Cited by 128Vitamin C and Antioxidants ResearchStress Responses and CortisolAntioxidant Activity and Oxidative Stress

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A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress

Brody, Stuart, Preut, Ragnar, Schommer, Kerstin, Schürmeyer, Thomas H.·2002·Psychopharmacology

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Abstract

Rationale Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals.Methods We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3 x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded.Results Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 microg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery.Conclusions Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.

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Authors: Brody, S., Preut, R., Schommer, K., & Schürmeyer, T. H.
Affiliations: Universität Trier (DE)
ORCID: Brody, Stuart
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2001-11-20
Volume: 159
Issue: 3
Pages: 319-324
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-001-0929-6
OpenAlex: W2131218255
Cited by: 127
References: 44
Citations by year: 2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 14 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
FWCI: 3.03
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Universität Trier
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: high-dose ascorbic acid, vitamin C, blood pressure, cortisol, acute psychological stress, stress reactivity, Trier Social Stress Test, plasma ascorbic acid levels, ACTH response, young adults
MeSH terms: Adult, Analysis of Variance, Antioxidants, Ascorbic Acid, Blood Pressure, Delayed-Action Preparations, Double-Blind Method, Female, Humans, Hydrocortisone, Male, Stress, Psychological, Chi-Square Distribution

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A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress

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