Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis

The functional anatomy of basal ganglia disorders

Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353 · see citing works

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works

D ₁ and D ₂ Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · see citing works

A psychomotor stimulant theory of addiction.

Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works

AMPA Receptor Trafficking and Synaptic Plasticity

Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

Brain Dopamine and Reward

Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968 · see citing works

Opioids excite dopamine neurons by hyperpolarization of local interneurons

Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637 · see citing works

Ca2 + Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

Hollmann, M., Hartley, M., & Heinemann, S. F. (1991) · Science · doi:10.1126/science.1709304 · Cited by 1,450 · see citing works

The many faces of CREB

Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works

D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · see citing works

Dopamine in drug abuse and addiction: results from imaging studies and treatment implications

Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works

Neuroleptics and operant behavior: The anhedonia hypothesis

Wise, R. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010372 · Cited by 1,022 · see citing works

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Spanagel, R., Herz, A., & Shippenberg, T. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2046 · Cited by 1,005 · see citing works

Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning

Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942 · see citing works

Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens

Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931 · see citing works

Psychotomimesis Mediated by κ Opiate Receptors

Pfeiffer, A., Brantl, V., Herz, A., & Emrich, H. M. (1986) · Science · doi:10.1126/science.3016896 · Cited by 857 · see citing works

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

Aghajanian, G. K. (1978) · Nature · doi:10.1038/276186a0 · Cited by 803 · see citing works

Addictive Drugs and Brain Stimulation Reward

Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works

Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey

Kessler, R. C., Zhao, S., Blazer, D. G., & Swartz, M. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00056-6 · Cited by 790 · see citing works

Regulation of cocaine reward by CREB

Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works

Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input

O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760 · see citing works

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90166-5 · Cited by 730 · see citing works

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641 · see citing works

Dopamine in Drug Abuse and Addiction: Results of Imaging Studies and Treatment Implications

Volkow, N. D., Fowler, J. S., Wang, G.-J., Swanson, J. M., & Telang, F. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1575 · Cited by 605 · see citing works

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

Bals-Kubik, R., Ableitner, A., Herz, A., & Shippenberg, T. S. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10296-6 · Cited by 525 · see citing works

Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior

McFarland, K., Davidge, S. B., Lapish, C. C., & Kalivas, P. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-03.2004 · Cited by 524 · see citing works

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works

Intracranial self-administration of morphine into the ventral tegmental area in rats

Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90148-x · Cited by 503 · see citing works

Cortical Dopaminergic Involvement in Cocaine Reinforcement

Goeders, N. E., & Smith, J. E. (1983) · Science · doi:10.1126/science.6879176 · Cited by 490 · see citing works

Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition

Swanson, G. T., Kamboj, S. K., & Cull-Candy, S. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00058.1997 · Cited by 489 · see citing works

Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S., & Carlezon, W. A. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046433 · Cited by 485 · see citing works

Nucleus Accumbens Neurons Are Innately Tuned for Rewarding and Aversive Taste Stimuli, Encode Their Predictors, and Are Linked to Motor Output

Roitman, M. F., Wheeler, R. A., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.055 · Cited by 453 · see citing works

Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum

Smith, K. S., & Berridge, K. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4205-06.2007 · Cited by 450 · see citing works

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Maldonado, R. J., Saiardi, A., Valverde, O., Samad, T. A., Roques, B. P., & Borrelli, E. (1997) · Nature · doi:10.1038/41567 · Cited by 431 · see citing works

Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens

Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1859-07.2007 · Cited by 429 · see citing works

FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains

Lobo, M. K., Karsten, S. L., Gray, M., Geschwind, D. H., & Yang, X. W. (2006) · Nature Neuroscience · doi:10.1038/nn1654 · Cited by 411 · see citing works

Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats

Carlezon, W. A., Béguin, C., DiNieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., Rothman, R. B., Ma, Z., Lee, D. Y.-W., & Cohen, B. M. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092304 · Cited by 390 · see citing works

Functional–anatomical implications of the nucleus accumbens core and shell subterritories

ZAHM, D. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09264.x · Cited by 384 · see citing works

Self-injection of amphetamine directly into the brain

Hoebel, B. G., Monaco, A. P., Hernandez, L., Aulisi, E. F., Stanley, B. G., & Lenard, L. (1983) · Psychopharmacology · doi:10.1007/bf00429012 · Cited by 367 · see citing works

Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study

Franklin, T. R., wang, Z., Wang, J., Sciortino, N., Harper, D., Li, Y., Ehrman, R., Kampman, K. M., O’Brien, C. P., Detre, J. A., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301371 · Cited by 359 · see citing works

CREB modulates excitability of nucleus accumbens neurons

Dong, Y., Green, T. A., Saal, D. B., Marie, H., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2006) · Nature Neuroscience · doi:10.1038/nn1661 · Cited by 356 · see citing works

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

Stinus, L., Le Moal, M., & Koob, G. F. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90106-e · Cited by 317 · see citing works

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect

Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313 · see citing works

Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and PsychostimulantsIn Vivo

Snyder, G. L., Allen, P. B., Fienberg, A. A., Valle, C. G., Huganir, R. L., Nairn, A. C., & Greengard, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04480.2000 · Cited by 311 · see citing works

Evidence That Separate Neural Circuits in the Nucleus Accumbens Encode Cocaine Versus “Natural” (Water and Food) Reward

Carelli, R. M., Ijames, S. G., & Crumling, A. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04255.2000 · Cited by 310 · see citing works

Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?

