Insulin resistant subjects lack islet adaptation to short-term dexamethasone-induced reduction in insulin sensitivity
Open accessAbstract
Aims/hypothesis To establish whether islet compensation to deterioration of insulin action depends on inherent insulin sensitivity.Methods We examined insulin and glucagon secretion after i.v. arginine (5 g) at fasting, 14 and greater than 25 mmol/l glucose concentrations before and after lowering of insulin sensitivity by oral dexamethasone (3 mg twice daily for 2 1/2 days) in 10 women with normal glucose tolerance, aged 58 or 59 years. Five women had high insulin sensitivity as shown by euglycaemic, hyperinsulinaemic clamp (99 +/- 12 nmol glucose.kg body weight-1.min-1/pmol insulin.l-1; means +/- SD) whereas five women had low insulin sensitivity (34 +/- 15 nmol glucose.kg body weight-1.min-1/pmol insulin.l-1).Results Dexamethasone reduced insulin sensitivity in both groups. Fasting insulin concentration increased by dexamethasone in high insulin sensitivity (72 +/- 10 vs 49 +/- 9 pmol/l, p = 0.043) but not in low insulin sensitivity (148 +/- 63 vs 145 +/- 78 pmol/l) whereas the fasting glucose concentration increased in low insulin sensitivity (6.5 +/- 0.8 vs 5.8 +/- 0.6 mmol/l, p = 0.043) but not in high insulin sensitivity (5.3 +/- 0.8 vs 5.3 +/- 0.6 mmol/l). Fasting glucagon concentration was not changed. Plasma insulin concentrations after raising glucose to 14 and more than 25 mmol/l and the insulin response to arginine at more than 25 mmol/l glucose were increased by dexamethasone in high insulin sensitivity (p < 0.05) but not changed by dexamethasone in low insulin sensitivity. Furthermore, in high but not in low insulin sensitivity, dexamethasone reduced the glucagon response to arginine (p = 0.043).Conclusion/interpretation The results show that adaptation in islets function to dexamethasone-induced short-term reduction in insulin sensitivity is lacking in subjects with low inherent insulin sensitivity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Daily administration of 36 mg prednisolone equivalent impaired glucose tolerance by reducing hepatic and peripheral insulin sensitivity.
“As such, daily administration of 36 mg prednisolone equivalent impaired glucose tolerance by reducing hepatic [8] and peripheral insulin sensitivity [9].”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [9]
The Research design section (page unavailable) reports 3 mg dexamethasone twice daily for two days, plus 3 mg on the test morning; it does not state a 36 mg prednisolone equivalence. The Results (page unavailable) show reduced clamp-measured insulin sensitivity in both groups, but increased fasting glucose only in women with initially low insulin sensitivity. The paper does not report that treatment impaired glucose tolerance in both groups or establish that the sensitivity reduction caused impaired glucose tolerance. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPrevious studies have generally used high doses of long-acting glucocorticoids and assessed β-cell function with intravenous glucose tests rather than standardized meals.
“However, previous studies have generally used high doses of long-acting GCs such as dexamethasone or betamethasone that are infrequently utilized for ambulatory treatment in clinical practice, and â-cell function has been assessed by tests using intravenous glucose loads such as the intravenous glucose tolerance test or the hyperglycaemic clamp12–14 rather than standardized meals.”
From Twenty‐four‐hour profiles of plasma glucose, insulin, C‐peptide and free fatty acid in subjects with varying degrees of glucose tolerance following short‐term, medium‐dose prednisone (20 mg/day) treatment: evidence for differing effects on insulin secretion and action (2012) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640 · cited 1× · see citing works
“As was predicted [ 1 ] and has been shown [2], the inverse relation between insulin sensitivity and insulin secretion has a hyperbolic relation.”
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508 · see citing works
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405 · see citing works
Diabetes Mellitus: Report of a WHO Study Group.
