The hippocampus and contextual memory retrieval in Pavlovian conditioning

Maren, Stephen; Holt, William

doi:10.1016/s0166-4328(99)00188-6

Cited by 256Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

The hippocampus and contextual memory retrieval in Pavlovian conditioning

Open access

Maren, Stephen, Holt, William·2000·Behavioural Brain Research

DOI 10.1016/s0166-4328(99)00188-6

Open this paper in CoChat — free account Open PDF

Abstract

Several theories of hippocampal function have suggested a role for the hippocampus in contextual memory retrieval. However, these theories are based on studies using permanent pretraining lesions, which confound the role of the hippocampus in learning with its role in retrieval. We argue that an alternative methodology is required to assess the role of the hippocampus in memory retrieval processes. This alternative methodology involves temporary inactivation of the hippocampus in Pavlovian paradigms that lend themselves to an examination of retrieval. An example of this approach is considered in a Pavlovian fear-conditioning paradigm. We examined the influence of hippocampal inactivation on the context-specific expression of latent inhibition, a response decrement displayed when excitatory conditioning is preceded by non-reinforced presentations of a to-be-conditioned stimulus. Reversible inactivation of the dorsal hippocampus prior to retrieval testing eliminated the context-specific expression of latent inhibition. The nature of the hippocampal role in retrieval processes is discussed in the light of these data.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0166-4328(99)00188-6

