Cited by 295Bone Metabolism and DiseasesWnt/β-catenin signaling in development and cancerAlkaline Phosphatase Research Studies

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Wnt signaling and cellular metabolism in osteoblasts

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Karner, Courtney M., Long, Fanxin·2017·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-016-2425-5PMC PMC5380548

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Abstract

The adult human skeleton is a multifunctional organ undergoing continuous remodeling. Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone resorption by osteoclasts and bone formation by osteoblasts; disturbance of such balance is the root cause for various bone disorders including osteoporosis. To develop effective and safe therapeutics to modulate bone formation, it is essential to elucidate the molecular mechanisms governing osteoblast differentiation and activity. Due to their specialized function in collagen synthesis and secretion, osteoblasts are expected to consume large amounts of nutrients. However, studies of bioenergetics and building blocks in osteoblasts have been lagging behind those of growth factors and transcription factors. Genetic studies in both humans and mice over the past 15 years have established Wnt signaling as a critical mechanism for stimulating osteoblast differentiation and activity. Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic glycolysis, glutamine catabolism as well as fatty acid oxidation in osteoblast-lineage cells. Such findings therefore reveal an important regulatory axis between bone anabolic signals and cellular bioenergetics. A comprehensive understanding of osteoblast metabolism and its regulation is likely to reveal molecular targets for novel bone therapies.

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Authors: Karner, C. M., & Long, F.
Affiliations: Duke University (US)
Washington University in St. Louis (US)
Corresponding author: Long, Fanxin
ORCID: Karner, Courtney M.
Long, Fanxin
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-11-26
Volume: 74
Issue: 9
Pages: 1649-1657
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-016-2425-5
PMC: PMC5380548
OpenAlex: W2552658430
Cited by: 295
References: 151
Citations by year: 2026: 19 · 2025: 19 · 2024: 39 · 2023: 35 · 2022: 39 · 2021: 36 · 2020: 46 · 2019: 27 · 2018: 19 · 2017: 14
FWCI: 1.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR060456, AR060674)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Keywords: Wnt signaling, osteoblasts, cellular metabolism, osteogenic differentiation, bone formation, bone remodeling, aerobic glycolysis, glutamine catabolism, fatty acid oxidation, bioenergetics, osteoporosis, bone anabolic therapy
MeSH terms: Animals, Bone and Bones, Humans, Models, Biological, Osteoblasts, Signal Transduction, Wnt Proteins, Wnt Signaling Pathway

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Wnt signaling and cellular metabolism in osteoblasts

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