Oxytocin Attenuates Stress-Induced c-fos mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity

Windle, Richard J.; Kershaw, Yvonne M.; Shanks, Nola; Wood, Susan A.; Lightman, Stafford L.; Ingram, Colin D.

doi:10.1523/jneurosci.3432-03.2004

Cited by 408Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Oxytocin Attenuates Stress-Induced c-fos mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity

Open access

Windle, Richard J., Kershaw, Yvonne M., Shanks, Nola, Wood, Susan A., Lightman, Stafford L., Ingram, Colin D.·2004·The Journal of Neuroscience

DOI 10.1523/jneurosci.3432-03.2004PMC PMC6729832

Open this paper in CoChat — free account Open PDF

Abstract

We reported previously that the neuropeptide oxytocin attenuates stress-induced hypothalamo-pituitary-adrenal (HPA) activity and anxiety behavior. This study sought to identify forebrain target sites through which oxytocin may mediate its anti-stress effects. Ovariectomized, estradiol-treated rats received intracerebroventricular infusions of oxytocin (1 or 10 ng/hr) or vasopressin (10 ng/hr), and the patterns of neuronal activation after restraint stress were determined by semiquantitative mapping of c-fos mRNA expression. Oxytocin administration significantly attenuated the release of ACTH and corticosterone and the increase in corticotropin-releasing factor mRNA expression in the hypothalamic paraventricular nucleus (PVN) in response to 30 min restraint. Restraint also induced the expression of c-fos mRNA in selective regions of the forebrain, including the PVN, paraventricular thalamic nucleus, habenula, medial amygdala, ventrolateral septum (LSV), most subfields of the dorsal and ventral hippocampus, and piriform and endopiriform cortices. In most cases, this level of gene expression was unaffected by concomitant administration of oxytocin. However, in the PVN, LSV, and throughout all subfields of the dorsal hippocampus, restraint evoked no detectable increase in c-fos mRNA in animals treated with either dose of oxytocin. Vasopressin had no effects on either HPA axis responses or neuronal activation in response to restraint, indicating that the effects were highly peptide selective. These data show that central oxytocin attenuates both the stress-induced neuroendocrine and molecular responses of the HPA axis and that the dorsal hippocampus, LSV, and PVN constitute an oxytocin-sensitive forebrain stress circuit.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.3432-03.2004

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

When delivered to the PVN, OT decreases HPA axis gain, as shown by decreased CORT and ACTH levels.
“Although OT can act at the pituitary to enhance CRH action, when delivered to the PVN, OT decreased HPA axis gain, as shown by decreased CORT and ACTH levels (Neumann, Krömer, Toschi, & Ebner, 2000; Windle et al., 2004; Windle, Shanks, Lightman, & Ingram, 1997).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Windle et al., 2004
The Results section reports that oxytocin reduced restraint-induced ACTH and corticosterone levels. However, the Methods section specifies delivery into the lateral ventricle, not directly into the PVN; the Discussion describes a PVN site of action as a possibility, not a demonstrated delivery site. Page numbers were not provided in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measured
Centrally administered oxytocin diminishes stress-induced adrenocorticotropic hormone and corticosterone release, and inhibits corticotropin releasing factor mRNA expression in the hypothalamus during restraint stress in rats.
“Centrally administered OT also diminishes stress-induced adrenocorticotropic hormone (ACTH) and cor-ticosterone release, and inhibits corticotropin releasing factor (CRF) mRNA expression in the hypothalamus during restraint stress in rats (Windle et al., 2004).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Windle et al., 2004
When administered intranasally, oxytocin attenuates the neuroendocrine stress response in rodents and monkeys and alters emotion regulation in humans.
“When administered intranasally, OT also attenuates the neuroendocrine stress response in rodents and monkeys and alters emotion regulation in humans (Heinrichs et al., 2003; Parker et al., 2005; Windle et al., 2004).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Windle et al., 2004

