Depression of glucose levels and partial restoration of pancreatic β-cell damage by melatonin in streptozotocin-induced diabetic rats
Abstract
Diabetes mellitus is a common but serious metabolic disorder associated with many functional and structural complications. Glucose metabolism is disturbed due to an absolute or relative insulin deficiency. The experiment was carried out to determine the effect of melatonin on blood glucose and insulin concentrations, and histopathology of pancreatic beta-cells in streptozotocin (STZ)-induced diabetic rats. The rats were randomly allocated into one of the four experimental groups: group A (control), group B (diabetic untreated), group C (diabetic treated with melatonin for 6 weeks) and group D (diabetic treated with melatonin for 8 weeks); each group contained ten animals. Diabetes was induced in B, C and D groups by a single intraperitoneal (i.p.) injection of STZ (50 mg/kg, freshly dissolved in 5 mmol/l citrate buffer, pH 4.5). The rats in melatonin-treated groups were subjected to the daily i.p injection of 10 mg kg(-1) of melatonin for 6 or 8 weeks starting the day after STZ injection. Control and diabetic untreated rats were injected with the same volume of isotonic NaCl as the melatonin treated groups. Almost all insulin-positive beta-cells were degranulated, degenerated or necrotic in the STZ-treated rats leading to decrease in insulin secretion and an increase in blood glucose concentration. Melatonin treatment caused a sharp decrease in the elevated serum glucose, a slight increase in the lowered serum insulin concentrations and small partial regeneration/proliferation of beta-cells of islets. It is concluded that the hypoglycemic action of melatonin could be partly due to small amelioration in the beta-cells of pancreatic islets causing a slight increase in insulin secretion, it is mostly due to the extrapancreatic actions of the melatonin.
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The underlying mechanism of melatonin in amelioration of insulin sensitivity encompasses induction of β-cell regeneration, hepatic glycogen synthesis promotion which reduce hyperglycemia in an animal model.
“The underlying mechanism of melatonin in amelioration of insulin sensitivity encompasses induction of β -cell regeneration, hepatic glycogen synthesis promotion which reduce hyperglycemia in an animal model. 13,27,28”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [28]
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MORPHOLOGICAL CHANGES PANCREAS AFTER OF MELATONIN’S EFFECT IN DIFFERENT SEASONS
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“13,27,28 Furthermore, melatonin prevents insulin resistance by activating the cyclic adenosine monophosphate (cAMP)- response element binding protein (CREB)-peroxisome proliferator-activated receptor gamma coactivator 1-(PGC-1α) pathway.”
Melatonin as a Chronobiotic and Cytoprotector in Healthy Aging
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Мелатонин при сахарном диабете: от патофизиологии к перспективам лечения
Klimontov, V. V., & Russian Federation (2013)
Cytoprotection by Melatonin: The Metabolic Syndrome as an Example
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- Authors
- Kanter, M., Uysal, H., Karaca, T., & Sagmanligil, H. O.
- Affiliations
- Trakya University (TR)
- Ankara University (TR)
- Van Yüzüncü Yıl Üniversitesi (TR)
- Corresponding author
- Kanter, Mehmet
- ORCID
- Karaca, Turan
- Venue
- Archives of Toxicology
- Published
- 2005-12-09
- Volume
- 80
- Issue
- 6
- Pages
- 362-369
- ISSN
- 0340-5761 (ISSN-L)
- 1432-0738
- OpenAlex
- W2022531681
- Cited by
- 70
- References
- 49
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 8 · 2015: 1 · 2014: 5 · 2013: 9 · 2012: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Van Yüzüncü Yıl University Academic Data Management System (submittedVersion)
- Trakya University's Institutional Open Access System (Trakya University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- melatonin, streptozotocin-induced diabetes, type 1 diabetes, pancreatic beta-cell damage, beta cell regeneration, hypoglycemic effect, insulin secretion, blood glucose, pancreatic islets
- MeSH terms
- Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Image Processing, Computer-Assisted, Insulin, Male, Melatonin, Regeneration, Free Radical Scavengers, Rats, Wistar, Insulin-Secreting Cells, Rats
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