Cited by 208Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesDiabetes, Cardiovascular Risks, and Lipoproteins

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Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study

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Ding, E. L., Song, Y., Manson, J. E., Rifai, N., Buring, J. E., Liu, S.·2007·Diabetologia

DOI 10.1007/s00125-007-0785-y

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Abstract

Aims/hypothesis Prospective data directly investigating the role of endogenous sex hormones in diabetes risk have been scant, particularly in women. We aimed to examine comprehensively plasma sex hormones in connection with risk of developing type 2 diabetes in postmenopausal women.Methods We conducted a prospective, nested case-control study of plasma oestradiol, testosterone and dehydroepiandrosterone sulfate and risk of type 2 diabetes in a cohort of women health professionals with a mean age of 60.3 and 12.2 years since menopause. Among women not using hormone therapy and free of baseline cardiovascular disease, cancer and diabetes, 359 incident cases of type 2 diabetes were matched with 359 controls during an average follow-up of 10 years.Results Oestradiol and testosterone were each strongly and positively associated with risk of type 2 diabetes. After adjustment for BMI, family history, lifestyle and reproductive variables, the multivariable relative risks (95% CI) comparing the highest vs lowest quintile were 12.6 (2.83-56.3) for total oestradiol (p = 0.002 for trend), 13.1 (4.18-40.8) for free oestradiol (p < 0.001 for trend), 4.15 (1.21-14.2) for total testosterone (p = 0.019 for trend) and 14.8 (4.44-49.2) for free testosterone (p < 0.001 for trend). These associations remained robust after adjusting and accounting for other metabolic syndrome components and baseline HbA(1c) levels.Conclusions/interpretation In postmenopausal women, higher plasma levels of oestradiol and testosterone were strongly and prospectively related to increased risk of developing type 2 diabetes. These prospective data indicate that endogenous levels of sex hormones may play important roles in the pathogenesis of type 2 diabetes. ClinicalTrials.gov ID no.: NCT00000479.

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Authors: Ding, E. L., Song, Y., Manson, J. E., Rifai, N., Buring, J. E., & Liu, S.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
Corresponding author: Ding, E. L.
Liu, S.
ORCID: Ding, E. L.
Song, Y.
Manson, J. E.
Rifai, N.
Buring, J. E.
Liu, S.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2007-08-14
Volume: 50
Issue: 10
Pages: 2076-2084
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-007-0785-y
OpenAlex: W2134314425
Cited by: 208
References: 59
Citations by year: 2026: 2 · 2025: 8 · 2024: 13 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 18 · 2016: 13 · 2015: 14 · 2014: 12 · 2013: 8 · 2012: 14
FWCI: 8.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Brigham and Women's Hospital
National Institutes of Health (5r01hl043851-10)
National Heart, Lung, and Blood Institute (HL43851)
National Cancer Institute (CA-47988, R01CA047988)
National Institute of Diabetes and Digestive and Kidney Diseases (DK066401, R01DK066401)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 2 diabetes, sex hormones, estradiol, testosterone, dehydroepiandrosterone sulfate, postmenopausal women, endogenous sex hormones, diabetes risk
MeSH terms: Aspirin, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Double-Blind Method, Estradiol, Female, Glycated Hemoglobin, Humans, Middle Aged, Risk Factors, Testosterone, Vitamin E, Body Mass Index, Postmenopause, Dehydroepiandrosterone Sulfate

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Plasma sex steroid hormones and risk of developing type 2 diabetes in women: a prospective study

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