Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder
Open accessAbstract
Rationale Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets.Objectives The aim of this study was to investigate amygdala and frontocortical responses to emotional face stimuli in BD and the influences of mood-stabilizing medications on these responses.Methods Functional magnetic resonance imaging was performed while 17 BD participants (5 unmedicated) and 17 healthy comparison (HC) participants viewed faces with happy, sad, fearful, or neutral expressions.Results The group by stimulus-condition interaction was significant (p<0.01) for amygdala activation, with the greatest effects in the happy face condition. Relative to HC, amygdala increases were greater in unmedicated BD, but lower in medicated BD. Rostral anterior cingulate (rAC) activation was decreased in unmedicated BD compared to HC; however, BD participants taking medication demonstrated rAC activation similar to HC participants.Conclusions Although the sample sizes were small, these preliminary results suggest that BD is associated with increased amygdala and decreased rAC response to emotional faces. The findings also provide preliminary evidence that mood-stabilizing medications may reverse abnormalities in BD in the response of an amygdala-frontal neural system to emotional stimuli.
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In a sample of bipolar patients with mixed illness states, amygdala activity in response to happy faces was greater in unmedicated patients but lower in medicated patients compared with controls.
“In a sample of patients with bipolar disorder with mixed illness states, amygdala activity in response to happy faces was greater in unmedicated patients but lower in medicated patients compared with controls.”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [80]
During passive viewing paradigms, patients with bipolar disorder and those with MDD demonstrate hypoactivity in the DLPFC and OFC and hyperactivity in the amygdala and anterior cingulate (subgenual and pregenual), although evidence is less consistent for subcortical regions such as the amygdala and paralimbic regions.
“During passive viewing paradigms, patients with bipolar disorder and those with MDD demonstrate hypoactivity in the DLPFC and OFC and hyperactivity in the amygdala and anterior cingulate (subgenual and pregenual), although evidence is less consistent for subcortical regions such as the amygdala and paralimbic regions.”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [80]
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- Authors
- Blumberg, H. P., Donegan, N. H., Sanislow, C. A., Collins, S., Lacadie, C., Skudlarski, P., Gueorguieva, R., Fulbright, R. K., McGlashan, T. H., Gore, J. C., & Krystal, J. H.
- Affiliations
- Yale University (US)
- Vanderbilt University (US)
- Corresponding author
- Blumberg, Hilary P.
- ORCID
- Venue
- Psychopharmacology
- Published
- 2005-10-26
- Volume
- 183
- Issue
- 3
- Pages
- 308-313
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2121060797
- Cited by
- 165
- References
- 31
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 12 · 2013: 8 · 2012: 19
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- green
- works.bepress.com
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Wesleyan University Digital Collections (Wesleyan University) (submittedVersion)
- Wesleyan University Digital Collections (Wesleyan University) (submittedVersion, public-domain)
- WESLEYAN
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (5k05aa014906-03)
- National Institute on Alcohol Abuse and Alcoholism (K05 AA 14906-01)
- National Institute of Mental Health (K05 MH-01654, K23MH073708, R01 MH69747, K05MH001654, R01MH069747, R01MH070902)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- bipolar disorder, amygdala, rostral anterior cingulate cortex, emotional face processing
- MeSH terms
- Adult, Amygdala, Bipolar Disorder, Emotions, Facial Expression, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged
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