PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity.
Open accessAbstract
A well balanced body energy budget controlled by limitation of calorie uptake and/or increment of energy expenditure, which is typically achieved by proper physical exercise, is most effective against obesity and diabetes mellitus. Recently, peroxisome proliferator-activated receptor (PPAR) gamma, a member of the nuclear receptor, and its cofactors have been shown to be involved in lipid metabolism and in the control of energy expenditure. Here we show that PPARgamma coactivator 1 (PGC-1) beta functions as ERRL1 (for ERR ligand 1), which can bind and activate orphan ERRs (estrogen receptor-related receptors) in vitro. Consistently, PGC-1beta/ERRL1 transgenic mice exhibit increased expression of the medium-chain acyl CoA dehydrogenase, a known ERR target and a pivotal enzyme of mitochondrial beta-oxidation in skeletal muscle. As a result, the PGC-1beta/ERRL1 mice show a state similar to an athlete; namely, the mice are hyperphagic and of elevated energy expenditure and are resistant to obesity induced by a high-fat diet or by a genetic abnormality. These results demonstrate that PGC-1beta/ERRL1 can function as a protein ligand of ERR, and that its level contributes to the control of energy balance in vivo, and provide a strategy for developing novel antiobesity drugs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PGC-1α and PGC-1β coactivate different nuclear receptors.
“In addition, PGC-1␣ and PGC-1 coactivate different nuclear receptors (272).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [272]
Modest overexpression of PGC-1α and transgenic overexpression of PGC-1β increase oxidative metabolism and insulin sensitivity.
“Taken together, these studies suggest that modest overexpression of PGC-1␣ (261, 262) and transgenic overexpression of PGC-1 (271, 272) increase oxidative metabolism and insulin sensitivity.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [272]
Whole-body transgenic overexpression of PGC-1β resulted in increased oxidative metabolism, protection from obesity induced by high-fat diet or hyperphagia, and enhanced insulin sensitivity.
“Consistent with these findings, whole-body transgenic overexpression of PGC-1 resulted in increased oxidative metabolism, protection from obesity induced by high-fat diet or hyperphagia, and enhanced insulin sensitivity (272).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [272]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
Efficient selection for high-expression transfectants with a novel eukaryotic vector
Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,135 · see citing works
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233 · see citing works
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150 · see citing works
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821 · see citing works
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works
Identification of a new class of steroid hormone receptors
Giguère, V., Yang, N., Segui, P., & Evans, R. M. (1988) · Nature · doi:10.1038/331091a0 · Cited by 867 · see citing works
Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 701 · see citing works
Lin, J., Puigserver, P., Donovan, J., Tarr, P., & Spiegelman, B. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100631200 · Cited by 552 · see citing works
SLADEK, R. M., Bader, J.-A., & Giguère, V. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5400 · Cited by 375 · see citing works
Andersson, U., & Scarpulla, R. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3738-3749.2001 · Cited by 374 · see citing works
Hong, H., Yang, L., & Stallcup, M. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22618 · Cited by 300 · see citing works
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine · doi:10.1038/80450 · Cited by 291 · see citing works
Vega, R. B., & Kelly, D. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31693 · Cited by 155 · see citing works
Eudy, J. D., Yao, S., Weston, M. D., Ma-Edmonds, M., Talmadge, C. B., Cheng, J. J., Kimberling, W. J., & Sümegi, J. (1998) · Genomics · doi:10.1006/geno.1998.5345 · Cited by 140 · see citing works
The agouti gene: turned on to yellow
Siracusa, L. D. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90112-0 · Cited by 118 · see citing works
Dietary fatty acids and insulin resistance
Lovejoy, J. C. (1999) · Current Atherosclerosis Reports · doi:10.1007/s11883-999-0035-5 · Cited by 86 · see citing works
Takada, I. (2000) · Molecular Endocrinology · doi:10.1210/me.14.5.733 · Cited by 74 · see citing works
Shigeta, H., Zuo, W., Yang, N., DiAugustine, R. P., & Teng, C. (1997) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0190299 · Cited by 70 · see citing works
PGC-1 and PERC, coactivators of the estrogen receptor-related receptor γ
Hentschke, M., Süsens, U., & Borgmeyer, U. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02753-5 · Cited by 67 · see citing works
Odle, J., Benevenga, N. J., & Crenshaw, T. D. (1991) · Journal of Nutrition · doi:10.1093/jn/121.5.605 · Cited by 66 · see citing works
Takada, I., Yu, R. T., Xu, H. E., Lambert, M. H., Montana, V. G., Kliewer, S. A., Evans, R. M., & Umesono, K. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.5.0456 · Cited by 47 · see citing works
Diet-induced thermogenesis in cafeteria-fed rats: a myth?
