Melatonin in type 2 diabetes mellitus and obesity

Karamitri, Angeliki; Jockers, Ralf

doi:10.1038/s41574-018-0130-1

Cited by 271Circadian rhythm and melatoninRegulation of Appetite and ObesityPancreatic function and diabetes

Melatonin in type 2 diabetes mellitus and obesity

Karamitri, Angeliki, Jockers, Ralf·2019·Nature Reviews Endocrinology

DOI 10.1038/s41574-018-0130-1

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Abstract

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT 2 receptor (which is encoded by MTNR1B). In this Review, we discuss the effect of melatonin and its receptors on glucose homeostasis, obesity and T2DM. Preclinical and clinical post-GWAS evidence of frequent and rare variants of the MTNR1B locus confirmed its importance in regulating glucose homeostasis and T2DM risk with minor effects on obesity. However, these studies did not solve the question of whether melatonin is beneficial or detrimental, an issue that will be discussed in the context of the peculiarities of the melatonergic system. Melatonin receptors might have therapeutic potential as they belong to the highly druggable G protein-coupled receptor superfamily. Clarifying the precise role of melatonin and its receptors on glucose homeostasis is urgent, as melatonin is widely used for other indications, either as a prescribed medication or as a supplement without medical prescription, in many countries in Europe and in the USA.

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The impairment of glucose tolerance and decrease in insulin secretion during late dinner timing might be partly due to the 3.5-fold higher melatonin concentrations.
“This difference might be partly due to the 3.5-fold higher melatonin concentrations, as supported by our earlier trial in which acute melatonin administration impaired glucose tolerance and in vitro b-cell experiments showing decreased insulin secretion due to melatonin (10,11,18,28).”
From Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [28]
The rs10830963 G variant in MTNR1B shows the strongest association among known single nucleotide polymorphisms with elevated fasting glucose and impaired insulin secretion.
“Notably, the common intronic gain-of-function variant rs10830963 G in MTNR1B shows the strongest association among known single nucleotide polymorphisms with elevated fasting glucose and impaired insulin secretion (6,7)”
From Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant (2026) · cites this paper as [6]
The common MTNR1B variant increases risk of type 2 diabetes.
“The common melatonin receptor 1B gene (MTNR1B) variant increases risk of type 2 diabetes”
From Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant (2026) · cites this paper as [6]

