Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Mitochondrial dysfunction and type 2 diabetes

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Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

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The multifaceted contributions of mitochondria to cellular metabolism

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Insulin and insulin resistance:

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Biochemical Adaptations in Muscle

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

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Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

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Insulin and insulin resistance.

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Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

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Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

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Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes

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Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

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Defining high-fat-diet rat models: Metabolic and molecular effects of different fat types

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Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle

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Pathogenesis of insulin resistance in skeletal muscle

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Lipid oxidation is reduced in obese human skeletal muscle

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Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

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Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

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Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I

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Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520 · see citing works

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

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The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man

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Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance

Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478 · see citing works

Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

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PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity

Lira, V. A., Benton, C. R., Yan, Z., & Bonen, A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00755.2009 · Cited by 412 · see citing works

Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance

Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407 · see citing works

Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity

Goodpaster, B. H., Katsiaras, A., & Kelley, D. E. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2191 · Cited by 390 · see citing works

Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

HOOD, M. S., LITTLE, J. P., TARNOPOLSKY, M. A., MYSLIK, F., & GIBALA, M. J. (2011) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/mss.0b013e3182199834 · Cited by 375 · see citing works

Type 2 Diabetes, Muscle Strength, and Impaired Physical Function

Sayer, A. A., Dennison, E. M., Syddall, H. E., Gilbody, H. J., Phillips, D. I. W., & Cooper, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2541 · Cited by 366 · see citing works

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet–induced insulin resistance

Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes · doi:10.2337/db08-1078 · Cited by 363 · see citing works

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

Meex, R. C. R., Schrauwen-Hinderling, V. B., Moonen-Kornips, E., Schaart, G., Mensink, M., Phielix, E., van de Weijer, T., Sels, J.-P., Schrauwen, P., & Hesselink, M. K. C. (2010) · Diabetes · doi:10.2337/db09-1322 · Cited by 355 · see citing works

Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle

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Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

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Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes.

Toledo, F. G. S., Menshikova, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., & Kelley, D. E. (2007) · Diabetes · doi:10.2337/db07-0141 · Cited by 321 · see citing works

The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes

Cusi, K. J. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0122-6 · Cited by 294 · see citing works

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282 · see citing works

Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia

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Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide

Dubé, J. J., Amati, F., Toledo, F. G. S., Stefanović-Račić, M., Rossi, A. P., Coen, P. M., & Goodpaster, B. H. (2011) · Diabetologia · doi:10.1007/s00125-011-2065-0 · Cited by 272 · see citing works

Ceramide Interaction with the Respiratory Chain of Heart Mitochondria

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Reactive oxygen species and insulin resistance: the good, the bad and the ugly

Tiganis, T. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.006 · Cited by 256 · see citing works

Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes

Hwang, H., Bowen, B. P., Lefort, N., Flynn, C. R., De Filippis, E. A., Roberts, C., Smoke, C. C., Meyer, C., Højlund, K., Yi, Z., et al. (2010) · Diabetes · doi:10.2337/db09-0214 · Cited by 255 · see citing works

Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle

Granata, C., Jamnick, N. A., & Bishop, D. J. (2018) · Sports Medicine · doi:10.1007/s40279-018-0936-y · Cited by 247 · cited 2× · see citing works

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

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Exercise Training-Induced Regulation of Mitochondrial Quality

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Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 229 · see citing works

Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content

Toledo, F. G. S., Menshikova, E. V., Azuma, K., Radiková, Z., Kelley, C. A., Ritov, V. B., & Kelley, D. E. (2008) · Diabetes · doi:10.2337/db07-1429 · Cited by 218 · see citing works

Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle

Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., & Bishop, D. J. (2016) · The FASEB Journal · doi:10.1096/fj.15-276907 · Cited by 215 · see citing works

Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia

Asmann, Y. W., Stump, C. S., Short, K. R., Coenen-Schimke, J. M., Guo, Z., Bigelow, M. L., & Nair, K. S. (2006) · Diabetes · doi:10.2337/db05-1230 · Cited by 207 · see citing works

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

Phielix, E., Meex, R., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2010) · Diabetologia · doi:10.1007/s00125-010-1764-2 · Cited by 206 · cited 6× · see citing works

Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults

Ryan, B. J., Schleh, M. W., Ahn, C., Ludzki, A. C., Gillen, J. B., Varshney, P., Pelt, D. W. V., Pitchford, L. M., Chenevert, T. L., Gioscia‐Ryan, R. A., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa345 · Cited by 206 · see citing works

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., et al. (2014) · Diabetes · doi:10.2337/db13-0967 · Cited by 201 · see citing works

Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?

