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Cited by 103Bone health and osteoporosis researchThyroid Disorders and TreatmentsMenopause: Health Impacts and Treatments

Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women

Kim, Duk Jae, Khang, Young Ho, Koh, Jung‐Min, Shong, Young Kee, Kim, Ghi Su·2006·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2005.02422.x
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Abstract

Summary: Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with low normal TSH levels may have mild hyperthyroidism and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD). Design A cross‐sectional hospital‐based survey. Participants Nine hundred and fifty‐nine healthy postmenopausal women. Measurements We measured BMD at the lumbar spine and femoral neck using dual energy X‐ray absorptiometry, and serum TSH concentrations using immunoluminometry. Results BMD at the lumbar spine and femoral neck increased with TSH level (P for trend < 0·001 at both sites). Even after adjustment for age, years since menopause and body mass index, subjects with low normal TSH levels (0·5–1·1 mU/l) had significantly lower BMDs at the lumbar spine (0·863 ± 0·009 g/cm 2vs 0·900 ± 0·009 g/cm 2, P = 0·004) and femoral neck (0·660 ± 0·006 g/cm 2vs 0·683 ± 0·006 g/cm 2, P = 0·006) than those with high normal TSH levels (2·8–5·0 mU/l), as well as a 2·2‐fold increased risk of osteoporosis (95% confidence interval: 1·2–4·0). Conclusion These results suggest that low normal TSH levels may not be physiological for postmenopausal women and, during treatment of hypothyroidism, may not be adequate for avoiding osteoporosis.

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Crossref · 10.1111/j.1365-2265.2005.02422.x

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  • Variation in thyroid status within the reference range in post-menopausal women is associated with altered bone mineral density and fracture risk.

    “Population studies have also shown that variation in thyroid status within the reference range in post-menopausal women is associated with altered BMD and fracture risk.”

    From Thyroid diseases and bone health (2018) · cites this paper as [43]

  • Lower TSH levels and higher levels of FT4 within the population reference-range are associated with increased risk of developing osteoporosis and suffering subsequent fractures in post-menopausal women.

    “Similar cross-sectional analyses have identified that lower TSH levels and higher levels of FT4 within the population reference-range are associated with increased risk of developing osteoporosis [70–73] and suffering subsequent fractures [71, 74] in post-menopausal women.”

    From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [73]

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Authors
Kim, D. J., Khang, Y. H., Koh, J., Shong, Y. K., & Kim, G. S.
Affiliations
Asan Medical Center (KR)
Corresponding author
Kim, Ghi Su
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2005-12-13
Volume
64
Issue
1
Pages
86-90
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2005.02422.x
OpenAlex
W2093677271
Cited by
103
References
23
Citations by year
2026: 4 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 8
FWCI
4.50
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
thyroid-stimulating hormone, bone mineral density, osteoporosis, postmenopausal women, hypothyroidism treatment, lumbar spine, femoral neck, bone loss
MeSH terms
Aged, Cross-Sectional Studies, Female, Femur Neck, Humans, Lumbar Vertebrae, Middle Aged, Reference Values, Regression Analysis, Testosterone, Thyrotropin, Time Factors, Bone Density, Body Mass Index, Postmenopause

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