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Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis

Wilmot, E. G., Edwardson, C. L., Achana, F. A., Davies, M. J., Gorely, T., Gray, L. J., Khunti, K., Yates, T., Biddle, S. J. H.·2012·Diabetologia

DOI 10.1007/s00125-012-2677-z

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Abstract

Aims/hypothesis Sedentary (sitting) behaviours are ubiquitous in modern society. We conducted a systematic review and meta-analysis to examine the association of sedentary time with diabetes, cardiovascular disease and cardiovascular and all-cause mortality. Methods Medline, Embase and the Cochrane Library databases were searched for terms related to sedentary time and health outcomes. Cross-sectional and prospective studies were included. RR/HR and 95% CIs were extracted by two independent reviewers. Data were adjusted for baseline event rate and pooled using a random-effects model. Bayesian predictive effects and intervals were calculated to indicate the variance in outcomes that would be expected if new studies were conducted in the future. Results Eighteen studies (16 prospective, two cross-sectional) were included, with 794,577 participants. Fifteen of these studies were moderate to high quality. The greatest sedentary time compared with the lowest was associated with a 112% increase in the RR of diabetes (RR 2.12; 95% credible interval [CrI] 1.61, 2.78), a 147% increase in the RR of cardiovascular events (RR 2.47; 95% CI 1.44, 4.24), a 90% increase in the risk of cardiovascular mortality (HR 1.90; 95% CrI 1.36, 2.66) and a 49% increase in the risk of all-cause mortality (HR 1.49; 95% CrI 1.14, 2.03). The predictive effects and intervals were only significant for diabetes. Conclusions/interpretation Sedentary time is associated with an increased risk of diabetes, cardiovascular disease and cardiovascular and all-cause mortality; the strength of the association is most consistent for diabetes.

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Authors: Wilmot, E. G., Edwardson, C. L., Achana, F. A., Davies, M. J., Gorely, T., Gray, L. J., Khunti, K., Yates, T., & Biddle, S. J. H.
Affiliations: University of Leicester (GB)
Loughborough University (GB)
Corresponding author: Yates, T.
ORCID: Wilmot, E. G.
Edwardson, C. L.
Achana, F. A.
Davies, M. J.
Gorely, T.
Gray, L. J.
Khunti, K.
Yates, T.
Biddle, S. J. H.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2012-08-14
Volume: 55
Issue: 11
Pages: 2895-2905
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-012-2677-z
OpenAlex: W2141398296
Semantic Scholar: 844e192c1ec7573f36b0c3299ff56059c77ca737
Cited by: 1,789
References: 61
Citations by year: 2026: 55 · 2025: 82 · 2024: 75 · 2023: 112 · 2022: 146 · 2021: 153 · 2020: 165 · 2019: 169 · 2018: 165 · 2017: 186 · 2016: 155 · 2015: 163 · 2014: 96 · 2013: 63
FWCI: 11.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Stirling Online Research Repository (University of Stirling) (submittedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Funders: National Institute for Health and Care Research (RP-DG-1210-10183, RP-PG-0606-1272)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: sedentary behavior, sitting time, diabetes mellitus, cardiovascular disease, cardiovascular mortality, all-cause mortality, health risks
MeSH terms: Adult, Cardiovascular Diseases, Diabetes Mellitus, Humans, Risk Factors, Sedentary Behavior

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Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis

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