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hippocampus is a medial temporal lobe region adjacent to the amygdala that is implicated in declarative memory, contextual memory and fear conditioning.
“the hippocampus, a medial temporal lobe region adjacent to the amygdala that is implicated in declarative memory,27 contextual memory28 and fear conditioning,29”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [28]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010 · see citing works
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128 · see citing works
Encoding specificity and retrieval processes in episodic memory.
Tulving, E., & Thomson, D. M. (1973) · Psychological Review · doi:10.1037/h0020071 · Cited by 4,540 · see citing works
Principles of Behavior
Skinner, B. F., & Hull, C. L. (1944) · The American Journal of Psychology · doi:10.2307/1416955 · Cited by 4,061 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works
A theory of attention: Variations in the associability of stimuli with reinforcement
Mackintosh, N. J. (1975) · Psychological Review · doi:10.1037/h0076778 · Cited by 2,733 · see citing works
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works
Context, time, and memory retrieval in the interference paradigms of Pavlovian learning
Bouton, M. E. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.1.80 · Cited by 1,896 · see citing works
Cognitive Processes in Animal Behavior
Hill, W. F., Hulse, S. H., Fowler, H., & Honig, W. K. (1979) · The American Journal of Psychology · doi:10.2307/1421585 · Cited by 1,595 · see citing works
Memory, amnesia, and the hippocampal system
(1994) · Choice Reviews Online · doi:10.5860/choice.31-5148 · Cited by 1,533 · see citing works
Cognitive Processes in Animal Behavior
(2018) · Routledge eBooks · doi:10.4324/9780203710029 · Cited by 1,116 · see citing works
The hippocampus and behavior.
Douglas, R. (1967) · Psychological bulletin · doi:10.1037/h0024599 · Cited by 1,092 · see citing works
Information Processing in Animals: Memory Mechanisms.
indicated, N. A. (1986) · Contemporary Psychology · doi:10.1037/024459 · Cited by 1,022 · see citing works
The hippocampus and contextual retrieval of information from memory: A theory
Hirsh, R. (1974) · Behavioral Biology · doi:10.1016/s0091-6773(74)92231-7 · Cited by 957 · see citing works
Information Processing in Animals
(2014) · Psychology Press eBooks · doi:10.4324/9781315798820 · Cited by 902 · see citing works
Latent inhibition.
Lubow, R. E. (1973) · Psychological Bulletin · doi:10.1037/h0034425 · Cited by 793 · see citing works
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
Maren, S., Aharonov, G., & Fanselow, M. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00088-0 · Cited by 765 · see citing works
Self-citation
Localization of a Memory Trace in the Mammalian Brain
Krupa, D. J., Thompson, J. K., & Thompson, R. F. (1993) · Science · doi:10.1126/science.8493536 · Cited by 515 · see citing works
Retrieval of memory in animals.
Spear, N. E. (1973) · Psychological Review · doi:10.1037/h0034326 · Cited by 505 · see citing works
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
Frankland, P. W., Cestari, V., Filipkowski, R. K., McDonald, R. J., & Silva, A. J. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.4.863 · Cited by 486 · see citing works
Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following hippocampal ablation.
Solomon, P. R., & Moore, J. W. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077183 · Cited by 473 · see citing works
Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat
Martin, J. H. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90784-q · Cited by 459 · see citing works
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
Frankland, P. W., Cestari, V., Filipkowski, R. K., et al. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.4.863 · Cited by 435 · see citing works
Memory, amnesia, and the hippocampal system
Holmes, G. L. (1994) · Journal of Epilepsy · doi:10.1016/0896-6974(94)90099-x · Cited by 422 · see citing works
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.683 · Cited by 382 · see citing works
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.4.683 · Cited by 382 · cited 1× · see citing works
“[55] Muller J, Corodimas KP, Fridel Z, LeDoux JE.”
Background
Configural association theory and the hippocampal formation: An appraisal and reconfiguration
Rudy, J. W., & Sutherland, R. J. (1995) · Hippocampus · doi:10.1002/hipo.450050502 · Cited by 379 · see citing works
Hippocampus and context in classical conditioning
Holland, P. C., & Bouton, M. E. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80027-0 · Cited by 377 · see citing works
Differential modulation of a common memory retrieval network revealed by positron emission tomography