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Pattern and time course of immediate early gene expression in rat brain following acute stress
Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056 · see citing works
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838 · see citing works
Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903320102 · Cited by 541 · see citing works
Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups
Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01733.x · Cited by 514 · see citing works
Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452 · see citing works
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446 · see citing works
Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442 · see citing works
Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402 · see citing works
Vasopressin and oxytocin receptors in the central nervous system
Tribollet, E., & Barberis, C. (1996) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v10.i1.60 · Cited by 399 · see citing works
Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387 · see citing works
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus, M. M., Deuster, P. A., Galliven, E., Carter, C. S., & Gold, P. W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559880 · Cited by 383 · see citing works
Central effects of oxytocin
Richard, P., Moos, F., & Freund-Mercier, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.331 · Cited by 379 · see citing works
Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes
Neumann, I. D., Johnstone, H. A., Hatzinger, M., Liebsch, G., Shipston, M. J., Russell, J. A., Landgraf, R., & Douglas, A. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.289br.x · Cited by 365 · see citing works
Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
Induction and habituation of immediate early gene expression in rat brain by acute and repeated restraint stress
Melia, K. R., Ryabinin, A. E., Schroeder, R., Bloom, F. E., & Wilson, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-05929.1994 · Cited by 359 · see citing works
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons
Wotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00683-0 · Cited by 345 · see citing works
Dendritic Release of Vasopressin and Oxytocin
Ludwig (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00279.x · Cited by 342 · see citing works
The Extended Amygdala: Are the Central Nucleus of the Amygdala and the Bed Nucleus of the Stria Terminalis Differentially Involved in Fear versus Anxiety?
DAVIS, M., & SHI, C. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09273.x · Cited by 328 · see citing works
An Anxiolytic Action of Oxytocin is Enhanced by Estrogen in the Mouse
MCCARTHY, M. M., MCDONALD, C. H., BROOKS, P. J., & GOLDMAN, D. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00212-0 · Cited by 328 · see citing works
The descending afferent connections of the paraventricular nucleus of the hypothalamus (PVN)
Silverman, A., Hoffman, D. L., & Zimmerman, E. A. (1981) · Brain Research Bulletin · doi:10.1016/s0361-9230(81)80068-8 · Cited by 326 · see citing works
Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: Correlations with cardiovascular, hypothermic and endocrine responses
Chen, X., & Herbert, J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00532-a · Cited by 313 · see citing works
Oxytocin unlike vasopressin is a stress hormone in the rat.
Lang, R. E., Heil, J. W. E., Ganten, D., Hermann, K., Unger, T., & Rascher, W. (2008) · Neuroendocrinology · doi:10.1159/000123566 · Cited by 304 · cited 1× · see citing works
“In the rat, the release of oxytocin into the peripheral circulation in response to physical and psychological stressors has long been established (Lang et al., 1983; Gibbs, 1984).”
Background
Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat
Harbuz, M. S., & Lightman, S. L. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220705 · Cited by 299 · see citing works
Self-citation
A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry
Chan, R., Brown, E., Ericsson, A., Kovacs, K., & Sawchenko, P. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05126.1993 · Cited by 289 · see citing works
Brain oxytocin inhibits the (re)activity of the hypothalamo–pituitary–adrenal axis in male rats: involvement of hypothalamic and limbic brain regions
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285 · see citing works
A Quantitative Analysis of the Physiological Role of Estradiol and Progesterone in the Control of Tonic and Surge Secretion of Luteinizing Hormone in the Rat*
Goodman, R. L. (1978) · Endocrinology · doi:10.1210/endo-102-1-142 · Cited by 277 · see citing works
Local circuit regulation of paraventricular nucleus stress integration
