavrilova, O., Ahmad, F., Pepin, L., Napolitano, M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24867 · Cited by 187

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

Xia, N., Daiber, A., Habermeier, A., Closs, E. I., Thum, T., Spanier, G., Lü, Q., Oelze, M. W., Torzewski, M., Lackner, K. J., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168724 · Cited by 186

Anti-inflammatory Effect of Resveratrol and Polydatin by In Vitro IL-17 Modulation

Lanzilli, G., Cottarelli, A., Nicotera, G., Guida, S., Ravagnan, G., & Fuggetta, M. P. (2011) · Inflammation · doi:10.1007/s10753-011-9310-z · Cited by 178

SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis

Shindler, K. S., Ventura, E. S., Rex, T. S., Elliott, P. J., & Rostami, A. M. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0131 · Cited by 174

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Semba, R. D., Ferrucci, L., Bartali, B., Urpí-Sardà, M., Zamora‐Ros, R., Sun, K., Cherubini, A., Bandinelli, S., & Andrés‐Lacueva, C. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.1582 · Cited by 172

Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure

Thandapilly, S. J., Wojciechowski, P. W., Behbahani, J., Louis, X. L., Yu, L., Juric, D., Kopilas, M. A., Anderson, H. D., & Netticadan, T. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.228 · Cited by 172

Calorie restriction and resveratrol in cardiovascular health and disease

Dolinsky, V. W., & Dyck, J. R. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.010 · Cited by 172

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control

Dao, T.-M. A., Waget, A., Klopp, P., Sérino, M., Vachoux, C., Pechère, L., Drucker, D. J., Champion, S., Barthélemy, S., Barra, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020700 · Cited by 168

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

Viswanathan, M., & Guarente, L. (2011) · Nature · doi:10.1038/nature10440 · Cited by 166

Resveratrol and life extension

Agarwal, B., & Baur, J. A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05850.x · Cited by 163

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

Suchankova, G., Nelson, L. E., Gerhart-Hines, Z., Kelly, M., Gauthier, M.-S., Saha, A. K., Ido, Y., Puigserver, P., & Ruderman, N. B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.130 · Cited by 162

Resveratrol stimulates nitric oxide production by increasing estrogen receptor αa‐Src‐caveolin‐1 interaction and phosphorylation in human umbilical vein endothelial cells

Klinge, C. M., Wickramasinghe, N. S. M. D., Ivanova, M. M., & Dougherty, S. M. (2008) · The FASEB Journal · doi:10.1096/fj.07-103366 · Cited by 162

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol

Xia, N., Strand, S., Schlufter, F., Siuda, D., Reifenberg, G., Kleinert, H., Förstermann, U., & Li, H. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.04.001 · Cited by 157

Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats

Miatello, R. M., VAZQUEZ, M., Renna, N. F., Cruzado, M., Zumino, A. Z. P., & Risler, N. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.12.012 · Cited by 152

Resveratrol Induces Apoptosis in Chemoresistant Cancer Cells via Modulation of AMPK Signaling Pathway

Hwang, J., KWAK, D. W., Sun, L., Kim, H. M., KIM, Y. M., & Park, O. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.047 · Cited by 152

Activation of AMP-Activated Protein Kinase by Interleukin-6 in Rat Skeletal Muscle

Kelly, M., Gauthier, M., Saha, A. K., & Ruderman, N. B. (2009) · Diabetes · doi:10.2337/db08-1293 · Cited by 151

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells

Desquiret‐Dumas, V., Guéguen, N., Leman, G., Baron, S., Nivet‐Antoine, V., Chupin, S., Chevrollier, A., Vessières, E., Ayer, A., Ferré, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.466490 · Cited by 147

The effects of 30-days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men

Konings, E., Timmers, S., Boekschoten, M. V., Goossens, G. H., Jocken, J. W., Afman, L. A., Müller, M., Schrauwen, P., Mariman, E. C., & Blaak, E. E. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.155 · Cited by 143

Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

Omar, B. A., Zmuda‐Trzebiatowska, E., Manganiello, V. C., Göransson, O., & Degerman, E. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.015 · Cited by 141

Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

Fiori, J. L., Shin, Y., Kim, W., Krzysik-Walker, S. M., González‐Mariscal, I., Carlson, O. D., Sanghvi, M., Moaddel, R., Farhang, K., Gadkaree, S. K., et al. (2013) · Diabetes · doi:10.2337/db13-0266 · Cited by 140

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

Nwachukwu, J. C., Srinivasan, S., Bruno, N. E., Parent, A. A., Hughes, T., Pollock, J. A., Gjyshi, O., Cavett, V. J., Nowak, J., Garcia-Ordoñez, R. D., et al. (2014) · eLife · doi:10.7554/elife.02057 · Cited by 137

Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment

Fujitaka, K., Otani, H., Jo, F., Jo, H., Nomura, E., Iwasaki, M., Nishikawa, M., Iwasaka, T., & Das, D. K. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.028 · Cited by 129

Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase

Nin, V., Escande, C., Chini, C. C. S., Giri, S., Camacho-Pereira, J., Matalonga, J., Lou, Z., & Chini, E. N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365874 · Cited by 123

Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence

Albani, D., Polito, L., & Forloni, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1215 · Cited by 122

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation

Qiang, L., Lin, H. V., Kim-Muller, J. Y., Welch, C. L., Gu, W., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.007 · Cited by 122

Sirt1 activation by resveratrol is substrate sequence-selective

Lakshminarasimhan, M., Rauh, D., Schutkowski, M., & Steegborn, C. (2013) · Aging · doi:10.18632/aging.100542 · Cited by 120

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

Rascón, B., Hubbard, B. P., Sinclair, D. A., & Amdam, G. V. (2012) · Aging · doi:10.18632/aging.100474 · Cited by 119

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang, C., Wheeler, C. T., Alberico, T., Sun, X., Seeberger, J., Laslo, M., Spangler, E. L., Kern, B., de Cabo, R., & Zou, S. (2011) · AGE · doi:10.1007/s11357-011-9332-3 · Cited by 118

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

Banerjee, K. K., Ayyub, C., Syed, Z. A., Mandot, V., Prasad, N. G., & Kolthur‐Seetharam, U. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.11.013 · Cited by 117

Chronic Resveratrol Enhances Endothelium-Dependent Relaxation but Does Not Alter eNOS Levels in Aorta of Spontaneously Hypertensive Rats

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Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β

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Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages

Chow, S., Hshu, Y.-C., Wang, J., & Chen, J. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00881.2006 · Cited by 111

Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus

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Is Resveratrol an Estrogen Agonist in Growing Rats?**This work was supported by NIH Grant AA-11140 and the Mayo Foundation.

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Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents

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PKA/AMPK signaling in relation to adiponectin’s antiproliferative effect on multiple myeloma cells

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Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization

Kaneko, H., Anzai, T., Morisawa, M., Kohno, T., Nagai, T., Anzai, A., Takahashi, T., Shimoda, M., Sasaki, A., Maekawa, Y., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.042 · Cited by 104

Protective Effect Of Resveratrol On Oxidative Damage In Male And Female Stroke‐Prone Spontaneously Hypertensive Rats

Mizutani, K., Ikeda, K., Kawai, Y., & Yamori, Y. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03415.x · Cited by 100

Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

Kawashima, T., Inuzuka, Y., Okuda, J., Kato, T., Niizuma, S., Tamaki, Y., Iwanaga, Y., Kawamoto, A., Narazaki, M., Matsuda, T., et al. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.09.013 · Cited by 93

Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective

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Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model

