The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.
Drug-induced stimulation and suppression of action monitoring in healthy volunteers
Abstract
Rationale Action monitoring has been studied extensively by means of measuring the error-related negativity (ERN). The ERN is an event-related potential (ERP) elicited immediately after an erroneous response and is thought to originate in the anterior cingulate cortex (ACC). Although the ACC has a central role in the brain, only a few studies have been performed to investigate directly the effects of drugs on action monitoring. A recent theory argues that the mesencephalic dopamine system carries an error signal to the ACC, where it generates the ERN.Methods ERPs and behavioral measurements were obtained from 12 healthy volunteers performing an Eriksen Flankers task. On each of the 4 test days, the stimulant D-amphetamine, the sedative lorazepam, the antidepressant mirtazapine, or a placebo was orally administered in a double-blind, four-way crossover design.Results The indirect dopamine agonist amphetamine led to a strong enlargement of ERN amplitudes without affecting reaction times. Lorazepam and mirtazapine both showed slowing of responses, but only lorazepam led to reduced ERN amplitudes.Conclusions Administration of amphetamine leads to stimulated action monitoring, reflected in increased ERN amplitudes. This result provides evidence for dopaminergic involvement in action monitoring and is in line with differences in ERN amplitude found in neuropsychiatric disorders also suggesting dopaminergic involvement. The different effects for lorazepam and mirtazapine are probably caused by the neurobiological characteristics of these two types of sedation. Action monitoring is suppressed after administration of lorazepam, because the GABAergic pathways directly inhibit ACC functioning, whereas the histaminergic pathways of mirtazapine do not innervate the ACC directly.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“five studies measured the effect of AMP on inhibitory or impulse control using Stop‐Signal Task (SST) or Eriksen Flanker task (EFT) (de Bruijn et al., 2004; de Wit et al., 2002; Dolder et al., 2018; Fillmore et al., 2005; Ilieva et al., 2013) and only two studies found main effects (de Wit et al., 2002; Dolder et al., 2018).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as de Bruijn et al., 2004
In the citing paper
“This is contradictory to evidence from adult studies showing that stimulants like Mph boost the response-locked ERN amplitude (De Bruijn et al., 2004; De Bruijn et al., 2005).”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as De Bruijn et al., 2004
Citations
Cites
Conflict monitoring and cognitive control
Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.624 · Cited by 7,351
Effects of noise letters upon the identification of a target letter in a nonsearch task
Eriksen, B. A., & Eriksen, C. W. (1974) · Perception & Psychophysics · doi:10.3758/bf03203267 · Cited by 7,230
A new method for off-line removal of ocular artifact
Gratton, G., Coles, M. G. H., & Donchin, E. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90135-9 · Cited by 5,055 · cited 2×
“Investigating performance adjustments at a more detailed trial-to-trial level can be achieved by investigating sequential congruency effects as proposed by Gratton et al. (1992). The standard congruency effect is characterized by shorter reaction times to congruent trials compared to incongruent ones.”
BackgroundMethodHolroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998) · Science · doi:10.1126/science.280.5364.747 · Cited by 3,273
A neural system for error detection and compensation
Gehring, W. J., Goss, B., Coles, M. G. H., Meyer, D. E., & Donchin, E. (1993) · Psychological Science · doi:10.1111/j.1467-9280.1993.tb00586.x · Cited by 2,862
The neural basis of error detection: Conflict monitoring and the error-related negativity
Yeung, N., Botvinick, M. M., & Cohen, J. D. (2004) · Psychological Review · doi:10.1037/0033-295x.111.4.931 · Cited by 1,924
Optimizing the use of information: Strategic control of activation of responses.
Gratton, G., COLES, M. G. H., & Donchin, E. (1992) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.121.4.480 · Cited by 1,866
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722 · cited 4×
“In addition, human and animal studies have shown that the ACC has high densities of different types of neuromodulators and that especially its rich dopamine innervation is exclusive for this part of the brain (Paus 2001).”
BackgroundInfluentialFalkenstein, M., Hohnsbein, J., Hoormann, J., & Blanke, L. (1991) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(91)90062-9 · Cited by 1,706
ERP components on reaction errors and their functional significance: A tutorial
Falkenstein, M., Hoormann, J., Christ, S., & Hohnsbein, J. (2000) · Biological Psychology · doi:10.1016/s0301-0511(99)00031-9 · Cited by 1,442 · cited 1×
“According to this mechanism, the ERN is generated when a representation of the actual behavior does not match with a representation of the desired behavior (Bernstein et al. 1995; Falkenstein et al. 2000; Coles et al. 2001).”