Carlezon, W. A., & Nestler, E. J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02289-0 · Cited by 281 · see citing works

Sensitization to Morphine Induced by Viral-Mediated Gene Transfer

Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J. (1997) · Science · doi:10.1126/science.277.5327.812 · Cited by 279 · see citing works

Rethinking Substance Abuse: What the Science Shows, and What We Should Do About It

Woolf, S. E., & Maisto, S. A. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02022_1.x · Cited by 273 · see citing works

Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

Todtenkopf, M. S., Marcus, J. F., Portoghese, P. S., & Carlezon, W. A. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1680-y · Cited by 273 · see citing works

Reinforcing effects of morphine in the nucleus accumbens

OLDS, M. E. (1982) · Brain Research · doi:10.1016/0006-8993(82)90454-1 · Cited by 259 · see citing works

Role of Dopamine D1and D2Receptors in the Nucleus Accumbens in Mediating Reward

Ikemoto, S., Glazier, B. S., Murphy, J. M., & McBride, W. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08580.1997 · Cited by 257 · see citing works

Ventral pallidum firing codes hedonic reward: when a bad taste turns good

Tindell, A. J., Smith, K. S., Peciña, S., Berridge, K. C., & Aldridge, J. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00576.2006 · Cited by 241 · see citing works

The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues

Yun, I. A., Wakabayashi, K. T., Fields, H. L., & Nicola, S. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5282-03.2004 · Cited by 238 · see citing works

Repeated Cocaine Alters Glutamate Receptor Subunit Levels in the Nucleus Accumbens and Ventral Tegmental Area of Rats that Develop Behavioral Sensitization

Churchill, L., Swanson, C. J., Urbina, M., & Kalivas, P. W. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722397.x · Cited by 237 · see citing works

Dopamine D 1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking

Hallett, P. J., Spoelgen, R., Hyman, B. T., Standaert, D. G., & Dunah, A. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0792-06.2006 · Cited by 226 · see citing works

Morphine-dopamine interaction: Ventral tegmental morphine increases nucleus accumbens dopamine release

Leone, P., Pocock, D., & Wise, R. A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90210-s · Cited by 226 · see citing works

Encoding of Palatability and Appetitive Behaviors by Distinct Neuronal Populations in the Nucleus Accumbens

Taha, S. A., & Fields, H. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3975-04.2005 · Cited by 217 · see citing works

The Synaptic Framework for Chemical Signaling in Nucleus Accumbens

Meredith, G. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09266.x · Cited by 215 · see citing works

Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome

Harris, G. C., & Aston‐Jones, G. (1994) · Nature · doi:10.1038/371155a0 · Cited by 214 · see citing works

Whole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons

Zhang, X.-F., Hu, X., & White, F. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00488.1998 · Cited by 208 · see citing works

Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior

Cheer, J. F., Aragona, B. J., Heien, M. L., Seipel, A. T., Carelli, R. M., & Wightman, R. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.021 · Cited by 202 · see citing works

Similar effects of daily cocaine and stress on mesocorticolimbic dopamine neurotransmission in the rat

Kalivas, P. W., & Duffy, P. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90271-0 · Cited by 199 · see citing works

Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats.

Kelley, A. E., Bless, E. P., & Swanson, C. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20805-9 · Cited by 185 · see citing works

Stress‐Related Activation of Cerebral Dopaminergic Systemsa

Dunn, A. J. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42106.x · Cited by 185 · see citing works

Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies

Ikemoto, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09305.2003 · Cited by 183 · see citing works

Habit-forming actions of nomifensine in nucleus accumbens

Carlezon, W. A., Devine, D. P., & Wise, R. A. (1995) · Psychopharmacology · doi:10.1007/bf02246095 · Cited by 170 · see citing works

Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration

Wheeler, R. A., Twining, R. C., Jones, J. L., Slater, J. M., Grigson, P. S., & Carelli, R. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.024 · Cited by 166 · see citing works

L-Type Ca2+Channels Are Essential for Glutamate-Mediated CREB Phosphorylation andc-fosGene Expression in Striatal Neurons

Rajadhyaksha, A. M., Barczak, A. K., Macias‐Konstantopoulos, W., Leveque, J., Lewis, S. E., & Konradi, C. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06348.1999 · Cited by 165 · see citing works

D1 dopamine receptor stimulation increases the rate of AMPA receptor insertion onto the surface of cultured nucleus accumbens neurons through a pathway dependent on protein kinase A

Mangiavacchi, S., & Wolf, M. E. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02248.x · Cited by 164 · see citing works

Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice

Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., & Malenka, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401553101 · Cited by 158 · see citing works

Cellular Sites for Dynorphin Activation of κ-Opioid Receptors in the Rat Nucleus Accumbens Shell

Svingos, A. L., Colago, E. E. O., & Pickel, V. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01804.1999 · Cited by 157 · see citing works

Effects of Dopamine D1-like and D2-likeAgonists in Rats that Self-Administer Cocaine

Caine, S. B., Negus, S. S., Mello, N. K., & Bergman, J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35108-0 · Cited by 153 · see citing works