Maguire, E. A., & Mummery, C. J. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:1 · Cited by 362 · see citing works
Selective hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning.
Honey, R. C., & Good, M. A. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.1.23 · Cited by 336 · see citing works
Analysis of the associative and occasion-setting properties of contexts participating in a Pavlovian discrimination.
Bouton, M. E., & Swartzentruber, D. (1986) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.12.4.333 · Cited by 335 · see citing works
Electrolytic Lesions of the Fimbria/Fornix, Dorsal Hippocampus, or Entorhinal Cortex Produce Anterograde Deficits in Contextual Fear Conditioning in Rats
Maren, S., & Fanselow, M. S. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3752 · Cited by 324 · see citing works
Self-citation
Functional Anatomic Studies of Memory Retrieval for Auditory Words and Visual Pictures
Buckner, R. L., Raichle, M. E., Miezin, F. M., & Petersen, S. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06219.1996 · Cited by 318 · see citing works
Effects of context manipulation on memory and reversal learning in rats with hippocampal lesions.
Winocur, G., & Olds, J. (1978) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077468 · Cited by 296 · see citing works
Selective hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning.
Honey, R. C., & Good, M. A. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.1.23 · Cited by 274 · see citing works
Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats.
Helmstetter, F. J., & Bellgowan, P. S. F. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.5.1005 · Cited by 265 · see citing works
Context, Ambiguity, and Classical Conditioning
Bouton, M. E. (1994) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10769943 · Cited by 259 · see citing works
Conditioning and contextual retrieval in hippocampal rats.
Good, M. A., & Honey, R. C. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.4.499 · Cited by 246 · see citing works
Occasion setting: Associative learning and cognition in animals.
(1998) · American Psychological Association eBooks · doi:10.1037/10298-000 · Cited by 245 · see citing works
NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: Immunization against amnesia by context preexposure.
Young, S. L., Bohenek, D. L., & Fanselow, M. S. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.19 · Cited by 240 · see citing works
Contextual effects in conditioning, latent inhibition, and habituation: Associative and retrieval functions of contextual cues.
Hall, G., & Honey, R. C. (1989) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.15.3.232 · Cited by 237 · see citing works
Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats.
Helmstetter, F. J., & Bellgowan, P. S. F. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.5.1005 · Cited by 219 · see citing works
Context specificity of conditioning, extinction, and latent inhibition.
Lovibond, P. F., Preston, G. C., & Mackintosh, N. J. (1984) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.10.3.360 · Cited by 218 · see citing works
Muscimol Inactivation of the Dorsal Hippocampus Impairs Contextual Retrieval of Fear Memory
Holt, W., & Maren, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-09054.1999 · Cited by 213 · see citing works
Self-citation
Hippocampectomy disrupts acquisition and retention of learned conditional responding.
Ross, R. T., Orr, W. B., Holland, P. C., & Berger, T. W. (1984) · Behavioral Neuroscience · doi:10.1037//0735-7044.98.2.211 · Cited by 205 · see citing works
Conditioning and contextual retrieval in hippocampal rats.
Good, M. A., & Honey, R. C. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.4.499 · Cited by 202 · see citing works
The hippocampus, conditional operations, and cognition
Hirsh, R. (1980) · Physiological Psychology · doi:10.3758/bf03332848 · Cited by 192 · see citing works
Preserved configural learning and spatial learning impairment in rats with hippocampal damage
Gallagher, M., & Holland, P. C. (1992) · Hippocampus · doi:10.1002/hipo.450020111 · Cited by 192 · see citing works
NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: Immunization against amnesia by context preexposure.
Young, S. L., Bohenek, D. L., & Fanselow, M. S. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.19 · Cited by 184 · see citing works
The hippocampus and conditioning to contextual cues.
Winocur, G., Rawlins, J. N. P., & Gray, J. A. (1987) · Behavioral Neuroscience · doi:10.1037/0735-7044.101.5.617 · Cited by 181 · see citing works
Hippocampus, context, and conditioning.
Penick, S., & Solomom, P. R. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.5.611 · Cited by 178 · see citing works
Conditioning of simultaneous and serial feature-positive discriminations
Ross, R. T., & Holland, P. C. (1981) · Animal Learning & Behavior · doi:10.3758/bf03197835 · Cited by 172 · see citing works
