Cited by 67Endoplasmic Reticulum Stress and DiseaseHeat shock proteins researchCell death mechanisms and regulation

The unfolded protein response and cancer: A brighter future unfolding?

Scriven, Peter, Brown, Nicola J., Pockley, A. Graham, Wyld, Lynda·2007·Journal of Molecular Medicine

Abstract

Mammalian cells are bathed in an interstitial fluid that has a tightly regulated composition in healthy states. Interstitial fluid provides cells with all the necessary metabolic substrates (oxygen, glucose, amino acids, etc.), and waste molecules are removed by diffusion gradients that are controlled by local vascular perfusion. The health and normal function of all cells within a body is dependent on the maintenance of this microenvironment. However, many disease states cause fluctuations in this, and in some instances, these might be of sufficient severity to stress and/or be toxic to the cell. Cells have developed a number of responses to enable their survival in a hostile environment. This article discusses one such pathway--the unfolded protein response and its relationship to cancer. The molecular signalling cascade, the mechanism of its activation in cancer and the consequences of its activation for a tumour are discussed, as are clinical studies and potential translational approaches for utilising this pathway for tumour targeting.

Integrity signals

Registry

Crossref · 10.1007/s00109-006-0150-5

Cites

139 of 139 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • The UPR is often activated in many cancers due to abnormal microcirculation and high glucose needs of tumours, resulting in metabolic stress.

    “The UPR is often activated in many cancers [27] due to their abnormal microcirculation (which leads to cellular hypoxia and acidosis) and the high glucose needs of tumours (Warberg effect), resulting in metabolic stress.”

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Authors
Scriven, P., Brown, N. J., Pockley, A. G., & Wyld, L.
Affiliations
Royal Hallamshire Hospital (GB)
Corresponding author
Scriven, Peter
Venue
Journal of Molecular Medicine
Published
2007-01-10
Volume
85
Issue
4
Pages
331-341
ISSN
  • 0946-2716 (ISSN-L)
  • 1432-1440
OpenAlex
W2101203508
Cited by
67
References
139
Citations by year
2026: 1 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2013: 4 · 2012: 5
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
unfolded protein response, cancer, tumor microenvironment, interstitial fluid, endoplasmic reticulum stress, tumor targeting, translational cancer therapy
MeSH terms
Animals, Endoplasmic Reticulum, Humans, Neoplasm Proteins, Neoplasms, Protein Processing, Post-Translational, Signal Transduction, Apoptosis, Protein Folding

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