Effects of Feeding and Drinking on Acetylcholine Release in the Nucleus Accumbens, Striatum, and Hippocampus of Freely Behaving Rats

Mark, G. P., Rada, P. V., Pothos, E. N., & Hoebel, B. G. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10973.x · Cited by 151 · see citing works

Phasic Firing of Single Neurons in the Rat Nucleus Accumbens Correlated with the Timing of Intravenous Cocaine Self-Administration

Peoples, L. L., & West, M. O. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03459.1996 · Cited by 149 · see citing works

Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation

Cheer, J. F., Heien, M. L. A. V., Garris, P. A., Carelli, R. M., & Wightman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509607102 · Cited by 143 · see citing works

Neurobiology of sexual behavior

Pfaus, J. G. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00034-3 · Cited by 133 · see citing works

Firing of Nucleus Accumbens Neurons During the Consummatory Phase of a Discriminative Stimulus Task Depends on Previous Reward Predictive Cues

Nicola, S. M., Yun, I. A., Wakabayashi, K. T., & Fields, H. L. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00658.2003 · Cited by 131 · see citing works

Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization

Turgeon, S. M., Pollack, A. E., & Fink, J. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01316-9 · Cited by 129 · see citing works

Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes

Tindell, A. J., Berridge, K. C., & Aldridge, J. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1437-03.2004 · Cited by 128 · see citing works

D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons

Chao, S. Z., Ariano, M. A., Peterson, D. A., & Wolf, M. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01164.x · Cited by 126 · see citing works

General, μ and κ opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions

Bodnar, R. J., Glass, M. J., Ragnauth, A. K., & Cooper, M. L. (1995) · Brain Research · doi:10.1016/0006-8993(95)00957-r · Cited by 124 · see citing works

Opiate Withdrawal-Induced Fos Immunoreactivity in the Rat Extended Amygdala Parallels the Development of Conditioned Place Aversion

Gracy, K. N. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00186-x · Cited by 124 · see citing works

A Review of the Properties of Spiradoline: A Potent and Selective k‐Opioid Receptor Agonist

Wadenberg, M.-L. (2003) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2003.tb00248.x · Cited by 123 · see citing works

Adverse Subjective Experience With Antipsychotics and Its Relationship to Striatal and Extrastriatal D 2 Receptors: a PET Study in Schizophrenia

Mizrahi, R. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.4.630 · Cited by 122 · see citing works

Acute and Chronic Dopamine Receptor Stimulation Modulates AMPA Receptor Trafficking in Nucleus Accumbens Neurons Cocultured with Prefrontal Cortex Neurons

Sun, X., Milovanovic, M., Zhao, Y., & Wolf, M. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0258-08.2008 · Cited by 111 · see citing works

Adverse Subjective Experience With Antipsychotics and Its Relationship to Striatal and Extrastriatal D 2 Receptors: a PET Study in Schizophrenia

Mizrahi, R., Rusjan, P., Agid, O., Graff, A., Mamo, D. C., Zipursky, R. B., & Kapur, S. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.630 · Cited by 111 · see citing works

Rethinking substance abuse: what the science shows, and what we should do about it.

Miller, W. R., & Carroll, K. M. (2006) · Cited by 108 · see citing works

Adherence to pharmacotherapy in patients with alcohol and opioid dependence

Weiss, R. D. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00884.x · Cited by 107 · see citing works

Morphine-Induced Dependence and Sensitization Are Altered in Mice Deficient in AMPA-Type Glutamate Receptor-A Subunits

Vekovischeva, O. Y., Zamanillo, D., Echenko, O., Seppälä, T., Uusi‐Oukari, M., Honkanen, A., Seeburg, P. H., Sprengel, R., & Korpi, E. R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04451.2001 · Cited by 102 · see citing works

Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue‐evoked goal‐directed behavior

Yun, I. A., Nicola, S. M., & Fields, H. L. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03476.x · Cited by 98 · see citing works

Cdk5 Modulates Cocaine Reward, Motivation, and Striatal Neuron Excitability

Benavides, D. R., Quinn, J. J., Zhong, P., Hawasli, A. H., Dileone, R., Kansy, J. W., Olausson, P., Yan, Z., Taylor, J. R., & Bibb, J. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4061-07.2007 · Cited by 97 · see citing works

Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration

Finlay, J. M., Damsma, G., & Fibiger, H. C. (1992) · Psychopharmacology · doi:10.1007/bf02801973 · Cited by 95 · see citing works

Cholinergic modulation of nucleus accumbens medium spiny neurons

de Rover, M., Lodder, J. C., Kits, K. S., Schoffelmeer, A. N. M., & Brussaard, A. B. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02289.x · Cited by 94 · see citing works

Desmethylimipramine attenuates cocaine withdrawal in rats

Markou, A., Hauger, R. L., & Koob, G. F. (1992) · Psychopharmacology · doi:10.1007/bf02245878 · Cited by 94 · see citing works

Behavioral and Molecular Effects of Dopamine D1 Receptor Stimulation during Naloxone-Precipitated Morphine Withdrawal

Chartoff, E. H., Mague, S. D., Barhight, M. F., Smith, A. M., & Carlezon, W. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0491-06.2006 · Cited by 85 · see citing works

Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats

Chang, J.-Y., Zhang, L., Janak, P. H., & Woodward, D. J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00012-7 · Cited by 83 · see citing works

Opiate influences on nucleus accumbens neuronal electrophysiology: dopamine and non-dopamine mechanisms

Hakan, R. L., & Henriksen, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03538.1989 · Cited by 81 · see citing works

Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine

Welter, M., Vallone, D., Samad, T. A., Méziane, H., Usiello, A., & Borrelli, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610790104 · Cited by 81 · see citing works

Dopaminergic Reduction of Excitability in Nucleus Accumbens Neurons Recorded in Vitro

O’Donnell, P. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00177-f · Cited by 80 · see citing works

Repeated Cocaine Administration Suppresses HVA-Ca2+Potentials and Enhances Activity of K+Channels in Rat Nucleus Accumbens Neurons

Hu, X., Basu, S., & White, F. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00217.2004 · Cited by 79 · see citing works

Dual Role of Medial A10 Dopamine Neurons in Affective Encoding

Liu, Z., Shin, R. S., & Ikemoto, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.4 · Cited by 73 · see citing works

Effects of dopamine D 1-like and D 2-like agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions

Caine, S. B., Negus, S. S., & Mello, N. K. (2000) · Psychopharmacology · doi:10.1007/s002130050023 · Cited by 73 · see citing works

Kappa agonist-induced reduction in dopamine release: site of action and tolerance.

Ba, D., Js, A., Mm, P., & Voigtlander, P. F. V. (1992) · PubMed · Cited by 73 · see citing works

Locally evoked potentials in slices of the rat nucleus accumbens: NMDA and non-NMDA receptor mediated components and modulation by GABA

Pennartz, C. M. A., Boeijinga, P. H., & Lopes, F. H. D. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90808-o · Cited by 72 · see citing works

Neural substrates of opiate reinforcement

Bozarth, M. A., & Wise, R. A. (1983) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(83)90027-1 · Cited by 69 · see citing works

Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration

Janak, P. H., Chang, J.-Y., & Woodward, D. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01245-1 · Cited by 65 · see citing works

Brain Reward Regulated by AMPA Receptor Subunits in Nucleus Accumbens Shell

Todtenkopf, M. S., Parsegian, A., Naydenov, A. V., Neve, R. L., Konradi, C. L., & Carlezon, W. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3070-06.2006 · Cited by 65 · see citing works

Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.

Wood, P. L. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33260-x · Cited by 62 · see citing works

Opioid receptors: past, present and future

Mansour, A., Watson, S. J., & Akil, H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80024-v · Cited by 60 · see citing works

Opposite effects of midazolam and β-carboline-3-carboxylate ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo mudialysis

Murai, T., Koshikawa, N., Kanayama, T., Takada, K., Tomiyama, K., & Kobayashi, M. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90301-8 · Cited by 60 · see citing works

Membrane properties and synaptic responses of the guinea pig nucleus accumbens neurons in vitro

Uchimura, N., Higashi, H., & Nishi, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.769 · Cited by 58 · see citing works

AMPA-Receptor GluR1 Subunits are Involved in the Control Over Behavior by Cocaine-Paired Cues

Mead, A. N., Zamanillo, D., Becker, N., & Stephens, D. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301045 · Cited by 53 · see citing works

Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice

Mead, A. N., Brown, G., Le Merrer, J., & Stephens, D. N. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2071-8 · Cited by 52 · see citing works

L-type calcium channels modulate glutamate-driven bursting activity in the nucleus accumbens in vivo

Cooper, D., & White, F. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02868-7 · Cited by 45 · see citing works

Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice

Elmer, G. I., Pieper, J. O., Levy, J., Rubinstein, M., Low, M. J., Grandy, D. K., & Wise, R. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0051-2 · Cited by 44 · see citing works

Lesions of the nucleus accumbens in rats reduce opiate reward but do not alter context-specific opiate tolerance.

Kelsey, J. E., Carlezon, W. A., & Falls, W. A. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.6.1327 · Cited by 42 · see citing works

Benzodiazepine self-administration in animals and humans: a comprehensive literature review.

Griffiths, R. R., & Na, A. (1980) · PubMed · Cited by 39 · see citing works

Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats

Guix, T., Hurd, Y. L., & Ungerstedt, U. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90490-x · Cited by 39 · see citing works

SPECT tracer [123I]IBZM has similar affinity to dopamine D2 and D3 receptors

Videb�k, C., Toska, K., Scheideler, M. A., Paulson, O. B., & Knudsen, G. M. (2000) · Synapse · doi:10.1002/1098-2396(20001201)38:3 · Cited by 38 · see citing works

Cocaine releases limbic acetylcholine through endogenous dopamine action on D1 receptors

Impérato, A., Obinu, M. C., Demontis, M. V., & Gessa, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90565-l · Cited by 38 · see citing works

The Role of Accumbal Hypoactivity in Cocaine Addiction.

Peoples, L. L., Kravitz, A. V., & Guillem, K. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.266 · Cited by 38 · see citing works

Effects of naltrexone on nucleus accumbens, lateral hypothalamic and ventral tegmental self-stimulation rate—frequency functions

West, T. E. G., & Wise, R. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90594-x · Cited by 37 · see citing works

Lesions of the nucleus accumbens in rats reduce opiate reward but do not alter context-specific opiate tolerance.