Effects of CS preexposures on avoidance learning in rats with hippocampal lesions.
Ackil, J. E., Mellgren, R. L., Halgren, C. R., & Frommer, G. P. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0028159 · Cited by 166 · see citing works
Slow reacquisition following extinction: Context, encoding, and retrieval mechanisms.
Bouton, M. E., & Swartzentruber, D. (1989) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.15.1.43 · Cited by 163 · see citing works
Disruption of Decrements in Conditioned Stimulus Processing by Selective Removal of Hippocampal Cholinergic Input
Baxter, M. G., Holland, P. C., & Gallagher, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05230.1997 · Cited by 154 · see citing works
Hippocampal lesions attenuate latent inhibition and the decline of the orienting response in rats.
Kaye, H., & Pearce, J. M. (1987) · PubMed · Cited by 152 · see citing works
Similarities vs. differences in place learning and circadian activity in rats after fimbria‐fornix section or ibotenate removal of hippocampal cells
Whishaw, I. Q., & Jarrard, L. E. (1995) · Hippocampus · doi:10.1002/hipo.450050610 · Cited by 152 · see citing works
Effect of Reversible Inactivation of Macaque Lateral Intraparietal Area on Visual and Memory Saccades
Li, C. R., Mazzoni, P., & Andersen, R. A. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1827 · Cited by 152 · see citing works
Hippocampectomy disrupts acquisition and retention of learned conditional responding.
Ross, R. T., Orr, W. B., Holland, P. C., et al. (1984) · Behavioral Neuroscience · doi:10.1037/0735-7044.98.2.211 · Cited by 149 · see citing works
Hippocampus, context, and conditioning.
Penick, S., & Solomom, P. R. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.5.611 · Cited by 144 · see citing works
Context, conditioning, and hippocampal rerepresentation in animal learning.
Myers, C. E., & Gluck, M. A. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.5.835 · Cited by 142 · see citing works
The role of the rat hippocampal system in several effects of context in extinction.
Wilson, A., Brooks, D. C., & Bouton, M. E. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.5.828 · Cited by 140 · see citing works
A Lateralized Deficit in Morphine Antinociception after Unilateral Inactivation of the Central Amygdala
Manning, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09453.1998 · Cited by 136 · see citing works
Contextual effects in latent inhibition with an appetitive conditioning procedure
Channell, S., & Hall, G. (1983) · Animal Learning & Behavior · doi:10.3758/bf03212309 · Cited by 134 · see citing works
What is conditioned fear?
Fanselow, M. S. (1984) · Trends in Neurosciences · doi:10.1016/s0166-2236(84)80253-2 · Cited by 125 · see citing works
A Search for Context-Stimulus Associations in Latent Inhibition
Hall, G., & Minor, H. (1984) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748408402200 · Cited by 125 · see citing works
Latent inhibition in rats is abolished by NMDA-induced neuronal loss in the retrohippocampal region, but this lesion effect can be prevented by systemic haloperidol treatment.
Yee, B. K., Feldon, J., & Rawlins, J. N. P. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.2.227 · Cited by 124 · see citing works
The role of the rat hippocampal system in several effects of context in extinction.
Wilson, A., Brooks, D. C., & Bouton, M. E. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.5.828 · Cited by 115 · see citing works
Context, conditioning, and hippocampal rerepresentation in animal learning.
Myers, C. E., & Gluck, M. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.5.835 · Cited by 113 · see citing works
The startled seahorse: is the hippocampus necessary for contextual fear conditioning?
Maren, S., Anagnostaras, S., & Fanselow, M. S. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01123-1 · Cited by 112 · see citing works
Self-citation
Latent inhibition in rats is abolished by NMDA-induced neuronal loss in the retrohippocampal region, but this lesion effect can be prevented by systemic haloperidol treatment.
Yee, B. K., Feldon, J., & Rawlins, J. N. P. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.2.227 · Cited by 111 · see citing works
Hippocampal lesions disrupt decrements but not increments in conditioned stimulus processing
Han, J., Gallagher, M., & Holland, P. C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07323.1995 · Cited by 109 · see citing works
On the hippocampus and learned conditional responding: Effects of aspiration versus ibotenate lesions
Jarrard, L. E., & Davidson, T. L. (1991) · Hippocampus · doi:10.1002/hipo.450010110 · Cited by 102 · see citing works
Temporal determinants of occasion setting in feature-positive discriminations
Holland, P. C. (1986) · Animal Learning & Behavior · doi:10.3758/bf03200045 · Cited by 99 · see citing works