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
Fagerberg, L., Hallström, B. M., Oksvold, P., Kampf, C., Djureinovic, D., Odeberg, J., Habuka, M., Tahmasebpoor, S., Danielsson, A., Edlund, K., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.035600 · Cited by 3,665 · see citing works
Trends in GPCR drug discovery: new agents, targets and indications
Hauser, A. S., Attwood, M. M., Rask‐Andersen, M., Schiöth, H. B., & Gloriam, D. E. I. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.178 · Cited by 2,609 · see citing works
A comprehensive map of molecular drug targets
Santos, R., Ursu, O., Gaulton, A., Bento, A. P., Donadi, R. S., Bologa, C. G., Karlsson, A., Al-Lazikani, B., Hersey, A., Oprea, T. I., et al. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.230 · Cited by 2,427 · see citing works
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30051-2 · Cited by 2,335 · see citing works
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators, Voight, B. F., The GIANT Consortium, Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.609 · Cited by 1,761 · see citing works
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550 · see citing works
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works
Trends in the Use of Complementary Health Approaches Among Adults in the United States
Jackson, C. (2015) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000088 · Cited by 1,174 · see citing works
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
Manchester, L. C., Coto‐Montes, A. M., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J. P., Tan, D. X., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 954 · see citing works
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation
Zisapel, N. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14116 · Cited by 893 · see citing works
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Circadian Rhythms in Man: A self-sustained oscillator with an inherent frequency underlies human 24-hour periodicity
Aschoff, J. (1965) · Science · doi:10.1126/science.148.3676.1427 · Cited by 752 · see citing works
Variants in MTNR1B influence fasting glucose levels
Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Þorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A., Aulchenko, Y. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.290 · Cited by 743 · see citing works
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko, V., Nagorny, C. L. F., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.288 · Cited by 742 · see citing works
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Sabatti, C., Service, S. K., Hartikainen, A., Pouta, A. M., Ripatti, S., Brodsky, J. F., Jones, C. G., Zaitlen, N., Varilo, T., Kaakinen, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.271 · Cited by 721 · see citing works
Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve
Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works
Melatonin membrane receptors in peripheral tissues: Distribution and functions
Slominski, R. M., Reiter, R. J., Schlabritz‐Loutsevitch, N., Ostrom, R. S., & Slominski, A. T. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.01.004 · Cited by 676 · see citing works
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective
Liu, J., Clough, S. J., Hutchinson, A. J., Adamah‐Biassi, E. B., Popovska‐Gorevski, M., & Dubocovich, M. L. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124742 · Cited by 645 · see citing works
Sleep disturbances compared to traditional risk factors for diabetes development: systematic review and meta-analysis
Anothaisintawee, T., Reutrakul, S., Van Cauter, E., & Thakkinstian, A. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.10.002 · Cited by 640 · see citing works
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
Dubocovich, M. L., Delagrange, P., Krause, D. N., Sugden, D., Cardinali, D. P., & Olcese, J. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002832 · Cited by 636 · see citing works
Pharmacogenomics of GPCR Drug Targets
Hauser, A. S., Chavali, S., Masuho, I., Jahn, L. J., Martemyanov, K. A., Gloriam, D. E. I., & Babu, M. M. (2017) · Cell · doi:10.1016/j.cell.2017.11.033 · Cited by 611 · see citing works
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611 · see citing works
Melatonin, energy metabolism, and obesity: a review
Cipolla‐Neto, J., do Amaral, F. G., Afeche, S. C., Tan, D. X., & Reiter, R. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12137 · Cited by 588 · see citing works
Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes
Tan, D. X., Manchester, L. C., Liu, X., Rosales‐Corral, S., Acuña-Castroviejo, D., & Reiter, R. J. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12026 · Cited by 584 · see citing works
The timed infusion paradigm for melatonin delivery: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses?
Badness, T. J., Powers, J. B., Hastings, M. H., Bittman, E. L., & Goldman, B. D. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00903.x · Cited by 531 · see citing works
Abnormal melatonin synthesis in autism spectrum disorders
Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, I. C., Delorme, R., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002016 · Cited by 511 · see citing works
Entrainment of free-running circadian rhythms by melatonin in blind people
Sack, R. L., Brandes, R. W., Kendall, A. R., & Lewy, A. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431503 · Cited by 490 · see citing works
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
Fadista, J., Vikman, P. J., Ottosson-Laakso, E., Mollet, I. G., Esguerra, J. L. S., Taneera, J., Storm, P., Osmark, P., Ladenvall, C., Prasad, R. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402665111 · Cited by 470 · see citing works
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000113293.15186.3b · Cited by 451 · see citing works
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Soranzo, N., Sanna, S., Wheeler, E., Gieger, C., Radke, D., Dupuis, J., Bouatia‐Naji, N., Langenberg, C., Prokopenko, I., Stolerman, E., et al. (2010) · Diabetes · doi:10.2337/db10-0502 · Cited by 445 · see citing works
Update on melatonin receptors: IUPHAR Review 20
Jockers, R., Delagrange, P., Dubocovich, M. L., Markus, R. P., Renault, N., Tosini, G., Cecon, E., & Zlotos, D. P. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13536 · Cited by 426 · see citing works
Self-citation
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
Suofu, Y., Li, W., Jean‐Alphonse, F., Jia, J., Khattar, N. K., Li, J., Baranov, S. V., Leronni, D., Mihalik, A. C., He, Y., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705768114 · Cited by 415 · see citing works
Self-citation
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., & Xu, B. (2018) · Molecules · doi:10.3390/molecules23020509 · Cited by 393 · see citing works
Meta-analysis on shift work and risks of specific obesity types
Sun, M., Feng, W., Wang, F., Li, P., Li, Z., Li, M., Tse, G., Vlaanderen, J., Vermeulen, R., & Tse, L. A. (2018) · Obesity Reviews · doi:10.1111/obr.12621 · Cited by 391 · see citing works
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton, K. J., Ferreira, T. C., Lee, Y., Raimondo, A., Mägi, R., Reschen, M. E., Mahajan, A., Locke, A. E., Rayner, N. W., Robertson, N., et al. (2015) · Nature Genetics · doi:10.1038/ng.3437 · Cited by 390 · see citing works
Evidence for melatonin synthesis in mouse and human bone marrow cells
Conti, A., Conconi, S., Hertens, E., Skwarło‐Sońta, K., Markowska, M., & Maestroni, G. J. M. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280401.x · Cited by 381 · see citing works
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 377 · see citing works
Melatonin: Both master clock output and internal time-giver in the circadian clocks network
Pévet, P., & Challet, É. (2011) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2011.07.001 · Cited by 372 · see citing works
Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt054 · Cited by 371 · see citing works
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370 · see citing works
Melatonin secretion and the incidence of type 2 diabetes
McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P. (2013) · JAMA · doi:10.1001/jama.2013.2710 · Cited by 369 · see citing works
Melatonin receptors: role on sleep and circadian rhythm regulation
Dubocovich, M. L. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.007 · Cited by 364 · see citing works
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
The Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC), Bonnefond, A., Clément, N., Fawcett, K., Yengo, L., Vaillant, E., Guillaume, J.-L., Dechaume, A., Payne, F., Roussel, R., et al. (2012) · Nature Genetics · doi:10.1038/ng.1053 · Cited by 363 · see citing works
Self-citation
Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology
Arendt, J. (1998) · Reviews of Reproduction · doi:10.1530/ror.0.0030013 · Cited by 347 · see citing works
The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J., Couturier, C., Delagrange, P., & Jockers, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601193 · Cited by 335 · see citing works
Self-citation
The Cells of the Islets of Langerhans
Xavier, G. D. S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7030054 · Cited by 300 · see citing works
Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome: Melatonin in metabolic syndrome
Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00835.x · Cited by 299 · see citing works
Melatonin receptors: molecular pharmacology and signalling in the context of system bias
Cecon, E., Oishi, A., & Jockers, R. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13950 · Cited by 286 · see citing works
Self-citation
A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
Kwak, S. H., Kim, S., Cho, Y. M., Go, M. J., Cho, Y. S., Choi, S. H., Moon, M. K., Jung, H. S., Shin, H. D., Kang, H. M., et al. (2012) · Diabetes · doi:10.2337/db11-1034 · Cited by 273 · see citing works
Activation of MT2melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock
Hunt, A. E., Al‐Ghoul, W. M., Gillette, M. U., & Dubocovich, M. L. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.1.c110 · Cited by 266 · see citing works
Melatonin Action and Signal Transduction in the Rat Suprachiasmatic Circadian Clock: Activation of Protein Kinase C at Dusk and Dawn
McArthur, A. J., Hunt, A. E., & Gillette, M. U. (1997) · Endocrinology · doi:10.1210/endo.138.2.4925 · Cited by 263 · see citing works
Increased melatonin signaling is a risk factor for type 2 diabetes
Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A.-K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.009 · Cited by 262 · see citing works
Distribution, function and physiological role of melatonin in the lower gut
Chen, C.-Q. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i34.3888 · Cited by 255 · see citing works
Use of complementary health approaches among children aged 4-17 years in the United States: National Health Interview Survey, 2007-2012.
Black, L. I., Clarke, T. C., Barnes, P. M., Stussman, B. J., & Nahin, R. L. (2015) · PubMed · Cited by 246 · see citing works
Maternal‐fetal transfer of melatonin in pregnant women near term
Okatani, Y., Okamoto, K., Hayashi, K., Wakatsuki, A., Tamura, S., & Sagara, Y. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00550.x · Cited by 235 · see citing works
Mitochondria Synthesize Melatonin to Ameliorate Its Function and Improve Mice Oocyte’s Quality under in Vitro Conditions
He, C., Wang, J., Zhang, Z., Yang, M., Li, Y., Tian, X., Ma, T., Tao, J., Zhu, K., Song, Y., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060939 · Cited by 226 · see citing works
Human Phase Response Curves to Three Days of Daily Melatonin: 0.5 mg Versus 3.0 mg
Burgess, H. J., Revell, V. L., Molina, T. A., & Eastman, C. I. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2590 · Cited by 221 · see citing works
Pinealectomy causes glucose intolerance and decreases adipose cell responsiveness to insulin in rats
Lima, F. B., Machado, U. F., Bartol, I., Seraphim, P. M., Sumida, D. H., de Moraes, S. M. F., Hell, N. S., Okamoto, M. M., Saad, M. J. A., Carvalho, C. R. D. O., et al. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.6.e934 · Cited by 220 · see citing works
