Cited by 295Bone Metabolism and DiseasesWnt/β-catenin signaling in development and cancerAlkaline Phosphatase Research Studies

The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.

Wnt signaling and cellular metabolism in osteoblasts

Open access

Karner, Courtney M., Long, Fanxin·2017·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-016-2425-5PMC PMC5380548

Open this paper in CoChat — free account

Abstract

The adult human skeleton is a multifunctional organ undergoing continuous remodeling. Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone resorption by osteoclasts and bone formation by osteoblasts; disturbance of such balance is the root cause for various bone disorders including osteoporosis. To develop effective and safe therapeutics to modulate bone formation, it is essential to elucidate the molecular mechanisms governing osteoblast differentiation and activity. Due to their specialized function in collagen synthesis and secretion, osteoblasts are expected to consume large amounts of nutrients. However, studies of bioenergetics and building blocks in osteoblasts have been lagging behind those of growth factors and transcription factors. Genetic studies in both humans and mice over the past 15 years have established Wnt signaling as a critical mechanism for stimulating osteoblast differentiation and activity. Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic glycolysis, glutamine catabolism as well as fatty acid oxidation in osteoblast-lineage cells. Such findings therefore reveal an important regulatory axis between bone anabolic signals and cellular bioenergetics. A comprehensive understanding of osteoblast metabolism and its regulation is likely to reveal molecular targets for novel bone therapies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-016-2425-5

Cites

151 of 151 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,281
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298