Psychological theories of hippocampal function
Schmajuk, N. A. (1984) · Physiological Psychology · doi:10.3758/bf03332187 · Cited by 93 · see citing works
Perplexing effects of hippocampal lesions on latent inhibition: A neural network solution.
Buhusi, C. V., Gray, J. A. B., & Schmajuk, N. A. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.2.316 · Cited by 88 · see citing works
Context-specific multi-site cingulate cortical, limbic thalamic, and hippocampal neuronal activity during concurrent discriminative approach and avoidance training in rabbits
Freeman, J. H., Cuppernell, C., Flannery, K., & Gabriel, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01538.1996 · Cited by 75 · see citing works
Perplexing effects of hippocampal lesions on latent inhibition: A neural network solution.
Buhusi, C. V., Gray, J. A. B., & Schmajuk, N. A. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.2.316 · Cited by 74 · see citing works
Contingent versus incidental context processing during conditioning: Dissociation after excitotoxic hippocampal plus dentate gyrus lesions
Good, M. A., de Hoz, L., & Morris, R. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:2 · Cited by 67 · see citing works
Dorsal hippocampal lesions: Effects of preconditioning CS exposure on flavor aversion
McFarland, D. J., Kostas, J., & Drew, W. G. (1978) · Behavioral Biology · doi:10.1016/s0091-6773(78)92501-4 · Cited by 66 · see citing works
Enhancement of latent inhibition in rats with electrolytic lesions of the hippocampus.
Purves, D. G., Bonardi, C., & Hall, G. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.2.366 · Cited by 65 · see citing works
Hippocampal lesions attenuate latent inhibition of a CS and of a neutral stimulus
Kaye, H., & Pearce, J. M. (1987) · Psychobiology · doi:10.3758/bf03327285 · Cited by 60 · see citing works
Latent inhibition of the rat eyeblink response: Effect of hippocampal aspiration lesions
Schmajuk, N. A., Lam, Y., & Christiansen, B. A. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90122-8 · Cited by 60 · see citing works
Enhancement of latent inhibition in rats with electrolytic lesions of the hippocampus.
Purves, D. G., Bonardi, C., & Hall, G. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.2.366 · Cited by 56 · see citing works
Inactivation of brainstem motor nuclei blocks expression but not acquisition of the rabbit's classically conditioned eyeblink response.
Krupa, D. J., Weng, J., & Thompson, R. F. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.219 · Cited by 53 · see citing works
Lesions of the entorhinal cortex disrupt behavioral and neuronal responses to context change during extinction of discriminative avoidance behavior
Freeman, J. H., Weible, A. P., Rossi, J. S., et al. (1997) · Experimental Brain Research · doi:10.1007/pl00005714 · Cited by 50 · see citing works
Inactivation of brainstem motor nuclei blocks expression but not acquisition of the rabbit's classically conditioned eyeblink response.
Krupa, D. J., Weng, J., & Thompson, R. F. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.219 · Cited by 50 · see citing works
Analogies between occasion setting and Pavlovian conditioning.
Miller, R. R., & Oberling, P. (2004) · American Psychological Association eBooks · doi:10.1037/10298-001 · Cited by 48 · see citing works
Effect of the infusion of the GABA-A receptor agonist, muscimol, on the role of the entorhinal cortex, amygdala, and hippocampus in memory processes
Jersalinsky, D., Quillfeldt, J. A., Walz, R., da Silva, R. C., Silva, M. B. E., Bianchin, M. M., Schmitz, P. K., Zanatta, M. S., Ruschel, A. C., Paczko, N., et al. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80066-4 · Cited by 33 · see citing works
Role of contextual discrimination in fear conditioning.
Dexter, W. R., & Merrill, H. K. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0028210 · Cited by 31 · see citing works
Contribution of the forebrain archistriatal gaze fields to auditory orienting behavior in the barn owl
Knudsen, E., & Knudsen, P. F. (1996) · Experimental Brain Research · doi:10.1007/bf00242901 · Cited by 27 · see citing works
Contextual control as occasion setting.
Hall, G., & Mondragón, E. (2004) · American Psychological Association eBooks · doi:10.1037/10298-007 · Cited by 27 · see citing works
Locomotor activity of rats in open field after microinjection of procaine into superior colliculus or underlying reticular formation
Dean, P., Redgrave, P., & Lewis, G. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90051-1 · Cited by 24 · see citing works
Latent inhibition from context-dependent retrieval of conflicting information
Wright, D. C., Skala, K. D., & Peuser, K. A. (1986) · Bulletin of the Psychonomic Society · doi:10.3758/bf03330531 · Cited by 12 · see citing works
Untitled work
(1999) · doi:10.1002/(sici)1098-1063(1999)9:2