Effects of photoperiod and gonadectomy on food intake, body weight, and body composition in Siberian hamsters
Wade, G. N., & Bartness, T. J. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.1.r26 · Cited by 215 · see citing works
Influence of beta-blockers on melatonin release
Stoschitzky, K., Sakotnik, A., Lercher, P., Zweiker, R., Maier, R., Liebmann, P. M., & Lindner, W. F. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050604 · Cited by 215 · see citing works
Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
Savaskan, E., Ayoub, M. A., Ravid, R., Angeloni, D., FRASCHINI, F., Meier, F., Eckert, A., Müller-Spahn, F., & Jockers, R. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00169.x · Cited by 207 · see citing works
Self-citation
Melatonin Enters the Cerebrospinal Fluid through the Pineal Recess
Tricoire-Leignel, H., Locatelli, A., Chemineau, P., & Malpaux, B. (2002) · Endocrinology · doi:10.1210/endo.143.1.8585 · Cited by 206 · see citing works
Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin‐receptor status
Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiß, U., Schneyer, U., Spessert, R., & Mühlbauer, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00287.x · Cited by 197 · see citing works
Self-weighing in weight management: A systematic literature review
Zheng, Y., Klem, M. L., Sereika, S. M., Danford, C. A., Ewing, L. J., & Burke, L. E. (2015) · Obesity · doi:10.1002/oby.20946 · Cited by 196 · see citing works
Immune‐pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
Markus, R. P., Fernandes, P. A. C. M., Kinker, G. S., Cruz‐Machado, S. D. S., & Marçola, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14083 · Cited by 196 · see citing works
Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes
Brydon, L., Petit, L., Delagrange, P., Strosberg, A. D., & Jockers, R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8423 · Cited by 190 · see citing works
Self-citation
Function and expression of melatonin receptors on human pancreatic islets
Ramracheya, R. D., Muller, D. S., Squires, P. E., Brereton, H., Sugden, D., Huang, G. C., Amiel, S. A., Jones, P. M., & Persaud, S. J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00523.x · Cited by 186 · see citing works
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening
Rubio-Sastre, P., Scheer, F. A. J. L., Gómez-Abellán, P., Madrid, J. A., & Garaulet, M. (2014) · SLEEP · doi:10.5665/sleep.4088 · Cited by 180 · see citing works
MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential
Zlotos, D. P., Jockers, R., Cecon, E., Rivara, S., & Witt‐Enderby, P. A. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401343c · Cited by 178 · see citing works
Self-citation
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko, I., Poon, W., Mägi, R., Prasad, R. B., Salehi, A. A., Almgren, P., Osmark, P., Bouatia‐Naji, N., Wierup, N., Fall, T., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004235 · Cited by 174 · see citing works
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors
van de Bunt, M., Fox, J. E. M., Dai, X.-Q., Barrett, A., Grey, C. L., Li, L., Bennett, A. J., Johnson, P. R. V., Rajotte, R. V., Gaulton, K. J., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005694 · Cited by 174 · see citing works
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
Beaumont, R. N., Warrington, N. M., Cavadino, A., Tyrrell, J., Nodzenski, M., Horikoshi, M., Geller, F., Myhre, R., Richmond, R. C., Paternoster, L., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddx429 · Cited by 174 · see citing works
Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men
Stančáková, A., Kuulasmaa, T., Paananen, J., Jackson, A., Bonnycastle, L. L., Collins, F. S., Boehnke, M., Kuusisto, J., & Laakso, M. (2009) · Diabetes · doi:10.2337/db09-0117 · Cited by 171 · see citing works
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
Solimena, M., Schulte, A. M., Marselli, L., Ehehalt, F., Richter, D., Kleeberg, M., Mziaut, H., Knoch, K.-P., Parnis, J., Bugliani, M., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4500-3 · Cited by 171 · see citing works
The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior
Ruiter, M., La Fleur, S. E., van Heijningen, C., van der Vliet, J., Kalsbeek, A., & Buijs, R. M. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1709 · Cited by 170 · see citing works
Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
Peschke, E., Bähr, I., & Mühlbauer, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14046981 · Cited by 167 · see citing works
Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice
Sartori, C. S., Dessen, P., Mathieu, C., Monney, A., Bloch, J., NICOD, P. H., Scherrer, U., & Duplain, H. (2009) · Endocrinology · doi:10.1210/en.2009-0425 · Cited by 164 · see citing works
The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus
Robitaille, J., & Grant, A. M. (2008) · Genetics in Medicine · doi:10.1097/gim.0b013e31816b8710 · Cited by 162 · see citing works
Prolonged melatonin administration decreases nocturnal blood pressure in women
CAGNACCI, A., CANNOLETTA, M., RENZI, A., BALDASSARI, F., ARANGINO, S., & VOLPE, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.008 · Cited by 156 · see citing works
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins
Chan, A. S. L., Lai, F. P. L., Lo, R. K. H., Voyno-Yasenetskaya, T., Stanbridge, E. J., & Wong, Y. H. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00240-6 · Cited by 146 · see citing works
G-allele of Intronic rs10830963 inMTNR1BConfers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release
Sparsø, T., Bonnefond, A., Galijatovic, E. A. A., Bouatia‐Naji, N., Holmkvist, J., Thørner, L. W., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., et al. (2009) · Diabetes · doi:10.2337/db08-1660 · Cited by 146 · see citing works
Heteromeric MT 1 /MT 2 Melatonin Receptors Modulate Photoreceptor Function
Baba, K., Benleulmi‐Chaachoua, A., Journé, A., Kamal, M. T., Guillaume, J., Dussaud, S., Gbahou, F., Yettou, K., Liu, C., Contreras‐Alcantara, S., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004302 · Cited by 145 · see citing works
Self-citation
The cost of circadian desynchrony: Evidence, insights and open questions
West, A. C., & Bechtold, D. A. (2015) · BioEssays · doi:10.1002/bies.201400173 · Cited by 143 · see citing works
Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose
Mühlbauer, E., Gross, E. C., Labucay, K., Wolgast, S., & Peschke, E. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.01.029 · Cited by 140 · see citing works
Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis
Wu, L., Cui, L., Tam, W. H., Ronald, C. W., & Wang, C. C. (2016) · Scientific Reports · doi:10.1038/srep30539 · Cited by 139 · see citing works
Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women
Cagnacci, A., Arangino, S., Renzi, A., Paoletti, A. M., Melis, G. B., Cagnacci, P., & Volpe, A. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01232.x · Cited by 139 · see citing works
Melatonin desensitizes endogenous MT 2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin
Gerdin, M. J., Masana, M. I., Rivera-Bermudez, M. A., Hudson, R. L., Earnest, D. J., Gillette, M. U., & Dubocovich, M. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-1339com · Cited by 137 · see citing works
New evidence for a role of melatonin in glucose regulation
Peschke, E., & Mühlbauer, E. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.09.001 · Cited by 137 · see citing works
Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function
Simonis-Bik, A. M. C., Nijpels, G., van Haeften, T. W., Houwing‐Duistermaat, J. J., Boomsma, D. I., Reiling, E., van Hove, E. C., Diamant, M., Kramer, M. H. H., Heine, R. J., et al. (2009) · Diabetes · doi:10.2337/db09-1048 · Cited by 135 · see citing works
Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse
Contreras‐Alcantara, S., Baba, K., & Tosini, G. (2010) · Obesity · doi:10.1038/oby.2010.24 · Cited by 133 · see citing works
Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study
Zisapel, N., Garfinkel, Zorin, Wainstein, J., Matas, & Zisapel, N. (2011) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s23904 · Cited by 130 · see citing works
Correction: Identifying and Characterizing Nodes Important to Community Structure Using the Spectrum of the Graph
Wang, Y., Di, Z., & Fan, Y. (2011) · PLoS ONE · doi:10.1371/annotation/1935b388-2831-4fb1-b8f2-914ab91c1ddc · Cited by 130 · see citing works
Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers
Kamal, M. T., Gbahou, F., Guillaume, J., Daulat, A. M., Benleulmi‐Chaachoua, A., Luka, M., Chen, P. B., Anaraki, D. K., Baroncini, M., la Cour, C. M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559542 · Cited by 128 · see citing works
Self-citation
Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study
Lopez-Minguez, J., Saxena, R., Bandín, C., Scheer, F. A., & Garaulet, M. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.04.003 · Cited by 124 · see citing works
Melatonin stimulates glucose transport via insulin receptor substrate‐1/phosphatidylinositol 3‐kinase pathway in C2C12 murine skeletal muscle cells
Ha, E., Yim, S., Chung, J., Yoon, K., Kang, I., Cho, Y. H., & Baik, H. H. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00334.x · Cited by 124 · see citing works
Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes
Huopio, H., Cederberg, H., Vangipurapu, J., Hakkarainen, H., Pääkkönen, M., Kuulasmaa, T., Heinonen, S. T., & Laakso, M. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0286 · Cited by 123 · see citing works
Absence of Melatonin Induces Night-Time Hepatic Insulin Resistance and Increased Gluconeogenesis Due to Stimulation of Nocturnal Unfolded Protein Response
Nogueira, T. C. A., Lellis‐Santos, C., de Jesus, D. S., Taneda, M., Rodrigues, S. C., do Amaral, F. G., Lopes, A. M. S., Cipolla‐Neto, J., Bordin, S. A., & Anhê, G. F. (2011) · Endocrinology · doi:10.1210/en.2010-1088 · Cited by 122 · see citing works
Identification and functional characterization of melatonin Mel 1a receptors in pancreatic β cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling
Kemp, D. M., Ubeda, M., & Habener, J. F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00064-3 · Cited by 122 · see citing works
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Depner, C. M., Melanson, E. L., McHill, A. W., & Wright, K. P. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714813115 · Cited by 122 · see citing works
Melatonin attenuates antipsychotic metabolic effects: an eight‐week randomized, double‐blind, parallel‐group, placebo‐controlled clinical trial
Romo‐Nava, F., Álvarez-Icaza, D., Fresán, A., Saracco-Álvarez, R. A., Becerra‐Palars, C., Moreno, J., Uribe, M. P. O., Berlanga, C., Heinze, G., & Buijs, R. M. (2014) · Bipolar Disorders · doi:10.1111/bdi.12196 · Cited by 119 · see citing works
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence
Barker, A., Sharp, S. J., Timpson, N. J., Bouatia-Naji, N., Warrington, N. M., Kanoni, S., Beilin, L. J., Brage, S., Deloukas, P., Evans, D. M., et al. (2011) · Diabetes · doi:10.2337/db10-1575 · Cited by 117 · see citing works
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., et al. (2017) · Diabetes · doi:10.2337/db16-1452 · Cited by 117 · see citing works
Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up.
Celiński, K., Konturek, P. C., Słomka, M., Cichoz-Lach, H., Brzozowski, T., Konturek, S. J., & Korolczuk, A. (2014) · PubMed · Cited by 114 · see citing works
Melatonin analogues as agonists and antagonists in the circadian system and other brain areas
Ying, S.-W., Rusak, B., Delagrange, P., Mocaër, E., Renard, P., & Guardiola-Lemaître, B. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00684-2 · Cited by 114 · see citing works
Melatonin ameliorates high fat diet‐induced diabetes and stimulates glycogen synthesis via a PKCζ‐Akt‐GSK3β pathway in hepatic cells
Shieh, J., Wu, H., Cheng, K., & Cheng, J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00720.x · Cited by 113 · see citing works
Melatonin and the pathologies of weakened or dysregulated circadian oscillators
Hardeland, R. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12377 · Cited by 111 · see citing works
A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals
Rönn, T., Wen, J., Yang, Z., Lü, B., Du, Y., Groop, L., Hu, R., & Ling, C. (2009) · Diabetologia · doi:10.1007/s00125-009-1297-8 · Cited by 108 · see citing works
Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin
Kadhim, H. M., Ismail, S. H., Hussein, K. I., Bakir, I. H., Sahib, A. S., Khalaf, B. H., & Hussain, S. A. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00353.x · Cited by 107 · see citing works
Identification of Pathway-Biased and Deleterious Melatonin Receptor Mutants in Autism Spectrum Disorders and in the General Population
Chaste, P., Clément, N., Mercati, O., Guillaume, J., Delorme, R., Goubran‐Botros, H., Pagan, C., Périvier, S., Scheid, I., Nygren, G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011495 · Cited by 103 · see citing works
Self-citation
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans
Garaulet, M., Gómez-Abellán, P., Rubio-Sastre, P., Madrid, J. A., Saxena, R., & Scheer, F. A. J. L. (2015) · Metabolism · doi:10.1016/j.metabol.2015.08.003 · Cited by 100 · see citing works
Involvement of the cGMP pathway in mediating the insulin‐inhibitory effect of melatonin in pancreatic β‐cells
Stumpf, I., Mühlbauer, E., & Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00593.x · Cited by 99 · see citing works
Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
Jonsson, A. E., Ladenvall, C., Ahluwalia, T. S., Kravić, J., Krus, U., Taneera, J., Isomaa, B., Tuomilehto, J., Renström, E., Groop, L., et al. (2013) · Diabetes · doi:10.2337/db12-1627 · Cited by 98 · see citing works
Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
Chambers, J. C., Zhang, W., Zabaneh, D., Sehmi, J., Jain, P., McCarthy, M. I., Froguel, P., Ruokonen, A., Balding, D. J., Järvelin, M., et al. (2009) · Diabetes · doi:10.2337/db08-1805 · Cited by 98 · see citing works
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology
Lane, J. M., Chang, A., Bjonnes, A., Aeschbach, D., Anderson, C., Cade, B. E., Cain, S. W., Czeisler, C. A., Gharib, S. A., Gooley, J. J., et al. (2016) · Diabetes · doi:10.2337/db15-0999 · Cited by 95 · see citing works
A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women
Mesri Alamdari, N., Mahdavi, R., Roshanravan, N., Lotfi Yaghin, N., Ostadrahimi, A., & Faramarzi, E. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1384587 · Cited by 93 · see citing works
Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet
Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92 · see citing works
A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells
Saini, C., Petrenko, V., Pulimeno, P., Giovannoni, L., Berney, T., Hebrok, M., Howald, C., Dermitzakis, E. T., & Dibner, C. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12616 · Cited by 91 · see citing works
Common variants at the GCK, GCKR, G6PC2–ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
Takeuchi, F., Katsuya, T., Chackrewarthy, S., Yamamoto, K., Fujioka, A., Serizawa, M., Fujisawa, T., Nakashima, E., Ohnaka, K., Ikegami, H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1595-1 · Cited by 90 · see citing works
Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population
Wang, Y., Nie, M., Li, W., Ping, F., Hu, Y., Ma, L., Gao, J., & Liu, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026953 · Cited by 89 · see citing works
Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients
Kędziora–Kornatowska, K., Szewczyk‐Golec, K., Kozakiewicz, M., Pawluk, H., Czuczejko, J., Kornatowski, T., Bartosz, G., & Kędziora, J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00666.x · Cited by 87 · see citing works
Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo‐controlled trial
Amstrup, A. K., Sikjær, T., Pedersen, S. B., Heickendorff, L., Mosekilde, L., & Rejnmark, L. (2015) · Clinical Endocrinology · doi:10.1111/cen.12942 · Cited by 87 · see citing works
Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
Ramos, E., Chen, G., Shriner, D., Doumatey, A. P., Gerry, N. P., Herbert, A. G., Huang, H., Zhou, J., Christman, M. F., Adeyemo, A., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-2002-7 · Cited by 87 · see citing works
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants
Thomsen, S. K., Ceroni, A., van de Bunt, M., Burrows, C., Barrett, A., Scharfmann, R., Ebner, D. V., McCarthy, M. I., & Gloyn, A. L. (2016) · Diabetes · doi:10.2337/db16-0361 · Cited by 86 · see citing works
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
Langenberg, C., Pascoe, L. A., Mari, A., Tura, A., Laakso, M., Frayling, T. M., Barroso, I., Loos, R. J. F., Wareham, N. J., & Walker, M. (2009) · Diabetologia · doi:10.1007/s00125-009-1392-x · Cited by 85 · see citing works
Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
Palmer, N. D., Goodarzi, M. O., Langefeld, C. D., Wang, N., Guo, X., Taylor, K. D., Fingerlin, T. E., Norris, J. M., Buchanan, T. A., Xiang, A. H., et al. (2014) · Diabetes · doi:10.2337/db14-0732 · Cited by 85 · see citing works
Melatonin Signal Transduction Pathways Require E-Box-Mediated Transcription of Per1 and Per2 to Reset the SCN Clock at Dusk
Kandalepas, P. C., Mitchell, J. W., & Gillette, M. U. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157824 · Cited by 85 · see citing works
Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI 3K activity
Owino, S., Sánchez‐Bretaño, A., Tchio, C. I. M., Cecon, E., Karamitri, A., Dam, J., Jockers, R., Piccione, G. G., Noh, H. L., Kim, T., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12462 · Cited by 85 · see citing works
Self-citation
Activation of melatonin signaling promotes β-cell survival and function
Costes, S., Boss, M., Thomas, A. P., & Matveyenko, A. V. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1293 · Cited by 84 · see citing works
Melatonin receptors activate heteromeric G-protein coupled Kir3 channels
Nelson, C. S., Marino, J. L., & Allen, C. N. (1996) · Neuroreport · doi:10.1097/00001756-199602290-00009 · Cited by 83 · see citing works
The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study.
Gonciarz, M., Gonciarz, Z., Bielański, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2012) · PubMed · Cited by 82 · see citing works
Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina
Bernard, M., Guerlotté, J. F., Grève, P., Gréchez‐Cassiau, A., Iuvone, P. M., Zatz, M., Chong, N. W., Klein, D. C., & Voisin, P. (1999) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19990305 · Cited by 81 · see citing works
Chronomedicine and type 2 diabetes: shining some light on melatonin
Forrestel, A. C., Miedlich, S. U., Yurcheshen, M. E., Wittlin, S. D., & Sellix, M. T. (2016) · Diabetologia · doi:10.1007/s00125-016-4175-1 · Cited by 80 · see citing works
Inhibition of Isoproterenol-Induced Lipolysis in Rat Inguinal Adipocytes in Vitro by Physiological Melatonin via a Receptor-Mediated Mechanism
Zalatan, F., Krause, J. A., & Blask, D. E. (2001) · Endocrinology · doi:10.1210/en.142.9.3783 · Cited by 79 · see citing works
Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes
Rees, S. D., Hydrie, M. Z. I., O'Hare, J. P., Kumar, S., Shera, A. S., Basit, A., Barnett, A. H., & Kelly, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024710 · Cited by 78 · see citing works
Melatonin treatment in peri‐ and postmenopausal women elevates serum high‐density lipoprotein cholesterol levels without influencing total cholesterol levels
Tamura, H., Nakamura, Y., Narimatsu, A., Yamagata, Y., Takasaki, A., Reiter, R. J., & Sugino, N. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00561.x · Cited by 77 · see citing works
The PDZ Protein Mupp1 Promotes Gi Coupling and Signaling of the Mt1 Melatonin Receptor
Guillaume, J., Daulat, A. M., Maurice, P., Levoye, A., Migaud, M., Brydon, L., Malpaux, B., Borg‐Capra, C., & Jockers, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802069200 · Cited by 77 · see citing works
Self-citation
Novel localization of a G protein, Gz-alpha, in neurons of brain and retina
Hinton, D., Blanks, J. C., Fong, H., Casey, P. J., Hildebrandt, E., & Simons, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02763.1990 · Cited by 76 · see citing works
Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion
Hu, C., Zhang, R., Wang, C., Yu, W., Lu, J., Ma, X., Wang, J., Jiang, F., Tang, S., Bao, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011761 · Cited by 76 · see citing works
Melatonin stimulates glucagon secretion in vitro and in vivo
Bähr, I., Mühlbauer, E., Schucht, H., & Peschke, E. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00848.x · Cited by 75 · see citing works
Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese
Ohshige, T., Iwata, M., Omori, S., Tanaka, Y., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Kashiwagi, A., Kawamori, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026911 · Cited by 75 · see citing works
Modulation of Blood Glucose by Melatonin: A Direct Action on Melatonin Receptors in Mouse Hepatocytes
Poon, A. M. S., Choy, E. H. Y., & Pang, S. (2001) · Neurosignals · doi:10.1159/000046904 · Cited by 75 · see citing works
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Goyal, A., Terry, P., Superak, H. M., Nell‐Dybdahl, C., Chowdhury, R., Phillips, L. S., & Kutner, M. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-124 · Cited by 74 · see citing works
Melatonin from Cerebrospinal Fluid but Not from Blood Reaches Sheep Cerebral Tissues Under Physiological Conditions
Legros, C., Chesneau, D., Boutin, J. A., Barc, C., & Malpaux, B. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12134 · Cited by 73 · see citing works
Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks
Owino, S., Contreras‐Alcantara, S., Baba, K., & Tosini, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148214 · Cited by 73 · see citing works
Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3′,5′-Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor*
Witt‐Enderby, P. A., Masana, M. I., & Dubocovich, M. L. (1998) · Endocrinology · doi:10.1210/endo.139.7.6102 · Cited by 72 · see citing works
The Endogenous Melatonin (MT) Signal Facilitates Reentrainment of the Circadian System to Light-Induced Phase Advances by Acting Upon MT2 Receptors
Pfeffer, M., Rauch, A., Korf, H., & von Gall, C. (2012) · Chronobiology International · doi:10.3109/07420528.2012.667859 · Cited by 71 · see citing works
Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling
Maurice, P., Daulat, A. M., Tureček, R., Ivankova-Susankova, K., Zamponi, F., Kamal, M. T., Clément, N., Guillaume, J., Bettler, B., Galès, C., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.236 · Cited by 70 · see citing works
Self-citation
Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization
Yi, W.-J., & Kim, T. S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.006 · Cited by 70 · see citing works
Depression of glucose levels and partial restoration of pancreatic β-cell damage by melatonin in streptozotocin-induced diabetic rats
Kanter, M., Uysal, H., Karaca, T., & Sagmanligil, H. O. (2006) · Archives of Toxicology · doi:10.1007/s00204-005-0055-z · Cited by 70 · see citing works
Blood pressure‐lowering effect of melatonin in type 1 diabetes
Cavallo, A., Daniels, S. R., Dolan, L. M., Bean, J. A., & Khoury, J. C. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00126.x · Cited by 69 · see citing works
Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development
Rosta, K., Al‐Aissa, Z., Hadarits, O., Harreiter, J., Nádasdi, Á., Kelemen, F., Bancher‐Todesca, D., Komlósi, Z. I., Németh, L., Rigó, J. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169781 · Cited by 68 · see citing works
Twenty‐four‐hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes
Isherwood, C., van der Veen, D. R., Johnston, J. D., & Skene, D. J. (2017) · The FASEB Journal · doi:10.1096/fj.201700323r · Cited by 67 · see citing works
Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders: The melatonin pathway in ADHD
Chaste, P., Clement, N., Botros, H. G., Guillaume, J.-L., Konyukh, M., Pagan, C., Scheid, I., Nygren, G., Anckarsäter, H., Rastam, M., et al. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00902.x · Cited by 67 · see citing works
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Short-Term Exposure to Melatonin Differentially Affects the Functional Sensitivity and Trafficking of the hMT1 and hMT2 Melatonin Receptors