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-4-597_2 · Cited by 1,030 · see citing works
Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
Bergman, R. N. (1989) · Diabetes · doi:10.2337/diab.38.12.1512 · Cited by 1,001 · see citing works
Direct antidiabetic effect of leptin through triglyceride depletion of tissues
Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4637 · Cited by 646 · see citing works
Fatty acids, lipotoxicity and insulin secretion
McGarry, J., & Dobbins, R. L. (1999) · Diabetologia · doi:10.1007/s001250051130 · Cited by 548 · see citing works
Emilsson, V., Liu, Y.-L., Cawthorne, M. A., Morton, N. M., & Davenport, M. (1997) · Diabetes · doi:10.2337/diab.46.2.313 · Cited by 532 · see citing works
Sorenson, R., & Brelje, T. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979040 · Cited by 531 · see citing works
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
Ward, W. K., Bolgiano, D. C., McKnight, B., Halter, J. B., & Porte, D. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111542 · Cited by 483 · see citing works
Ehrmann, D. A., Sturis, J., Byrne, M. M., Karrison, T., Rosenfield, R. L., & Polonsky, K. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118064 · Cited by 426 · see citing works
Lambillotte, C., Gilon, P., & Henquin, J. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119175 · Cited by 419 · see citing works
THE PLASMA INSULIN RESPONSE TO GLUCOSE INFUSION IN HEALTHY SUBJECTS AND IN DIABETES MELLITUS
Cerasi, E., & Luft, R. (1967) · Acta Endocrinologica · doi:10.1530/acta.0.0550278 · Cited by 371 · see citing works
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J. P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.11.1663 · Cited by 328 · see citing works
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.4.587 · Cited by 240 · see citing works
Larsson, H. E., & Åhrén, B. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954054 · Cited by 207 · see citing works
Self-citationEffect of exercise on insulin action, glucose tolerance, and insulin secretion in aging
Kahn, S. E., Larson, V., Beard, J. C., Cain, K. C., Fellingham, G. W., Schwartz, R. S., Veith, R. C., Stratton, J. R., Cerqueira, M., & Abrass, I. B. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.6.e937 · Cited by 198 · see citing works
Kahn, S. E., Beard, J. C., Schwartz, M. W., Ward, W. K., Ding, H. L., Bergman, R. N., Taborsky, G. J., & Porte, D. (1989) · Diabetes · doi:10.2337/diab.38.5.562 · Cited by 181 · see citing works
Halter, J. B., Graf, R. J., & Porte, D. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-6-946 · Cited by 150 · see citing works
Emilsson, V., Liu, Y. L., Cawthorne, M. A., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.2.313 · Cited by 134 · see citing works
Plasma Leptin Levels Correlate to Islet Function Independently of Body Fat in Postmenopausal Women
Larsson, H., Elmståhl, S., & Åhrén, B. (1996) · Diabetes · doi:10.2337/diab.45.11.1580 · Cited by 133 · see citing works
Self-citationÅhrén, B., Simonsson, E., Scheurink, A. J. W., Mulder, H., Myrsén-Axcrona, U., & Sundler, F. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90175-x · Cited by 131 · see citing works
Effect of Corticosterone on Insulin and Glucagon Secretion by the Isolated Perfused Rat Pancreas*
Barseghian, G., & Levine, R. (1980) · Endocrinology · doi:10.1210/endo-106-2-547 · Cited by 118 · see citing works
Alford, F., Beck-Nielsen, H., Ward, G. M., & Henriksen, J. E. (1997) · Diabetologia · doi:10.1007/s001250050847 · Cited by 115 · see citing works
Cerasi, E., Efendić, S., & Luft, R. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90599-0 · Cited by 113 · see citing works
Beard, J. C., Halter, J. B., Best, J. D., Pfeifer, M. A., & Porte, D. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.5.e592 · Cited by 109 · see citing works
Wajngot, A., Giacca, A., Grill, V, Vranic, M., & Efendic, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6035 · Cited by 105 · see citing works