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00681-5 · Cited by 274 · see citing works
High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats
Uvnäs‐Moberg, K., Ahlenius, S., Hillegaart, V., & Alster, P. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90462-6 · Cited by 254 · see citing works
Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress
Gibbs, D. M. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90241-8 · Cited by 233 · cited 1× · see citing works
“In the rat, the release of oxytocin into the peripheral circulation in response to physical and psychological stressors has long been established (Lang et al., 1983; Gibbs, 1984).”
Background
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐<i>fos</i> Induction Associated with Audiogenic Stress
Campeau, S., & Watson, S. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00593.x · Cited by 227 · see citing works
Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit corticosterone release
Kalsbeek, A., Buijs, R. M., van Heerikhuize, J. J., Arts, M., & van der Woude, T. P. (1992) · Brain Research · doi:10.1016/0006-8993(92)90927-2 · Cited by 226 · see citing works
Endocrine and Behavioural Responses to Noise Stress:Comparison of Virgin and Lactating Female Ratsduring Non‐Disrupted Maternal Activity
Windle, R. J., Wood, S. A., Shanks, N. M., Perks, P., Condé, G. L., Costa, A. P. C., Ingram, C. D., & Lightman, S. L. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00587.x · Cited by 226 · see citing works
Self-citation
In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin, and oxytocin
RIVIER, C. L., & Shen, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-01985.1994 · Cited by 214 · see citing works
Stress increases oxytocin release within the hypothalamic paraventricular nucleus
Nishioka, T., Anselmo-Franci, J. A., Li, P., Callahan, M. F., & Morris, M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01159-1 · Cited by 214 · see citing works
Pharmacological characteristics and anatomical distribution of [3H]oxytocin-binding sites in the wistar rat brain studied by autoradiography
Freund-Mercier, M. J., Stoeckel, M. E., Palacios, J. M., Pazos, A., Reichhart, J. M., Porte, A., & Richard, P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90113-8 · Cited by 192 · see citing works
Induction of c-fos mRNA in rat brain by conditioned and unconditioned stressors
Smith, M. A., Banerjee, S., Gold, P. W., & Glowa, J. R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90240-a · Cited by 173 · see citing works
Chapter 8 Peripartum plasticity within the hypothalamo-pituitary-adrenal axis
Lightman, S. L., Windle, R. J., Wood, S. A., Kershaw, Y. M., Shanks, N. M., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33009-1 · Cited by 171 · see citing works
Self-citation
Emotional Stress Triggers Intrahypothalamic But Not Peripheral Release of Oxytocin in Male Rats
Engelmann, Ebner, Landgraf, Holsboer, & Wotjak (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00403.x · Cited by 170 · see citing works
Differential forebrain c-fos mRNA induction by ether inhalation and novelty: evidence for distinctive stress pathways
Emmert, M. H., & Herman, J. P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01931-9 · Cited by 170 · see citing works
Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats<sup>1</sup>
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Self-citation
Regional Changes in Brain Oxytocin Receptors Post‐Partum: Time‐Course and Relationship to Maternal Behaviour
Insel, T. R. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00445.x · Cited by 164 · see citing works
Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats
Petersson, M., Hulting, A., & Uvnäs‐Moberg, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00159-7 · Cited by 156 · see citing works
Pharmacological characterization of two specific binding sites for neurohypophyseal hormones in hippocampal synaptic plasma membranes of the rat.
Audigier, S., & Barberis, C. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03794.x · Cited by 156 · see citing works
Expression of c-fos in regions of the basal limbic forebrain following intra-cerebroventricular corticotropin-releasing factor in unstressed or stressed male rats
Arnold, F. J. L., de Lucas Bueno, M., Shiers, H., Hancock, D. C., Evan, G. I., & Herbert, J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90322-s · Cited by 155 · see citing works
Induction and adaptation of Fos expression in the rat brain by two types of acute restraint stress
Mohammad, G., Chowdhury, I., Fujioka, T., & Nakamura, S. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00231-8 · Cited by 153 · see citing works
Oxytocin receptors on oxytocin neurones: histoautoradiographic detection in the lactating rat.
