Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
Abstract
Objective Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive deficits. The present study was designed to further our understanding of changes in brain function in humans that might result from chronic high dose use of MA after at least 3 months of abstinence.Method Brain function in abstinent users was compared to controls using neuroimaging of monoamine transporters and cognitive assessment. Striatal levels of DA transporter (DAT) and vesicular monoamine transporter type-2 (VMAT2) were determined using [11C]methylphenidate and [11C]dihydrotetrabenazine positron emission tomography, respectively. Cognitive function was evaluated using tests of motor function, memory, learning, attention, and executive function.Results Striatal DAT was approximately 15% lower and VMAT2 was 10% lower in MA abusers across striatal subregions. The MA abusers performed within the normal range but performed more poorly compared to controls on three of the 12 tasks.Conclusions Failure to find more substantial changes in transporter levels and neurocognitive function may be attributed to the length of time that MA users were abstinent (ranging from 3 months to more than 10 years, mean 3 years), although there were no correlations with length of abstinence. Persistent VMAT2 reductions support the animal literature indicating a toxic effect of MA on nigrostriatal nerve terminals. However, the magnitude of the MA effects on nigrostriatal projection integrity is sufficiently small that it is questionable whether clinical signs of DA deficiency are likely to develop.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Methamphetamine abusers show a consistent and long-lasting decrease in the dopamine transporter, the main target of methamphetamine.
“Alternatively, studies in methamphetamine abusers show a consistent and long lasting decrease in the dopamine transporter, which is the main target of this drug (Chou et al., 2007; Johanson et al., 2006; McCann et al., 1998; McCann et al., 2008; Sekine et al., 2001; Volkow et al., 2001b).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Johanson et al., 2006
Cites
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 7,925 · see citing works
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020 · see citing works
Wechsler Adult Intelligence Scale--Third Edition
Wechsler, D. (2019) · PsycTESTS Dataset · doi:10.1037/t49755-000 · Cited by 2,327 · see citing works
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021 · see citing works
Structured Clinical Interview for DSM-III-R Personality Disorders
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2012) · PsycTESTS Dataset · doi:10.1037/t07827-000 · Cited by 1,403 · see citing works
Robbins, T. W., James, M., Owen, A. M., Sahakian, B. J., McInnes, L., & Rabbitt, P. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106735 · Cited by 1,078 · see citing works
Self-citation(2001) · Medical Entomology and Zoology · Cited by 1,044 · see citing works
Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
Volkow, N. D., Chang, L. L., Wang, G., Fowler, J. S., Leonido–Yee, M., Franceschi, D., Sedler, M. J., Gatley, S. J., HITZEMANN, R. J., Ding, Y. ‐., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.377 · Cited by 984 · see citing works
Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine
Thompson, P. M., Hayashi, K. M., Simon, S. L., Geaga, J. A., Hong, M., Sui, Y., Lee, J. Y., Toga, A. W., Ling, W. W., & London, E. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0713-04.2004 · Cited by 760 · see citing works
Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence
Volkow, N. D., Chang, L. L., Wang, G., Fowler, J. S., Franceschi, D., Sedler, M. J., Gatley, S. J., Miller, E. N., HITZEMANN, R. J., Ding, Y., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09414.2001 · Cited by 754 · see citing works
Striatal dopamine nerve terminal markers in human, chronic methamphetamine users
Wilson, J. M., Kalasinsky, K. S., Levey, A. I., Bergeron, C., Reiber, G. D., Anthony, R. M., Schmunk, G. A., Shannak, K. S., Haycock, J. W., & Kish, S. J. (1996) · Nature Medicine · doi:10.1038/nm0696-699 · Cited by 718 · see citing works
Robbins, T. W., James-Galton, M., Owen, A. M., Sahakian, B. J., Lawrence, A. D., McInnes, L., & Rabbitt, P. (1998) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617798455073 · Cited by 607 · see citing works