Larsson, H. E., & Åhrén, B. (1998) · Diabetologia · doi:10.1007/s001250050986 · Cited by 103 · see citing works
Self-citationRegulation of circulating leptin in humans
Åhrén, B., Larsson, H., Wilhelmsson, C., Näsman, B., & Olsson, T. (1997) · Endocrine · doi:10.1007/bf02778056 · Cited by 92 · see citing works
Self-citationDirect Effect of Corticosterone upon Insulin Secretion Studied by Three Different Techniques
Billaudel, B. J. L., & Sutter, B. C. J. (1979) · Hormone and Metabolic Research · doi:10.1055/s-0028-1092779 · Cited by 74 · see citing works
POTENTIATION OF INSULIN RELEASE BY GLUCOSE IN MAN
Cerasi, E. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.0790511 · Cited by 74 · see citing works
Åhrén, B., & Pacini, G. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e701 · Cited by 66 · see citing works
Larsson, H. E., & Ahr�n, B. (1996) · Diabetologia · doi:10.1007/bf00400660 · Cited by 60 · see citing works
Self-citationLarsson, H., & Ahr�n, B. (1996) · Diabetologia · doi:10.1007/s001250050559 · Cited by 60 · see citing works
Self-citationEffect of Dexamethasone and Cortisone on Insulin Receptors in Normal Human Male*
Pirro, R. D., Bertoli, A., Fusco, A., Testa, I., Greco, A. V., & Lauro, R. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-503 · Cited by 56 · see citing works
Time and dose dependencies for priming effect of glucose on insulin secretion
Grill, V. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.1.e24 · Cited by 54 · see citing works
Ling, Z.-C., Khan, A. W., Delauny, F., Davani, B., Östenson, C., Gustafsson, J.-Α., Okret, S., Landau, B. R., & Efendić, S. (1998) · Diabetologia · doi:10.1007/s001250050961 · Cited by 52 · see citing works
Johnston, C. B., Raghu, P., McCulloch, D. K., Beard, J. C., Ward, W. K., Klaff, L. J., McKnight, B., Bergman, R. N., & Palmer, J. P. (1987) · Diabetes · doi:10.2337/diab.36.7.829 · Cited by 50 · see citing works
Islet dysfunction in obese women with impaired glucose tolerance
Larsson, H., & Ahrén, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90227-9 · Cited by 44 · see citing works
Self-citationLudvik, B. H., Clodi, M., Kautzky‐Willer, A., Capek, M., Hartter, E., Pacini, G., & Prager, R. (1993) · Diabetologia · doi:10.1007/bf00399099 · Cited by 44 · see citing works
Potentiated β-cell response to non-glucose stimuli in insulin-resistant C57BL/6J mice
Simonsson, E., & Åhrén, B. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00236-2 · Cited by 31 · see citing works
POTENTIATION OF INSULIN RELEASE BY GLUCOSE IN MAN
Cerasi, E. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.0790502 · Cited by 30 · see citing works
Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women
Larsson, H., Elmstahl, S., & Åhrén, B. (1996) · Diabetes · doi:10.2337/diabetes.45.11.1580 · Cited by 30 · see citing works
Self-citationEndocrine pancreatic function in women with gestational diabetes
Kühl, C., & HORNNES, P. J. (1986) · European Journal of Endocrinology · doi:10.1530/acta.0.111s019 · Cited by 14 · see citing works
In vivo β-cell function at the transition to early non-insulin-dependent diabetes mellitus
Swinburn, B. A., Gianchandani, R. Y., Saad, M. F., & Lillioja, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90189-2 · Cited by 14 · see citing works
Grill, V., Alvarsson, M., & Efendić, S. (1992) · Diabetologia · doi:10.1007/bf00401204 · Cited by 6 · see citing works
The effect of dexamethasone on the enteroinsular axis
Groop, P., Groop, L., Tötterman, K. J., & Fyhrquist, F. (1987) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365518709168456 · Cited by 2 · see citing works
The effect of dexamethasone on the enteroinsular axis
Groop, P. H., Groop, L. C., Tötterman, K.-J., et al. (1987) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518709168456 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Van Raalte, D. H., Ouwens, D. M., & Diamant, M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02067.x · Cited by 439 · see citing works
Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers.