Gerdin, M. J., Masana, M. I., Ren, D., Miller, R. J., & Dubocovich, M. L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044990 · Cited by 67 · see citing works
Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor
von Gall, C., Weaver, D. R., Kock, M., Korf, H., & Stehle, J. H. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00002 · Cited by 65 · see citing works
Effects of melatonin on islet neogenesis and beta cell apoptosis in streptozotocin-induced diabetic rats: an immunohistochemical study
Şi̇mşek, N., Kaya, M., Kara, A., Can, I., Karadeniz, A., & Kalkan, Y. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.02.002 · Cited by 65 · see citing works
Exploring the typology of night eating syndrome
Striegel‐Moore, R. H., Franko, D. L., Thompson, D., Affenito, S. G., May, A. M., & KRAEMER, H. C. (2008) · International Journal of Eating Disorders · doi:10.1002/eat.20514 · Cited by 64 · see citing works
Pinealectomy interferes with the circadian clock genes expression in white adipose tissue
de Farias, T. D. S. M., de Oliveira, A. C., Andreotti, S., do Amaral, F. G., Chimin, P., de Proença, A. R. A., Torres‐Leal, F. L., Sertié, R. A. L., Campaña, A. B., Lopes, A. B., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12211 · Cited by 64 · see citing works
The regulation of insulin action in isolated adipocytes. Role of the periodicity of food intake, time of day and melatonin.
Lima, F. B., Matsushita, D. H., Hell, N. S., Dolnikoff, M. S., Okamoto, M. M., & Neto, J. C. (1994) · PubMed · Cited by 64 · see citing works
Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling
Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J.-L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aan6622 · Cited by 62 · see citing works
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MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1Cand impaired beta-cell function in Chinese Hans from Shanghai
Liu, C., Wu, Y., Li, H., Qi, Q., Langenberg, C., Loos, R. J. F., & Xu, L. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-59 · Cited by 62 · see citing works
The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis.
Cichoż‐Lach, H., Celiński, K., Konturek, P. C., Konturek, S. J., & Słomka, M. (2010) · PubMed · Cited by 62 · see citing works
MT1 melatonin receptor internalization underlies melatonin‐induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation
Bondi, C., McKeon, R. M., Bennett, J. M., Ignatius, P. F., Brydon, L., Jockers, R., Melan, M. A., & Witt‐Enderby, P. A. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00525.x · Cited by 61 · see citing works
Self-citation
Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2Receptor Variants with Type 2 Diabetes
Karamitri, A., Renault, N., Clément, N., Guillaume, J., & Jockers, R. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1101 · Cited by 61 · see citing works
Self-citation
Design and validation of the first cell‐impermeant melatonin receptor agonist
Gbahou, F., Cecon, E., Viault, G., Gerbier, R., Jean‐Alphonse, F., Karamitri, A., Guillaumet, G., Delagrange, P., Friedlander, R. M., Vilardaga, J., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13856 · Cited by 61 · see citing works
Self-citation
Antioxidative effects of melatonin administration in elderly primary essential hypertension patients
Kędziora–Kornatowska, K., Szewczyk‐Golec, K., Czuczejko, J., Pawluk, H., de Lumen, K. V. M., Kozakiewicz, M., Bartosz, G., & Kędziora, J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00592.x · Cited by 60 · see citing works
Common Genetic Determinants of Glucose Homeostasis in Healthy Children
Kelliny, C., Ekelund, U., Andersen, L. B., Brage, S., Loos, R. J. F., Wareham, N. J., & Langenberg, C. (2009) · Diabetes · doi:10.2337/db09-0374 · Cited by 59 · see citing works
Melatonin stimulates inositol‐1,4,5‐trisphosphate and Ca2+release from INS1 insulinoma cells
Bach, A. G., Wolgast, S., Mühlbauer, E., & Peschke, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00253.x · Cited by 58 · see citing works
Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function
Oishi, A., Cecon, E., & Jockers, R. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.02.002 · Cited by 58 · see citing works
Self-citation
Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism
Walford, G. A., Green, T. J., Neale, B. M., Isakova, T., Rotter, J. I., Grant, S. F. A., Fox, C. S., Pankow, J. S., Wilson, J. G., Meigs, J. B., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2353-8 · Cited by 57 · see citing works
The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin.
Gonciarz, M., Gonciarz, Z., Bielański, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2010) · PubMed · Cited by 57 · see citing works
The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT2C receptors
Millan, M. J., Marin, P., Kamal, M. T., Jockers, R., Chanrion, B., Labasque, M., Bockaert, J., & la Cour, C. M. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001045 · Cited by 57 · see citing works
Self-citation
Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI
Zhao, J., Bradfield, J. P., Zhang, H., Annaiah, K., Wang, K., Kim, C., Glessner, J., Frackelton, E. C., Otieno, F. G., Doran, J., et al. (2009) · Diabetes · doi:10.2337/db09-0972 · Cited by 56 · see citing works
Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin
Gonciarz, M., Bielański, W., Partyka, R., Brzozowski, T., Konturek, P. C., Eszyk, J., Celiński, K., Reiter, R. J., & Konturek, S. J. (2013) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01023.x · Cited by 56 · see citing works
Variants in glucose- and circadian rhythm–related genes affect the response of energy expenditure to weight-loss diets: the POUNDS LOST Trial
Mirzaei, K., Xu, M., Qi, Q., de Jonge, L., Bray, G. A., Sacks, F. M., & Qi, L. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.072066 · Cited by 55 · see citing works
Protein interactome mining defines melatonin MT 1 receptors as integral component of presynaptic protein complexes of neurons
Benleulmi‐Chaachoua, A., Chen, L., Sokolina, K., Wong, V., Jurišica, I., Emerit, M. B., Darmon, M. C., Espin, A., Štagljar, I., Tafelmeyer, P., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12294 · Cited by 54 · see citing works
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Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps
Hart, L. M. ‘., Simonis-Bik, A. M. C., Nijpels, G., van Haeften, T. W., Schäfer, S., Houwing‐Duistermaat, J. J., Boomsma, D. I., Groenewoud, M. J., Reiling, E., van Hove, E. C., et al. (2009) · Diabetes · doi:10.2337/db09-0736 · Cited by 53 · see citing works
Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder
Nagy, A. D., Iwamoto, A., Kawai, M., Goda, R., Matsuo, H., Otsuka, T., Nagasawa, M., Furuse, M., & Yasuo, S. (2014) · Chronobiology International · doi:10.3109/07420528.2014.992525 · Cited by 52 · see citing works
Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women.
Chojnacki, C. J., Walecka‐Kapica, E., Klupińska, G., Pawłowicz, M., Błońska, A., & Chojnacki, J. (2015) · PubMed · Cited by 51 · see citing works
Melatonin influences insulin secretion primarily via MT1 receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets
Mühlbauer, E., Albrecht, E., Bazwinsky‐Wutschke, I., & Peschke, E. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.00959.x · Cited by 50 · see citing works
Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes
Grotenfelt, N. E., Wasenius, N., Rönö, K., Laivuori, H. M., Stach‐Lempinen, B., Orho‐Melander, M., Schulz, C., Kautiainen, H., Koivusalo, S. B., & Eriksson, J. G. (2016) · Diabetologia · doi:10.1007/s00125-016-3989-1 · Cited by 50 · see citing works
Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster
Champney, T. H., Brainard, G. C., Richardson, B. A., & Reiter, R. J. (1983) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(83)90314-6 · Cited by 48 · see citing works
Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program
Florez, J. C., Jablonski, K. A., McAteer, J. B., Franks, P. W., Mason, C. C., Mather, K. J., Horton, E. S., Goldberg, R. B., Dabelea, D., Kahn, S. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044424 · Cited by 47 · see citing works
Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions
Oishi, A., Karamitri, A., Gerbier, R., Lahuna, O., Ahmad, R., & Jockers, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-08996-7 · Cited by 47 · see citing works
Self-citation
Melatonin Receptor Type 1 Signals to Extracellular Signal-Regulated Kinase 1 and 2 via Giand GsDually Coupled Pathways in HEK-293 Cells
Chen, L., He, X., Zhang, Y., Chen, X., Lai, X., Shao, J., Shi, Y., & Zhou, N. (2014) · Biochemistry · doi:10.1021/bi500092e · Cited by 46 · see citing works
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men
Vangipurapu, J., Stančáková, A., Pihlajamäki, J., Kuulasmaa, T., Kuulasmaa, T., Paananen, J., Kuusisto, J., Ferrannini, E., & Laakso, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1977-4 · Cited by 45 · see citing works
MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans
Galijatovic, E. A. A., Holst, B., Sparsø, T., Grarup, N., Banasik, K., Holmkvist, J., Jørgensen, T., Borch‐Johnsen, K., Egerod, K. L., Lauritzen, T., et al. (2010) · Diabetes · doi:10.2337/db09-1757 · Cited by 45 · see citing works
Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction
Sauer, L. A., Dauchy, R. T., & Blask, D. E. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01062-1 · Cited by 45 · see citing works
GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin
Hablitz, L. M., Molzof, H. E., Abrahamsson, K. E., Cooper, J. M., Prosser, R. A., & Gamble, K. L. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1597-15.2015 · Cited by 44 · see citing works
Photoperiod: Its importance as an impeller of pineal and seasonal reproductive rhythms
Reiter, R. J. (1980) · International Journal of Biometeorology · doi:10.1007/bf02245542 · Cited by 44 · see citing works
Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women
Wakatsuki, A., Okatani, Y., Ikenoue, N., Kaneda, C., & Fukaya, T. (2001) · Maturitas · doi:10.1016/s0378-5122(00)00221-8 · Cited by 43 · see citing works
Blood pressure response to melatonin in type 1 diabetes
Cavallo, A., Daniels, S. R., Dolan, L. M., Khoury, J. C., & Bean, J. A. (2004) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2004.00031.x · Cited by 40 · see citing works
The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
Vlassi, M., Gazouli, M., Paltoglou, G., CHRISTOPOULOS, P. F., Florentin, L., Kassi, G., & Mastorakos, G. P. (2012) · HORMONES · doi:10.1007/bf03401539 · Cited by 40 · see citing works
Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass
Kimple, M. E., Moss, J. B., Brar, H. K., Rosa, T. C., Truchan, N. A., Pasker, R. L., Newgard, C. B., & Casey, P. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.359745 · Cited by 39 · see citing works
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits
Fujita, H., Hara, K., Shojima, N., Horikoshi, M., Iwata, M., Hirota, Y., Tobe, K., Seino, S., & Kadowaki, T. (2012) · Journal of Human Genetics · doi:10.1038/jhg.2012.110 · Cited by 38 · see citing works
The hormone melatonin: Animal studies
Pévet, P., Klosen, P., & Felder‐Schmittbuhl, M. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.10.010 · Cited by 37 · see citing works
Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes
Prunet‐Marcassus, B., Ambid, L., Viguerie, N., Pénicaud, L., & Casteilla, L. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.300206.x · Cited by 36 · see citing works
A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial
Goñi, L., Sun, D., Heianza, Y., Wang, T., Huang, T., Martínez, J. A., Shang, X., Bray, G. A., Smith, S. R., Sacks, F. M., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1660-y · Cited by 36 · see citing works
Circadian control of metabolism and pathological consequences of clock perturbations
Mayeuf-Louchart, A., Zecchin, M., Staels, B., & Duez, H. (2017) · Biochimie · doi:10.1016/j.biochi.2017.07.017 · Cited by 35 · see citing works
Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults
Eze, I. C., Imboden, M., Foraster, M., Schaffner, E., Kumar, A., Vienneau, D., Héritier, H., Rudzik, F., Thiesse, L., Pieren, R., et al. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14121492 · Cited by 35 · see citing works