Self-citationMcCann, U. D., Wong, D. F., Yokoi, F., Villemagne, V., Dannals, R. F., & Ricaurte, G. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08417.1998 · Cited by 602 · see citing works
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1652 · Cited by 528 · see citing works
Wagner, G. C., Ricaurte, G. A., Seiden, L. S., Schuster, C. R., Miller, R. J., & Westley, J. (1980) · Brain Research · doi:10.1016/0006-8993(80)91265-2 · Cited by 523 · see citing works
Self-citationDopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain
Ricaurte, G. A., Guillery, R. W., Seiden, L. S., Schuster, C. R., & Moore, R. Y. (1982) · Brain Research · doi:10.1016/0006-8993(82)90198-6 · Cited by 479 · see citing works
Self-citationHotchkiss, A. J., & Gibb, J. W. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32165-8 · Cited by 443 · see citing works
Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers
Ornstein, T. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00097-x · Cited by 429 · see citing works
Kløve, H. (1963) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)33515-5 · Cited by 411 · see citing works
Sekine, Y., Iyo, M., Ouchi, Y., Matsunaga, T., Tsukada, H., Okada, H., Yoshikawa, E., Futatsubashi, M., Takei, N., & Mori, N. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1206 · Cited by 408 · see citing works
Magnetic Resonance Spectroscopy
Gujar, S. K., Maheshwari, S., Bj??rkman-Burtscher, I., & Sundgren, P. C. (2005) · Journal of Neuro-Ophthalmology · doi:10.1097/01.wno.0000177307.21081.81 · Cited by 380 · see citing works
Evidence for long-term neurotoxicity associated with methamphetamine abuse
Ernst, T., Chang, L., Leonido–Yee, M., & Speck, O. (2000) · Neurology · doi:10.1212/wnl.54.6.1344 · Cited by 373 · see citing works
California Verbal Learning Test--Second Edition
Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1987) · PsycTESTS Dataset · doi:10.1037/t15072-000 · Cited by 347 · see citing works
Cognitive Impairment in Individuals Currently Using Methamphetamine
Simon, S. L., Domier, C. P., Carnell, J., Brethen, P., Rawson, R. A., & Ling, W. W. (2000) · American Journal on Addictions · doi:10.1080/10550490050148053 · Cited by 322 · see citing works
Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys
Seiden, L. S., Fischman, M. W., & Schuster, C. R. (1976) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(76)90030-2 · Cited by 307 · see citing works
Self-citationKalechstein, A. D., Newton, T. F., & Green, M. M. (2003) · Journal of Neuropsychiatry · doi:10.1176/jnp.15.2.215 · Cited by 288 · see citing works
Positron Emission Tomography of Monoaminergic Vesicular Binding in Aging and Parkinson Disease
Bohnen, N. I., Albin, R. L., Koeppe, R. A., Wernette, K., Kilbourn, M. R., Minoshima, S., & Frey, K. A. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600276 · Cited by 254 · see citing works
Self-citationSekine, Y., Minabe, Y., Ouchi, Y., Takei, N., Iyo, M., Nakamura, K., Suzuki, K., Tsukada, H., Okada, H., Yoshikawa, E., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1699 · Cited by 242 · see citing works
Cognitive Performance of Current Methamphetamine and Cocaine Abusers
Simon, S. L., Domier, C. P., Sim, T., Richardson, K., Rawson, R. A., & Ling, W. W. (2001) · Journal of Addictive Diseases · doi:10.1300/j069v21n01_06 · Cited by 228 · see citing works
Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
Chang, L., Ernst, T., Speck, O., Patel, H., DeSilva, M., Leonido–Yee, M., & Miller, E. N. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00004-5 · Cited by 224 · see citing works
Western psychological services
Madden, S. (1996) · Journal of Adolescent Health · doi:10.1016/s1054-139x(96)00178-4 · Cited by 207 · see citing works
The vesicular monoamine transporter is not regulated by dopaminergic drug treatments
Borght, T. V., Kilbourn, M. R., Desmond, T. J., Kuhl, D. E., & Frey, K. A. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00594-3 · Cited by 205 · see citing works
Self-citationPreliminary evidence of reduced cognitive inhibition in methamphetamine-dependent individuals
Salo, R. E., NORDAHL, T. E., Possin, K. L., Leamon, M. H., Gibson, D. R., Galloway, G. P., Flynn, N. M., Henik, A., Pfefferbaum, A., & Sullivan, E. V. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00111-7 · Cited by 187 · see citing works
Self-citationWhy is parkinsonism not a feature of human methamphetamine users?
