Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress
Open accessAbstract
Aims/hypothesis To determine if acute overexpression of peroxisome proliferator-activated receptor, gamma, coactivator 1 beta (Pgc-1β [also known as Ppargc1b]) in skeletal muscle improves insulin action in a rodent model of diet-induced insulin resistance.Methods Rats were fed either a low-fat or high-fat diet (HFD) for 4 weeks. In vivo electroporation was used to overexpress Pgc-1β in the tibialis cranialis (TC) and extensor digitorum longus (EDL) muscles. Downstream effects of Pgc-1β on markers of mitochondrial oxidative capacity, oxidative stress and muscle lipid levels were characterised. Insulin action was examined ex vivo using intact muscle strips and in vivo via a hyperinsulinaemic-euglycaemic clamp.Results Pgc-1β gene expression was increased >100% over basal levels. The levels of proteins involved in mitochondrial function, lipid metabolism and antioxidant defences, the activity of oxidative enzymes, and substrate oxidative capacity were all increased in muscles overexpressing Pgc-1β. In rats fed a HFD, increasing the levels of Pgc-1β partially ameliorated muscle insulin resistance, in association with decreased levels of long-chain acyl-CoAs (LCACoAs) and increased antioxidant defences.Conclusions Our data show that an increase in Pgc-1β expression in vivo activates a coordinated subset of genes that increase mitochondrial substrate oxidation, defend against oxidative stress and improve lipid-induced insulin resistance in skeletal muscle.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Upregulating PGC1β or activating heat shock protein 72 to increase mitochondrial function above the physiological adaptive response triggered by lipid oversupply mitigates lipid-induced insulin resistance.
“In agreement with this, upregulating PGC 1β or activating heat shock protein 72 to increase mitochondrial function above the physiological adaptive response triggered by lipid oversupply mitigate lipid-induced insulin resistance (Wright et al., 2011; Henstridge et al., 2014).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Wright et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600 · see citing works
RetractedA SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
[12] Assays of glutathione peroxidase
Flohé, L., & Günzler, W. A. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05015-1 · Cited by 4,954 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works
Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry
Ejsing, C. S., Sampaio, J. L., Surendranath, V., Duchoslav, E., Ekroos, K., Klemm, R. W., Simons, K., & Shevchenko, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811700106 · Cited by 1,071 · see citing works
Reactive oxygen species enhance insulin sensitivity
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581 · see citing works
St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works
Insulin resistance is a cellular antioxidant defense mechanism
Hoehn, K. L., Salmon, A. B., Hohnen-Behrens, C., Turner, N., Hoy, A. J., Maghzal, G. J., Stocker, R., Van Remmen, H., Kraegen, E. W., Cooney, G. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902380106 · Cited by 540 · see citing works
Self-citationHigh-fat diets cause insulin resistance despite an increase in muscle mitochondria
Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · see citing works
Turner, N., Li, J.-Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., Taketo, M. M., Cooney, G. J., Kraegen, E. W., James, D. E., et al. (2008) · Diabetes · doi:10.2337/db07-1552 · Cited by 535 · see citing works
Self-citationExcess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle
Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520 · see citing works
Self-citationKoves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works
Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works
Arany, Z., Lebrasseur, N., Morris, C., Smith, E., Yang, W., Ma, Y., Chin, S., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.12.003 · Cited by 370 · see citing works
Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes · doi:10.2337/db08-1078 · Cited by 363 · see citing works
Self-citationKamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O., & Kakizuka, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135217100 · Cited by 357 · see citing works
Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J. F. P., Beck‐Nielsen, H., Groop, L., & Vaag, A. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421889 · Cited by 300 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J., Beck-Nielsen, H., Groop, L., & Vaag, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21889 · Cited by 300 · see citing works
Lelliott, C. J., Medina-Gomez, G., Petrovic, N., Kis, A., Feldmann, H. M., Bjursell, M., Parker, N., Curtis, K., Campbell, M., Hu, P., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040369 · Cited by 280 · cited 1× · see citing works
“Gain- and loss-of-function studies have shown that PGC1β regulates the expression of genes involved in mitochondrial function and lipid metabolism [15, 16, 38, 39].”