Show all 151 references

Sorted by citations

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359
The Regulation of Bone Metabolism and Disorders by Wnt Signaling
Maeda, K., Kobayashi, Y., Koide, M., Uehara, S., Okamoto, M., Ishihara, A., Kayama, T., Saito, M., & Marumo, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225525 · Cited by 360
Osteoporosis pathogenesis and treatment: existing and emerging avenues
Liang, B., Burley, G., Lin, S., & Shi, Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00371-3 · Cited by 250
Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis
Kovács, B., Vajda, E., & Nagy, E. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184653 · Cited by 224
Self-powered implantable electrical stimulator for osteoblasts’ proliferation and differentiation
Tian, J., Shi, R., Liu, Z., Ouyang, H., Yu, M., Zhao, C., Zou, Y., Jiang, D., Zhang, J., & Li, Z. (2019) · Nano Energy · doi:10.1016/j.nanoen.2019.02.073 · Cited by 196
ROS signaling cascades: dual regulations for osteoclast and osteoblast
Tao, H., Ge, G., Liang, X., Zhang, W., Sun, H., Li, M., & Geng, D. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa098 · Cited by 182
Glucose metabolism in bone
Karner, C. M., & Long, F. (2017) · Bone · doi:10.1016/j.bone.2017.08.008 · Cited by 163
Self-citation
Targeting strategies for bone diseases: signaling pathways and clinical studies
Xu, H., Wang, W., Liu, X., Huang, W. H., Chen, Z., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01467-8 · Cited by 177
Interferon-Gamma-Mediated Osteoimmunology
Tang, M., Tian, L., Luo, G., & Yu, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01508 · Cited by 163
Insights into Oxidative Stress in Bone Tissue and Novel Challenges for Biomaterials
Cerqueni, G., Scalzone, A., Licini, C., Gentile, P., & Mattioli‐Belmonte, M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112433 · Cited by 131
Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
Williams, D. F. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.08.014 · Cited by 135
The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States
Choi, J. U. A., Kijas, A. W., Lauko, J., & Rowan, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770143 · Cited by 133
The Development of Molecular Biology of Osteoporosis
Gao, Y., Patil, S., & Jia, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158182 · Cited by 116
Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis
Estell, E. G., & Rosen, C. J. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00426-5 · Cited by 115
Gut microbiota and bone metabolism
Lu, L., Chen, X., Liu, Y., & Yu, X. (2021) · The FASEB Journal · doi:10.1096/fj.202100451r · Cited by 127
The role of Wnt signaling pathway in tumor metabolic reprogramming
Mo, Y., Wang, Y., Zhang, L., Yang, L., Zhou, M., Li, X., Li, Y., Li, G., Zeng, Z., Xiong, W., et al. (2019) · Journal of Cancer · doi:10.7150/jca.31166 · Cited by 106
Mechanical Properties of Compact Bone Defined by the Stress-Strain Curve Measured Using Uniaxial Tensile Test: A Concise Review and Practical Guide
Lin, C.-Y., & Kang, J. (2021) · Materials · doi:10.3390/ma14154224 · Cited by 105
The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism
Zhang, J., Hu, W., Zou, Z., Li, Y., Kang, F., Li, J., & Dong, S. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101122 · Cited by 111
Wnt target genes and where to find them
Ramakrishnan, A., & Cadigan, K. M. (2017) · F1000Research · doi:10.12688/f1000research.11034.1 · Cited by 90
Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders
Caspi, M., Wittenstein, A., Kazelnik, M., Shor-Nareznoy, Y., & Rosin‐Arbesfeld, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.010 · Cited by 91
Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials
Hutchings, G., Moncrieff, L., Dompé, C., Janowicz, K., Sibiak, R., Bryja, A., Jankowski, M., Mozdziak, P. E., Bukowska, D., Antosik, P., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010139 · Cited by 93
Recent Progresses in the Treatment of Osteoporosis
Li, S., He, S., Xie, P.-Y., Li, W., Zhang, X., Li, T.-F., & Li, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.717065 · Cited by 91
Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy
Liu, D., Chen, L., Zhao, H., Vaziri, N. D., Ma, S., & Zhao, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108990 · Cited by 84