Flagged first, then by citations

Research works printed but not linked: 4

Han J-S, Gallagher M, Holland P. Hippocampal lesions enhance configural learning by reducing proactive interference. Hippocampus 1998;8:138 -46.
Holland PC, Lamoureux JA, Han J-S, Gallagher M. Hippocam- pal lesions interfere with Pavlovian negative occasion setting. Hippocampus 1999;9:143 -57.
Penick S, Solomon PR. Hippocampus, context, and condition- ing. Behav Neurosci 1991;105:611-7.
Schacter DL, Wagner AD. Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus 1999;9:7 -24.

Sorted by citations

Context and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808 · see citing works
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547 · see citing works
Self-citation
Contextual and temporal modulation of extinction: behavioral and biological mechanisms
Bouton, M. E., Westbrook, R. F., Corcoran, K. A., & Maren, S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.015 · Cited by 671 · see citing works
Self-citation
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684 · see citing works
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
McQuown, S. C., Barrett, R. M., Matheos, D. P., Post, R. J., Rogge, G. A., Alenghat, T., Mullican, S. E., Jones, S., Rusche, J. R., Lazar, M. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5052-10.2011 · Cited by 507 · see citing works
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature · doi:10.1038/nature22405 · Cited by 514 · see citing works
Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder
Sripada, R. K., King, A. P., Garfinkel, S. N., Wang, X., Sripada, C. S., Welsh, R. C., & Liberzon, I. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110069 · Cited by 352 · see citing works
Prefrontal-Hippocampal Interactions in Memory and Emotion
Jin, J., & Maren, S. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00170 · Cited by 313 · see citing works
“For these reasons, models of episodic retrieval have largely focused on the influence of contextual representations encoded in the HPC on memory retrieval processes guided by the mPFC (Maren and Holt, 2000; Hasselmo and Eichenbaum, 2005; Ranganath, 2010).”
BackgroundMethodSelf-citation
Hippocampal involvement in contextual modulation of fear extinction
Ji, J., & Maren, S. (2007) · Hippocampus · doi:10.1002/hipo.20331 · Cited by 297 · see citing works
Self-citation
Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory
Maren, S. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.023 · Cited by 259 · see citing works
“Moreover, the hippocampus is involved in the context-dependence of extinction, particularly for regulating the renewal of fear to an extinguished CS outside of the extinction context (Maren and Holt, 2000).”
BackgroundSelf-citation
The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
Riddell, D. R., Zhou, H., Comery, T. A., Kouranova, E., Lo, C. F., Warwick, H. K., Ring, R. H., Kirksey, Y., Aschmies, S., Xu, J., et al. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.011 · Cited by 244 · see citing works
Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory
Barrett, R. M., Malvaez, M., Kramar, E., Matheos, D. P., Arrizon, A., Cabrera, S. M., Lynch, G., Greene, R. W., & Wood, M. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.61 · Cited by 243 · see citing works
Reinstatement of Conditioned Fear in Humans Is Context Dependent and Impaired in Amnesia.
LaBar, K. S., & Phelps, E. A. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.3.677 · Cited by 184 · see citing works
Hippocampal GLP-1 Receptors Influence Food Intake, Meal Size, and Effort-Based Responding for Food through Volume Transmission
Hsu, T. M., Hahn, J. D., Konanur, V. R., Lam, A., & Kanoski, S. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.175 · Cited by 176 · see citing works
Context, emotion, and the strategic pursuit of goals: interactions among multiple brain systems controlling motivated behavior
Gruber, A. J., & McDonald, R. J. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00050 · Cited by 173 · see citing works
Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage
Fernando, W. M. A. D. B., Martins, I. J., Morici, M., Bharadwaj, P., Rainey-Smith, S. R., Lim, W. L. F., & Martins, R. N. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190120 · Cited by 164 · see citing works
Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder
Shin, L. M., Lasko, N. B., Macklin, M. L., Karpf, R. D., Milad, M. R., Orr, S. P., Goetz, J. M., Fischman, A. J., Rauch, S. L., & Pitman, R. K. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.138 · Cited by 151 · see citing works
Differential alterations of resting‐state functional connectivity in generalized anxiety disorder and panic disorder
Cui, H., Zhang, J., Liu, Y., Li, Q., Li, H., Zhang, L., Hu, Q., Cheng, W., Luo, Q., Li, J., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23113 · Cited by 123 · see citing works
Differential roles for <i>Nr4a1</i> and <i>Nr4a2</i> in object location vs. object recognition long-term memory
McNulty, S. E., Barrett, R. M., Vogel-Ciernia, A., Malvaez, M., Hernandez, N., Davatolhagh, M. F., Matheos, D. P., Schiffman, A., & Wood, M. A. (2012) · Learning & Memory · doi:10.1101/lm.026385.112 · Cited by 117 · see citing works
Is posttraumatic stress disorder a stress‐induced fear circuitry disorder?
Shin, L. M., & Handwerger, K. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20442 · Cited by 102 · see citing works
Do hippocampal pyramidal cells respond to nonspatial stimuli?
O’Keefe, J., & Krupic, J. (2021) · Physiological Reviews · doi:10.1152/physrev.00014.2020 · Cited by 93 · see citing works
Stress generates emotional memories and retrograde amnesia by inducing an endogenous form of hippocampal LTP
Diamond, D. M., Park, C. R., & Woodson, J. C. (2004) · Hippocampus · doi:10.1002/hipo.10186 · Cited by 95 · see citing works
Hippocampal network oscillations at the interplay between innate anxiety and learned fear
Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72 · see citing works
Functional Imaging of Stimulus Convergence in Amygdalar Neurons during Pavlovian Fear Conditioning
Barot, S. K., Chung, A., Kim, J. J., & Bernstein, I. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006156 · Cited by 66 · see citing works
Nicotinic receptor activation in perirhinal cortex and hippocampus enhances object memory in rats
Melichercik, A. M., Elliott, K. S., Bianchi, C., Ernst, S. M., & Winters, B. D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.008 · Cited by 54 · see citing works
Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
Mead, A. N., Brown, G., Le Merrer, J., & Stephens, D. N. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2071-8 · Cited by 52 · see citing works
A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework
Tewari, S., & Parpura, V. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00145 · Cited by 35 · see citing works