Bishop, D. J., Granata, C., & Eynon, N. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.012 · Cited by 191 · see citing works

Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity

Menshikova, E. V., Ritov, V. B., Toledo, F. G. S., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00322.2004 · Cited by 189 · see citing works

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

Nair, K. S., Bigelow, M. L., Asmann, Y. W., Chow, L. S., Coenen-Schimke, J. M., Klaus, K. A., Guo, Z.-K., Sreekumar, R., & Irving, B. A. (2008) · Diabetes · doi:10.2337/db07-1556 · Cited by 187 · see citing works

Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle

Perreault, L., Newsom, S. A., Strauss, A., Kerege, A., Kahn, D. E., Harrison, K. A., Snell-Bergeon, J. K., Nemkov, T., D’Alessandro, A., Jackman, M. R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.96805 · Cited by 184 · see citing works

High-intensity exercise and mitochondrial biogenesis: current controversies and future research directions

Bishop, D. J., Botella, J., Genders, A. J., Lee, M. J.-C., Saner, N. J., Kuang, J., Yan, X., & Granata, C. (2019) · Physiology · doi:10.1152/physiol.00038.2018 · Cited by 180 · see citing works

Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism

Koves, T. R., Noland, R. C., Bates, A. L., Henes, S. T., Muoio, D. M., & Cortright, R. N. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00391.2004 · Cited by 178 · see citing works

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

Holloszy, J. O. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717c · Cited by 175 · see citing works

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

Lebon, V., Dufour, S., Petersen, K. F., Ren, J., Jucker, B. M., Slezak, L. A., Cline, G. W., Rothman, D. L., & Shulman, G. I. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111775 · Cited by 174 · see citing works

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

Lebon, V., Dufour, S., Petersen, K. F., Ren, J., Jucker, B. M., Slezak, L. A., Cline, G. W., Rothman, D. L., & Shulman, G. I. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11775 · Cited by 173 · see citing works

Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle

Ukropcova, B., Sereda, O., de Jonge, L., Bogacka, I., Nguyen, T., Xie, H., Bray, G. A., & Smith, S. R. (2007) · Diabetes · doi:10.2337/db06-0521 · Cited by 165 · see citing works

The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects

Bruce, C. R., Mertz, V. A., Heigenhauser, G. J. F., & Dyck, D. J. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3154 · Cited by 164 · see citing works

Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility

Chomentowski, P., Coen, P. M., Radiková, Z., Goodpaster, B. H., & Toledo, F. G. S. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-0822 · Cited by 163 · see citing works

Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle

Nielsen, J., Mogensen, M., Vind, B. F., Sahlin, K., Højlund, K., Schrøder, H. D., & Ørtenblad, N. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00692.2009 · Cited by 158 · see citing works

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.008 · Cited by 156 · see citing works

Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery

Coen, P. M., Menshikova, E. V., Distéfano, G., Zheng, D., Tanner, C., Standley, R., Helbling, N., Dubis, G. S., Ritov, V., Xie, H., et al. (2015) · Diabetes · doi:10.2337/db15-0809 · Cited by 155 · see citing works

Muscle mitochondrial changes with aging and exercise

Lanza, I. R., & Nair, K. S. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717d · Cited by 152 · see citing works

Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.