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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A. A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14748 · Cited by 704 · see citing works
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes
Kumari, S., Carmona, A. V., Tiwari, A. K., & Trippier, P. C. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00530 · Cited by 692 · see citing works
The circadian regulation of food intake
Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428 · see citing works
Obesity and chronic kidney disease
Jiang, Z., Wang, Y., Zhao, X., Cui, H., Han, M., Ren, X., Gang, X., & Wang, G. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2022 · Cited by 267 · see citing works
Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging
Tamura, H., Jozaki, M., Tanabe, M., Shirafuta, Y., Mihara, Y., Shinagawa, M., Tamura, I., Maekawa, R., Sato, S., Taketani, T., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031135 · Cited by 237 · see citing works
Genetics of circadian rhythms and sleep in human health and disease
Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236 · see citing works
Melatonin effects on glucose metabolism: time to unlock the controversy
Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.11.011 · Cited by 193 · see citing works
Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D
Nuszkiewicz, J., Woźniak, A., & Szewczyk-Golec, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165804 · Cited by 156 · see citing works
Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space
Kim, Y. H., & Lazar, M. A. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa014 · Cited by 146 · see citing works
Mechanisms of Melatonin in Obesity: A Review
Guan, Q., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010218 · Cited by 142 · see citing works
Melatonin potentials against viral infections including COVID-19: Current evidence and new findings
Juybari, K. B., Pourhanifeh, M. H., Hosseinzadeh, A., Hemati, K., & Mehrzadi, S. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198108 · Cited by 129 · see citing works
NAFLD in Some Common Endocrine Diseases: Prevalence, Pathophysiology, and Principles of Diagnosis and Management
Lonardo, A., Mantovani, A., Lugari, S., & Targher, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112841 · Cited by 117 · see citing works
Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism
Owino, S., Buonfiglio, D. D. C., Tchio, C. I. M., & Tosini, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00488 · Cited by 124 · see citing works
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis
Morvaridzadeh, M., Sadeghi, E., Agah, S., Nachvak, S. M., Fazelian, S., Moradi, F., Persad, E., & Heshmati, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105210 · Cited by 115 · see citing works
Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease
Kopustinskienė, D. M., & Bernatonienė, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020129 · Cited by 120 · see citing works
Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
Mousavi, R., Alizadeh, M., Jafarabadi, M. A., Heidari, L., Nikbakht, R., Babaahmadi‐Rezaei, H., & Karandish, M. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02725-y · Cited by 108 · see citing works
Melatonin Ameliorates Hepatic Ferroptosis in NAFLD by Inhibiting ER Stress via the MT2/cAMP/PKA/IRE1 Signaling Pathway
Guan, Q., Wang, Z., Hu, K., Cao, J., Dong, Y., & Chen, Y. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85883 · Cited by 102 · see citing works
CD147-spike protein interaction in COVID-19: Get the ball rolling with a novel receptor and therapeutic target
Behl, T., Kaur, I., Aleya, L., Sehgal, A., Singh, S., Sharma, N., Bhatia, S., Al‐Harrasi, A., & BUNGAU, S. G. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152072 · Cited by 102 · see citing works
Melatonin Target Proteins: Too Many or Not Enough?
Liu, L., Labani, N., Cecon, E., & Jockers, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00791 · Cited by 102 · see citing works
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Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19
El-Missiry, M. A., El-Missiry, Z. M. A., & Othman, A. I. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173329 · Cited by 98 · see citing works
Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior
Rumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 93 · see citing works
Circadian clock, diurnal glucose metabolic rhythm, and dawn phenomenon
Peng, F., Li, X., Xiao, F., Zhao, R., & Sun, Z. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.03.010 · Cited by 84 · see citing works
Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol
Lü, Y., Liu, Y., Zhou, J., Li, D., & Gao, W. (2020) · Medicinal Research Reviews · doi:10.1002/med.21751 · Cited by 76 · see citing works
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial
Garaulet, M., Lopez-Minguez, J., Dashti, H. S., Vetter, C., Hernández-Martínez, A. M., Pérez-Ayala, M., Baraza, J. C., Wang, W., Florez, J. C., Scheer, F. A. J. L., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1314 · Cited by 77 · see citing works
Melatonin Inhibits the Ferroptosis Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K/AKT/mTOR Signaling Axis to Attenuate Steroid‐Induced Osteoporosis
Li, M., Yang, N., Li, H., Zhou, W., Li, L., Liu, L., Yang, F., Xu, L., Yao, G., Zhu, C., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8223737 · Cited by 72 · see citing works
Structural basis of the ligand binding and signaling mechanism of melatonin receptors
Wang, Q., Lu, Q., Guo, Q., Teng, M., Gong, Q., Li, X., Du, Y., Liu, Z., & Tao, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-28111-3 · Cited by 71 · see citing works
Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications
Genário, R., Cipolla‐Neto, J., Bueno, A. A., & Santos, H. O. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105254 · Cited by 68 · see citing works
New insights into the function of melatonin and its role in metabolic disturbances
do Amaral, F. G., Andrade-Silva, J., Kuwabara, W. M. T., & Cipolla‐Neto, J. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1631158 · Cited by 66 · see citing works
Anti-Inflammatory Activity of Melatonin: a Focus on the Role of NLRP3 Inflammasome
Ashrafizadeh, M., Najafi, M., Kaviyani, N., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2021) · Inflammation · doi:10.1007/s10753-021-01428-9 · Cited by 64 · see citing works
Personal light exposure patterns and incidence of type 2 diabetes: analysis of 13 million hours of light sensor data and 670,000 person-years of prospective observation
Windred, D. P., Burns, A. C., Rutter, M. K., Yeung, C. H. C., Lane, J. M., Xiao, Q., Saxena, R., Cain, S. W., & Phillips, A. J. K. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2024.100943 · Cited by 59 · see citing works
Diabetes mellitus and melatonin: Where are we?
Patel, R., PARMAR, N. R., Palit, S. P., RATHWA, N. N., Ramachandran, A. V., & Begum, R. (2022) · Biochimie · doi:10.1016/j.biochi.2022.01.001 · Cited by 58 · see citing works
Melatonin ameliorates cerebral ischemia‐reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1‐BMAL1 pathway
Liu, L., Cao, Q., Gao, W., Li, B., Zeng, C., Xia, Z., & Zhao, B. (2021) · The FASEB Journal · doi:10.1096/fj.202002718rr · Cited by 55 · see citing works
Genetic Studies of Gestational Diabetes and Glucose Metabolism in Pregnancy
Powe, C. E., & Kwak, S. H. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01355-3 · Cited by 55 · see citing works
Melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT 1 receptor in bovine mammary epithelial cells
Wang, Y., Guo, W., Xu, H., Tang, K., Zan, L., & Yang, W. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12593 · Cited by 53 · see citing works
Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins
Chen, M., Cecon, E., Karamitri, A., Gao, W., Gerbier, R., Ahmad, R., & Jockers, R. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12641 · Cited by 53 · see citing works
Self-citation
Molecular Biomarkers for Gestational Diabetes Mellitus and Postpartum Diabetes
Lu, W., & Hu, C. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002160 · Cited by 52 · see citing works
Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147)
Şehirli, A. Ö., Sayıner, S., & Serakıncı, N. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05830-8 · Cited by 51 · see citing works
Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease
Bonmatí‐Carrión, M., & Rol, M. A. (2023) · Antioxidants · doi:10.3390/antiox13010034 · Cited by 54 · see citing works
Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences
Malicki, M., Karuga, F. F., Szmyd, B. M., Sochal, M., & Gabryelska, A. (2022) · Metabolites · doi:10.3390/metabo13010060 · Cited by 49 · see citing works
Structure-based discovery of potent and selective melatonin receptor agonists
Patel, N., Huang, X., Grandner, J. M., Johansson, L. C., Stauch, B., McCorvy, J. D., Liu, Y., Roth, B. L., & Katritch, V. (2020) · eLife · doi:10.7554/elife.53779 · Cited by 48 · see citing works
Melatonin alleviates LPS‐induced endoplasmic reticulum stress and inflammation in spermatogonial stem cells
Yang, D., Wei, Y., Lu, Q., Qin, D., Zhang, M., Du, X., Xu, W., Yu, X., He, C., Li, N., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30088 · Cited by 46 · see citing works
Gut microbiota regulates host melatonin production through epithelial cell MyD88
Liu, B., Fan, L., Wang, Y., Wang, H., Yan, Y., Chen, S., Hung, I., Liu, C., Wei, H., Ge, L., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2313769 · Cited by 45 · see citing works
Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve
Yang, C., Liu, Q.-H., Chen, Y., Wang, X.-D., Ran, Z., Fang, F., Xiong, J.-J., Liu, G.-S., Li, X., Yang, L.-G., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02042-z · Cited by 42 · see citing works
Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation
Fang, X., Huang, W., Sun, Q., Zhao, Y., Sun, R., Liu, F., Huang, D., Zhang, Y., Gao, F., & Wang, B. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122108 · Cited by 43 · see citing works
A multi‐level assessment of the bidirectional relationship between aging and the circadian clock
Buijink, M. R., & Michel, S. H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15286 · Cited by 41 · see citing works
The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story
Zhu, H., Zhao, Z., Liu, H., Cai, J., Lu, Q., Ji, L., & Xu, J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2191218 · Cited by 41 · see citing works
Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality
Azuma, K., Ikeda, K., & Inoue, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093182 · Cited by 40 · see citing works
Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects
Bagherifard, A., Hosseinzadeh, A., Koosha, F., Sheibani, M., Behnagh, A. K., Reiter, R. J., & Mehrzadi, S. (2023) · Osteoporosis International · doi:10.1007/s00198-023-06836-1 · Cited by 39 · see citing works
Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview
Mantle, D., Smits, M. G., Boss, M., Miedema, I., & van Geijlswijk, I. M. (2020) · Sleep Medicine X · doi:10.1016/j.sleepx.2020.100022 · Cited by 41 · see citing works
Gut microbiota mediate melatonin signalling in association with type 2 diabetes
Huang, X., Qiu, Y., Gao, Y., Zhou, R., Hu, Q., He, Z., Lv, Y., Wang, X., Chen, W., Deng, Y., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05747-w · Cited by 39 · see citing works
Melatonin Treatment in Kidney Diseases
Markowska, M., Niemczyk, S., & Romejko, K. (2023) · Cells · doi:10.3390/cells12060838 · Cited by 38 · see citing works
The Effect of Sleep Disruption on Cardiometabolic Health
Hong, S., Lee, D.-B., Yoon, D. W., Yoo, S.-L., & Kim, J. (2025) · Life · doi:10.3390/life15010060 · Cited by 45 · see citing works
Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites
Liu, X., Dun, M., Jian, T., Sun, Y., Wang, M., Zhang, G., & Ling, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1134429 · Cited by 37 · see citing works
SLC30A8, CDKAL1, TCF7L2, KCNQ1 and IGF2BP2 are Associated with Type 2 Diabetes Mellitus in Iranian Patients
Yazdi, K. V., Kalantar, S. M., Houshmand, M., Rahmanian, M., Manaviat, M. R., Jahani, M. R., Kamalıdehghan, B., & Almasi‐Hashiani, A. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s225968 · Cited by 36 · see citing works