Kelsey, J. E., Carlezon, W. A., & Falls, W. A. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.6.1327 · Cited by 37 · see citing works

Opioid receptors: past, present and future

Mansour, A. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93876-y · Cited by 32 · see citing works

Opiate antagonists and self-stimulation: extinction-like response patterns suggest selective reward deficit

Trujillo, K. A., Belluzzi, J. D., & Stein, L. (1989) · Brain Research · doi:10.1016/0006-8993(89)90884-6 · Cited by 29 · see citing works

Microinjection of the L-Type Calcium Channel Antagonist Diltiazem into the Ventral Nucleus Accumbens Shell Facilitates Cocaine-Induced Conditioned Place Preferences

Chartoff, E. H., Pliakas, A. M., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.024 · Cited by 26 · see citing works

Disruption of conditioned taste aversion in the rat by stimulation of amygdala: A conditioning effect, not amnesia.

Phillips, A. G., & LePiane, F. G. (1980) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077701 · Cited by 22 · see citing works

SEXUAL BEHAVIOR, EATING AND MESOLIMBIC DOPAMINE

Fibiger, H. C., Nomikos, G. G., Pfaus, J. G., & Damsma, G. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00294 · Cited by 21 · see citing works

Intracerebral dopaminergic transplants are not activated by electrical footshock stress activating in situ mesocorticolimbic neurons

Herman, J. P., Rivet, J., Abrous, D. N., & Moal, M. L. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90791-4 · Cited by 17 · see citing works

Depressant actions of enkephalins on neurones in the nucleus accumbens [proceedings].

McCarthy, P. S., Walker, R. J., & Gn, W. (1977) · PubMed · Cited by 7 · see citing works

Pleasure Systems in the Brain

Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730 · see citing works

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073 · see citing works

Reward Processing by the Opioid System in the Brain

Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013 · see citing works

Cortico-Basal Ganglia Reward Network: Microcircuitry

Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works

Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward

Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880 · see citing works

Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens

Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716 · see citing works

Sleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms

Harvey, A. G., Murray, G., Chandler, R. A., & Soehner, A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.003 · Cited by 609 · see citing works

The first taste is always with the eyes: A meta-analysis on the neural correlates of processing visual food cues

van der Laan, L. N., de Ridder, D. T. D., Viergever, M. A., & Smeets, P. A. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.055 · Cited by 602 · see citing works

Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain

Baliki, M. N., Geha, P., Fields, H. L., & Apkarian, A. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.002 · Cited by 549 · see citing works

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

Alhadeff, A. L., Rupprecht, L. E., & Hayes, M. R. (2012) · Endocrinology · doi:10.1210/en.2011-1443 · Cited by 515 · see citing works

Endocannabinoid signalling in reward and addiction

Parsons, L. H., & Hurd, Y. L. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4004 · Cited by 474 · see citing works

Disentangling pleasure from incentive salience and learning signals in brain reward circuitry

Smith, K. S., Berridge, K. C., & Aldridge, J. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101920108 · Cited by 464 · see citing works

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

Witten, I. B., Lin, S.-C., Brodsky, M., Prakash, R., Diester, I., Anikeeva, P., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2010) · Science · doi:10.1126/science.1193771 · Cited by 467 · see citing works

Dynorphin, stress, and depression

Knoll, A. T., & Carlezon, W. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.074 · Cited by 465 · see citing works

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.021 · Cited by 379 · see citing works

Alterations in brain structure and functional connectivity in prescription opioid-dependent patients

Upadhyay, J., Maleki, N., Potter, J. S., Elman, I., Rudrauf, D., Knudsen, J., Wallin, D. J., Pendse, G., McDonald, L., Griffin, M. L., et al. (2010) · Brain · doi:10.1093/brain/awq138 · Cited by 394 · see citing works

Keep off the grass? Cannabis, cognition and addiction

Curran, H. V., Freeman, T. P., Mokrysz, C., Lewis, D. A., Morgan, C. J. A., & Parsons, L. H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.28 · Cited by 381 · see citing works

“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications

Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346 · see citing works

Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli

Roitman, M. F., Wheeler, R. A., Wightman, R. M., & Carelli, R. M. (2008) · Nature Neuroscience · doi:10.1038/nn.2219 · Cited by 343 · see citing works

The neurobiology of social play and its rewarding value in rats

Vanderschuren, L. J. M. J., Achterberg, E. J. M., & Trezza, V. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.025 · Cited by 329 · see citing works

The mesoaccumbens dopamine in coping with stress

Cabib, S., & Puglisi-Allegra, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.012 · Cited by 329 · see citing works

Natural rewards, neuroplasticity, and non-drug addictions

Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works

Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry

Castro, D. C., Cole, S. L., & Berridge, K. C. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00090 · Cited by 333 · see citing works

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works

Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data

Spear, L. P. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.08.001 · Cited by 292 · see citing works

A neurobehavioral evolutionary perspective on the mechanisms underlying empathy

Jean Decety, A., Norman, G. J., Berntson, G. G., & Cacioppo, J. T. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.001 · Cited by 289 · see citing works

AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine

Wolf, M. E., & Ferrario, C. R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.013 · Cited by 271 · see citing works

What about the “Self” is Processed in the Posterior Cingulate Cortex?