Moszczyńska, A., Fitzmaurice, P. S., Ang, L. C., Kalasinsky, K. S., Schmunk, G. A., Peretti, F. J., Aiken, S. S., Wickham, D. J., & Kish, S. J. (2004) · Brain · doi:10.1093/brain/awh046 · Cited by 152 · see citing works
Dyadic Short Forms of the Wechsler Adult Intelligence Scale–III
Ringe, W. K., Saine, K. C., Lacritz, L. H., Hynan, L. S., & Cullum, C. M. (2002) · Assessment · doi:10.1177/1073191102009003004 · Cited by 144 · see citing works
Harvey, D. C., Laćan, G., Tanious, S. P., & Melega, W. P. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02439-2 · Cited by 127 · see citing works
A new PET ligand for the dopamine transporter: studies in the human brain.
Volkow, N. D., Ding, Y., Fowler, J. S., Wang, G., Logan, J., Gatley, S. J., Schlyer, D. J., & Pappas, N. R. (1995) · PubMed · Cited by 119 · see citing works
Frey, K. A., Kilbourn, M. R., & Robinson, T. E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01152-7 · Cited by 104 · see citing works
Self-citationBorght, T. M. V., Sima, A. A. F., Kilbourn, M. R., Desmond, T. J., Kuhl, D. E., & Frey, K. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00167-h · Cited by 99 · see citing works
Self-citationNORDAHL, T. E., Salo, R. E., Possin, K. L., Gibson, D. R., Flynn, N. M., Leamon, M. H., Galloway, G. P., Pfefferbaum, A., Spielman, D. M., Elfar Adalsteinsson, A., et al. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00088-4 · Cited by 95 · see citing works
Self-citationLorez, H. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90053-9 · Cited by 93 · see citing works
Koeppe, R. A., Frey, K. A., Kume, A., Albin, R. L., Kilbourn, M. R., & Kuhl, D. E. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199709000-00001 · Cited by 90 · see citing works
Self-citationKoeppe, R. A., Frey, K. A., Kuhl, D. E., & Kilbourn, M. R. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199912000-00011 · Cited by 77 · see citing works
Self-citationHighly selective neurotoxins : basic and clinical applications
Kostrzewa, R. M. (1998) · Humana Press eBooks · Cited by 58 · see citing works
Evidence for and Mechanism of Action of Neurotoxicity of Amphetamine Related Compounds
Lew, R., Malberg, J. E., Ricuarte, G. A., & Seiden, L. S. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-477-1_9 · Cited by 25 · see citing works
Analysis of Four Dopaminergic Tracers Kinetics Using Two Different Tissue Input Function Methods
Sossi, V., Holden, J. E., Chan, G. L.-Y., Krzywinski, M. I., Stoessl, A. J., & Ruth, T. J. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200004000-00002 · Cited by 21 · see citing works
The effects of methamphetamine on fine motor control in rhesus monkeys
Johanson, C. E., Aigner, T. G., Seiden, L. S., & Schuster, C. R. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90134-5 · Cited by 16 · see citing works
Self-citationEffects of dopaminergic agents on eye tracking before and after repeated methamphetamine
Ando, K., Johanson, C. E., & Schuster, C. R. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90576-9 · Cited by 14 · see citing works
Self-citationEvidence for and Mechanism of Action of Neurotoxicity of Amphetamine Related Compounds
Lew, R., Malberg, J. E., Ricuarte, G. A., & Seiden, L. S. (2003) · Humana Press eBooks · doi:10.1385/0-89603-465-8:235 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A review of the clinical pharmacology of methamphetamine.
