The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Wnt signaling and cellular metabolism in osteoblasts
Open accessAbstract
The adult human skeleton is a multifunctional organ undergoing continuous remodeling. Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone resorption by osteoclasts and bone formation by osteoblasts; disturbance of such balance is the root cause for various bone disorders including osteoporosis. To develop effective and safe therapeutics to modulate bone formation, it is essential to elucidate the molecular mechanisms governing osteoblast differentiation and activity. Due to their specialized function in collagen synthesis and secretion, osteoblasts are expected to consume large amounts of nutrients. However, studies of bioenergetics and building blocks in osteoblasts have been lagging behind those of growth factors and transcription factors. Genetic studies in both humans and mice over the past 15 years have established Wnt signaling as a critical mechanism for stimulating osteoblast differentiation and activity. Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic glycolysis, glutamine catabolism as well as fatty acid oxidation in osteoblast-lineage cells. Such findings therefore reveal an important regulatory axis between bone anabolic signals and cellular bioenergetics. A comprehensive understanding of osteoblast metabolism and its regulation is likely to reveal molecular targets for novel bone therapies.
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“Wnt proteins bind to their receptors (Frizzled) and coreceptors (LRP5/6) to promote the stabilization of β-catenin in the cytoplasm, which translocates to the nucleus, where it induces the expression of osteogenesis-related genes.38,39”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [39]
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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519
Bone remodeling: an operational process ensuring survival and bone mechanical competence
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
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The Regulation of Bone Metabolism and Disorders by Wnt Signaling
Maeda, K., Kobayashi, Y., Koide, M., Uehara, S., Okamoto, M., Ishihara, A., Kayama, T., Saito, M., & Marumo, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225525 · Cited by 360
Osteoporosis pathogenesis and treatment: existing and emerging avenues
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Metadata
- Authors
- Karner, C. M., & Long, F.
- Affiliations
- Duke University (US)
- Washington University in St. Louis (US)
- Corresponding author
- Long, Fanxin
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-11-26
- Volume
- 74
- Issue
- 9
- Pages
- 1649-1657
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC5380548
- OpenAlex
- W2552658430
- Cited by
- 295
- References
- 151
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 39 · 2023: 35 · 2022: 39 · 2021: 36 · 2020: 46 · 2019: 27 · 2018: 19 · 2017: 14
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR060456, AR060674)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- Wnt signaling, osteoblasts, cellular metabolism, osteogenic differentiation, bone formation, bone remodeling, aerobic glycolysis, glutamine catabolism, fatty acid oxidation, bioenergetics, osteoporosis, bone anabolic therapy
- MeSH terms
- Animals, Bone and Bones, Humans, Models, Biological, Osteoblasts, Signal Transduction, Wnt Proteins, Wnt Signaling Pathway
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