The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
Abstract
Rationale Oxytocin (OT) acts as a neuromodulator/neurotransmitter within the central nervous system (CNS) and regulates a diverse range of CNS functions. Notably, evidence from studies in females has revealed an important role for OT in regulating anxiety behavior.Objectives The objective of this study was to examine the effects of OT on both behavioral and autonomic parameters of the anxiety response in male mice using three pharmacologically validated preclinical models of anxiety: the four-plate test (FPT), elevated zero maze (EZM), and stress-induced hyperthermia (SIH).Results In the FPT, both peripherally (3-30 mg/kg i.p.) and centrally (1-10 microg i.c.v.) administered OT produced dose-dependent increases in punished crossings, indicating an anxiolytic-like effect. The effects of centrally administered OT in the FPT were blocked with peripheral administration of a brain-penetrant OT receptor (OTR) antagonist WAY-162720 (30 mg/kg i.p.), and the effects of peripherally administered OT were blocked with central administration of a non-penetrant OTR antagonist L-371,257, suggesting OT acts centrally. In the EZM, centrally administered OT (0.1-1.0 microg, i.c.v.) produced significant increases in the percentage time spent in the open quadrants of the maze, comparable to alprazolam (0.5-1.0 microg, i.c.v.). In SIH, OT (1-10 mg/kg i.p.) dose-dependently attenuated stress-induced increases in core body temperature, comparable to the reference anxiolytic chlordiazepoxide (CDP) (10 mg/kg i.p.).Conclusions These results provide specific behavioral and autonomic evidence of anxiolytic-like effects for oxytocin in males and, together with previously reported observations in females, suggest the potential utility of OTR agonism as a therapeutically relevant mechanism of action for novel anxiolytics in both sexes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Physiologically, oxytocin acts in the brain by reducing anxiety and fear [19,20], enhancing social memory [16][17][18]21] and activating neural reward circuits [21].”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [19]
In the citing paper
“Significantly, peripheral measures of oxytocin from plasma or urine correlate positively with psychological and behavioural patterns, such as aversion reduction in male mice [19], social contact in marmosets [40], lactation in rhesus macaques [41], rates of affiliative behaviours in pair-bonded tamarins [42] and grooming in closely bonded chimpanzees [15], indicating that peripheral oxytocin level”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [19]
In the citing paper
“Centrally-administered oxytocin reduced anxiety-related behavior in male mice during non-social behavioral tasks (Ring et al., 2006).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Ring et al., 2006
In the citing paper
“The results of a number of other studies have suggested that oxytocin is anxiolytic19–21 or attenuates measures of fear conditioning15–18.”
From Oxytocin enhances observational fear in mice (2017) · cites this paper as [19]
Citations
Cites
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J., & Dourish, C. T. (1994) · Psychopharmacology · doi:10.1007/bf02244871 · Cited by 739
The Neurobiology of Parental Behavior
(2003) · Hormones, Brain, and Behavior · doi:10.1007/b97533 · Cited by 684
Oxytocin, vasopressin, and social recognition in mammals
Bielsky, I. F., & Young, L. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.019 · Cited by 460
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
Cooper, J. E. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.1.85-a · Cited by 425
Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402
Research works printed but not linked: 1
- Ring RH (2005) The central vasopressinergic and oxytocinergic systems as targets for psychiatric drug development neurohypophyseal hormones: from genomics and physiology to disease. American Physiological Society, Steamboat Springs, Colorado, p 162
Cited by
Sorted by citations
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743
Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., & Nishimori, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5593-08.2009 · Cited by 608
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Metadata
- Authors
- Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S.
- Affiliations
- Wyeth (US)
- Corresponding author
- Ring, Robert H.
- Venue
- Psychopharmacology
- Published
- 2006-01-18
- Volume
- 185
- Issue
- 2
- Pages
- 218-225
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2093922373
- Cited by
- 319
- References
- 45
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 29 · 2019: 11 · 2018: 14 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 25 · 2013: 18 · 2012: 18
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, anxiolytic-like activity, anxiety, male mice, oxytocin receptor, four-plate test, elevated zero maze, stress-induced hyperthermia, centralized management, autonomic effects, sex differences, anxiolytic drug development
- MeSH terms
- Animals, Behavior, Animal, Chlordiazepoxide, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Injections, Intraventricular, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Oxazines, Oxytocin, Piperidines, Anti-Anxiety Agents, Receptors, Oxytocin, Benzoxazines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