Maxwell, G. M., Nobbs, S., & Bates, D. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.3.e264 · Cited by 20 · see citing works
Estimation of Daily Minimum Energy Expenditure in Free-moving Rats and Mice.
Komenami, N., Yamamoto, Y., & Miyoshi, M. (1995) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.41.395 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · see citing works
“…+ ND fatty-acid oxidation Wang et al., 2003 PPARγ + + UCP1/GyK induction Guan et al., 2005; Puigserver et al., 1998 Huss et al., 2002; Huss et al., 2004; Kamei et al., 2003; ERRα,β,γ + + mitochondrial genes Mootha et al., 2004; Schreiber et al., 2004 TRβ + + cpt-1 induction Wu et al., 2002; Zhang…”
BackgroundInfluentialPGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,427 · see citing works
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119 · see citing works
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
Michalik, L., Auwerx, J. H., Berger, J. P., Chatterjee, K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O’Rahilly, S., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.5 · Cited by 997 · see citing works
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works
Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 892 · see citing works
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718 · see citing works
Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St. Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401401101 · Cited by 688 · see citing works
Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works
Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP
Lin, J. D., Yang, R., Tarr, P. T., Wu, P., Handschin, C., Li, S., Yang, W., Pei, L., Uldry, M., Tontonoz, P., et al. (2005) · Cell · doi:10.1016/j.cell.2004.11.043 · Cited by 618 · see citing works
Transcriptional Control of Mitochondrial Biogenesis and Function
Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 616 · see citing works
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 584 · see citing works
Kamei, Y., Miura, S., SUZUKI, M. T., Kai, Y., Mizukami, J., Taniguchi, T., Mochida, K., Tomoko, H. A. T. A., Matsuda, J., Aburatani, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400674200 · Cited by 574 · see citing works
Zhou, W., Choi, M. P., Margineantu, D. H., Margaretha, L., Hesson, J., Cavanaugh, C., Blau, C. A., Horwitz, M. S., Hockenbery, D. M., Ware, C. B., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.71 · Cited by 555 · see citing works
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works
Mitochondrial energy metabolism in heart failure: a question of balance
Huss, J. M., & Kelly, D. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24405 · Cited by 533 · see citing works
PPARδ regulates glucose metabolism and insulin sensitivity
Lee, C., Olson, P., Hevener, A. L., Mehl, I. R., Chong, L.-W., Olefsky, J. M., Gonzalez, F. J., Ham, J., Kang, H., Peters, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511253103 · Cited by 495 · see citing works
Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 485 · see citing works
Nuclear Receptor Signaling and Cardiac Energetics
Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 472 · see citing works
Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ
Dufour, C. R., Wilson, B. J., Huss, J. M., Kelly, D. P., Alaynick, W. A., Downes, M., Evans, R. M., Blanchette, M., & Giguère, V. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.007 · Cited by 418 · see citing works
PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
Lira, V. A., Benton, C. R., Yan, Z., & Bonen, A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00755.2009 · Cited by 412 · see citing works
Villena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 404 · see citing works
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
Martin, B., Mattson, M. P., & Maudsley, S. R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.002 · Cited by 394 · see citing works
Arany, Z., Lebrasseur, N., Morris, C., Smith, E., Yang, W., Ma, Y., Chin, S., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.12.003 · Cited by 370 · see citing works
Nonalcoholic fatty liver disease and mitochondrial dysfunction
Wei, Y., Rector, R. S., Thyfault, J. P., & Ibdah, J. A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.193 · Cited by 370 · see citing works
Nuclear receptor corepressor RIP140 regulates fat accumulation
Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366 · see citing works
Identification of the circadian transcriptome in adult mouse skeletal muscle
McCarthy, J. J., Andrews, J. L., McDearmon, E. L., Campbell, K. S., Barber, B. K., Miller, B. H., Walker, J. R., Hogenesch, J. B., Takahashi, J. S., & Esser, K. A. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00066.2007 · Cited by 363 · see citing works
Kanayama, T., Kobayashi, N., Mamiya, S., Nakanishi, T., & Nishikawa, J. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.008409 · Cited by 354 · see citing works
Lu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 360 · see citing works