Holloway, G. P., Thrush, A. B., Heigenhauser, G. J. F., Tandon, N. N., Dyck, D. J., Bonen, A., & Spriet, L. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00639.2006 · Cited by 147 · see citing works

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats

Benton, C. R., Holloway, G. P., Han, X.-X., Yoshida, Y., Snook, L. A., Lally, J., Glatz, J. F. C., Luiken, J. J. F. P., Chabowski, A., & Bonen, A. (2010) · Diabetologia · doi:10.1007/s00125-010-1773-1 · Cited by 143 · see citing works

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.029 · Cited by 141 · see citing works

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes

Hey‐Mogensen, M., Højlund, K., Vind, B. F., Wang, L., Dela, F., Beck‐Nielsen, H., Fernström, M., & Sahlin, K. (2010) · Diabetologia · doi:10.1007/s00125-010-1813-x · Cited by 136 · see citing works

Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism

Wicks, S. E., Vandanmagsar, B., Haynie, K. R., Fuller, S. E., Warfel, J. D., Stephens, J. M., Wang, M., Han, X., Zhang, J., Noland, R. C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418560112 · Cited by 131 · see citing works

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

Smith, A. C., Mullen, K. L., Junkin, K. A., Nickerson, J., Chabowski, A., Bonen, A., & Dyck, D. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00677.2006 · Cited by 127 · see citing works

Mitochondrial Deficiency Is Associated With Insulin Resistance

Goodpaster, B. (2013) · Diabetes · doi:10.2337/db12-1612 · Cited by 123 · see citing works

Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro‐elongation phenotype

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Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction.

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Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training

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Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes

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“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance

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Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

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Differential responses to endurance training in subsarcolemmal and intermyofibrillar mitochondria

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High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity

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Maximal fat oxidation during exercise is positively associated with 24-hour fat oxidation and insulin sensitivity in young, healthy men

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High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII

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Skeletal Muscle Mitochondrial Bioenergetics and Morphology in High Fat Diet Induced Obesity and Insulin Resistance: Focus on Dietary Fat Source

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A perspective on the determination of mitochondrial biogenesis

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The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging

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Mitochondrial metabolic function assessed in vivo and in vitro

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Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans

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Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats

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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo

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Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging

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Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss

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Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans

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Training-induced improvement in lipid oxidation in type 2 diabetes mellitus is related to alterations in muscle mitochondrial activity. Effect of endurance training in type 2 diabetes

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Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance

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Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality

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Supplementation with dietary ω‐3 mitigates immobilization‐induced reductions in skeletal muscle mitochondrial respiration in young women

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Exercising your fat (metabolism) into shape: a muscle-centred view

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Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without polycystic ovary syndrome

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Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress

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Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction

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Compensatory increases in nuclear PGC1α protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats.

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Short‐term bed rest‐induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission

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UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction

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Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

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Your mitochondria are what you eat: a high-fat or a high-sucrose diet eliminates metabolic flexibility in isolated mitochondria from rat skeletal muscle

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Skeletal muscle fiber-type-specific changes in markers of capillary and mitochondrial content after low-volume interval training in overweight women

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Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training

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The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats

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Determinants of maximal whole‐body fat oxidation in elite cross‐country skiers: Role of skeletal muscle mitochondria

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Nine Days of Intensive Exercise Training Improves Mitochondrial Function But Not Insulin Action in Adult Offspring of Mothers with Type 2 Diabetes

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Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance

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Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

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Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling

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Exercise and Regulation of Protein Metabolism

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Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle

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Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes

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Mitochondrial ATP synthase β‐subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity

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Quantification of Mitochondrial Oxidative Phosphorylation in Metabolic Disease: Application to Type 2 Diabetes

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Physical activity prevents alterations in mitochondrial ultrastructure and glucometabolic parameters in a high-sugar diet model

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Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle

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Proteomics Analysis of Skeletal Muscle from Leptin‐Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition

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High Incomplete Skeletal Muscle Fatty Acid Oxidation Explains Low Muscle Insulin Sensitivity in Poorly Controlled T2D

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Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile

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Increased intrinsic mitochondrial respiratory capacity in skeletal muscle from rats with streptozotocin-induced hyperglycemia

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Impact of prolonged overfeeding on skeletal muscle mitochondria in healthy individuals

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Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice

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Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential

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Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet

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Adenosine Triphosphate Production of Muscle Mitochondria after Acute Exercise in Lean and Obese Humans

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Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport

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Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes

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Measuring mitochondrial protein synthesis to assess biogenesis

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Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects

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Obesity-Driven Metabolic Disorders: The Interplay of Inflammation and Mitochondrial Dysfunction

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Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms

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Anthocyanin Bioactivity in Obesity and Diabetes: The Essential Role of Glucose Transporters in the Gut and Periphery