Louis, M., & Punjabi, N. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91523.2008 · Cited by 342 · see citing works
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions
Li, J.-X., & Cummins, C. L. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00683-6 · Cited by 273 · see citing works
Glucocorticoid‐induced hyperglycemia (糖皮质激素诱导的高血糖)
Pérez, A., Jansen‐Chaparro, S., Saigí, I., Bernal-López, M. R., Miñambres, I., & Gómez-Huelgas, R. (2013) · Journal of Diabetes · doi:10.1111/1753-0407.12090 · Cited by 241 · see citing works
Rafacho, A., Ortsäter, H., Nadal, A., & Quesada, I. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0373 · Cited by 216 · see citing works
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad ?
Pofi, R., Caratti, G., Ray, D. W., & Tomlinson, J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad016 · Cited by 225 · see citing works
Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men
van Raalte, D. H., Nofrate, V., Bunck, M. C., van Iersel, T., Elassaiss Schaap, J., Nässander, U. K., Heine, R. J., Mari, A., Dokter, W. H. A., & Diamant, M. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-1034 · Cited by 170 · see citing works
van Raalte, D. H., Brands, M., van der Zijl, N. J., Muskiet, M. H., Pouwels, P. J. W., Ackermans, M. T., Sauerwein, H. P., Serlie, M. J., & Diamant, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2174-9 · Cited by 109 · see citing works
“As such, 36 mg prednisolone equivalent daily impaired glucose tolerance by reducing hepatic [8] and peripheral insulin sensitivity [9].”
BackgroundSteroid-induced hyperglycemia: An underdiagnosed problem or clinical inertia? A narrative review
Bonaventura, A., & Montecucco, F. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.006 · Cited by 108 · see citing works
Cortisol Is Negatively Associated with Insulin Sensitivity in Overweight Latino Youth
Adam, T. C., Hasson, R. E., Ventura, E. E., Toledo-Corral, C., Le, K.-A., Mahurkar, S., Lane, C. J., Weigensberg, M. J., & Goran, M. I. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0322 · Cited by 95 · see citing works
Impact of Glucocorticoid Excess on Glucose Tolerance: Clinical and Preclinical Evidence
Pasieka, A. M., & Rafacho, A. (2016) · Metabolites · doi:10.3390/metabo6030024 · Cited by 91 · see citing works
Islet adaptation to insulin resistance: mechanisms and implications for intervention
Åhrén, B., & Pacini, G. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00361.x · Cited by 85 · see citing works
Davani, B., Portwood, N., Bryzgalova, G., Reimer, M. K., Heiden, T., Östenson, C., Okret, S., Åhrén, B., Efendić, S., & Khan, A. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s51 · Cited by 82 · see citing works
Blüher, M., Kratzsch, J., & Paschke, R. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.328 · Cited by 75 · see citing works
Influence of glucocorticoids and growth hormone on insulin sensitivity in humans
Yuen, K. C. J., Chong, L. E., & Riddle, M. (2013) · Diabetic Medicine · doi:10.1111/dme.12184 · Cited by 69 · see citing works
Tietge, U. J. F., Selberg, O., Kreter, A., Bahr, M. J., Pirlich, M., Burchert, W., Müller, M. J., Manns, M. P., & Böker, K. H. W. (2004) · Liver Transplantation · doi:10.1002/lt.20147 · Cited by 61 · see citing works
Yuen, K. C. J., McDaniel, P. A., & Riddle, M. C. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04242.x · Cited by 58 · see citing works
Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death
Reich, E., Tamary, A., Sionov, R. V., & Melloul, D. (2012) · Diabetologia · doi:10.1007/s00125-011-2422-z · Cited by 56 · see citing works
Effect of Dexamethasone on Oral Glucose Tolerance in Healthy Adults
Abdelmannan, D. K., Tahboub, R., GENUTH, S. M., & Ismail‐Beigi, F. (2010) · Endocrine Practice · doi:10.4158/ep09373.or · Cited by 48 · see citing works