Lai, L., Leone, T. C., Zechner, C., Schaeffer, P. J., Kelly, S. M., Flanagan, D. P., Medeiros, D. M., Kovacs, A., & Kelly, D. P. (2008) · Genes & Development · doi:10.1101/gad.1661708 · Cited by 326 · see citing works
The Human Obesity Gene Map: The 2004 Update
Përusse, L., Rankinen, T., Zuberi, A. R., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G. A., Walts, B., Snyder, E. E., & Bouchard, C. (2005) · Obesity Research · doi:10.1038/oby.2005.50 · Cited by 326 · see citing works
ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart
Alaynick, W. A., Kondo, R. P., Xie, W., He, W., Dufour, C. R., Downes, M., Jonker, J. W., Giles, W. R., Naviaux, R. K., Giguère, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.007 · Cited by 311 · see citing works
LXRs regulate the balance between fat storage and oxidation
Kalaany, N. Y., Gauthier, K. C., Zavacki, A. M., Mammen, P. P. A., Kitazume, T., Peterson, J. A., Horton, J. D., Garry, D. J., Bianco, A. C., & Mangelsdorf, D. J. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.001 · Cited by 304 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J. F. P., Beck‐Nielsen, H., Groop, L., & Vaag, A. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421889 · Cited by 300 · see citing works
Finck, B. N., & Kelly, D. P. (2007) · Circulation · doi:10.1161/circulationaha.107.670588 · Cited by 281 · see citing works
Lelliott, C. J., Medina-Gomez, G., Petrovic, N., Kis, A., Feldmann, H. M., Bjursell, M., Parker, N., Curtis, K., Campbell, M., Hu, P., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040369 · Cited by 280 · see citing works
“]. Thus PGC-1β increases mitochondrial energy production through a combination of activated fatty acid oxidation gene expression with increased mitochondrial activity. A role for PGC-1β enhancing mitochondrial activity is further supported by the fact that transgenic overexpression of PGC-1β in mice results in elevate…”
BackgroundTamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives
Shagufta, & Ahmad, I. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.11.056 · Cited by 268 · see citing works
Sonoda, J., Mehl, I. R., Chong, L.-W., Nofsinger, R. R., & Evans, R. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611623104 · Cited by 266 · see citing works
Regulation of Skeletal Muscle Function by Amino Acids
Kamei, Y., Hatazawa, Y., Uchitomi, R., Yoshimura, R., & Miura, S. (2020) · Nutrients · doi:10.3390/nu12010261 · Cited by 254 · see citing works
ERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · see citing works
“Second, ERRα, which is a weak activator of transcription in cells with low PGC-1 activity and where other NRs are transcriptionally active, is transformed to a potent transcriptional activator when PGC-1α or PGC-1β is introduced into the system [23,24,27].”
BackgroundPGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss
Wei, W., Wang, X., Yang, M., Smith, L. C., Dechow, P. C., & Wan, Y. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.015 · Cited by 243 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J., Beck-Nielsen, H., Groop, L., & Vaag, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21889 · Cited by 300 · see citing works
Powelka, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26040 · Cited by 236 · see citing works
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond
Deblois, G., & Giguère, V. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3396 · Cited by 226 · see citing works
Angiopoietin-related growth factor antagonizes obesity and insulin resistance
Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., et al. (2005) · Nature Medicine · doi:10.1038/nm1214 · Cited by 219 · see citing works
Huss, J. M., Garbacz, W. G., & Xie, W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.016 · Cited by 217 · see citing works
Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defensePreprint
Sonoda, J., Laganière, J., Mehl, I. R., Barish, G. D., Chong, L.-W., Li, X., Scheffler, I. E., Mock, D. C., Bataille, A. R., Robert, F., et al. (2007) · Genes & Development · doi:10.1101/gad.1553007 · Cited by 217 · see citing works
Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis
Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., & Kralli, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607696104 · Cited by 215 · see citing works
Gao, C., Zhu, C., Zhao, Y., Chen, X.-H., Ji, C., Zhang, C., Zhu, J., Xia, Z., Tong, M., & Guo, X. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.039 · Cited by 203 · see citing works
The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARγ Expression
Waki, H., Park, K. W., Mitro, N., Pei, L., Damoiseaux, R. D., Wilpitz, D. C., Reue, K., Sáez, E., & Tontonoz, P. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.010 · Cited by 202 · see citing works
Eichner, L. J., & Giguère, V. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.121 · Cited by 200 · see citing works