Brewer, J. A., Garrison, K. A., & Whitfield-Gabrieli, S. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00647 · Cited by 263 · see citing works

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works

Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance

Zheng, P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.07.001 · Cited by 263 · see citing works

Current Emotion Research in Health Behavior Science

Williams, D. M., & Evans, D. R. (2014) · Emotion Review · doi:10.1177/1754073914523052 · Cited by 265 · see citing works

Role of kappa-opioid receptors in stress and anxiety-related behavior

Veer, A. V., & Carlezon, W. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3195-5 · Cited by 254 · see citing works

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

Soares-Cunha, C., de Vasconcelos, N. A. P., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., Gaspar, R., Sotiropoulos, I., Sousa, N., & Rodrigues, A. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0484-3 · Cited by 256 · see citing works

Chronic pain: The role of learning and brain plasticity

Mansour, A. R., Farmer, M., Baliki, M. N., & Apkarian, A. V. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139003 · Cited by 238 · see citing works

Predicting transition to chronic pain

Apkarian, A. V., Baliki, M. N., & Farmer, M. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32836336ad · Cited by 232 · see citing works

Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal

Sharma, S., Fernandes, M. F., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.197 · Cited by 231 · see citing works

Defeat stress in rodents: from behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works

The Behavioral Activation System and Mania

Johnson, S. L., Edge, M. D., Holmes, M. K., & Carver, C. S. (2012) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032511-143148 · Cited by 230 · see citing works

Reward deficiency and anti-reward in pain chronification

Borsook, D., Linnman, C., Faria, V., Strassman, A. M., Becerra, L. R., & Elman, I. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.033 · Cited by 227 · see citing works

The Distribution of Toxoplasma gondii Cysts in the Brain of a Mouse with Latent Toxoplasmosis: Implications for the Behavioral Manipulation Hypothesis

Berenreiterová, M., Jaroslav Flegr, A., Kuběna, A. A., & Němec, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028925 · Cited by 216 · see citing works

Pain and suicidality: Insights from reward and addiction neuroscience

Elman, I., Borsook, D., & Volkow, N. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.003 · Cited by 220 · see citing works

The Brain Circuitry Underlying the Temporal Evolution of Nausea in Humans

Napadow, V., Sheehan, J. D., Kim, J., LaCount, L. T., Park, K., Kaptchuk, T. J., Rosen, B. R., & Kuo, B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs073 · Cited by 215 · see citing works

Functional Connectivity and Coactivation of the Nucleus Accumbens: A Combined Functional Connectivity and Structure-Based Meta-analysis

Cauda, F., Cavanna, A. E., D’Agata, F., Sacco, K., Duca, S., & Geminiani, G. C. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2011.21624 · Cited by 208 · see citing works

VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons

Qi, J., Zhang, S., Wang, H., Barker, D. J., Miranda-Barrientos, J. A., & Morales, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4281 · Cited by 203 · see citing works

What the Laboratory Rat has Taught us About Social Play Behavior: Role in Behavioral Development and Neural Mechanisms

Vanderschuren, L. J. M. J., & Trezza, V. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/978-3-662-45758-0_268 · Cited by 200 · see citing works

Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine

Kourrich, S., Hayashi, T., Chuang, J., Tsai, S., Su, T., & Bonci, A. (2013) · Cell · doi:10.1016/j.cell.2012.12.004 · Cited by 195 · see citing works

Nature's clocks and human mood: the circadian system modulates reward motivation

Murray, G., Nicholas, C. L., Kleiman, J., Dwyer, R., Carrington, M. J., Allen, N. B., & Trinder, J. (2009) · Emotion · doi:10.1037/a0017080 · Cited by 185 · see citing works

Affective valence in the brain: modules or modes?

Berridge, K. C. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0122-8 · Cited by 183 · see citing works

Reward processing in obesity, substance addiction and non‐substance addiction

García‐García, I., Horstmann, A., Jurado, M. Á., Garolera, M., Chaudhry, S. J., Margulies, D. S., Villringer, A., & Neumann, J. (2014) · Obesity Reviews · doi:10.1111/obr.12221 · Cited by 180 · see citing works

Balancing Risk and Reward: A Rat Model of Risky Decision Making

Simon, N. W., Gilbert, R. J., Mayse, J. D., Bizon, J. L., & Setlow, B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.48 · Cited by 177 · see citing works

Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley

Richard, J. M., Castro, D. C., DiFeliceantonio, A. G., Robinson, M. J. F., & Berridge, K. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.008 · Cited by 175 · see citing works

Emotion and episodic memory in neuropsychiatric disorders

Dere, E., Pause, B. M., & Pietrowsky, R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.017 · Cited by 165 · see citing works

New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system

Volman, S. F., Lammel, S., Margolis, E. B., Kim, Y., Richard, J. M., Roitman, M. F., & Lobo, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3250-13.2013 · Cited by 168 · see citing works

The nucleus accumbens is involved in both the pursuit of social reward and the avoidance of social punishment

Kohls, G., Perino, M. T., Taylor, J. M., Madva, E. N., Cayless, S. J., Troiani, V., Price, E., Faja, S., Herrington, J. D., & Schultz, R. T. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.07.020 · Cited by 170 · see citing works

Integrins in synapse regulation

Park, Y. K., & Goda, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.138 · Cited by 167 · see citing works

Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain

Chang, P.-C., Pollema-Mays, S. L., Centeno, M. V., Procissi, D., Contini, M., Baria, A. T., Martina, M., & Apkarian, A. V. (2014) · Pain · doi:10.1016/j.pain.2014.02.019 · Cited by 161 · see citing works

A Pause in Nucleus Accumbens Neuron Firing Is Required to Initiate and Maintain Feeding

Krause, M., German, P. W., Taha, S. A., & Fields, H. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0197-10.2010 · Cited by 164 · see citing works

Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum

van Kerkhof, L. W., Damsteegt, R., Trezza, V., Voorn, P., & Vanderschuren, L. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.83 · Cited by 161 · see citing works

Migraine Attacks the Basal Ganglia

Maleki, N., Becerra, L. R., Nutile, L. M., Pendse, G., Brawn, J., BIGAL, M. E., Burstein, R., & Borsook, D. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-71 · Cited by 160 · see citing works

Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials

Carlezon, W. A., & Krystal, A. D. (2016) · Depression and Anxiety · doi:10.1002/da.22500 · Cited by 160 · see citing works

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Tejeda, H. A., Shippenberg, T. S., & Henriksson, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0844-x · Cited by 155 · see citing works

Kappa-opioid ligands in the study and treatment of mood disorders

Carlezon, W. A., Béguin, C., Knoll, A. T., & Cohen, B. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.008 · Cited by 156 · see citing works

Intrinsic plasticity: an emerging player in addiction

Kourrich, S., Calu, D. J., & Bonci, A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3877 · Cited by 151 · see citing works

Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder

Murrough, J. W., Henry, S. E., Hu, J., Gallezot, J., Planeta‐Wilson, B., Neumaier, J. F., & Neumeister, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1881-0 · Cited by 155 · see citing works

Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell

Li, Z., Chen, Z., Fan, G., Li, A., Yuan, J., & Xu, T. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00084 · Cited by 155 · see citing works

Encoding of Aversion by Dopamine and the Nucleus Accumbens

McCutcheon, J. E., Ebner, S. R., Loriaux, A. L., & Roitman, M. F. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00137 · Cited by 146 · see citing works

Nucleus Accumbens Dopamine/Glutamate Interaction Switches Modes to Generate Desire versus Dread: D1Alone for Appetitive Eating But D1and D2Together for Fear

Richard, J. M., & Berridge, K. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1339-11.2011 · Cited by 152 · see citing works

Neural circuit competition in cocaine‐seeking: roles of the infralimbic cortex and nucleus accumbens shell

LaLumiere, R. T., Smith, K. C., & Kalivas, P. W. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07991.x · Cited by 148 · see citing works

Neuronal Correlates of Depression

Chaudhury, D., Liu, H., & Han, M.-H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 139 · see citing works

Targeting glutamate uptake to treat alcohol use disorders

Rao, P. S. S., Bell, R. L., Engleman, E. A., & Sari, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00144 · Cited by 136 · see citing works

Kappa Opioid Receptor Signaling in the Basolateral Amygdala Regulates Conditioned Fear and Anxiety in Rats

Knoll, A. T., Muschamp, J. W., Daws, S. E., Ferguson, D., Dietz, D., Meloni, E. G., Carroll, F. I., Nestler, E. J., Konradi, C. L., & Carlezon, W. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.017 · Cited by 141 · see citing works

Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment

Brierley, D. I., & Davidson, C. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.001 · Cited by 137 · see citing works

Avoidance of harm and anxiety: A role for the nucleus accumbens

Levita, L., Hoskin, R., & Champi, S. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.059 · Cited by 137 · see citing works

Architectural Representation of Valence in the Limbic System

Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 133 · see citing works

Dark control: The default mode network as a reinforcement learning agent

Dohmatob, E., Dumas, G., & Bzdok, D. (2020) · Human Brain Mapping · doi:10.1002/hbm.25019 · Cited by 121 · see citing works

It’s MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system

Chartoff, E. H., & Connery, H. S. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00116 · Cited by 128 · see citing works

Overexpression of CREB in the Nucleus Accumbens Shell Increases Cocaine Reinforcement in Self-Administering Rats

Larson, E. B., Graham, D. L., Arzaga, R. R., Buzin, N., Webb, J., Green, T. A., Bass, C. E., Neve, R. L., Terwilliger, E. F., Nestler, E. J., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3070-11.2011 · Cited by 127 · see citing works

Regulation of Nucleus Accumbens Activity by the Hypothalamic Neuropeptide Melanin-Concentrating Hormone

Sears, R. M., Liu, R.-J., Narayanan, N. S., Sharf, R., Yeckel, M. F., Laubach, M., Aghajanian, G. K., & Dileone, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5858-09.2010 · Cited by 125 · see citing works

Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder

Blood, A. J., Iosifescu, D. V., Makris, N., Perlis, R. H., Kennedy, D. N., Dougherty, D. D., Kim, B. W., Lee, M. J., Wu, S., Lee, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013945 · Cited by 126 · see citing works