Freund‐Mercier, M. J., Stoeckel, M. E., & Klein, M. J. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020349 · Cited by 153 · see citing works
Effects of stress and glucocorticoids on CNS oxytocin receptor binding
Liberzon, I., & Young, E. A. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00045-0 · Cited by 147 · see citing works
Excitation of neurones in the rat paraventricular nucleus in vitro by vasopressin and oxytocin.
Inenaga, K., & Yamashita, H. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp015928 · Cited by 138 · see citing works
Region-specific reduction in stress-induced c- fos mRNA expression during pregnancy and lactation
Costa, A. P. C., Wood, S. A., Ingram, C. D., & Lightman, S. L. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00962-6 · Cited by 135 · see citing works
Self-citation
A single social defeat experience selectively stimulates the release of oxytocin, but not vasopressin, within the septal brain area of male rats
Ebner, K., Wotjak, C. T., Landgraf, R., & Engelmann, M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02464-1 · Cited by 129 · see citing works
Oxytocin as well as vasopressin potentiate ovine CRF in vitro
Antoni, F. A., Holmes, M. C., & Jones, M. T. (1983) · Peptides · doi:10.1016/0196-9781(83)90041-4 · Cited by 120 · see citing works
Estradiol induces oxytocin binding sites in rat hypothalamic ventromedial nucleus
de Kloet, E. R., Voorhuis, T. A. M., & Elands, J. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90679-x · Cited by 116 · see citing works
Characterization of a uterine-type oxytocin receptor in the rat hippocampus.
Mühlethaler, M., Sawyer, W. H., Manning, M., & Dreifuss, J. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.21.6713 · Cited by 106 · see citing works
Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin
Gibbs, D. M., Vale, W., Rivier, J., & Yen, S. S. C. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90212-1 · Cited by 100 · see citing works
Behavioural impact of intraseptally released vasopressin and oxytocin in rats
Englemann, M., Wotjak, C. T., Ebner, K., & Landgraf, R. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00015.x · Cited by 94 · see citing works
Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale
Zaninetti, M., & Raggenbass, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00290.x · Cited by 82 · see citing works
Histoautoradiographic detection of oxytocin‐ and vasopressin‐binding sites in the telencephalon of the rat
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330304 · Cited by 80 · see citing works
Oxytocin binding sites in rat limbic and hypothalamic structures: Site-specific modulation by adrenal and gonadal steroids
Patchev, V. K., Schlosser, S. F., Hassan, A. H., & Almeida, O. F. X. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90003-x · Cited by 77 · see citing works
Homologous regulation of brain oxytocin receptors.
Insel, T. R., Winslow, J. T., & Witt, D. M. (1992) · Endocrinology · doi:10.1210/endo.130.5.1315251 · Cited by 63 · see citing works
Correlation between oxytocin neuronal sensitivity and oxytocin-binding sites in the amygdala of the rat: electrophysiological and histoautoradiographic study
Condés‐Lara, M., Veinante, P., Rabai, M., & Freund‐Mercier, M. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91245-9 · Cited by 54 · see citing works
Oxytocin excites neurones in the bed nucleus of the stria terminalis of the lactating rat in vitro
Ingram, C. D., Cutler, K., & Wakerley, J. B. (1990) · Brain Research · doi:10.1016/0006-8993(90)91078-u · Cited by 43 · see citing works
Self-citation
Post-partum increase in oxytocin-induced excitation of neurones in the bed nuclei of the stria terminalis in vitro
Ingram, C. D., & Wakerley, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90697-l · Cited by 38 · see citing works
Self-citation
Estrogen‐Sensitive Oxytocin Binding Sites are Differently Regulated by Progesterone in the Telencephalon and the Hypothalamus of the Rat
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00759.x · Cited by 22 · see citing works
Electrophysiological effects of oxytocin within the bed nuclei of the stria terminalis: Influence of reproductive stage and ovarian steroids
Wakerley, J. B., Terenzi, M. G., Sj, H., Jiang, Q. B., & Ingram, C. D. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61578-2 · Cited by 21 · see citing works
Self-citation
HAEMODYNAMIC AND HUMORAL CONSEQUENCES OF CHRONIC INFUSION OF VASOPRESSIN IN CONSCIOUS RATS
Tsuchihashi, T., TAKATA, Y., Nakao, Y., et al. (1993) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1993.tb01730.x · Cited by 1 · see citing works
Distribution of oxytocin- and vasopressin-binding sites in the rat extended amygdala: a histoautoradiographic study
Veinante, P., & Freund-Mercier, M.-J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970707)383:3

Flagged first, then by citations

Sorted by citations

The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
a neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation
depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958 · see citing works
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 784 · see citing works
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743 · see citing works
Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development
Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739 · see citing works
Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity
Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710 · see citing works
“Although OT can act at the pituitary to enhance CRH action, when delivered to the PVN, OT decreased HPA axis gain, as shown by decreased CORT and ACTH levels (Neumann, Kr€omer, Toschi, & Ebner, 2000; Windle et al., 2004; Windle, Shanks, Lightman, & Ingram, 1997).”
BackgroundResult
The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620 · see citing works
Effects of different kinds of couple interaction on cortisol and heart rate responses to stress in women
Ditzen, B., Neumann, I. D., Bodenmann, G., von Dawans, B., Turner, R. A., Ehlert, U., & Heinrichs, M. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.011 · Cited by 525 · see citing works
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468 · see citing works
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479 · see citing works
Social buffering of the stress response: diversity, mechanisms, and functions
Hennessy, M. B., Kaiser, S., & Sachser, N. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.06.001 · Cited by 477 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis
Handa, R. J., & Weiser, M. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.001 · Cited by 408 · see citing works
A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
Hypothalamic Oxytocin Mediates Social Buffering of the Stress Response
Smith, A. S., & Wang, Z. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.017 · Cited by 359 · see citing works
Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319 · see citing works
Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation
Brunton, P. J., Russell, J. A., & Douglas, A. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01735.x · Cited by 298 · see citing works
Oxytocin receptors in the nucleus accumbens facilitate “spontaneous” maternal behavior in adult female prairie voles
Olazábal, D. E., & Young, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.017 · Cited by 289 · see citing works
Attachment, aggression and affiliation: the role of oxytocin in female social behavior
Campbell, A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.001 · Cited by 269 · see citing works
Opposite effects of maternal separation on intermale and maternal aggression in C57BL/6 mice: Link to hypothalamic vasopressin and oxytocin immunoreactivity
Veenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263 · see citing works
Centrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261 · see citing works
The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-Diol Inhibit the Hypothalamo–Pituitary–Adrenal Response to Stress by Acting through Estrogen Receptor β-Expressing Neurons in the Hypothalamus
Lund, T. D., Hinds, L. R., & Handa, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3777-05.2006 · Cited by 236 · see citing works
The neurochemistry and social flow of singing: bonding and oxytocin
Keeler, J. R., Roth, E. A., Neuser, B. L., Spitsbergen, J. M., Waters, D. J. M., & Vianney, J.-M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00518 · Cited by 220 · see citing works
Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
Bosch, O. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0085 · Cited by 194 · see citing works
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.002 · Cited by 204 · see citing works
The molecular physiology of CRH neurons
Aguilera, G., & Liu, Y. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.08.002 · Cited by 198 · see citing works
Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation
Grippo, A. J., Cushing, B. S., & Carter, C. S. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802f054b · Cited by 196 · see citing works
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195 · see citing works
Reduced plasma oxytocin levels in female patients with borderline personality disorder
Bertsch, K., Schmidinger, I., Neumann, I. D., & Herpertz, S. C. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.013 · Cited by 189 · see citing works
Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?
McGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171 · see citing works
Advances in human oxytocin measurement: challenges and proposed solutions
Tabak, B. A., Leng, G., Szeto, A., Parker, K. J., Verbalis, J. G., Ziegler, T. E., Lee, M. R., Neumann, I. D., & Mendez, A. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01719-z · Cited by 170 · see citing works
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.014 · Cited by 171 · see citing works
The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162 · see citing works
Preliminary evidence that plasma oxytocin levels are elevated in major depression
Parker, K. J., Kenna, H. A., Zeitzer, J. M., Keller, J., Blasey, C. M., Amico, J. A., & Schatzberg, A. F. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.09.017 · Cited by 163 · see citing works
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143 · see citing works
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143 · see citing works
Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems
Rutherford, H. J. V., Williams, S. K., Moy, S., Mayes, L. C., & Johns, J. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00037 · Cited by 140 · see citing works
The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice
Zanos, P., Georgiou, P., Wright, S. R., Hourani, S. M., Kitchen, I., Winsky-Sommerer, R., & Bailey, A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.285 · Cited by 133 · see citing works
Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia
Karelina, K., Stuller, K. A., Jarrett, B., Zhang, N., Wells, J., Norman, G. J., & DeVries, A. C. (2011) · Stroke · doi:10.1161/strokeaha.111.628008 · Cited by 138 · see citing works
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135 · see citing works
Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity
Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01525.x · Cited by 133 · see citing works
Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131 · see citing works
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
Oxytocin and Estrogen Receptor β in the Brain: An Overview
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00160 · Cited by 124 · see citing works
Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress
Lee, S.-Y., Park, S.-H., Chung, C., Kim, J. J., Choi, S.-Y., & Han, J.-S. (2015) · Scientific Reports · doi:10.1038/srep18540 · Cited by 119 · see citing works
The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103 · see citing works
Hypothalamic oxytocin mediates adaptation mechanism against chronic stress in rats
Zheng, J., Babygirija, R., Bülbül, M., Cerjak, D., Ludwig, K., & Takahashi, T. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00483.2009 · Cited by 104 · see citing works
Repeated intranasal oxytocin administration in early life dysregulates the HPA axis and alters social behavior
Rault, J.-L., Carter, C. S., Garner, J. P., Marchant, J. N., Richert, B. T., & Lay, D. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.007 · Cited by 94 · see citing works
Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
Cohen, H., Kaplan, Z., Kozlovsky, N., Gidron, Y., Matar, M. A., & Zohar, J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02003.x · Cited by 94 · see citing works
Telencephalic binding sites for oxytocin and social organization: A comparative study of eusocial naked mole‐rats and solitary cape mole‐rats
Kalamatianos, T., Faulkes, C. G., Oosthuizen, M. K., Poorun, R., Bennett, N. C., & Coen, C. W. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22302 · Cited by 92 · see citing works
Salubrious effects of oxytocin on social stress-induced deficits
Smith, A. S., & Wang, Z. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.010 · Cited by 88 · see citing works
Hydration State Controls Stress Responsiveness and Social Behavior
Krause, E. G., de Kloet, A. D., Flak, J. N., Smeltzer, M. D., Solomon, M. B., Evanson, N. K., Woods, S. C., Sakai, R. R., & Herman, J. P. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6078-10.2011 · Cited by 85 · see citing works
Distribution and chemical composition of estrogen receptor β neurons in the paraventricular nucleus of the female and male mouse hypothalamus
Oyola, M. G., Thompson, M. K., Handa, A. Z., & Handa, R. J. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24295 · Cited by 53 · see citing works
Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats
Shi, D.-D., Zhang, Y.-D., Ren, Y.-Y., Peng, S.-Y., Yuan, T.-F., & Wang, Z. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01293-w · Cited by 63 · see citing works
The impact of oxytocin on stress: the role of sex
Love, T. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.018 · Cited by 56 · see citing works
Oxytocin attenuates stress-induced reinstatement of alcohol seeking behavior in male and female mice
King, C. E., & Becker, H. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05233-z · Cited by 53 · see citing works
Oxytocin modulates unconditioned fear response in lactating dams: An fMRI study
Febo, M., Shields, J., Ferris, C. F., & King, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.043 · Cited by 47 · see citing works
Oxytocin and the Social Brain
Fineberg, S. K., & Ross, D. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.004 · Cited by 40 · see citing works
Intranasal application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioural performance of rats
Ludwig, M., Tobin, V. A., Callahan, M. F., Papadaki, E., Becker, A., Engelmann, M., & Leng, G. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12046 · Cited by 37 · see citing works
Regional c-Fos expression induced by peripheral oxytocin administration is prevented by the vasopressin 1A receptor antagonist SR49059
Hicks, C., Ramos, L., Dampney, B., Baracz, S. J., McGregor, I. S., & Hunt, G. E. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.005 · Cited by 22 · see citing works
Alteration in oxytocin levels induced by early social environment affects maternal behavior and estrogen receptor alpha in mandarin voles (Microtus mandarinus)
Feng, T., An, S., Kinden, R., Zhang, X., Jia, R., & Tai, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.038 · Cited by 18 · see citing works
Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion
Chun, E. K., Donovan, M., Liu, Y., & Wang, Z. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100427 · Cited by 18 · see citing works
Actions of intravenous injections of <scp>AVP</scp> and oxytocin on plasma <scp>ACTH</scp>, <scp>GH</scp>, insulin and glucagon concentrations in goats
Roh, S., Koiwa, K., Sato, K., Ohtani, Y., Takahashi, T., & Katoh, K. (2014) · Animal Science Journal · doi:10.1111/asj.12142 · Cited by 7 · see citing works
Anti-stress Effect of Hypothalamic Oxytocin, Importance of Somatosensory Stimulation and Social Buffering: Takahashi T et al. Oxytocin and stress
Takahashi, T., Department of Surgery, M. C. O. W., Babygirija, R., & Ludwig, K. (2015) · International Journal of Neurology Research · doi:10.17554/j.issn.2313-5611.2015.01.18 · Cited by 4 · see citing works

Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain
Freeman, S. M., Ngo, J., Singh, B., Masnaghetti, M., Bales, K. L., & Blevins, J. E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.037 · Cited by 37 · see citing works
Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers
Rayatpour, A., Radahmadi, M., Izadi, M. S., & Ghasemi, M. (2023) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202320200221 · Cited by 4 · see citing works
Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis
Erb, S. M., Funk, D. R., Borkowski, S., Watson, S. J., & Akil, H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.031 · Cited by 19 · see citing works
Desipramine prevents the sustained increase in corticotropin‐releasing hormone‐like immunoreactivity induced by repeated immobilization stress in the rat central extended amygdala
Santibañez, M., Gysling, K., & Forray, M. I. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21023 · Cited by 26 · see citing works
Glucagon‐like peptide‐1 in the rat brain: Distribution of expression and functional implication
Gu, G., Roland, B. L., Tomaselli, K. J., Dolman, C. S., Lowe, C., & Heilig, J. S. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23282 · Cited by 119 · see citing works

Authors: Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D.
Affiliations: Bristol Royal Infirmary (GB)
University of Nottingham (GB)
Royal Victoria Infirmary (GB)
ORCID: Windle, Richard J.
Kershaw, Yvonne M.
Lightman, Stafford L.
Ingram, Colin D.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2004-03-24
Volume: 24
Issue: 12
Pages: 2974-2982
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3432-03.2004
PMC: PMC6729832
OpenAlex: W2117679221
Cited by: 408
References: 67
Citations by year: 2026: 10 · 2025: 3 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 24 · 2020: 11 · 2019: 20 · 2018: 27 · 2017: 10 · 2016: 23 · 2015: 26 · 2014: 22 · 2013: 29 · 2012: 21
FWCI: 27.30
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Explore Bristol Research (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, stress response, hypothalamic-pituitary-adrenal axis, c-fos mRNA, restraint stress, paraventricular nucleus, dorsal hippocampus, corticotropin-releasing factor, ACTH, corticosterone, vasopressin, anxiety
MeSH terms: Animals, Female, Hypothalamo-Hypophyseal System, Injections, Intraventricular, Oxytocin, Pituitary-Adrenal System, Restraint, Physical, RNA, Messenger, Stress, Physiological, Gene Expression, Prosencephalon, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin Attenuates Stress-Induced c-fos mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks