Cited by 348Schizophrenia research and treatmentMental Health and PsychiatryHallucinations in medical conditions

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Advances in understanding and treating persecutory delusions: a review

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Freeman, Daniel, Garety, Philippa·2014·Social Psychiatry and Psychiatric Epidemiology

DOI 10.1007/s00127-014-0928-7PMC PMC4108844

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Abstract

PURPOSE: Persecutory delusions are a central psychotic experience, at the severe end of a paranoia spectrum in the general population. The aim of the review is to provide an introduction to the understanding of persecutory delusions, highlight key putative causal factors that have the potential to be translated into efficacious treatment, and indicate future research directions. METHODS: A narrative literature review was undertaken to highlight the main recent areas of empirical study concerning non-clinical and clinical paranoia. RESULTS: Six main proximal causal factors are identified: a worry thinking style, negative beliefs about the self, interpersonal sensitivity, sleep disturbance, anomalous internal experience, and reasoning biases. Each has plausible mechanistic links to the occurrence of paranoia. These causal factors may be influenced by a number of social circumstances, including adverse events, illicit drug use, and urban environments. CONCLUSIONS: There have been numerous replicated empirical findings leading to a significant advance in the understanding of persecutory delusions, now beginning to be translated into cognitive treatments. The first trials specifically focussed on patients who have persecutory delusions in the context of psychotic diagnoses are occurring. Initial evidence of efficacy is very promising.

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Authors: Freeman, D., & Garety, P.
Affiliations: Warneford Hospital (GB)
King's College London (GB)
Corresponding author: Freeman, Daniel
ORCID: Freeman, Daniel
Garety, Philippa
Venue: Social Psychiatry and Psychiatric Epidemiology
Publisher: Springer Science and Business Media LLC
Published: 2014-07-09
Volume: 49
Issue: 8
Pages: 1179-1189
ISSN: 0933-7954 (ISSN-L)
1433-9285
DOI: 10.1007/s00127-014-0928-7
PMC: PMC4108844
OpenAlex: W2013939918
Cited by: 348
References: 157
Citations by year: 2026: 14 · 2025: 23 · 2024: 24 · 2023: 22 · 2022: 18 · 2021: 22 · 2020: 36 · 2019: 41 · 2018: 37 · 2017: 43 · 2016: 35 · 2015: 29 · 2014: 4
FWCI: 5.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Social Psychiatry and Psychiatric Epidemiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion, other-oa)
Funders: South London and Maudsley NHS Foundation Trust
National Institute for Health and Care Research (NF-SI-0510-10121)
King's College London
Medical Research Council (G0902308)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords: persecutory delusions, paranoia, negative self-beliefs, interpersonal sensitivity, sleep disorders, reasoning biases, cognitive intervention, psychosis, illicit drug use, urban environment, life events
MeSH terms: Adult, Aged, Anxiety, Culture, Delusions, Female, Humans, Internal-External Control, Male, Middle Aged, Paranoid Disorders, Psychotic Disorders, Risk Factors, Schizophrenia, Paranoid, Severity of Illness Index, Thinking, Cognitive Behavioral Therapy

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Advances in understanding and treating persecutory delusions: a review

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