Enhancing effects of myricetin on the osteogenic differentiation of human periodontal ligament stem cells via BMP-2/Smad and ERK/JNK/p38 mitogen-activated protein kinase signaling pathway
Kim, H.-Y., Park, S., & Choung, S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.012 · Cited by 83
MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism
Zheng, H., Liu, J., Tycksen, E., Nunley, R. M., & McAlinden, A. (2019) · Bone · doi:10.1016/j.bone.2019.03.020 · Cited by 76
An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells
Mollentze, J., Durandt, C., & Pepper, M. S. (2021) · Stem Cells International · doi:10.1155/2021/9919361 · Cited by 81
Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone
Prisby, R. D. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0666 · Cited by 75
7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis
Fan, X., Zhao, Z., Gu, Y., Han, J., Ye, K., & Zhang, Y. (2021) · eLife · doi:10.7554/elife.64872 · Cited by 74
Metabolic reprogramming in skeletal cell differentiation
Bertels, J., He, G., & Long, F. (2024) · Bone Research · doi:10.1038/s41413-024-00374-0 · Cited by 78
Self-citation
Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis
Yang, J., Ueharu, H., & Mishina, Y. M. (2020) · Bone · doi:10.1016/j.bone.2020.115467 · Cited by 76
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome
Dai, W., Wang, M., Wang, P., Wen, J., Wang, J., Cha, S., Xiao, X., He, Y., Shu, R., & Bai, D. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4827 · Cited by 73
Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis
Zhou, T., Yang, Y., Chen, Q., & Xie, L. (2019) · Stem Cells International · doi:10.1155/2019/8928934 · Cited by 73
A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme
Wei, F., Neal, C. J., Sakthivel, T. S., Fu, Y., Omer, M., Adhikary, A., Ward, S., Ta, K. M., Moxon, S., Molinari, M., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.011 · Cited by 74
Osteometabolism: Metabolic Alterations in Bone Pathologies
Srivastava, R. K., Sapra, L., & Mishra, P. K. (2022) · Cells · doi:10.3390/cells11233943 · Cited by 79
Increased glycolysis mediates Wnt7b‐induced bone formation
Chen, H., Ji, X., Lee, W., Shi, Y., Li, B., Abel, E. D., Jiang, D., Huang, W., & Long, F. (2019) · The FASEB Journal · doi:10.1096/fj.201900201rr · Cited by 72
Self-citation
Lactate induces osteoblast differentiation by stabilization of HIF1α
Wu, Y., Wang, M., Feng, H., Peng, Y., Sun, J., Qu, X., & Li, C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.017 · Cited by 71
Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
Fang, F., VanCleave, A. M., Helmuth, R., de Oliveira, H. T., Rickel, K., Wollenzien, H., Sun, H., Zeng, E., Zhao, J., & Tao, J. (2018) · Oncotarget · doi:10.18632/oncotarget.26377 · Cited by 71
Circadian rhythms affect bone reconstruction by regulating bone energy metabolism
Luo, B., Zhou, X., Tang, Q., Yin, Y., Feng, G., Li, S., & Chen, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03068-x · Cited by 72
Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway
Kim, J., Yang, Y.-S., Hong, J., Chaugule, S. R., Chun, H., van der Meulen, M. C. H., Xu, R., Greenblatt, M. B., & Shim, J. (2022) · eLife · doi:10.7554/elife.78069 · Cited by 72
Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome
Lee, J., Faderl, S. H., Pagel, J. M., Jung, C. W., Yoon, S., Pardanani, A. D., Becker, P. S., Lee, H., Choi, J., Lee, K.-J., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000757 · Cited by 66
Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β‐catenin signaling pathways
Yu, A. X., Xu, M. L., Yao, P., Kwan, K. K., Liu, Y., Duan, R., Dong, T. T.-X., Ko, K., & Tsim, K. W. K. (2020) · The FASEB Journal · doi:10.1096/fj.201902319rrr · Cited by 64
Influence of HIV Infection and Antiretroviral Therapy on Bone Homeostasis
Delpino, M. V., & Quarleri, J. F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00502 · Cited by 63
Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice
Stegen, S., Devignes, C.-S., Torrekens, S., Looveren, R. V., Carmeliet, P., & Carmeliet, G. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4219 · Cited by 67
The Mental Health Nursing Clinical Confidence Scale: a tool for measuring undergraduate learning on mental health clinical placements.
