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Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes
Open accessAbstract
Aims/hypothesis Long-term trials in insulin-treated subjects with type 2 diabetes have shown that adjunctive treatment with the amylin analogue pramlintide reduces HbA(1)c levels and elicits weight loss. While amylin reduces food intake in rodents, pramlintide's effect on satiety and food intake in humans has not yet been assessed. Methods In this randomised, double-blind, placebo-controlled crossover study, 11 insulin-treated men with type 2 diabetes (age 60+/-9 years, BMI 28.9+/-4.8 kg/m(2)) and 15 non-diabetic obese men (age 41+/-21 years, BMI 34.4+/-4.5 kg/m(2)) underwent two standardised meal tests. After fasting overnight, subjects received single subcutaneous injections of either pramlintide (120 microg) or placebo, followed by a preload meal. After 1 h, subjects ate an ad libitum buffet meal. Energy intake and meal duration were measured, as were hunger ratings (using visual analogue scales), and plasma cholecystokinin, glucagon-like peptide-1 and peptide YY concentrations over time. Results Compared with placebo, pramlintide reduced energy intake in both the type 2 diabetes (Delta-202+/-64 kcal, -23+/-8%, p<0.01) and obese (Delta-170+/-68 kcal, -16+/-6%, p<0.02) groups, without affecting meal duration. Hunger and hormonal analyte profiles provided evidence that pramlintide may exert a primary satiogenic effect, independently of other anorexigenic gut peptides. Conclusions/interpretation The results indicate that enhanced satiety and reduced food intake may explain the weight loss observed in long-term pramlintide trials.
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“Injection prior to meals acts to suppress glucagon secretion, delay gastric emptying, and promote satiety (247-250).”
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Metadata
- Authors
- Chapman, I., Parker, B., Doran, S., Feinle-Bisset, C., Wishart, J., Strobel, S., Wang, Y., Burns, C., Lush, C., Weyer, C., & Horowitz, M.
- Affiliations
- Royal Adelaide Hospital (AU)
- Corresponding author
- Weyer, C.
- Venue
- Diabetologia
- Published
- 2005-04-21
- Volume
- 48
- Issue
- 5
- Pages
- 838-848
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1965851116
- Cited by
- 205
- References
- 49
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 5 · 2013: 9 · 2012: 11
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- pramlintide, amylin analogues, satiety, dietary intake, obesity, type 2 diabetes, energy intake, hunger, cholecystokinin, glucagon-like peptide-1, peptide YY, weight loss, insulin-treated patients
- MeSH terms
- Adult, Amyloid, Energy Intake, Diabetes Mellitus, Type 2, Double-Blind Method, Energy Metabolism, Female, Humans, Hunger, Hypoglycemic Agents, Male, Middle Aged, Obesity, Placebos, Satiation, Body Mass Index, Diabetes Complications, Islet Amyloid Polypeptide
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