Liu, Z., Yan, S., Zhang, X., Liu, Z., Zhang, W., Mao, W., Wang, W., Cui, W., Zhang, X., Jia, X., et al. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04303.x · Cited by 88

Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet

Poulsen, M. M., Larsen, J. Ø., Hamilton-Dutoit, S. J., Clasen, B. F., Jessen, N., Paulsen, S. K., Kjær, T. N., Richelsen, B., & Pedersen, S. B. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.08.004 · Cited by 86

Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissue in Vivo

Pulinilkunnil, T., He, H., Kong, D., Asakura, K., Peroni, O. D., Lee, A. D., & Kahn, B. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.218719 · Cited by 85

Resveratrol Improves Cardiovascular Function in DOCA-Salt Hypertensive Rats

Chan, V., Fenning, A. S., Iyer, A., Hoey, A. J., & Brown, L. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111794480552 · Cited by 84

Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohnʼs disease

Rahal, K., Schmiedlin‐Ren, P., Adler, J., Dhanani, M., Sultani, V., Rittershaus, A. C., Reingold, L. J., Zhu, J., McKenna, B. J., Christman, G. M., et al. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21843 · Cited by 84

Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines

Hussain, A. R., Shahab Uddin, M. S., Bu, R., Khan, O. S., Ahmed, S. O., Ahmed, M., & Al-Kuraya, K. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024703 · Cited by 83

Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

Toklu, H. Z., Şehırlı, Ö., Erşahin, M., Süleymanoğlu, S., Yiğiner, Ö., Emekli‐Alturfan, E., Yarat, A., Yeğen, B. Ç., & Şener, G. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01197.x · Cited by 80

The Red Wine Antioxidant Resveratrol Prevents Cardiomyocyte Injury Following Ischemia-Reperfusion Via Multiple Sites and Mechanisms

Goh, S. S. C., Woodman, O. L., Pepe, S., Cao, A. H., Qin, C. X., & Ritchie, R. H. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.101 · Cited by 80

Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B

Zhang, R., Maratos–Flier, E., & Flier, J. S. (2009) · Endocrinology · doi:10.1210/en.2009-0108 · Cited by 79

Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri

Yu, X., & Li, G. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.009 · Cited by 78

Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

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Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation

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Resveratrol suppresses interferon-γ-induced biochemical pathways in human peripheral blood mononuclear cells in vitro

Wirleitner, B., Schroecksnadel, K., Winkler, C., Schennach, H., & Fuchs, D. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.03.008 · Cited by 77

Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention

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Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats

Beaudoin, M., Snook, L. A., Arkell, A. M., Simpson, J. A., Holloway, G. P., & Wright, D. C. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00200.2013 · Cited by 73

Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK

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Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus

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The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release

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C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest

Fogarty, S., & Hardie, D. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806152200 · Cited by 63

Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway

Thandapilly, S. J., Louis, X. L., Yang, T., Defries, D. M., Yu, L., Zhang, S., Wigle, J. T., Kardami, E., Zahradka, P. C., Taylor, C. G., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.042 · Cited by 61

Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae

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Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase

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Effects of trans‐resveratrol on hypertension‐induced cardiac hypertrophy using the partially nephrectomized rat model

Liu, Z., Song, Y., Zhang, X., Liu, Z., Zhang, W., Mao, W., Wang, W., Cui, W., Zhang, X., Jia, X., et al. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04299.x · Cited by 55

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice

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Resveratrol (RV): A pharmacological review and call for further research

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Resveratrol and Its Effects on the Vascular System

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Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

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An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

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Therapeutic Versatility of Resveratrol Derivatives

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Resveratrol and obesity: can resveratrol relieve metabolic disturbances?

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Metabolic effects of resveratrol: experimental and human clinical aspects

Poulsen, M. M. (2013)

Resveratrol in metabolic health: an overview of the current evidence and perspectives

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Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

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Progress in the Preclinical and Clinical Study of Resveratrol for Vascular Metabolic Disease

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