Mosili, P., Mkhize, B. C., Ngubane, P. S., Sibiya, N. H., & Khathi, A. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00532-1 · Cited by 45 · see citing works
Hypertension and other morbidities with Cushing’s syndrome associated with corticosteroids: a review
Peppa, Μ., Boutati, E. I., Krania, M., & Raptis, S. (2011) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s9486 · Cited by 40 · see citing works
Wojtusciszyn, A., Mourad, G., Bringer, J., & Renard, É. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.10.007 · Cited by 38 · see citing works
Karlsson, S., stlund, B. R., Myrsén-Axcrona, U., Sundler, F., & Ahr�n, B. (2001) · Pancreas · doi:10.1097/00006676-200103000-00007 · Cited by 36 · see citing works
Self-citationvan Raalte, D. H., Kwa, K. A. A., van Genugten, R. E., Tushuizen, M. E., Holst, J. J., Deacon, C. F., Karemaker, J. M., Heine, R. J., Mari, A., & Diamant, M. (2012) · Metabolism · doi:10.1016/j.metabol.2012.10.007 · Cited by 34 · see citing works
Giozzet, V. A. G., Rafacho, A., Boschero, A. C., Carneiro, E. M., & Bosqueiro, J. R. (2008) · Metabolism · doi:10.1016/j.metabol.2007.12.004 · Cited by 33 · see citing works
Vrbíková, J., Stanická, S., Dvorakova, K., Hill, M., Vondra, K., Bendlová, B., & Stárka, L. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500215 · Cited by 31 · see citing works
Fransson, L., dos Santos, C., Wolbert, P., Sjöholm, Å., Rafacho, A., & Ortsäter, H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-3 · Cited by 30 · see citing works
The multifaceted roles of NLRP3-modulating proteins in virus infection
Harris, J., & Borg, N. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.987453 · Cited by 30 · see citing works
Dejager, L., Pinheiro, I., Puimège, L., Fan, Y.-D., Gremeaux, L., Vankelecom, H., & Libert, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.154484 · Cited by 30 · see citing works
Current Challenges and Future Directions in the Assessment of Glucocorticoid Status
Clarke, S. A., Eng, P. C., Comninos, A. N., Lazarus, K., Choudhury, S., Tsang, C., Meeran, K. M., Tan, T., Dhillo, W. S., & Abbara, A. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae016 · Cited by 30 · see citing works
Parker, L., Lin, X., GARNHAM, A. P., McConell, G. K., Stepto, N. K., Hare, D. L., Byrnes, E., Ebeling, P. R., Seeman, E., Brennan‐Speranza, T. C., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3574 · Cited by 29 · see citing works
Åhrén, B. (2008) · Diabetologia · doi:10.1007/s00125-008-0995-y · Cited by 29 · see citing works
Rasouli, N., Hale, T. C., Kahn, S. E., Spencer, H. J., & Elbein, S. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0048 · Cited by 29 · see citing works
Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome
Hanna, F., Wu, P., Heald, A. H., & Fryer, A. A. (2023) · BMJ · doi:10.1136/bmj-2022-071675 · Cited by 30 · see citing works
Fransson, L., Rosengren, V., Saha, T. K., Grankvist, N., Islam, T., Honkanen, R. E., Sjöholm, Å., & Ortsäter, H. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.12.010 · Cited by 28 · see citing works
Protzek, A. O. P., Costa-Júnior, J. M., de Rezende, L. F., dos Santos, G. J., Araújo, T. G., Vettorazzi, J. F., Ortis, F., Carneiro, E. M., Rafacho, A., & Boschero, A. C. (2014) · International Journal of Endocrinology · doi:10.1155/2014/983453 · Cited by 28 · see citing works
Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats
Angelini, N., Rafacho, A., Boschero, A. C., & Bosqueiro, J. R. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.11.008 · Cited by 27 · see citing works
Gustavson, S. M., Sandoval, D. A., Ertl, A. C., Bao, S., Raj, S. R., & Davis, S. N. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00589.2007 · Cited by 25 · see citing works
Glycometabolic Alterations in Secondary Adrenal Insufficiency: Does Replacement Therapy Play a Role?