Striatum on the anxiety map: Small detours into adolescence

Lago, T. R., Davis, A. A., Grillon, C., & Ernst, M. (2016) · Brain Research · doi:10.1016/j.brainres.2016.06.006 · Cited by 123 · see citing works

Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats

Carr, G. V., Bangasser, D. A., Bethea, T. T., Young, M., Valentino, R. J., & Lucki, I. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.183 · Cited by 124 · see citing works

Neurocircuitry of drug reward

Ikemoto, S., & Bonci, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.031 · Cited by 122 · see citing works

A theory of behaviour on progressive ratio schedules, with applications in behavioural pharmacology

Bradshaw, C. M., & Killeen, P. R. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2771-4 · Cited by 119 · see citing works

Glucagon-Like Peptide-1 Receptor Activation in the Nucleus Accumbens Core Suppresses Feeding by Increasing Glutamatergic AMPA/Kainate Signaling

Mietlicki‐Baase, E. G., Ortinski, P. I., Reiner, D. J., Sinon, C. G., McCutcheon, J. E., Pierce, R. C., Roitman, M. F., & Hayes, M. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0115-14.2014 · Cited by 122 · see citing works

Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence

Cole, S. L., Robinson, M. J. F., & Berridge, K. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207694 · Cited by 108 · see citing works

Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura

Yuan, K., Zhao, L., Cheng, P., Yu, D., Zhao, L., Dong, T., Xing, L., Bi, Y., Yang, X., von Deneen, K. M., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.02.010 · Cited by 118 · see citing works

Mixing pleasures: Review of the effects of drugs on sex behavior in humans and animal models

Frohmader, K. S., Pitchers, K. K., Balfour, M. E., & Coolen, L. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.11.009 · Cited by 117 · see citing works

A kinesin signaling complex mediates the ability of GSK-3β to affect mood-associated behaviors

Du, J., Wei, Y., Liu, L., Wang, Y., Khairova, R. A., Blumenthal, R., Tragon, T. R., Hunsberger, J. G., Machado‐Vieira, R., Drevets, W. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913138107 · Cited by 116 · see citing works

The emergence of gonadal hormone influences on dopaminergic function during puberty

Kuhn, C., Johnson, M., Thomae, A., Luo, B., Simon, S. A., Zhou, G., & Walker, Q. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.10.015 · Cited by 113 · see citing works

The Missing P in Psychiatric Training

Elman, I., Zubieta, J.-K., & Borsook, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.174 · Cited by 115 · see citing works

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

Diniz, G. B., & Bittencourt, J. C. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00032 · Cited by 115 · see citing works

A Thalamo-Hippocampal-Ventral Tegmental Area Loop May Produce the Positive Feedback that Underlies the Psychotic Break in Schizophrenia

Lisman, J. E., Pi, H. J., Zhang, Y., & Otmakhova, N. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.007 · Cited by 115 · see citing works

Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression

Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works

Excessive disgust caused by brain lesions or temporary inactivations: mapping hotspots of the nucleus accumbens and ventral pallidum

Ho, C., & Berridge, K. C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12720 · Cited by 115 · see citing works

The role of mesocorticolimbic dopamine in regulating interactions between drugs of abuse and social behavior

Young, K. A., Gobrogge, K. L., & Wang, Z. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.004 · Cited by 111 · see citing works

Does the kappa opioid receptor system contribute to pain aversion?

Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works

Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats

Nemeth, C. L., Paine, T. A., Rittiner, J. E., Béguin, C., Carroll, F. I., Roth, B. L., Cohen, B. M., & Carlezon, W. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1834-7 · Cited by 104 · see citing works

Sex and the migraine brain

Borsook, D., Erpelding, N., Lebel, A., Linnman, C., Veggeberg, R., Grant, P. E., Buettner, C., Becerra, L. R., & Burstein, R. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.008 · Cited by 108 · see citing works

Activation of CREB in the Nucleus Accumbens Shell Produces Anhedonia and Resistance to Extinction of Fear in Rats

Muschamp, J. W., Veer, A. V., Parsegian, A., Gallo, M. S., Chen, M., Neve, R. L., Meloni, E. G., & Carlezon, W. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5973-10.2011 · Cited by 105 · see citing works

Identifying a Network of Brain Regions Involved in Aversion-Related Processing: A Cross-Species Translational Investigation

Hayes, D. J., & Northoff, G. (2011) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2011.00049 · Cited by 106 · see citing works

Disinhibitory feedback loops for reward and aversion

Juarez, B., & Zweifel, L. S. (2021) · Cell Research · doi:10.1038/s41422-021-00601-x · Cited by 2 · see citing works

Nucleus Accumbens Modulation in Reward and Aversion

Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works

Few but Not Futile: A Sparse Nucleus Accumbens Corticotropin-Releasing Factor Population Regulates Reward Learning

Roland, A. V. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.01.004 · Cited by 1 · see citing works

The nucleus accumbens in reward and aversion processing: insights and implications

Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 77 · see citing works

Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice

Zhou, K., Xu, H. Z., Lu, S., Jiang, S., Hou, G., Deng, X., He, M., & Zhu, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33843-3 · Cited by 105 · see citing works