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The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes

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The impact of bed rest on human skeletal muscle metabolism

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Effects of resistance training on insulin sensitivity in the elderly: A meta-analysis of randomized controlled trials

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Germ‐free mice are not protected against diet‐induced obesity and metabolic dysfunction

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Transcription Factor Movement and Exercise-Induced Mitochondrial Biogenesis in Human Skeletal Muscle: Current Knowledge and Future Perspectives

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Exercise as a tool to mitigate metabolic disease

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Interplay of mitochondria and diabetes: Unveiling novel therapeutic strategies

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Biomarkers and genetic polymorphisms associated with maximal fat oxidation during physical exercise: implications for metabolic health and sports performance

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Skeletal muscle mechanisms contributing to improved glycemic control following intense interval exercise and training

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Targeting mitochondrial transporters and metabolic reprogramming for disease treatment

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A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity

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Overview of methods that determine mitochondrial function in human disease

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A Narrative Review of Non-Pharmacological Strategies for Managing Sarcopenia in Older Adults with Cardiovascular and Metabolic Diseases

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Eating Speed, Physical Activity, and Cardiorespiratory Fitness Are Independent Predictors of Metabolic Syndrome in Korean University Students

Kang, M., Joo, M., Hong, H., & Kang, H. (2021) · Nutrients · doi:10.3390/nu13072420 · Cited by 20 · see citing works

Is insulin resistance tissue-dependent and substrate-specific? The role of white adipose tissue and skeletal muscle

Calderón-DuPont, D., Torre-Villalvazo, I., & Díaz‐Villaseñor, A. (2022) · Biochimie · doi:10.1016/j.biochi.2022.08.021 · Cited by 19 · see citing works

No effect of five days of bed rest or short‐term resistance exercise prehabilitation on markers of skeletal muscle mitochondrial content and dynamics in older adults

Marshall, R. N., Smeuninx, B., Seabright, A. P., Morgan, P. T., Atherton, P. J., Philp, A., & Breen, L. (2022) · Physiological Reports · doi:10.14814/phy2.15345 · Cited by 17 · see citing works

Passive heat stress induces mitochondrial adaptations in skeletal muscle

Marchant, E. D., Nelson, W. B., Hyldahl, R. D., Gifford, J. R., & Hancock, C. R. (2023) · International Journal of Hyperthermia · doi:10.1080/02656736.2023.2205066 · Cited by 18 · see citing works

Strength training improves insulin resistance and differently affects mitochondria in skeletal muscle and visceral adipose tissue in high-fat fed mice

Costa, J. S. R., Fonseca, G. F. A. C., Ottone, N. C. D. S., Silva, P. A., Antonaccio, R. F., Silva, G., Rocha, M. D. S. A., Coimbra, C. C., Esteves, E. A., Mang, Z. A., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119639 · Cited by 17 · see citing works

Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance

Huang, R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.800432 · Cited by 13 · see citing works

BPA exposure in L6 myotubes increased basal glucose metabolism in an estrogen receptor-dependent manner but induced insulin resistance

Kasongo, A. A., Leroux, M., Amrouche-Mekkioui, I., Belhadji-Domecq, M., & Aguer, C. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113505 · Cited by 12 · see citing works

Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α

Liu, B., Xie, D., Huang, X., Jin, S., Dai, Y., Sun, X., Li, D., Bennett, A. M., Diano, S., & Huang, Y. (2024) · Diabetologia · doi:10.1007/s00125-023-06073-5 · Cited by 10 · see citing works

Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome

González-Franquesa, A., Peijs, L., Cervone, D. T., Koçana, C., Zierath, J. R., & Deshmukh, A. S. (2021) · Proteomes · doi:10.3390/proteomes9030037 · Cited by 9 · see citing works

Measuring Mitochondrial Function: From Organelle to Organism

Lewis, M. T., Levitsky, Y., Bazil, J. N., & Wiseman, R. W. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2309-1_10 · Cited by 9 · see citing works

Physiological 4-phenylbutyrate promotes mitochondrial biogenesis and metabolism in C2C12 myotubes

