Mitochondria and aging in the vascular system
Open accessAbstract
This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants.
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Mitochondrial dysregulation is implicated in impaired arterial function in animal models of cardiovascular disease.
“Accumulating evidence implicates mitochondrial dysregulation in impaired arterial function both in animal models of cardiovascular disease (94, 161, 182)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [182]
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Research works printed but not linked: 2
- [48]Csiszar A Labinskyy N Jimenez R Pinto JT Ballabh P Losonczy G Pearson KJ de Cabo R Ungvari Z 2009 Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1 Mech Ageing Dev 130 518 527 10.1016/j.mad.2009.06.004 19549533 PMC2756526 · DOI
- [53]Ungvari Z Labinskyy N Mukhopadhyay P Pinto JT Bagi Z Ballabh P Zhang C Pacher P Csiszar A 2009 Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells Am J Physiol Heart Circ Physiol 297 H1876 H1881 10.1152/ajpheart.00375.2009 19749157 PMC2781360 · DOI
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- Authors
- Ungvari, Z., Sonntag, W. E., & Csiszar, A.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Ungvari, Zoltan
- Venue
- Journal of Molecular Medicine
- Published
- 2010-08-17
- Volume
- 88
- Issue
- 10
- Pages
- 1021-1027
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- PMC
- PMC3045746
- OpenAlex
- W2156612696
- Cited by
- 103
- References
- 59
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 9 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 11
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Institute on Aging (AG-11370, P01AG011370)
- National Heart, Lung, and Blood Institute (R01HL077256, HL077256)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- mitochondrial dysfunction, aging, vascular system, oxidative stress, vascular inflammation, endothelial cell apoptosis, age-related vascular disease, caloric restriction, caloric restriction mimetics, somatotropic axis, mitochondria-targeted antioxidants, vascular protection
- MeSH terms
- Aging, Blood Vessels, Endothelium, Humans, Inflammation, Mitochondria, Vascular Diseases, Reactive Oxygen Species, Oxidative Stress
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