Bell, A., Horsfall, J. M., & Goodin, W. (1998) · PubMed · Cited by 63
Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation
Shen, L., Sharma, D., Yu, Y., Long, F., & Karner, C. (2020) · Journal of Cell Science · doi:10.1242/jcs.251645 · Cited by 61
Self-citation
Role of Wnt signaling in synaptic plasticity and memory
Narvaes, R. F., & Furini, C. R. G. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107558 · Cited by 64
Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis
Qiao, L., Liu, X., He, Y., Zhang, J., Huang, H., Bian, W., Chilufya, M. M., Zhao, Y., & Han, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111932 · Cited by 64
The plasticity of biocompatibility
Williams, D. F. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122077 · Cited by 62
Effect of the Wnt signal-RANKL/OPG axis on the enhanced osteogenic integration of a lithium incorporated surface
Huang, T., Li, Y., Ke, Y., Zhou, Y., Wang, Y., Jiang, Z., Wang, H., & Yang, G. (2018) · Biomaterials Science · doi:10.1039/c8bm01411f · Cited by 59
Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome
Yang, M., Guo, Q., Peng, H., Xiao, Y., Xiao, Y., Huang, Y. H., Li, C., Su, T., Zhang, Y.-L., Lei, M., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181554 · Cited by 60
Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
Lu, Z., Yue, Y., Yuan, C., Liu, J., Chen, Z., Niu, C., Sun, X., Zhu, S., Zhao, H., Guo, T., et al. (2020) · Animals · doi:10.3390/ani10010170 · Cited by 59
Single-cell RNA sequencing of human femoral head in vivo
Qiu, X., Liu, Y., Shen, H., Wang, Z., Gong, Y., Yang, J., Li, X., Zhang, H., Chen, Y., Zhou, C., et al. (2021) · Aging · doi:10.18632/aging.203124 · Cited by 58
Human cells with osteogenic potential in bone tissue research
Dvorakova, J., Wiesnerova, L., Chocholata, P., Kulda, V., Landsmann, L., Cedikova, M., Kripnerova, M., Eberlova, L., & Babuska, V. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-023-01096-w · Cited by 58
Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells
Yu, F., Wu, F., Li, F., Liao, X., Wang, Y., Li, X., Wang, C., Shi, Y., & Ye, L. (2020) · Stem Cells · doi:10.1002/stem.3192 · Cited by 55
Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women
Zolfaroli, I., Murillo, E. O., García‐Pérez, M. Á., Hidalgo‐Mora, J. J., Tarín, J. J., & Cano, A. (2021) · Maturitas · doi:10.1016/j.maturitas.2021.03.001 · Cited by 57
Cardiovascular Outcomes of Romosozumab and Protective Role of Alendronate
Asadipooya, K., & Weinstock, A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312371 · Cited by 56
Osteoblast role in the pathogenesis of rheumatoid arthritis
Berardi, S., Corrado, A., Maruotti, N., Cici, D., & Cantatore, F. P. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06288-y · Cited by 56
Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review
Hanga-Fărcaș, A., Miere, F. G., Filip, G. A., Clichici, S. V., Fritea, L., Vicaș, L. G., Marian, E., Pallag, A., Jurca, T., Filip, S. M., et al. (2023) · Plants · doi:10.3390/plants12102055 · Cited by 55
Bone turnover markers and novel biomarkers in lung cancer bone metastases
Lang, J., Zhao, Q., He, Y., & Yu, X. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1463566 · Cited by 54
Duck Egg White–Derived Peptide VSEE (Val‐Ser‐Glu‐Glu) Regulates Bone and Lipid Metabolisms by Wnt/β‐Catenin Signaling Pathway and Intestinal Microbiota
Guo, D., Liu, W., Zhang, X., Zhao, M., Zhu, B., Hou, T., & He, H. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900525 · Cited by 54
How zoledronic acid improves osteoporosis by acting on osteoclasts
Wang, B., Zhan, Y., Yan, L. W., & Hao, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.961941 · Cited by 52
Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials
Yang, S., Sun, Y., Капилевич, Л. В., Zhang, X., & Huang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1249418 · Cited by 52
Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders
Han, J., Zhang, J., Zhang, X., Luo, W., Liu, L., Zhu, Y., Liu, Q., & Zhang, X. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04011-9 · Cited by 59
SLC1A5 provides glutamine and asparagine necessary for bone development in mice
Sharma, D., Yu, Y., Shen, L., Zhang, G., & Karner, C. M. (2021) · eLife · doi:10.7554/elife.71595 · Cited by 51
Self-citation
Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment
Pećina‐Šlaus, N., Aničić, S., Bukovac, A., & Kafka, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076733 · Cited by 52
Wnt signaling: An attractive target for periodontitis treatment
Bao, J., Yang, Y., Xia, M., Sun, W., & Chen, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110935 · Cited by 54
Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges
Hu, X., Wu, X., Xu, J., & Xu, X. M. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.11.010 · Cited by 51
Osteoblast as a target of anti-osteoporotic treatment
Corrado, A., Sanpaolo, E. R., Bello, S. D., & Cantatore, F. P. (2017) · Postgraduate Medicine · doi:10.1080/00325481.2017.1362312 · Cited by 51
Global MicroRNA Profiling in Human Bone Marrow Skeletal—Stromal or Mesenchymal–Stem Cells Identified Candidates for Bone Regeneration
Chang, C.-C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M. S., & Kjems, J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.018 · Cited by 52
Consequences of Aging on Bone
Zhang, L., Guan, Q., Wang, Z., Feng, J., Zou, J., & Gao, B. (2023) · Aging and Disease · doi:10.14336/ad.2023.1115 · Cited by 57
Bioinspired fabrication of carbonated hydroxyapatite/chitosan nanohybrid scaffolds loaded with TWS119 for bone regeneration
Chen, Y., Yu, J. J., Ke, Q., Gao, Y., Zhang, C., & Guo, Y. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.02.010 · Cited by 48
An update on the problem of osteoporosis in people with epilepsy taking antiepileptic drugs
Miziak, B., Chrościńska–Krawczyk, M., & Czuczwar, S. J. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1625887 · Cited by 48
Fermented Oyster Extract Promotes Osteoblast Differentiation by Activating the Wnt/β-Catenin Signaling Pathway, Leading to Bone Formation
Molagoda, I. M. N., Karunarathne, W. A. H. M., Choi, Y. H., Park, E. K., Jeon, Y., Lee, B.-J., Kang, C., & Kim, G. (2019) · Biomolecules · doi:10.3390/biom9110711 · Cited by 48
Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing
Song, D., He, G., Song, F., Wang, Z., Liu, X., Liao, L., Ni, J., Silva, M. J., & Long, F. (2020) · Bone Research · doi:10.1038/s41413-019-0081-8 · Cited by 47
Self-citation
Biomechanical Interfaces of Corticotomies on Periodontal Tissue Remodeling during Orthodontic Tooth Movement
Liu, R., Huang, L., Xiao, X., Guan, Y., Jiang, Y., Yin, X., Zou, S., & Ye, Q. (2020) · Coatings · doi:10.3390/coatings11010001 · Cited by 50
Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling
Wu, Y., Wang, M., Zhang, K., Li, Y., Xu, M., Tang, S., Qu, X., & Li, C. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.069 · Cited by 46
Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
Xiang, Q., Wu, Z., Zhao, Y., Tian, S., Lin, J., Wang, L., Jiang, S., Sun, Z., & Li, W. (2024) · Bone Research · doi:10.1038/s41413-024-00388-8 · Cited by 52
Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform
Silva, D. I., dos Santos, B. P., Leng, J., Oliveira, H., & Amédée, J. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0034-3 · Cited by 46
Impact of aging on bone, marrow and their interactions
Hoffman, C. M., Han, J., & Calvi, L. M. (2018) · Bone · doi:10.1016/j.bone.2018.07.012 · Cited by 48
Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model
Li, X., Liu, D., Li, J., Yang, S., Xu, J., Yokota, H., & Zhang, P. (2019) · The FASEB Journal · doi:10.1096/fj.201802711r · Cited by 46
Extracellular vesicles in bone: “dogrobbers” in the “eternal battle field”
Tao, S., & Guo, S. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0319-5 · Cited by 45
Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2/HO-1 signaling pathway
Jin, W., Zhu, X., Yao, F., Xu, X., Chen, X., Luo, Z.-J., Zhao, D., Li, X., Leng, X., & Sun, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109676 · Cited by 44
Development of selective bispecific Wnt mimetics for bone loss and repair
Fowler, T. W., Mitchell, T. L., Janda, C. Y., Xie, L., Tu, S., Chen, H., Zhang, H., Ye, J., Ouyang, B., Yuan, T. Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23374-8 · Cited by 44
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration
Tower, R. J., Busse, E., Jaramillo, J., Lacey, M., Hoffseth, K., Guntur, A. R., Simkin, J., & Sammarco, M. C. (2022) · eLife · doi:10.7554/elife.71542 · Cited by 43
