Cited by 171Sarcoma Diagnosis and TreatmentMesenchymal stem cell researchCancer Cells and Metastasis

Mesenchymal stroma: Role in osteosarcoma progression

Cortini, Margherita, Avnet, Sofia, Baldini, Nicola·2017·Cancer Letters

Abstract

The initiation and progression of malignant tumors are supported by their microenvironment: cancer cells per se cannot explain growth and formation of the primary or metastasis, and a combination of proliferating tumor cells, cancer stem cells, immune cells mesenchymal stromal cells and/or cancer-associated fibroblasts all contribute to the tumor bulk. The interaction between these multiple players, under different microenvironmental conditions of biochemical and physical stimuli (i.e. oxygen tension, pH, matrix mechanics), regulates the production and biological activity of several soluble factors, extracellular matrix components, and extracellular vesicles that are needed for growth, maintenance, chemoresistance and metastatization of cancer. In osteosarcoma, a very aggressive cancer of young adults characterized by the extensive need for more effective therapies, this aspect has been only recently explored. In this view, we will discuss the role of stroma, with a particular focus on the mesenchymal stroma, contributing to osteosarcoma progression through inherent features for homing, neovascularization, paracrine cross-feeding, microvesicle secretion, and immune modulation, and also by responding to the changes of the microenvironment that are induced by tumor cells. The most recent advances in the molecular cues triggered by cytokines, soluble factors, and metabolites that are partially beginning to unravel the axis between stromal elements of mesenchymal origin and osteosarcoma cells, will be reviewed providing insights likely to be used for novel therapeutic approaches against sarcomas.

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2017.07.024

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150 of 150 references verified0 citation errors · 0 not checkable

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  • Mesenchymal stem cells have been implicated in osteosarcoma metastasis and therapeutic resistance.

    “Mesenchymal stem cells (MSCs) have been implicated in osteosarcoma metastasis and therapeutic resistance 57,58,59 .”

    From Osteosarcoma (2022) · cites this paper as [59]

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Authors
Cortini, M., Avnet, S., & Baldini, N.
Affiliations
Istituto Ortopedico Rizzoli (IT)
Corresponding author
Baldini, Nicola
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2017-10
Volume
405
Pages
90-99
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2739497725
Cited by
171
References
150
Citations by year
2026: 13 · 2025: 14 · 2024: 15 · 2023: 19 · 2022: 24 · 2021: 36 · 2020: 23 · 2019: 16 · 2018: 9 · 2017: 2
FWCI
2.49
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Funders
Associazione Italiana per la Ricerca sul Cancro (11426)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
mesenchymal stem cells, osteosarcoma, tumor microenvironment, tumor progression, cancer-associated fibroblasts, cancer stem cells, neovascularization, paracrine signaling, extracellular vesicles, microvesicles, immunomodulation, chemoresistance, metastasis, cytokines, cancer metabolism, sarcoma treatment
MeSH terms
Antigens, Surface, Extracellular Matrix, Humans, Osteosarcoma, Biomarkers, Tumor, Neoplastic Stem Cells, Disease Progression, Tumor Microenvironment, Mesenchymal Stem Cells

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