MiRNA-132/212 encapsulated by adipose tissue-derived exosomes worsen atherosclerosis progression
Guo, B., Zhuang, T., Li, C., Li, F., Shan, S., Zheng, M.-H., Xu, Q.-S., Wang, Y., Lei, L.-M., Tang, K.-X., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02404-x · Cited by 35 · see citing works
Melatonin receptors, brain functions, and therapies
Oishi, A., Gbahou, F., & Jockers, R. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00022-4 · Cited by 33 · see citing works
Self-citation
Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice
Shah, N. Z., Abdalla, M. A., Deshmukh, H., & Sathyapalan, T. (2021) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188211042145 · Cited by 38 · see citing works
A new prospective on the role of melatonin in diabetes and its complications
Mok, J. X., Ooi, J. H., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2019) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2019-0036 · Cited by 33 · see citing works
Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight
Li, Y., Hung, S. W., Zhang, R., Man, G. C. W., Zhang, T., Chung, J. P. W., Fang, L., & Wang, C. C. (2022) · Nutrients · doi:10.3390/nu14194087 · Cited by 32 · see citing works
Associations between evening shift work, irregular sleep timing, and gestational diabetes in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b)
Wallace, D. A., Reid, K. J., Grobman, W. A., Facco, F., Silver, R. M., Pien, G. W., Louis, J. M., Zee, P. C., Redline, S. S., & Sofer, T. (2022) · SLEEP · doi:10.1093/sleep/zsac297 · Cited by 31 · see citing works
Cardioprotective effects of melatonin: Focusing on its roles against diabetic cardiomyopathy
Song, Y., Zhong, C., & Wu, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110260 · Cited by 31 · see citing works
Metabolomic and genetic architecture of gestational diabetes subtypes
Lee, K., Kuang, A., Bain, J. R., Hayes, M. G., Muehlbauer, M. J., Ilkayeva, O., Newgard, C. B., Powe, C. E., Hivert, M., Scholtens, D. M., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06110-x · Cited by 30 · see citing works
Bioinformatics Methodologies to Identify Interactions Between Type 2 Diabetes and Neurological Comorbidities
Rahman, M. H., Peng, S., Hu, X., Chen, C., Uddin, S., Quinn, J. M. W., & Moni, M. A. (2019) · IEEE Access · doi:10.1109/access.2019.2960037 · Cited by 30 · see citing works
Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy
Wang, S., Chen, K., Wang, Y., Wang, Z., Li, Z., Guo, J., Chen, J., Liu, W., Guo, X., Yan, G., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00377-8 · Cited by 30 · see citing works
Molecular Mechanisms of the Melatonin Receptor Pathway Linking Circadian Rhythm to Type 2 Diabetes Mellitus
Xia, A., Zhu, H., Zhao, Z., Liu, H., Wang, P.-H., Ji, L., & Xu, J. (2023) · Nutrients · doi:10.3390/nu15061406 · Cited by 28 · see citing works
Melatonin Improves Endoplasmic Reticulum Stress-Mediated IRE1α Pathway in Zücker Diabetic Fatty Rat
Aouichat, S., Navarro‐Alarcón, M., Alarcón‐Guijo, P., Salagre, D., Ncir, M., Zourgui, L., & Agil, A. (2021) · Pharmaceuticals · doi:10.3390/ph14030232 · Cited by 27 · see citing works
Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta‐analysis
Lauritzen, E. S., Kampmann, U., Smedegaard, S. B., & Støy, J. (2021) · Clinical Endocrinology · doi:10.1111/cen.14576 · Cited by 28 · see citing works
Melatonin content in walnuts and other commercial nuts. Influence of cultivar, ripening and processing (roasting)
Verde, A., Míguez, J. M., Leão, J. M., Gago-Martı́nez, A., & Gallardo, M. (2021) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2021.104180 · Cited by 29 · see citing works
A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus
Huang, B., Wang, Y., Qin, L., Qin, W. D., Liu, N., Jiang, M., Yu, H., & Yu, X. (2019) · Bioscience Reports · doi:10.1042/bsr20190744 · Cited by 27 · see citing works
Development and Validation of a Novel Model for Predicting the 5‐Year Risk of Type 2 Diabetes in Patients with Hypertension: A Retrospective Cohort Study
Cai, X., Zhu, Q., Wu, T., Zhu, B., Aierken, X., Ahmat, A., & Li, N. (2020) · BioMed Research International · doi:10.1155/2020/9108216 · Cited by 27 · see citing works
Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models
Tain, Y., & Hsu, C. (2024) · Antioxidants · doi:10.3390/antiox13020226 · Cited by 26 · see citing works
Association between night shift work and the risk of type 2 diabetes mellitus: a cohort-based meta-analysis
Xie, F., Hu, K. Q., Fu, R., Zhang, Y., Xiao, K., & Tu, J. (2024) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01808-w · Cited by 26 · see citing works
The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
Ramos, E., Lopez-Munoz, F. J., Gil‐Martín, E., Egea, J., Álvarez‐Merz, I., Painuli, S., Semwal, P., Martins, N. A., Hernández-Guijo, J. M., & Romero, A. (2021) · Antioxidants · doi:10.3390/antiox10071152 · Cited by 25 · see citing works
Melatonin attenuates aortic oxidative stress injury and apoptosis in STZ-diabetes rats by Notch1/Hes1 pathway
Ren, B., Zhang, W., Zhang, W., Ma, J., Pei, F., & Li, B.-Y. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105948 · Cited by 26 · see citing works
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors
Maity, J., Dey, T., Banerjee, A., Chattopadhyay, A., Das, A. R., & Bandyopadhyay, D. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12847 · Cited by 26 · see citing works
Injectable hydrogel microspheres encapsulating extracellular vesicles derived from melatonin-stimulated NSCs promote neurogenesis and alleviate inflammation in spinal cord injury
Zeng, J., Gu, C., Zhuang, Y., Lin, K., Xie, Y., & Chen, X. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.144121 · Cited by 26 · see citing works
Exploration of metabolite profiles in the biofluids of dairy cows by proton nuclear magnetic resonance analysis
Kim, H. S., Kim, E. T., Eom, J. S., Choi, Y., Lee, S. J., Lee, S., Chung, C. D., & Lee, S. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246290 · Cited by 26 · see citing works
Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury
Siemiński, M., Reimus, M., Kałas, M., & Stępniewska, E. (2024) · Antioxidants · doi:10.3390/antiox14010025 · Cited by 25 · see citing works
The role of gut microbiota and amino metabolism in the effects of improvement of islet β-cell function after modified jejunoileal bypass
Tan, C. N., Zheng, Z., Wan, X., Cao, J., Wei, R., & Duan, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-84355-x · Cited by 25 · see citing works
Cardiometabolic comorbidities and complications of obesity and chronic kidney disease (CKD)
Ali, M., Parveen, S., Williams, V. R., Dons, R. F., & Uwaifo, G. (2024) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2024.100341 · Cited by 32 · see citing works
Melatonin Alleviates Glucose and Lipid Metabolism Disorders in Guinea Pigs Caused by Different Artificial Light Rhythms
Liu, W., Zhang, Y., Chen, Q., Liu, S., Xu, W., Shang, W., Wang, L., & Yu, J. (2020) · Journal of Diabetes Research · doi:10.1155/2020/4927403 · Cited by 24 · see citing works
Advances in the study of RNA-binding proteins in diabetic complications
Chen, X., Wu, J., Li, Z., Han, J., Xia, P., Shen, Y., Ma, J., Liu, X., Zhang, J., & Yu, P. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101515 · Cited by 25 · see citing works
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
Deota, S., Pendergast, J. S., Kolthur‐Seetharam, U., Esser, K. A., Gachon, F., Asher, G., Dibner, C., Benitah, S. A., Escobar, C., Muoio, D. M., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01237-6 · Cited by 23 · see citing works
Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway
Wang, B., Li, J., Bao, M., Chen, R., Li, H., Lu, B., Chen, M., Huang, D., Zhang, Y., Gao, F., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8882130 · Cited by 23 · see citing works
Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C‐terminal domain
Cecon, E., Ivanova, A., Luka, M., Gbahou, F., Friederich, A., Guillaume, J., Keller, P., Knoch, K. P., Ahmad, R., Delagrange, P., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12540 · Cited by 23 · see citing works
Self-citation
Time for Novel Strategies to Mitigate Cardiometabolic Risk in Shift Workers
Schilperoort, M., Rensen, P. C. N., & Kooijman, S. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.10.005 · Cited by 22 · see citing works
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men
Kampmann, U., Lauritzen, E. S., Grarup, N., Jessen, N., Hansen, T., Møller, N., & Støy, J. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12706 · Cited by 24 · see citing works
Weighted Single-Step GWAS for Body Mass Index and Scans for Recent Signatures of Selection in Yorkshire Pigs
Vahedi, S. M., Ardestani, S. S., Karimi, K., & Banabazi, M. H. (2022) · Journal of Heredity · doi:10.1093/jhered/esac004 · Cited by 22 · see citing works
The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus
Ding, W., Yang, X., Lai, K., Jiang, Y., & Liu, Y. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01490-5 · Cited by 21 · see citing works
Protective Effect of Melatonin Administration against SARS-CoV-2 Infection: A Systematic Review
Molina‐Carballo, A., Palacios-López, R., Jerez-Calero, A. E., Augustin-Morales, M. D. C., Agil, A., Muñoz‐Hoyos, A., & Muñoz-Gallego, A. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb44010003 · Cited by 21 · see citing works
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co‐expression network analysis
Liu, Q., Dong, Y., Escames, G., Wu, X., Ren, J. T., Yang, W., Zhang, S., Zhu, Y., Tian, Y., Acuña-Castroviejo, D., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10384 · Cited by 21 · see citing works
Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives
Mafi, A., Rismanchi, H., Gholinezhad, Y., Mohammadi, M. M., Mousavi, V., Hosseini, S. A., Milasi, Y. E., Reiter, R. J., Ghezelbash, B., Rezaee, M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1224151 · Cited by 21 · see citing works
Maternal MTNR1B genotype, maternal gestational weight gain, and childhood obesity
Liang, Z., Liu, H., Wang, L., Chen, Y., Zhou, T., Heianza, Y., Li, W., Leng, J., Wang, J., Gao, R., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz296 · Cited by 21 · see citing works
Genotype-guided dietary supplementation in precision nutrition
Gkouskou, K. K., Grammatikopoulou, M. G., Vlastos, I. M., Sanoudou, D., & Eliopoulos, A. G. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa132 · Cited by 21 · see citing works
Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells
Kim, J. S., Jung, Y. H., Lee, H. J., Chae, C. W., Choi, G. E., Lim, J. R., Kim, S. Y., Lee, J., & Han, H. J. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02181-4 · Cited by 20 · see citing works
MnTE-2-PyP protects fibroblast mitochondria from hyperglycemia and radiation exposure
Chatterjee, A., Sakallioglu, I. T., Murthy, D., Kosmacek, E. A., Singh, P. K., McDonald, J. T., Powers, R., & Oberley‐Deegan, R. E. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102301 · Cited by 20 · see citing works
Potential Neuroprotective Role of Melatonin in Sepsis-Associated Encephalopathy Due to Its Scavenging and Anti-Oxidative Properties
Siemiński, M., Szaruta-Raflesz, K., Szypenbejl, J., & Krzyżaniak, K. (2023) · Antioxidants · doi:10.3390/antiox12091786 · Cited by 22 · see citing works
Pharmacological Actions of Carbamate Insecticides at Mammalian Melatonin Receptors
Glatfelter, G. C., Jones, A., Rajnarayanan, R. V., & Dubocovich, M. L. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000065 · Cited by 18 · see citing works
The Plasmodium falciparum eIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on parasite cell cycle
Dias, B. K. D. M., Nakabashi, M., Alves, M. R. R., Portella, D. P., dos Santos, B. M., Almeida, F. C. D. S., Ribeiro, R. Y., Schuck, D. C., Jordão, A. K., & Garcia, C. R. S. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12685 · Cited by 18 · see citing works
Impact of light therapy on rotating night shift workers: the EuRhythDia study
Rizza, S., Luzi, A., Mavilio, M., Ballanti, M., Massimi, A., Porzio, O., Magrini, A., Hannemann, J., Menghini, R., Cridland, J., et al. (2022) · Acta Diabetologica · doi:10.1007/s00592-022-01956-2 · Cited by 17 · see citing works