Regulation of bone mass in inflammatory diseases
Adami, G. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101611 · Cited by 41
A lithium-containing nanoporous coating on entangled titanium scaffold can enhance osseointegration through Wnt/β-catenin pathway
Liu, W. X., Chen, D., Jiang, G., Li, Q., Wang, Q., Cheng, M., He, G., & Zhang, X. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.006 · Cited by 41
The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration
Yu, T., Wang, H., Zhang, Y., Wang, X., & Han, B. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00445 · Cited by 40
Injectable Bacteria-Sensitive Hydrogel Promotes Repair of Infected Fractures via Sustained Release of miRNA Antagonist
Yu, C., Chen, L., Zhou, W., Hu, L., Xie, X., Lin, Z., Panayi, A. C., Zhan, X., Tao, R., Mi, B., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c08491 · Cited by 41
RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss
Shi, W., Xu, C., Gong, Y., Wang, J., Ren, Q., Yan, Z., Mei, L., Tang, C., Ji, X., Hu, X., et al. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00071-3 · Cited by 38
Osteoporosis and vascular calcification: A shared scenario
Gómez, M. C. G., & Vilahur, G. (2020) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2019.03.008 · Cited by 37
ROS Dependent Wnt/β-Catenin Pathway and Its Regulation on Defined Micro-Pillars—A Combined In Vitro and In Silico Study
Staehlke, S., Haack, F., Waldner, A.-C., Koczan, D., Moerke, C., Mueller, P., Uhrmacher, A. M., & Nebe, J. B. (2020) · Cells · doi:10.3390/cells9081784 · Cited by 36
Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration
Gao, Y., Zou, Y., Sokolowskei, D., Xing, X., Tower, R. J., Lai, Z., Shi, J., Zhu, L., Zheng, Q., James, A. W., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.034 · Cited by 37
Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway
Luo, J., Zhu, S., Yu, T., Zhang, Y., Li, Y., Cao, L., Kong, M., Luo, M., Bi, Q., & Zhang, Q. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03168-9 · Cited by 36
Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration
Liu, J., Zhou, Z., Hou, M., Xia, X., Liu, Y., Zhao, Z., Wu, Y., Deng, Y., Zhang, Y., He, F., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100956 · Cited by 35
Vitamin E-stabilized UHMWPE: Biological response on human osteoblasts to wear debris
Galliera, E., Ragone, V., Marazzi, M. G., Selmin, F., Banci, L., & Romanelli, M. M. C. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.07.012 · Cited by 35
Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway
Guo, D., He, H., Zhao, M., Zhang, G., & Hou, T. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15067 · Cited by 35
FOXO1 differentially regulates bone formation in young and aged mice
Xiong, Y., Zhang, Y., Zhou, F., Liu, Y., Yi, Z., Gong, P., & Wu, Y. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110438 · Cited by 36
Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy
Wu, X., Wang, T., Zhao, J., Zhang, L., Liu, Z., Chen, Y., Luo, Y., Liu, Y., Chen, Y., Jiang, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202504293 · Cited by 36

Authors: Karner, C. M., & Long, F.
Affiliations: Duke University (US)
Washington University in St. Louis (US)
Corresponding author: Long, Fanxin
ORCID: Karner, Courtney M.
Long, Fanxin
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-11-26
Volume: 74
Issue: 9
Pages: 1649-1657
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-016-2425-5
PMC: PMC5380548
OpenAlex: W2552658430
Cited by: 295
References: 151
Citations by year: 2026: 19 · 2025: 19 · 2024: 39 · 2023: 35 · 2022: 39 · 2021: 36 · 2020: 46 · 2019: 27 · 2018: 19 · 2017: 14
FWCI: 1.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR060456, AR060674)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Keywords: Wnt signaling, osteoblasts, cellular metabolism, osteogenic differentiation, bone formation, bone remodeling, aerobic glycolysis, glutamine catabolism, fatty acid oxidation, bioenergetics, osteoporosis, bone anabolic therapy
MeSH terms: Animals, Bone and Bones, Humans, Models, Biological, Osteoblasts, Signal Transduction, Wnt Proteins, Wnt Signaling Pathway

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Wnt signaling and cellular metabolism in osteoblasts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks