Cited by 110Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesAlcohol Consumption and Health Effects

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Metabolic effects of resveratrol: addressing the controversies

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Bitterman, Jacob L., Chung, Jay H.·2015·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-014-1808-8PMC PMC6324849

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Abstract

Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol.

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1 retracted

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Authors: Bitterman, J. L., & Chung, J. H.
Affiliations: National Institutes of Health (US)
Corresponding author: Chung, Jay H.
ORCID: Chung, Jay H.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2014-12-30
Volume: 72
Issue: 8
Pages: 1473-1488
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-014-1808-8
PMC: PMC6324849
OpenAlex: W1981445076
Cited by: 109
References: 216
Citations by year: 2026: 5 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 14 · 2018: 9 · 2017: 15 · 2016: 18 · 2015: 4
FWCI: 1.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (Z01HL002243)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: resveratrol, polyphenols, metabolic effects, mitochondrial function, obesity, type 2 diabetes, inflammation, cancer cell growth, cardiovascular dysfunction, clinical trials, treatment development
MeSH terms: Resveratrol, Animals, Antioxidants, Diabetes Mellitus, Type 2, Humans, Longevity, Obesity, Stilbenes, Signal Transduction, Neuroprotective Agents, Cyclic Nucleotide Phosphodiesterases, Type 4, AMP-Activated Protein Kinases, Sirtuin 1

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Metabolic effects of resveratrol: addressing the controversies

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