BackgroundSelf-citationChoi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y.-J., Liu, Z.-X., Lee, H.-Y., Distefano, A., Samuel, V. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810339105 · Cited by 279 · see citing works
Ellis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e554 · Cited by 273 · see citing works
Self-citationPGC-1 coactivators and skeletal muscle adaptations in health and disease
Arany, Z. P. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.018 · Cited by 244 · see citing works
McMahon, J. M., Signori, E., Wells, K., Fazio, V. M., & Wells, D. J. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301522 · Cited by 235 · see citing works
Benton, C. R., Nickerson, J. G., Lally, J., Han, X.-X., Holloway, G. P., Glatz, J. F. C., Luiken, J. J. F. P., Graham, T. E., Heikkila, J. J., & Bonen, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m704332200 · Cited by 214 · see citing works
Free fatty acids and skeletal muscle insulin resistance
Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 206 · see citing works
Self-citationHypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance.
Vianna, C. R., Huntgeburth, M., Coppari, R., Choi, C. S., Lin, J., Krauss, S., Barbatelli, G., Tzameli, I., Kim, Y.-B., Cinti, S., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.003 · Cited by 181 · see citing works
Is mitochondrial dysfunction a cause of insulin resistance?
Turner, N. A., & Heilbronn, L. K. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.001 · Cited by 163 · see citing works
Self-citationTurner, N. A., Hariharan, K., Tid-Ang, J. D., Frangioudakis, G., Beale, S. M., Wright, L. E., Zeng, X., Leslie, S. J., Li, J.-Y., Kraegen, E. W., et al. (2009) · Diabetes · doi:10.2337/db09-0784 · Cited by 162 · see citing works
Self-citationHoman, R., & Anderson, M. K. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(97)00651-8 · Cited by 159 · see citing works
Antinozzi, P. A., Segall, L., Prentki, M., McGarry, J., & Newgard, C. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16146 · Cited by 149 · see citing works
Miura, S., Kai, Y., Ono, M., & Ezaki, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304312200 · Cited by 146 · see citing works
Benton, C. R., Holloway, G. P., Han, X.-X., Yoshida, Y., Snook, L. A., Lally, J., Glatz, J. F. C., Luiken, J. J. F. P., Chabowski, A., & Bonen, A. (2010) · Diabetologia · doi:10.1007/s00125-010-1773-1 · Cited by 143 · see citing works
Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.029 · Cited by 141 · see citing works
Thompson, A. L., & Cooney, G. J. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1761 · Cited by 132 · see citing works
Self-citationHoy, A. J., Brandon, A. E., Turner, N., Watt, M. J., Bruce, C. R., Cooney, G. J., & Kraegen, E. W. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90945.2008 · Cited by 92 · see citing works
Self-citationThe effects of apelin treatment on skeletal muscle mitochondrial content
Frier, B. C., Williams, D. B., & Wright, D. C. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00422.2009 · Cited by 71 · see citing works
Tsintzas, K., Chokkalingam, K., Jewell, K., Norton, L., Macdonald, I. A., & Constantin‐Teodosiu, D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1104 · Cited by 69 · see citing works
Espinoza, D., Boros, L. G., Crunkhorn, S., Gami, H., & Patti, M. (2009) · The FASEB Journal · doi:10.1096/fj.09-133728 · Cited by 60 · see citing works
Holloway, G. P., Perry, C. G. R., Thrush, A. B., Heigenhauser, G. J. F., Dyck, D. J., Bonen, A., & Spriet, L. L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00726.2007 · Cited by 48 · see citing works
Lelliott, C. J., Ljungberg, A., Ahnmark, A., William‐Olsson, L., Ekroos, K., Elmgren, A., Arnerup, G., Shoulders, C. C., Oscarsson, J., & Lindén, D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.155739 · Cited by 44 · see citing works
