A cross-sectional study to examine the correlation between serum TSH levels and the osteoporosis of the lumbar spine in healthy women with normal thyroid function
Abstract
Unlabelled We examined the association between serum TSH levels and osteoporosis of the lumbar spine in 756 Korean women aged 65 years or older with normal thyroid function. Low-normal serum TSH levels might be a potential risk factor for the osteoporosis in non-obese elderly women. Introduction We aimed to examine the association between serum thyroid-stimulating hormone (TSH) levels and osteoporosis of the lumbar spine in healthy elderly Korean women with normal thyroid function. Methods In this cross-sectional study, we evaluated the correlations between serum TSH levels and the osteoporosis of the lumbar spine depending on the body mass index (BMI) in a total of 756 women aged 65 years or older who underwent bone mineral density (BMD) measurement and thyroid function test in a routine health screening examination at our medical institution. Results After the adjustment of the age and BMI, there was a significant positive correlation between serum TSH level within normal range and the BMD of the lumbar spine (r = 0.165, P Conclusions In conclusion, our results suggest that low-normal serum TSH levels might be a potential risk factor for the osteoporosis of the lumbar spine in non-obese elderly women. But further prospective, large-scale, randomized controlled studies are warranted to establish our results.
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TSH and thyroid hormone levels within the normal range are negatively correlated with BMD among euthyroid adults.
“TSH and thyroid hormone levels within the normal range are negatively correlated with BMD among euthyroid adults [40, 41].”
From Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis (2025) · cites this paper as [40]
Variation in thyroid status within the reference range in post-menopausal women is associated with altered bone mineral density and fracture risk.
“Population studies have also shown that variation in thyroid status within the reference range in post-menopausal women is associated with altered BMD and fracture risk.”
From Thyroid diseases and bone health (2018) · cites this paper as [47]
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- Authors
- Noh, H.-M., Park, Y. S., Lee, J., & Lee, W.
- Affiliations
- Hallym University Sacred Heart Hospital (KR)
- Hallym University (KR)
- Samsung Medical Center (KR)
- Corresponding author
- Park, Y. S.
- Lee, J.
- ORCID
- Venue
- Osteoporosis International
- Published
- 2014-09-25
- Volume
- 26
- Issue
- 3
- Pages
- 997-1003
- ISSN
- 0937-941X (ISSN-L)
- 1433-2965
- OpenAlex
- W1986935872
- Cited by
- 47
- References
- 30
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 12 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Osteoporosis International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- thyroid-stimulating hormone, lumbar spine osteoporosis, bone mineral density, older women, body mass index, obesity, thyroid function, osteoporosis risk factors, Korean women
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Humans, Lumbar Vertebrae, Mass Screening, Thyroid Gland, Thyrotropin, Bone Density, Osteoporosis, Postmenopausal, Body Mass Index, Republic of Korea
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