Graziadio, C., Hasenmajer, V., Venneri, M. A., Gianfrilli, D., Isidori, A. M., & Sbardella, E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00434 · Cited by 25 · see citing works
Cushing Syndrome, Hypercortisolism, and Glucose Homeostasis: A Review
DeFronzo, R. A., & Auchus, R. J. (2025) · Diabetes · doi:10.2337/db25-0120 · Cited by 30 · see citing works
Sato, S., Saisho, Y., Inaishi, J., Kou, K., Murakami, R., Yamada, T., & Itoh, H. (2015) · Diabetes · doi:10.2337/db15-0151 · Cited by 23 · see citing works
Ortsäter, H., Sjöholm, Å., & Rafacho, A. (2012) · InTech eBooks · doi:10.5772/51759 · Cited by 14 · see citing works
Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus.
Hare, K. J. (2010) · PubMed · Cited by 14 · see citing works
Medical treatment of Cushing’s disease with concurrent diabetes mellitus
Mehlich, A., Bolanowski, M., Mehlich, D., & Witek, P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1174119 · Cited by 13 · see citing works
Johansson, A., Olsson, T., Cederquist, K., Forsberg, H., Holst, J. J., Seckl, J. R., & Ahren, B. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460397 · Cited by 13 · see citing works
Kuroki, Y., Kaji, H., Kawano, S., Kanda, F., Takai, Y., Kajikawa, M., & Sugimoto, T. (2010) · Internal Medicine · doi:10.2169/internalmedicine.49.3161 · Cited by 12 · see citing works
Rafacho, A., Antonio, C., & Ortsäter, H. (2012) · InTech eBooks · doi:10.5772/50233 · Cited by 11 · see citing works
Karagiannopoulos, A., Westholm, E., Ofori, J. K., Cowan, E., Esguerra, J. L. S., & Eliasson, L. (2023) · iScience · doi:10.1016/j.isci.2023.106555 · Cited by 10 · see citing works
Shah, M., Adel, M., Tahsin, B., Guerra, Y., & Fogelfeld, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231190 · Cited by 7 · see citing works
Is It Time for a New Algorithm for the Pharmacotherapy of Steroid-Induced Diabetes?
Ostrowska-Czyżewska, A., Zgliczyński, W., Papierska, L., & Mrozikiewicz‐Rakowska, B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195801 · Cited by 9 · see citing works
Kovalik, M., Thoday, K. L., Evans, H., van den Broek, A., & Mellanby, R. J. (2011) · The Veterinary Journal · doi:10.1016/j.tvjl.2011.06.002 · Cited by 9 · see citing works
Taheri, N., Aminorroaya, A., Ismail‐Beigi, F., & Amini, M. (2012) · Endocrine Practice · doi:10.4158/ep12057.or · Cited by 8 · see citing works
Carrig, S., Bijjiga, E., Wopat, M. J., & Martino, A. T. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.073 · Cited by 7 · see citing works
Ando, A., Yatagai, T., Rokkaku, K., Nagasaka, S., Ishikawa, S., & Ishibashi, S. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1484 · Cited by 7 · see citing works
Åhrén, B., & Pacini, G. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00519.2005 · Cited by 7 · see citing works
Genetic contributions to glucose intolerance in polycystic ovary syndrome
Ehrmann, D. A. (2004) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62106-2 · Cited by 7 · see citing works
Thibault, O., Cubbage, T., Brink, M., McCarthy, J., Gunn, C., Torres, I., Faulkner, P. C., Hala, D. N., & Petersen, L. H. (2020) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2020.110851 · Cited by 6 · see citing works
Glucocorticoid Regulation of Body Composition and Metabolism
