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Cited by 320Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

Ring, Robert H., Malberg, Jessica E., Potestio, Lisa, Ping, Julia, Boikess, Steve, Luo, Bin, Schechter, Lee E., Rizzo, Stacey, Rahman, Zia, Rosenzweig-Lipson, Sharon·2006·Psychopharmacology
DOI 10.1007/s00213-005-0293-z
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Abstract

Rationale Oxytocin (OT) acts as a neuromodulator/neurotransmitter within the central nervous system (CNS) and regulates a diverse range of CNS functions. Notably, evidence from studies in females has revealed an important role for OT in regulating anxiety behavior.Objectives The objective of this study was to examine the effects of OT on both behavioral and autonomic parameters of the anxiety response in male mice using three pharmacologically validated preclinical models of anxiety: the four-plate test (FPT), elevated zero maze (EZM), and stress-induced hyperthermia (SIH).Results In the FPT, both peripherally (3-30 mg/kg i.p.) and centrally (1-10 microg i.c.v.) administered OT produced dose-dependent increases in punished crossings, indicating an anxiolytic-like effect. The effects of centrally administered OT in the FPT were blocked with peripheral administration of a brain-penetrant OT receptor (OTR) antagonist WAY-162720 (30 mg/kg i.p.), and the effects of peripherally administered OT were blocked with central administration of a non-penetrant OTR antagonist L-371,257, suggesting OT acts centrally. In the EZM, centrally administered OT (0.1-1.0 microg, i.c.v.) produced significant increases in the percentage time spent in the open quadrants of the maze, comparable to alprazolam (0.5-1.0 microg, i.c.v.). In SIH, OT (1-10 mg/kg i.p.) dose-dependently attenuated stress-induced increases in core body temperature, comparable to the reference anxiolytic chlordiazepoxide (CDP) (10 mg/kg i.p.).Conclusions These results provide specific behavioral and autonomic evidence of anxiolytic-like effects for oxytocin in males and, together with previously reported observations in females, suggest the potential utility of OTR agonism as a therapeutically relevant mechanism of action for novel anxiolytics in both sexes.

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Research works printed but not linked: 1

  1. Ring RH (2005) The central vasopressinergic and oxytocinergic systems as targets for psychiatric drug development neurohypophyseal hormones: from genomics and physiology to disease. American Physiological Society, Steamboat Springs, Colorado, p 162

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Metadata

Authors
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S.
Affiliations
Wyeth (US)
Corresponding author
Ring, Robert H.
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2006-01-18
Volume
185
Issue
2
Pages
218-225
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-005-0293-z
OpenAlex
W2093922373
Cited by
319
References
45
Citations by year
2026: 5 · 2025: 9 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 29 · 2019: 11 · 2018: 14 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 25 · 2013: 18 · 2012: 18
FWCI
22.49
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
oxytocin, anxiolytic-like activity, anxiety, male mice, oxytocin receptor, four-plate test, elevated zero maze, stress-induced hyperthermia, centralized management, autonomic effects, sex differences, anxiolytic drug development
MeSH terms
Animals, Behavior, Animal, Chlordiazepoxide, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Injections, Intraventricular, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Oxazines, Oxytocin, Piperidines, Anti-Anxiety Agents, Receptors, Oxytocin, Benzoxazines, Mice

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