Rivera, C. N., Smith, C. E., Draper, L. V., Watne, R. M., Wommack, A. J., & Vaughan, R. A. (2023) · Biochimie · doi:10.1016/j.biochi.2023.11.009 · Cited by 9 · see citing works

Excess Branched-Chain Amino Acids Suppress Mitochondrial Function and Biogenic Signaling but Not Mitochondrial Dynamics in a Myotube Model of Skeletal Muscle Insulin Resistance

VanDerStad, L. R., Wyatt, E. C., & Vaughan, R. A. (2024) · Metabolites · doi:10.3390/metabo14070389 · Cited by 8 · see citing works

Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss

van der Kolk, B. W., Pirinen, E., Nicoll, R., Pietiläinen, K. H., & Heinonen, S. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.08.002 · Cited by 8 · see citing works

Mitochondrial Transplantation: A Paradigm Shift in Osteoporosis Therapy

Shen, J., Lai, Y., Peng, Q., Lin, X., Chen, S., Guo, L., Xu, M., Lu, Y., Zhu, J., Lin, X., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s537166 · Cited by 8 · see citing works

New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes

Maude, H., Lau, W., Maniatis, N., & Andrew, T. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.694893 · Cited by 7 · see citing works

Leptin receptor defect with diabetes causes skeletal muscle atrophy in female obese Zucker rats where peculiar depots networked with mitochondrial damages

Gilloteaux, J., Nicaise, C., Sprimont, L., Bissler, J. J., Finkelstein, J. A., & Payne, W. R. (2021) · Ultrastructural Pathology · doi:10.1080/01913123.2021.1983099 · Cited by 6 · see citing works

Sarcopenia and non-alcoholic fatty liver disease: shared pathogenesis mechanisms as possible targets of therapy and prevention

Sheptulina, A. F., Dzhioeva, O. N., & Drapkina, O. M. (2021) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20212404157 · Cited by 5 · see citing works

Exercise, aerobic fitness, and muscle strength in relation to glucose tolerance 6 to 10 years after gestational diabetes

Andersson-Hall, U. K., Pour, D. H., Grau, S., Börjesson, M., & Holmäng, A. B. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.110078 · Cited by 5 · see citing works

Stevia Extract Improves Skeletal Muscle Metabolism and Mitochondrial Function While Attenuating Muscle Atrophy in Palmitate‐Treated C2C12 Myotubes and db / db Mice

Yoon, J., Park, M., & Lee, H. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70425 · Cited by 4 · see citing works

Mitochondrial dysfunction–driven inflammation and β-Cell apoptosis in type 2 diabetes mellitus: mechanistic insights and therapeutic implications

Yadav, S., Kumar, G., Kumar, S., Aran, K. R., & Kosey, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11851-6 · Cited by 4 · see citing works

Whole body lipid oxidation during exercise is impaired with poor insulin sensitivity but not with obesity per se

Arad, A. D., DiMenna, F. J., Kittrell, H. D., Kissileff, H. R., & Albu, J. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00042.2022 · Cited by 4 · see citing works

Exercise does not improve insulin resistance and mitochondrial characteristics together

Genders, A. J., Kuang, J., Marin, E. C., Saner, N. J., Botella, J., Jacques, M., McConell, G. K., Andrade-Souza, V. A., Chagolla, J., & Bishop, D. J. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0242 · Cited by 4 · see citing works

The effect of Semaglutide on mitochondrial function and insulin sensitivity in a myotube model of insulin resistance

Spry, E. R., Travis, K. B., Ragland, K. J., Klein, A. J., Zimmerman, J. M., & Vaughan, R. A. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112629 · Cited by 3 · see citing works

Loss of Trim28 in muscle alters mitochondrial signalling but not systemic metabolism

King, E. J., Bond, S. T., Yang, C., Liu, Y., Calkin, A. C., Henstridge, D. C., & Drew, B. G. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0210 · Cited by 3 · see citing works

Positive Changes in Body Composition and Profiles of Individuals with Diabetes 3 Years Following Laparoscopic Sleeve Gastrectomy in Japanese Patients with Obesity

Ozeki, Y., Masaki, T., Miyamoto, S., Yoshida, Y., Okamoto, M., Gotoh, K., Endo, Y., Inomata, M., & Shibata, H. (2024) · Nutrients · doi:10.3390/nu16223926 · Cited by 3 · see citing works