Willy, P. J., Murray, I., Qian, J., Busch, B. B., Stevens, W. C., Martin, R., Mohan, R., Zhou, S., Ordentlich, P., Wei, P. Y., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401420101 · Cited by 195 · see citing works
Uchitomi, R., Oyabu, M., & Kamei, Y. (2020) · Nutrients · doi:10.3390/nu12103189 · Cited by 193 · see citing works
The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal Muscle
Seth, A., Steel, J. H., Nichol, D., Pocock, V., Kumaran, M. K., Fritah, A., Mobberley, M. A., Ryder, T. A., Rowlerson, A. M., Scott, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.004 · Cited by 189 · see citing works
Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development
Melnik, B. C., Stremmel, W., Weiskirchen, R., John, S. M., & Schmitz, G. (2021) · Biomolecules · doi:10.3390/biom11060851 · Cited by 185 · see citing works
Skeletal muscle and nuclear hormone receptors: Implications for cardiovascular and metabolic disease
Smith, A. G., & Muscat, G. E. O. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.002 · Cited by 183 · see citing works
The PGC-1/ERR signaling axis in cancer
Deblois, G., St‐Pierre, J., & Giguère, V. (2012) · Oncogene · doi:10.1038/onc.2012.529 · Cited by 180 · see citing works
Regulatory circuits controlling white versus brown adipocyte differentiation
Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178 · see citing works
Audet‐Walsh, É., & Giguère, V. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.121 · Cited by 175 · see citing works
Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size
Takahashi, M. M., Kamei, Y., & Ezaki, O. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00244.2004 · Cited by 170 · see citing works
Estrogen-Related Receptors as Emerging Targets in Cancer and Metabolic Disorders
Ariazi, E. A., & Jordan, V. C. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026610606030203 · Cited by 169 · see citing works
Laganière, J., Tremblay, G. B., Dufour, C. R., Giroux, S., Rousseau, F., & Giguère, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313543200 · Cited by 162 · see citing works
Hallberg, M., Morganstein, D. L., Kiskinis, E., Shah, K., Kralli, A., Dilworth, S. M., White, R., Parker, M. G., & Christian, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00504-08 · Cited by 164 · see citing works
Deblois, G., Hall, J. A., Perry, M.-C., Laganière, J., Ghahremani, M., Park, M., Hallett, M. T., & Giguère, V. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1251 · Cited by 160 · see citing works
Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression
Zhang, Y., Ma, K., Sadana, P., Chowdhury, F., Gaillard, S. L., Wang, F., McDonnell, D. P., Unterman, T. G., Elam, M. B., & Park, E. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608657200 · Cited by 159 · see citing works
Nuclear receptors, mitochondria and lipid metabolism
Alaynick, W. A. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.02.001 · Cited by 157 · see citing works
PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα
Shao, D., Liu, Y., Liu, X., Zhu, L., Cui, Y., Cui, A., Qiao, A., Kong, X., Liu, Y. U., Chen, Q., et al. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.012 · Cited by 155 · see citing works
Miura, S., Kai, Y., Kamei, Y., & Ezaki, O. (2008) · Endocrinology · doi:10.1210/en.2008-0466 · Cited by 150 · see citing works
The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
Krist, B., Florczyk, U., Pietraszek‐Gremplewicz, K., Józkowicz, A., & Dulak, J. (2015) · International Journal of Endocrinology · doi:10.1155/2015/281756 · Cited by 144 · see citing works
Patch, R. J., Searle, L. L., Kim, A. J., De, D., Zhu, X., Askari, H. B., O’Neill, J. C., Abad, M. C., Rentzeperis, D., Liu, J., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101063h · Cited by 141 · see citing works
Nitric oxide and mitochondrial biogenesis: A key to long-term regulation of cellular metabolism
Clementi, E., & Nisoli, E. (2005) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.04.022 · Cited by 136 · see citing works
Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
Holloway, G. P., Bonen, A., & Spriet, L. L. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717b · Cited by 140 · see citing works
Dwyer, M. A., Joseph, J. D., Wade, H. E., Eaton, M. L., Kunder, R. S., Kazmin, D. A., Chang, C., & McDonnell, D. P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0226 · Cited by 140 · see citing works
Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics
Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 136 · see citing works
Wang, L., Zuercher, W. J., Consler, T. G., Lambert, M. H., Miller, A. B., Orband‐Miller, L. A., McKee, D. D., Willson, T. M., & Nolte, R. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608410200 · Cited by 137 · see citing works
Fuel economy in food‐deprived skeletal muscle: signaling pathways and regulatory mechanisms
de Lange, P., Moreno, M., Silvestri, E., Lombardi, A., Goglia, F., & Lanni, A. (2007) · The FASEB Journal · doi:10.1096/fj.07-8527rev · Cited by 133 · see citing works