Self-citationCleasby, M. E., Davey, J. R., Reinten, T. A., Graham, M. W., James, D. E., Kraegen, E. W., & Cooney, G. J. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2702 · Cited by 36 · see citing works
Self-citationOita, R. C., Mazzatti, D. J., Lim, F.-L., Powell, J. R., & Merry, B. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.004 · Cited by 30 · see citing works
Hernández‐Álvarez, M. I., Chiellini, C., Manco, M., Naón, D., Liesa, M., Palacı́n, M., Mingrone, G., & Zorzano, A. (2009) · Diabetologia · doi:10.1007/s00125-009-1403-y · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondrial dysfunction and insulin resistance: an update
Montgomery, M. K., & Turner, N. A. (2014) · Endocrine Connections · doi:10.1530/ec-14-0092 · Cited by 530 · see citing works
Self-citationTurner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430 · see citing works
Self-citationVillena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 404 · see citing works
Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347 · see citing works
Castan‐Laurell, I., Dray, C., Attané, C., Duparc, T., Knauf, C., & Valet, P. (2011) · Endocrine · doi:10.1007/s12020-011-9507-9 · Cited by 297 · see citing works
Barreto, R., Waning, D. L., Gao, H., Liu, Y., Zimmers, T. A., & Bonetto, A. (2016) · Oncotarget · doi:10.18632/oncotarget.9779 · Cited by 199 · see citing works
Williams, L. M., Campbell, F., Drew, J. E., Koch, C. E., Hoggard, N., Rees, W. D., Kamolrat, T., Ngo, H. T., Steffensen, I., Gray, S. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106159 · Cited by 176 · see citing works
Jin, T., Song, Z., Weng, J., & Fantus, I. G. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00285.2017 · Cited by 128 · see citing works
Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle
Montgomery, M. K., Osborne, B., Brown, S. H. J., Small, L., Mitchell, T. W., Cooney, G. J., & Turner, N. A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m040451 · Cited by 112 · see citing works
Self-citationMitochondrial Stress Signaling Promotes Cellular Adaptations
Barbour, J. A., & Turner, N. A. (2014) · International Journal of Cell Biology · doi:10.1155/2014/156020 · Cited by 102 · see citing works
Self-citationQuinn, L. S., Anderson, B. G., Conner, J. D., & Wolden-Hanson, T. (2013) · Endocrinology · doi:10.1210/en.2012-1773 · Cited by 102 · see citing works
Estrogens and the regulation of glucose metabolism
Alemany, M. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i10.1622 · Cited by 97 · see citing works
Moraes, É. A., Natal, D. I. G., Queiróz, V. A. V., Schaffert, R. E., Cecon, P. R., de Paula, S. O., Benjamin, L. D. A., Ribeiro, S. M. R., & Martino, H. S. D. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.029 · Cited by 88 · see citing works
Montgomery, M. K., Brown, S. H. J., Lim, X. Y., Fiveash, C. E., Osborne, B., Bentley, N. L., Braude, J. P., Mitchell, T. W., Coster, A. C. F., Don, A. S., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.016 · Cited by 88 · see citing works
Self-citationMenshikova, E. V., Ritov, V. B., Dube, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Coen, P. M., & Goodpaster, B. H. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw328 · Cited by 80 · see citing works
Dirks, M. L., Miotto, P. M., Goossens, G. H., Senden, J. M., Petrick, H. L., van Kranenburg, J. M. X., van Loon, L. J. C., & Holloway, G. P. (2019) · The Journal of Physiology · doi:10.1113/jp278920 · Cited by 53 · see citing works
Lipid signals and insulin resistance
Zhang, C.-B., Klett, E., & Coleman, R. (2013) · Clinical Lipidology · doi:10.2217/clp.13.67 · Cited by 49 · see citing works
Charles, A., Meyer, A., Dal-Ros, S., Auger, C., Keller, N., Ramamoorthy, T. G., Zoll, J., METZGER, D., Schini‐Kerth, V. B., & Gény, B. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.067496 · Cited by 53 · see citing works
Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?