Opata, A. A., Cheesman, K. C., & Geer, E. B. (2016) · Springer eBooks · doi:10.1007/978-3-319-45950-9_1 · Cited by 6 · see citing works
Ishibashi, C., Yasuda, T., Matsuoka, T., Hirai, K., Sakamoto, F., Kitamura, T., Kozawa, J., Otsuki, M., Funahashi, T., Imagawa, A., et al. (2015) · Diabetology International · doi:10.1007/s13340-015-0209-z · Cited by 4 · see citing works
Mathias, P. C. D. F., Rodrigues, A. M. D., Lisboa, P. C., Miranda, R. A., Malta, A., Ribeiro, T. A., Barella, L. F., Miranda, G. D. S., de Lima, T. A. L., Gomes, R. M., et al. (2024) · Biology · doi:10.3390/biology13121036 · Cited by 3 · see citing works
Tijani, O. K., Moreno-Lopez, M., Louvet, I., Acosta-Montalvo, A., Coddeville, A., Gmyr, V., Kerr-Conte, J., Pattou, F. N., Vantyghem, M., Saponaro, C., et al. (2024) · Annales d Endocrinologie · doi:10.1016/j.ando.2024.101676 · Cited by 3 · see citing works
Cushing’s glucocorticoid syndrome in the practice of a rheumatologist (A review of literature)
Satybaldyev, A. M. (2013) · Modern Rheumatology Journal · doi:10.14412/1996-7012-2013-2443 · Cited by 3 · see citing works
Taheri, N., Aminorroaya, A., Ismail‐Beigi, F., & Amini, M. (2018) · Endocrine Practice · doi:10.4158/ep-2018-0188 · Cited by 2 · see citing works
Ethnic Differences in Insulin Resistance as a Mediator of Cancer Disparities
Hasson, R. E., & Goran, M. I. (2014) · Springer eBooks · doi:10.1007/978-3-319-06103-0_8 · Cited by 2 · see citing works
Dimas-Ramírez, C. A., Fortanell-Meza, L. A., Agustín-Morales, D. S., Muslera, E. B., Mejia-Vilet, J. M., Almeda‐Valdés, P., Vázquez-Cárdenas, P., Merayo‐Chalico, J., & Barrera‐Vargas, A. (2025) · Lupus · doi:10.1177/09612033251315976 · Cited by 1 · see citing works
Insulin Resistance in Chronic Disease
Hamiel, U., & Pinhas‐Hamiel, O. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_3 · Cited by 1 · see citing works
Fransson, L. (2014) · Figshare
Cortínez, A., & Medicina, F. D. (2011)
Гл юкокортикоидный синдром Кушинга в практике ревматолога (обзор литературы)
Satybaldyev, A. M., & Nasonova, V. A. (2013)
Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells
Boortz, K. A. (2016)
Diabetes Mellitus: Review of the Common, Rare, and Uncommon (Conceptual and Metaphorical) Types
Pliszka, M., & Szablewski, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219611
- Authors
- Larsson, H., & Ahrén, B.
- Affiliations
- Lund University (SE)
- ORCID
- Larsson, H.
- Venue
- Diabetologia
- Published
- 1999-07-29
- Volume
- 42
- Issue
- 8
- Pages
- 936-943
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2032125948
- Cited by
- 73
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lunds Universitet
- Malmö Högskola
- Medical Research Council
- Medicinska Fakulteten, Lunds Universitet
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin resistance, dexamethasone, insulin sensitivity, insulin secretion, glucagon secretion, arginine stimulation, beta-cell adaptation, glucocorticoids, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Insulin Secretion, Arginine, Blood Glucose, Dexamethasone, Fasting, Female, Glucagon, Glucocorticoids, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Infusions, Intravenous, Insulin, Insulin Resistance, Islets of Langerhans, Middle Aged, Glucose Clamp Technique, Postmenopause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