Pyrazoline Derivatives: Exploring the Synthesis and Development of New Ligands for Anti-Cancer Therapy

Sharma, R. R., Salahuddin, Mazumder, A., Kumar, R., Chauhan, A., Ahsan, M. J., Yar, M. S., Maqsood, R., & Singh, S. K. (2025) · Medicinal Chemistry · doi:10.2174/0115734064339011241129075522 · Cited by 2 · see citing works

Mitochondrial remodeling in obesity: mechanistic links to impaired energy metabolism and therapeutic perspectives

Neto, W. H. J., Ramos, C. D. O., & de Souza, C. T. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115427 · Cited by 2 · see citing works

The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes—A Perspective from Psychoneuroimmunology

Wevers, A., Román-Mata, S. S., Ledesma, S. N., & Pruimboom, L. (2024) · Biomedicines · doi:10.3390/biomedicines12112539 · Cited by 2 · see citing works

The association between insulin resistance indices and the occurrence of major adverse cardiovascular events in patients with premature myocardial infarction: a prospective cohort study

Zhou, Y., Wang, Y. Y., Chen, J., Jiang, L., Chu, R., Tian, W. W., Wang, J., Liu, Y., & Gao, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1724362 · Cited by 1 · see citing works

Exercise‐Induced Extracellular Vesicles as Mediators of Mitochondrial Biogenesis and Insulin Sensitivity in Metabolic Adaptation

Wang, J., & Wu, L. (2026) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70257 · Cited by 1 · see citing works

Ammonium chloride administration prevents training-induced improvements in mitochondrial respiratory function in the soleus muscle of male rats

Genders, A. J., Kuang, J., Saner, N. J., Botella, J., & Bishop, D. J. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00165.2022 · Cited by 1 · see citing works

relationship between visceral adiposity tissue and functional exercise capacity among type 2 diabetes

Jassem, M. S., & Mahmood, H. J. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns6.11956

SIRT1 Controls Lipid Metabolism Under Physiological and Pathological Conditions: Implications in Atherosclerosis

Poznyak, A. V., Недосугова, Л. В., Khotina, V. A., Beloyartsev, D. F., Golovyuk, A. L., Sukhorukov, V. N., Sukhorukov, V. N., Melnichenko, A. A., & Orekhov, A. N. (2024) · OnLine Journal of Biological Sciences · doi:10.3844/ojbsci.2024.584.596

A Data-Driven Approach to Cardiometabolic Risk Stratification: Development of the Adiposity-Fitness Imbalance Index Using a National Chilean Dataset

Yáñez-Sepúlveda, R., Tornero-Aguilera, J. F., Muñoz-López, M., Sancho-Haro, E. S., Concha‐Cisternas, Y., García-Carrillo, E., Páez‐Herrera, J., Montalva-Valenzuela, F., & Guzmán-Muñoz, E. (2026) · Data · doi:10.3390/data11050108

Glucose-Lowering Therapies in Type 2 Diabetes-Associated Sarcopenia: Mechanisms, Clinical Evidence and a Muscle-Centred Framework

Zhang, J., Zhai, X., Sha, S., & Zhang, L. (2026) · Drugs · doi:10.1007/s40265-026-02408-9

Insulin resistance and mitochondrial function in skeletal muscle

Dela, F., & Helge, J. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.09.019 · Cited by 53 · see citing works

Skeletal muscle mitochondrial function: is it quality or quantity that makes the difference in insulin resistance?

Porter, C. C., & Wall, B. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.241083 · Cited by 31 · see citing works

The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

Pagel-Langenickel, I., Bao, J., Pang, L., & Sack, M. N. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0003 · Cited by 154 · see citing works

Can non-equilibrium thermodynamics explain skeletal muscle insulin resistance due to low mitochondrial content?

Mandarino, L. J., & Willis, W. T. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00032-3 · Cited by 1 · see citing works

The manifold role of the mitochondria in skeletal muscle insulin resistance

Cade, W. T. (2018) · Current Opinion in Clinical Nutrition &amp; Metabolic Care · doi:10.1097/mco.0000000000000480 · Cited by 21 · see citing works