Seasonality of birth in children and young adults (0–29 years) with type 1 diabetes in Ukraine
Open accessAbstract
Aims/hypothesis Numerous epidemiological studies have shown differences in seasonality of birth patterns between the general population and the group who develop type 1 diabetes mellitus. This finding indicates that environmental factors operating during pre- and/or postnatal development could be aetiologically important. We examined whether the pattern of month of birth for type 1 diabetes patients in Ukraine differs from that for total live births.Methods Data consist of prevalent cases of type 1 diabetes in Ukraine by the end of 2003. Cases are restricted to persons born after 1 January 1960, diagnosed with type 1 diabetes before the age of 30 years (n = 20,117). People born during the same time in the general population (n = 29,105,560) were the reference standard. Seasonal patterns were estimated using logistic regression with harmonic terms.Results We found a strongly significant seasonal pattern of type 1 diabetes incidence rates (p < 0.001), with the lowest rates in December and the highest in April. The rate ratio between the extremes was 1.32 (95% CI 1.27-1.39). Tests for seasonal patterns in subgroups defined by sex and age or by sex and date of birth were all significant with p values less than 0.02. We found no interactions with sex (p = 0.142) or age at diagnosis (p = 0.207), but found a strong interaction with period of birth (p < 0.0001).Conclusions/interpretation The results obtained indicate that early-life factors linked to seasons may influence type 1 diabetes risk later in life.
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The SEARCH birth month effect was not observed in southern centers (South Carolina, Hawaii, Southern California) but only in northern latitudes (Colorado, Washington, Ohio).
“This birth month effect was not observed in youth recruited from the centers in the more southern locations (South Carolina, Hawaii, Southern California), but only in the more northern latitudes (Colorado, Washington, and Ohio)54.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [54]
Among 9,737 SEARCH youth with type 1 diabetes, the percentage of observed to expected births differed across months, with a deficit of November-February births and an excess of April-July births.
“Among 9,737 youth with T1D in the SEARCH study, the percentage of observed to expected births differed across the months with a deficit of November-February births and an excess in April–July births.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [54]
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Environmental factors in the etiology of type 1 diabetes
Åkerblom, H. K., Vaarala, O., Hyöty, H., Ilonen, J., & Knip, M. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10340 · Cited by 307 · see citing works
A test for seasonality of events with a variable population at risk.
Walter, S. D., & Elwood, M. (1975) · Journal of Epidemiology & Community Health · doi:10.1136/jech.29.1.18 · Cited by 211 · see citing works
The epidemiology of type 1 diabetes mellitus is not the same in young adults as in children
Kyvik, K. O., Nystrom, L., Gorus, F., Songini, M., Oestman, J., Castell, C., Green, A., Guyrus, E., Ionescu-Tirgoviste, C., McKinney, P. A., et al. (2004) · Diabetologia · doi:10.1007/s00125-004-1331-9 · Cited by 150 · see citing works
Life-long echoes–a critical analysis of the developmental origins of adult disease model
Gluckman, P. D., Hanson, M. A., Morton, S. M. B., & Pinal, C. S. (2005) · Neonatology · doi:10.1159/000082311 · Cited by 126 · see citing works
Seasonality of birth in patients with childhood Type I diabetes in 19 European regions
McKinney, P. A., & on behalf of the EURODIAB Seasonality of Birth Group (2001) · Diabetologia · doi:10.1007/pl00002957 · Cited by 62 · see citing works
Month of birth and risk of developing insulin dependent diabetes in south east Sweden
Samuelsson, U., Johansson, C., & Ludvigsson, J. (1999) · Archives of Disease in Childhood · doi:10.1136/adc.81.2.143 · Cited by 51 · see citing works
Seasonality of birth in children with diabetes in Europe: multicentre cohort study
Rothwell, P. M., Gutnikov, S. A., McKinney, P. A., et al. (1999) · BMJ · doi:10.1136/bmj.319.7214.887 · Cited by 49 · see citing works
Kimpimäki, T., Kulmala, P., Savola, K., Vähäsalo, P., Reijonen, H., Ilonen, J., Åkerblom, H. K., & Knip, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6466 · Cited by 48 · see citing works
Seasonality of birth in patients with childhood diabetes in The Netherlands
Jongbloet, P. H., Groenewoud, H. M. M., Hirasing, R. A., & Van Buuren, S. (1998) · Diabetes Care · doi:10.2337/diacare.21.1.190 · Cited by 45 · see citing works
Laron, Z. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10338 · Cited by 36 · see citing works
MONTH OF BIRTH AND TESTICULAR CANCER RISK IN DENMARK
PRENER, A., & Carstensen, B. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115468 · Cited by 16 · see citing works
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DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31320-5 · Cited by 1,561 · see citing works
Epidemiology of type 1 diabetes
Maahs, D. M., West, N. A., Lawrence, J. M., & Mayer-Davis, E. J. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.011 · Cited by 1,092 · see citing works
Mitri, J., & Pittas, A. G. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.010 · Cited by 258 · see citing works
Association of Type 1 Diabetes With Month of Birth Among U.S. Youth
Kahn, H. S., Morgan, T. M., Case, L. D., Dabelea, D., Mayer-Davis, E. J., Lawrence, J. M., Marcovina, S. M., Imperatore, G., & for the SEARCH for Diabetes in Youth Study Group (2009) · Diabetes Care · doi:10.2337/dc09-0891 · Cited by 105 · see citing works
- Authors
- Vaiserman, A. M., Carstensen, B., Voitenko, V. P., Tronko, M. D., Kravchenko, V. I., Khalangot, M. D., & Mechova, L. V.
- Affiliations
- D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA)
- Steno Diabetes Centers (DK)
- V.P. Komisarenko Institute of Endocrinology and Metabolism (UA)
- Corresponding author
- Vaiserman, A. M.
- Venue
- Diabetologia
- Published
- 2006-11-09
- Volume
- 50
- Issue
- 1
- Pages
- 32-35
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2098802325
- Cited by
- 62
- References
- 11
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- type 1 diabetes, birth seasonality, birth month, environmental risk factors, prenatal and postnatal exposure, children and young adults, Ukraine
- MeSH terms
- Adolescent, Adult, Birth Certificates, Birth Rate, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Infant, Infant, Newborn, Male, Risk Factors, Seasons, Ukraine, Incidence, Logistic Models
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