Genders, A. J., Holloway, G. P., & Bishop, D. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186948 · Cited by 51 · see citing works
Xu, J.-K., Pei, Y., Lu, J., Liang, X.-J., Li, Y., Wang, J.-H., & Zhang, Y.-G. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107150 · Cited by 47 · see citing works
Haohao, Z., Guijun, Q., Juan, Z., Wen, K., & Lulu, C. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0392-1 · Cited by 42 · see citing works
Montgomery, M. K., Brown, S. H. J., Mitchell, T. W., Coster, A. C. F., Cooney, G. J., & Turner, N. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-14214-1 · Cited by 40 · see citing works
Self-citationLudzki, A. C., Paglialunga, S., Smith, B. K., Herbst, E. A. F., Allison, M. K., Heigenhauser, G. J. F., Neufer, P. D., & Holloway, G. P. (2015) · Diabetes · doi:10.2337/db14-1838 · Cited by 38 · see citing works
Small, L., Brandon, A. E., Quek, L., Krycer, J. R., James, D. E., Turner, N. A., & Cooney, G. J. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00386.2017 · Cited by 35 · see citing works
Self-citationDefining lipid mediators of insulin resistance: controversies and challenges
Metcalfe, L. K., Smith, G. C., & Turner, N. A. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0023 · Cited by 35 · see citing works
Self-citationZamora, M., Pardo, R., & Villena, J. A. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.032 · Cited by 32 · see citing works
Liu, Y., Wang, C., Wang, Y., Ma, Z., Xiao, J., McClain, C. J., Li, X., & Feng, W. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.08.003 · Cited by 32 · see citing works
Strekalova, T. V., Costa-Nunes, J. P., Veniaminova, E. A., Kubatiev, A. A., Lesch, K., Chekhonin, V. P., Evans, M. C., & Steinbusch, H. W. M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.045 · Cited by 31 · see citing works
Huang, S., Huang, S., Wang, X., Zhang, Q., Liu, J., & Leng, Y. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.17149 · Cited by 27 · see citing works
Kawanishi, N., Takagi, K., Lee, H., Nakano, D., Okuno, T., Yokomizo, T., & Machida, S. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00371.2017 · Cited by 26 · see citing works
Holloway, G. P., Han, X., Jain, S. S., Bonen, A., & Chabowski, A. (2014) · Diabetologia · doi:10.1007/s00125-014-3169-0 · Cited by 26 · see citing works
Zhang, H., Qin, G.-J., Li, X., Zhang, Y., Du, P., Zhang, P.-Y., Zhao, Y., & Wu, J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0396-x · Cited by 25 · see citing works
Matravadia, S., Zabielski, P., Chabowski, A., Mutch, D. M., & Holloway, G. P. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00297.2015 · Cited by 24 · see citing works
Miotto, P. M., Horbatuk, M., Proudfoot, R., Matravadia, S., Bakovic, M., Chabowski, A., & Holloway, G. P. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00438.2016 · Cited by 21 · see citing works
Roles of Fatty Acid Oversupply and Impaired Oxidation in Lipid Accumulation in Tissues of Obese Rats
Oakes, N. D., Kjellstedt, A., Thalén, P., Ljung, B., & Turner, N. A. (2013) · Journal of Lipids · doi:10.1155/2013/420754 · Cited by 20 · see citing works
Self-citationSong, G., Ren, L., Chen, S., Wang, C., Liu, N., Wei, L., Li, F., Sun, W., Peng, L., & Tang, Y. P. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12017 · Cited by 20 · see citing works
Passaro, A., Sanz, J. M., Naumovski, N., & Sergi, D. (2024) · Advances in Redox Research · doi:10.1016/j.arres.2024.100100 · Cited by 17 · see citing works
Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver
Nagarajan, S. R., Brandon, A. E., McKenna, J. A., Shtein, H. C., Nguyen, T., Suryana, E., Poronnik, P., Cooney, G. J., Saunders, D. N., & Hoy, A. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174431 · Cited by 14 · see citing works
Self-citationZhong, R., Zhu, Y., Zhang, H., Huo, Y., Huang, Y., Cheng, W., & Liang, P. (2022) · Food & Function · doi:10.1039/d2fo02736d · Cited by 13 · see citing works
Bakshi, I., Brown, S. H. J., Brandon, A. E., Suryana, E., Mitchell, T. W., Turner, N. A., & Cooney, G. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32354-w · Cited by 14 · see citing works
Self-citationAkerstrom, T. C. A., Vedel, K., Needham, J., Højman, P., Kontou, E. E., Hellsten, Y., & Wojtaszewski, J. F. P. (2015) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2015.10.007 · Cited by 12 · see citing works
Takagi, H., Ikehara, T., Hashimoto, K., Tanimoto, K., Shimazaki, A., Kashiwagi, Y., Sakamoto, S. X., & Yukioka, H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174451 · Cited by 11 · see citing works
Vidyadharan, V. A., Betancourt, A., Smith, C., Yallampalli, C., & Blesson, C. S. (2022) · Nutrients · doi:10.3390/nu14061158 · Cited by 10 · see citing works
Maude, H., Lau, W., Maniatis, N., & Andrew, T. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.694893 · Cited by 7 · see citing works
Mitochondrial Metabolism and Insulin Action
Turner, N. A. (2013) · InTech eBooks · doi:10.5772/56449 · Cited by 6 · see citing works
Self-citationEffect of Ethyl Pyruvate on Skeletal Muscle Metabolism in Rats Fed on a High Fat Diet
Olek, R. A., Ziółkowski, W., Wierzba, T. H., & Kaczor, J. J. (2013) · Nutrients · doi:10.3390/nu5072372 · Cited by 7 · see citing works
Zhang, C., Steadman, M., Junior, H. P. D. O. S., Shaikh, S. R., & Xavier, R. M. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.02.004 · Cited by 4 · see citing works
Handschin, C. (2011) · Diabetologia · doi:10.1007/s00125-011-2135-3 · Cited by 4 · see citing works
Rahman, M. M., Sarker, M. T., Ahmed, S., Uddin, M. N., Islam, M. R., Islam, M. R., Das, S., Mukherjee, N., Hemeg, H. A., Rauf, A., et al. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.07.007 · Cited by 4 · see citing works
SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance
Osborne, B., Wright, L. E., Brandon, A. E., Stuart, E., Small, L., Joris Hoeks, J., Schrauwen, P., Sinclair, D. A., Montgomery, M. K., Cooney, G. J., et al. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0101 · Cited by 1 · see citing works
Self-citationShang, J., Ma, L., Su, R., Jiang, X., Jiang, Y., Fan, Y., Wang, Y., Li, X., You, M., Tian, Z., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121523 · Cited by 1 · see citing works
Effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats
Kazemi, F., Khosroo, E., & Asl, S. Z. (2016) · Research in Medicine · Cited by 1 · see citing works
Brockman, D. A. (2013) · University of Minnesota Digital Conservancy (University of Minnesota) · Cited by 1 · see citing works
Master Switch of Mitochondrial Biogenesis: A Clinical Target for Health Span Enhancement?
Mendelsohn, A. R., & Larrick, J. W. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1194 · Cited by 1 · see citing works
Matravadia, S. (2016) · The Atrium (University of Guelph)
(2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283543033
- Authors
- Wright, L. E., Brandon, A. E., Hoy, A. J., Forsberg, G.-B., Lelliott, C. J., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G. J., & Turner, N.
- Affiliations
- Garvan Institute of Medical Research (AU)
- AstraZeneca (Sweden) (SE)
- Corresponding author
- Turner, N.
- ORCID
- Venue
- Diabetologia
- Published
- 2011-02-18
- Volume
- 54
- Issue
- 6
- Pages
- 1417-1426
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2151974497
- Cited by
- 57
- References
- 50
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of New South Wales
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PGC-1β, PPARGC1B, insulin resistance, skeletal muscle, high-fat diet, long-chain acyl-CoA, oxidative stress, mitochondrial function, antioxidant defense, in vivo electroporation, hyperinsulinemic-euglycemic clamp, lipid metabolism
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Acyl Coenzyme A, Animals, Dietary Fats, Insulin Resistance, Male, Mitochondria, Muscle, Time Factors, Transcription Factors, RNA-Binding Proteins, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Models, Animal, Lipid Metabolism, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review