BackgroundThe Timing of Action-Monitoring Processes in the Anterior Cingulate Cortex
van Veen, V., & Carter, C. S. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/08989290260045837 · Cited by 1,332
The anterior cingulate as a conflict monitor: fMRI and ERP studies
VANVEEN, V, & CARTER, C. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00930-7 · Cited by 1,258 · cited 5×
“2001 ; Van Veen and Carter 2002a ; Yeung et al .”
BackgroundMethodInfluentialLocalization of a Neural System for Error Detection and Compensation
Dehaene, S., Posner, M. I., & Tucker, D. M. (1994) · Psychological Science · doi:10.1111/j.1467-9280.1994.tb00630.x · Cited by 1,255
Nieuwenhuis, S., Yeung, N., van den Wildenberg, W., & Ridderinkhof, K. R. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.1.17 · Cited by 1,250
Errors and error correction in choice-response tasks.
Rabbitt, P. (1966) · Journal of Experimental Psychology · doi:10.1037/h0022853 · Cited by 1,024
Error processing and the rostral anterior cingulate: An event-related fMRI study
Kiehl, K. A., Liddle, P. F., & Hopfinger, J. B. (2000) · Psychophysiology · doi:10.1111/1469-8986.3720216 · Cited by 676
Action-Monitoring Dysfunction in Obsessive-Compulsive Disorder
Gehring, W. J., Himle, J., & Nisenson, L. G. (2000) · Psychological Science · doi:10.1111/1467-9280.00206 · Cited by 670
N200 in the flanker task as a neurobehavioral tool for investigating executive control
Kopp, B., Rist, F., & Mattler, U. (1996) · Psychophysiology · doi:10.1111/j.1469-8986.1996.tb00425.x · Cited by 630
Chemoarchitecture of the Brain
Nieuwenhuys, R. (1985) · Springer eBooks · doi:10.1007/978-3-642-70426-0 · Cited by 500
Coles, M. G. H., Scheffers, M. K., & Holroyd, C. B. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00076-x · Cited by 484
Anterior cingulate and prefrontal cortex: who's in control?
Cohen, J. D., Botvinick, M., & Carter, C. S. (2000) · Nature Neuroscience · doi:10.1038/74783 · Cited by 436
Chemoarchitecture of the brain
(1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90305-7 · Cited by 416
Carter, C. S., MacDonald, A. W., Ross, L. L., & Stenger, V. A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1423 · Cited by 411
Carter, C. S., Mintun, M. A., Nichols, T. E., & Cohen, J. D. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.12.1670 · Cited by 389
Holroyd, C. B., Dien, J., & COLES, M. G. H. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00035-4 · Cited by 354
Alcohol Consumption Impairs Detection of Performance Errors in Mediofrontal Cortex
Ridderinkhof, K. R., de Vlugt, Y., Bramlage, A., Spaan, M., ELTON, M., Snel, J., & Band, G. P. H. (2002) · Science · doi:10.1126/science.1076929 · Cited by 352
Ursu, S., Stenger, V. A., Shear, M. K., Jones, M. R., & Carter, C. S. (2003) · Psychological Science · doi:10.1111/1467-9280.24411 · Cited by 341
Error-related brain activity in obsessive-compulsive undergraduates
Hajcak, G., & Simons, R. F. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00034-3 · Cited by 326
Adler, C. M., McDonough-Ryan, P., Sax, K. W., Holland, S. K., Arndt, S., & Strakowski, S. M. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00022-4 · Cited by 313
"Where did I go wrong?" A psychophysiological analysis of error detection.
Bernstein, P. S., Scheffers, M. K., & Coles, M. G. H. (1995) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.21.6.1312 · Cited by 295
Response-monitoring dysfunction in schizophrenia: An event-related brain potential study.