Cheung, C. P., Yu, S., Wong, K., Chan, L. W., Lai, F. M., Wang, X., Suetsugi, M., Chen, S., & Chan, F. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1421 · Cited by 136 · see citing works
Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N. (2010) · Metabolism · doi:10.1016/j.metabol.2009.10.023 · Cited by 136 · see citing works
Chang, C., Kazmin, D. A., Jasper, J. S., Kunder, R. S., Zuercher, W. J., & McDonnell, D. P. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.023 · Cited by 134 · see citing works
Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease
Deblois, G., & Giguère, V. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.009 · Cited by 135 · see citing works
Wan, Y. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.006 · Cited by 134 · see citing works
The NR3B Subgroup: An Overrview
Tremblay, A., & Giguère, V. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05009 · Cited by 134 · see citing works
The Drosophila PGC‐1 homologue Spargel coordinates mitochondrial activity to insulin signalling
Tiefenböck, S. K., Baltzer, C., Egli, N. A., & Frei, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.330 · Cited by 131 · see citing works
GCN5-mediated Transcriptional Control of the Metabolic Coactivator PGC-1β through Lysine Acetylation
Kelly, T. J., Lerín, C., Haas, W., Gygi, S. P., & Puigserver, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.015164 · Cited by 130 · see citing works
Greschik, H., Flaig, R., Renaud, J., & Moras, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402195200 · Cited by 130 · see citing works
PGC-1α is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle
Rowe, G. C., El‐Khoury, R., Patten, I. S., Rustin, P., & Arany, Z. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041817 · Cited by 127 · see citing works
Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance
Zorzano, A., Liesa, M., & Palacı́n, M. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802676335 · Cited by 123 · see citing works
Binding of PFOS to Serum Albumin and DNA: Insight into the Molecular Toxicity of Perfluorochemicals
Zhang, X., Chen, L., Fei, X.-C., Ma, Y.-S., & Gao, H.-W. (2009) · BMC Molecular Biology · doi:10.1186/1471-2199-10-16 · Cited by 119 · see citing works
The metabolic modulator PGC-1α in cancer.
Bost, F., & Kaminski, L. (2019) · Europe PMC (PubMed Central) · Cited by 119 · see citing works
Spector, N. L., Yarden, Y., Smith, B. L., Lyass, L., Trusk, P. B., Pry, K. J., Hill, J. E., Xia, W., Seger, R., & Bacus, S. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701286104 · Cited by 117 · see citing works
Zehnder, T., Petrelli, F., Romanos, J., Figueiredo, E. C. D. O., Lewis, T. L., Déglon, N., Polleux, F., Santello, M., & Bezzi, P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108952 · Cited by 110 · see citing works
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRαPreprint
Yan, M., Audet‐Walsh, É., Manteghi, S., Dufour, C. R., Walker, B., Baba, M., St‐Pierre, J., Giguère, V., & Pause, A. (2016) · Genes & Development · doi:10.1101/gad.281410.116 · Cited by 108 · see citing works
Metabolic regulation by the nuclear receptor corepressor RIP140
Christian, M., White, R., & Parker, M. G. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.06.008 · Cited by 106 · see citing works
Carrier, J. C., Deblois, G., Champigny, C., Levy, E. H., & Giguère, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410337200 · Cited by 107 · see citing works
Corton, J. C., & Brown-Borg, H. M. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1494 · Cited by 106 · see citing works
Tremblay, A., Wilson, B. J., Yang, X., & Giguère, V. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0357 · Cited by 105 · see citing works
The PGC-1 cascade as a therapeutic target for heart failure
Schilling, J. D., & Kelly, D. P. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.09.021 · Cited by 105 · see citing works
- Authors
- Kamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O., & Kakizuka, A.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Kakizuka, Akira
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-10-06
- Volume
- 100
- Issue
- 21
- Pages
- 12378-12383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC218766
- OpenAlex
- W1965989272
- Cited by
- 357
- References
- 26
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 12 · 2018: 14 · 2017: 10 · 2016: 9 · 2015: 16 · 2014: 11 · 2013: 15 · 2012: 16
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- PGC-1β, orphan nuclear receptor, protein ligands, energy expenditure, obesity resistance, high-fat diet, medium-chain acyl-CoA dehydrogenase, mitochondrial beta-oxidation, skeletal muscle, hyperphagia, energy balance, anti-obesity drugs
- MeSH terms
- ERRalpha Estrogen-Related Receptor, Amino Acid Sequence, Animals, Base Sequence, DNA, Energy Metabolism, Ligands, Mice, Transgenic, Molecular Sequence Data, Obesity, Receptors, Estrogen, Recombinant Proteins, Transcription Factors, Gene Expression, Receptors, Cytoplasmic and Nuclear, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