Effects of context novelty vs. familiarity on latent inhibition with a conditioned taste aversion procedure
Quintero, E., Díaz, E., Vargas, J. P., Schmajuk, N. A., López, J. C., & la Casa, L. G. D. (2010) · Behavioural Processes · doi:10.1016/j.beproc.2010.12.011 · Cited by 28 · see citing works
Latent inhibition as a function of CS intensity in taste aversion learning
Rodrı́guez, G., & Alonso, G. (2002) · Behavioural Processes · doi:10.1016/s0376-6357(02)00119-5 · Cited by 16 · see citing works
Contextual conditioning and the US preexposure effect in conditioned fear.
Baker, A. G., Mercier, P., Gabel, J., & Baker, P. A. (1981) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.7.2.109 · Cited by 89 · see citing works
How Fast is Fear?
Åsli, O., & Flaten, M. A. (2012) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000063 · Cited by 10 · see citing works
Application of Pavlovian higher-order conditioning to the analysis of the neural substrates of fear conditioning
Gewirtz, J. C., & Davis, M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00036-7 · Cited by 32 · see citing works

Authors: Maren, S., & Holt, W.
Affiliations: University of Michigan (US)
Corresponding author: Maren, Stephen
ORCID: Maren, Stephen
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2000-06
Volume: 110
Issue: 1-2
Pages: 97-108
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(99)00188-6
OpenAlex: W2127967352
Cited by: 256
References: 96
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 12 · 2017: 12 · 2016: 14 · 2015: 14 · 2014: 4 · 2013: 18 · 2012: 10
FWCI: 5.63
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institutes of Health (5r29mh057865-03, 1r03mh057360-01)
National Institute of Mental Health (MH57865, MH57360)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampus, classical conditioning, latent inhibition, dorsal hippocampus, hippocampal inactivation, fear conditioning, memory retrieval
MeSH terms: Animals, Conditioning, Classical, Hippocampus, Humans, Memory, Models, Psychological, Reflex, Startle

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The hippocampus and contextual memory retrieval in Pavlovian conditioning

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks