Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

Napoli, Claudio; Ignarro, Louis J.

doi:10.1007/s12272-009-1801-1

Cited by 283Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

Napoli, Claudio, Ignarro, Louis J.·2009·Archives of Pharmacal Research

DOI 10.1007/s12272-009-1801-1

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Abstract

Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is a cause of, or result of endothelial dysfunction or both pathogenic events. Disturbances in NO bioavailability have been linked to cause endothelial dysfunction, leading to increased susceptibility to atherosclerotic lesion progression, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis and stroke.

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Vascular disease, cardiovascular disease, and metabolic syndrome all share effective loss of NO function.
“Similarly, vascular disease, cardiovascular disease (CVD), and metabolic syndrome all share effective loss of NO function[23,35–39].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [35]

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Authors: Napoli, C., & Ignarro, L. J.
Affiliations: University of California, Los Angeles (US)
Venue: Archives of Pharmacal Research
Publisher: Springer Science and Business Media LLC
Published: 2009-08
Volume: 32
Issue: 8
Pages: 1103-1108
ISSN: 0253-6269 (ISSN-L)
1976-3786
DOI: 10.1007/s12272-009-1801-1
OpenAlex: W2049131838
Cited by: 281
References: 37
Citations by year: 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 9 · 2015: 18 · 2014: 23 · 2013: 17 · 2012: 24
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Pharmacal Research (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide, NO bioavailability, endothelial dysfunction, vascular disease, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis, stroke, vascular tone, vascular smooth muscle cell proliferation, hemostasis, fibrinolysis
MeSH terms: Animals, Humans, Nitric Oxide, Oxidation-Reduction, Vascular Diseases, Kruppel-Like Transcription Factors, Nitric Oxide Synthase Type III

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Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

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