The role of melatonin in type 2 diabetes and obesity
Przezak, A., Bielka, W., Arciszewski, M., & Banach, B. (2021) · Farmacja Polska · doi:10.32383/farmpol/133607 · Cited by 1 · see citing works
Increased melatonin signaling is a risk factor for type 2 diabetes
Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A.-K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.009 · Cited by 262 · see citing works
The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm
Bonnefond, A., Karamitri, A., Jockers, R., & Froguel, P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.015 · Cited by 18 · see citing works
Self-citation
Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?
Bonnefond, A., & Froguel, P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0957-1 · Cited by 29 · see citing works
From Association to Function: MTNR1B
Bonnefond, A., & Lyssenko, V. (2016) · Springer eBooks · doi:10.1007/978-3-319-01574-3_19 · Cited by 2 · see citing works

Authors: Karamitri, A., & Jockers, R.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Jockers, Ralf
ORCID: Karamitri, Angeliki
Jockers, Ralf
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2018-12-07
Volume: 15
Issue: 2
Pages: 105-125
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-018-0130-1
OpenAlex: W2904409392
Cited by: 268
References: 242
Citations by year: 2026: 19 · 2025: 23 · 2024: 35 · 2023: 44 · 2022: 41 · 2021: 42 · 2020: 45 · 2019: 18 · 2018: 1
FWCI: 3.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche (ANR-11-META-0003, ANR-11-BSV1-0012)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: melatonin, type 2 diabetes, obesity, MTNR1B, MT2 receptor, glucose homeostasis, genetic variants, G protein-coupled receptors, melatonin supplementation, diabetes risk
MeSH terms: Animals, Diabetes Mellitus, Type 2, Female, Gene Expression Regulation, Glucose, Homeostasis, Humans, Male, Melatonin, Mutation, Obesity, RNA, Messenger, Genetic Variation, Signal Transduction, Receptor, Melatonin, MT2, Mice, Genome-Wide Association Study

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Melatonin in type 2 diabetes mellitus and obesity

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