The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress
Abstract
Rationale Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals.Methods We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3 x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded.Results Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 microg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery.Conclusions Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.
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“Both studies with sustained-release vitamin C as the intervention were placebo-controlled [29,31].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [29]
In the citing paper
“From the assessment of the methodological quality of thirteen RCTs, ten (77%) showed a low risk of bias [12,16,27,28,29,30,31,32,35,37,38], two (15%) showed a high risk of bias [33,36] and one (8%) showed an unclear risk of bias [34].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [29]
In the citing paper
“The study on sustained-release vitamin C (3000 mg daily for 14 days) did not find significant differences in adverse events between the intervention and placebo groups [29].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [29]
In the citing paper
“An upset stomach was reported by 19% of participants taking sustained-release vitamin C in comparison with 15% in the placebo group; diarrhea was reported by 22% vs. 24%; and all other minor complaints by 39% vs. 37%, respectively.”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [29]
In the citing paper
“The studies on sustained-release vitamin C were all against placebo, disabling any conclusion to be made on its benefits over ascorbic acid or other, advanced formulations such as Ester-C®, etc. [29,31].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [29]
Citations
Cites
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093
Psychosocial Influences on Mortality after Myocardial Infarction
Ruberman, W., Weinblatt, E., Goldberg, J. D., & Chaudhary, B. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408303110902 · Cited by 979
Dressendörfer, R. A., Kirschbaum, C., Rohde, W., Stahl, F., & Strasburger, C. J. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90294-s · Cited by 882
Ascorbate regulation and its neuroprotective role in the brain
Rice, M. E. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01543-x · Cited by 835
Das State-Trait-Angstinventar (STAI) : theoretische Grundlagen und Handanweisung
Laux, L. (1981) · Beltz eBooks · Cited by 750
Rozanski, A., Merz, C. N. B., Krantz, D. S., Friedman, J. D., Resser, K. J., Morell, M., Hilton-Chalfen, S., Hestrin, L., Bietendorf, J., & Berman, D. S. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804213181601 · Cited by 744
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672
Kirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00009 · Cited by 666
Khaw, K., Bingham, S. A., Welch, A. A., Luben, R., Wareham, N. J., Oakes, S., & Day, N. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04128-3 · Cited by 576
Decreased memory performance in healthy humans induced by stress-level cortisol treatment
Newcomer, J. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.527 · Cited by 546
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Dickerson, B., Gonzalez, D. E., Sowinski, R., Xing, D., Leonard, M., Kendra, J., Jenkins, V., Gopalakrishnan, S., Yoo, C., Ko, J., et al. (2024) · Nutrients · doi:10.3390/nu16193358 · Cited by 1
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García-González, N., Asensio‐Vegas, C., Rico, D., Olmedilla‐Alonso, B., Nova, E., Peñas, E., & Martín‐Diana, A. B. (2018) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-6-6-1 · Cited by 1
Shittu, S.-T. T., Lasisi, T. J., Ogundele, J. O., & Kpai, T. (2018) · Journal of African Association of Physiological Sciences · Cited by 1
Henderson, A. (2015) · UC Research Repository (University of Canterbury) · doi:10.26021/8030 · Cited by 1
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Saller, R., Römer-Lüthi, C., Brignoli, R., & Meier, R. F. (2007) · Schweizerische Zeitschrift für Ganzheitsmedizin / Swiss Journal of Integrative Medicine · doi:10.1159/000283713
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Brody, S., & Potterat, J. J. (2004) · Sexually Transmitted Diseases · doi:10.1097/01.olq.0000105329.65658.27
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Marteney, C., Rodier, H., & Faculty (2008)
Arthur, R. (2016) · Springer eBooks · doi:10.1007/978-3-319-42307-4_10
Psychopharmacological Profile of Ascorbate in aged Wistar Rats
RostirolaElsner, V., Moysés, F. D. S., Bertoldi, K., & Siqueira, I. R. (2017) · Journal of Systems and Integrative Neuroscience · doi:10.15761/jsin.1000153
Karpukhina, O. V., Bokieva, S. B., Gumargalieva, K. Z., & Inozemtsev, A. N. (2019) · Trace Elements in Medicine (Moscow) · doi:10.19112/2413-6174-2019-20-2-39-46
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Namratha, M. V., Jain, P., & Markande, G. B. (2021) · International Ayurvedic Medical Journal · doi:10.46607/iamj2509092021
Isaza, A. (2021) · Food Science & Nutrition Research · doi:10.33425/2641-4295.1043
Korábečný, J., & Soukup, O. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-1797-1
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Joshi, T., Nandave, M., & Sah, A. N. (2023) · Springer eBooks · doi:10.1007/978-981-99-7652-2_25
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Betson, J., Fein, E. C., Long, D. N., & Horrocks, P. (2024) · International Journal of Paramedicine · doi:10.56068/qhqm3379
Pinheiro, E. F., da Costa, N. S. S., Martins, M. L., Saito, G. A., Assad, N., Cardoso, P. B., Batista, E. D. J. O., de Moraes, S. A. S., Passos, A. D. C. F., Leão, L. K. R., et al. (2025) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/8867221
Rudnitsky, S. I., Kirillov, D. O., Alexina, O. V., Shvid, E. S., Klimov, A. A., & Subbotin, V. V. (2025) · Messenger of Anesthesiology and Resuscitation · doi:10.24884/2078-5658-2025-22-5-6-14
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Beigrezaei, S., Darabi, Z., Davies, I. G., Mazidi, M., Ghayour-Mobarhan, M., & Khayyatzadeh, S. S. (2023) · Figshare · doi:10.6084/m9.figshare.24655742
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Elova, N. A., Bekmurodova, G. A., Ikramovna, Z. S., & Miralimova, S. M. (2026) · Theoretical & Applied Science · doi:10.15863/tas.2026.02.154.5
Sohail, Z., Hadi, N. B. A., Rehman, A., Asghar, M., & Zaman, F. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1833900
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Baranauskaitė, R., & Gulbinaitė, N. (2026) · Sveikatos mokslai · doi:10.35988/sm-hs.2026.250
Metadata
- Authors
- Brody, S., Preut, R., Schommer, K., & Schürmeyer, T. H.
- Affiliations
- Universität Trier (DE)
- ORCID
- Brody, Stuart
- Venue
- Psychopharmacology
- Published
- 2001-11-20
- Volume
- 159
- Issue
- 3
- Pages
- 319-324
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2131218255
- Cited by
- 127
- References
- 44
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 14 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universität Trier
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- high-dose ascorbic acid, vitamin C, blood pressure, cortisol, acute psychological stress, stress reactivity, Trier Social Stress Test, plasma ascorbic acid levels, ACTH response, young adults
- MeSH terms
- Adult, Analysis of Variance, Antioxidants, Ascorbic Acid, Blood Pressure, Delayed-Action Preparations, Double-Blind Method, Female, Humans, Hydrocortisone, Male, Stress, Psychological, Chi-Square Distribution
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