Mathalon, D. H., Fedor, M., Faustman, W. O., Gray, M., Askari, N., & Ford, J. M. (2002) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.111.1.22 · Cited by 266
Action monitoring, error detection, and the basal ganglia: an ERP study
Falkenstein, M., Hielscher, H., Dziobek, I., Schwarzenau, P., Hoormann, J., Sundermann, B., & Hohnsbein, J. (2001) · Neuroreport · doi:10.1097/00001756-200101220-00039 · Cited by 198
Decreased Dopamine D2 Receptor Binding in the Anterior Cingulate Cortex in Schizophrenia
Suhara, T., Okubo, Y., Yasuno, F., Sudo, Y., Inoue, M., Ichimiya, T., Nakashima, Y., Nakayama, K., Tanada, S., Suzuki, K., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.1.25 · Cited by 194
Neurophysiological Evidence of Error-monitoring Deficits in Patients with Schizophrenia
Alain, C. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.8.840 · Cited by 191
Changes of error-related ERPs with age
Falkenstein, M., Hoormann, J., & Hohnsbein, J. (2001) · Experimental Brain Research · doi:10.1007/s002210100712 · Cited by 187
Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia
Laurens, K. R. (2003) · Brain · doi:10.1093/brain/awg056 · Cited by 178
Patterns of recreational drug use at dance events in Edinburgh, Scotland
Riley, S. C. E., James, C., Gregory, D., Dingle, H., & Cadger, M. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.967103513.x · Cited by 171
Error-related negativity and correct response negativity in schizophrenia
Bates, A. T., Kiehl, K. A., Laurens, K. R., & Liddle, P. F. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00154-2 · Cited by 168
Error negativity and response control
Pailing, P. E., Segalowitz, S. J., Dywan, J., & Davies, P. L. (2002) · Psychophysiology · doi:10.1111/1469-8986.3920198 · Cited by 161
Kopp, B., & Rist, F. (1999) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.108.2.337 · Cited by 142
Treasure, T. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91763-9 · Cited by 101
Vollenweider, F. X., Maguire, R. P., Leenders, K. L., Mathys, K., & Angst, J. (1998) · Psychiatry Research: Neuroimaging · doi:10.1016/s0925-4927(98)00033-x · Cited by 83
Oxazepam alters action monitoring
Johannes, S., Wieringa, B. M., Nager, W., Dengler, R., & Münte, T. F. (2001) · Psychopharmacology · doi:10.1007/s002130100680 · Cited by 79
Hsu, F., Garside, M. J., Massey, A. E., & McAllister-Williams, H. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1413-2 · Cited by 78
Spared error-related potentials in mild to moderate Parkinson’s disease
Holroyd, C. B., Praamstra, P., Plat, E., & COLES, M. G. H. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00052-0 · Cited by 72
It wasn't me... or was it? How false feedback affects performance
Era., D. B., Mars, R. B., & Hulstijn, W. (2004) · Cited by 25
Self-citation
Cited by
Sorted by citations
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Ridderinkhof, K. R., van den Wildenberg, W. P. M., Segalowitz, S. J., & Carter, C. S. (2004) · Brain and Cognition · doi:10.1016/j.bandc.2004.09.016 · Cited by 1,407
Anterior cingulate cortex and conflict detection: an update of theory and data
Carter, C. S., & van Veen, V. (2007) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.7.4.367 · Cited by 1,056
Theta lingua franca: A common mid‐frontal substrate for action monitoring processes
Cavanagh, J. F., Zambrano‐Vazquez, L., & Allen, J. J. B. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01293.x · Cited by 651
Frontal midline theta reflects anxiety and cognitive control: Meta-analytic evidence
Cavanagh, J. F., & Shackman, A. J. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.04.003 · Cited by 684
Metadata
- Authors
- de Bruijn, E. R. A., Hulstijn, W., Verkes, R. J., Ruigt, G. S. F., & Sabbe, B. G. C.
- Affiliations
- Radboud University Nijmegen (NL)
- Organon (Netherlands) (NL)
- Venue
- Psychopharmacology
- Published
- 2004-05-15
- Volume
- 177
- Issue
- 1-2
- Pages
- 151-160
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2116254744
- Cited by
- 282
- References
- 49
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 6 · 2021: 10 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 7 · 2016: 12 · 2015: 18 · 2014: 12 · 2013: 17 · 2012: 14
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Arts and Humanities › Philosophy › Free Will and Agency
- Keywords
- action monitoring, error-related negativity, anterior cingulate cortex, dopamine, amphetamine, lorazepam, mirtazapine, flanker task, response inhibition, GABAergic inhibition, stimulants, sedatives
- MeSH terms
- Mirtazapine, Adult, Cerebral Cortex, Dextroamphetamine, Double-Blind Method, Evoked Potentials, Female, Gyrus Cinguli, Humans, Lorazepam, Male, Mianserin, Psychomotor Performance, Reaction Time, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