Cruickshank, C., & Dyer, K. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02564.x · Cited by 747 · see citing works
Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis
Scott, J. C., Woods, S. P., Matt, G. E., Meyer, R. A., Heaton, R. K., Atkinson, J. H., & Grant, I. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9031-0 · Cited by 669 · see citing works
Courtney, K. E., & Ray, L. A. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.08.003 · Cited by 502 · see citing works
Drug Addiction and the Memory Systems of the Brain
Robbins, T. W., Ersche, K. D., & Everitt, B. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.020 · Cited by 446 · see citing works
Self-citationMethamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Panenka, W. J., Procyshyn, R. M., Lecomte, T., MacEwan, G. W., Flynn, S. W., Honer, W. G., & Barr, A. M. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.11.016 · Cited by 432 · see citing works
Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
Chang, L., Alicata, D., Ernst, T. M., & Volkow, N. D. (2007) · Addiction · doi:10.1111/j.1360-0443.2006.01782.x · Cited by 431 · see citing works
Cognitive deficits in individuals with methamphetamine use disorder: A meta-analysis
Potvin, S., Pelletier, J., Grot, S., Hébert, C., Barr, A. M., & Lecomte, T. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.01.021 · Cited by 359 · see citing works
Ashok, A. H., Mizuno, Y., Volkow, N. D., & Howes, O. D. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0135 · Cited by 330 · see citing works
Kutlu, M. G., & Gould, T. J. (2016) · Learning & Memory · doi:10.1101/lm.042192.116 · Cited by 324 · see citing works
Bickel, W. K., Jarmolowicz, D., Mueller, E. T., Gatchalian, K., & Mcclure, S. M. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2689-x · Cited by 316 · see citing works
An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans
Dean, A. C., Groman, S. M., Morales, A. M., & London, E. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.179 · Cited by 251 · see citing works
Is Cognitive Functioning Impaired in Methamphetamine Users? A Critical Review
Hart, C. L., Marvin, C. B., Silver, R., & Smith, E. E. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.276 · Cited by 242 · see citing works
Gender differences in methamphetamine use and responses: A review
Dluzen, D. E., & Liu, B. (2008) · Gender Medicine · doi:10.1016/s1550-8579(08)80005-8 · Cited by 232 · see citing works
Neuropathology of substance use disorders
Cadet, J. L., Bisagno, V., & Milroy, C. M. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1221-7 · Cited by 207 · see citing works
Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users
McCann, U. D., Kuwabara, H., Kumar, A., Palermo, M., Abbey, R., Brašić, J. R., Ye, W., Alexander, M., Dannals, R. F., Wong, D. F., et al. (2007) · Synapse · doi:10.1002/syn.20471 · Cited by 205 · see citing works
Boileau, I., Payer, D., Chugani, B., Lobo, D. S. S., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., & Zack, M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.163 · Cited by 198 · see citing works
German, C. L., Baladi, M. G., McFadden, L. M., Hanson, G. R., & Fleckenstein, A. E. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010397 · Cited by 195 · see citing works
Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine
Halpin, L. E., Collins, S. A., & Yamamoto, B. K. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.07.014 · Cited by 194 · see citing works
Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging
London, E. D., Kohno, M., Morales, A. M., & Ballard, M. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.044 · Cited by 187 · see citing works
Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology
Yu, S., Zhu, L., Shen, Q., Bai, X., & Di, X. (2015) · Behavioural Neurology · doi:10.1155/2015/103969 · Cited by 176 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment
Ersche, K. D., & Sahakian, B. J. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9033-y · Cited by 166 · see citing works
Bowyer, J. F., & Ali, S. F. (2006) · Synapse · doi:10.1002/syn.20324 · Cited by 162 · see citing works
Neurologic Manifestations of Chronic Methamphetamine Abuse
Rusyniak, D. E. (2013) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2013.02.005 · Cited by 162 · see citing works
Neuroimaging for drug addiction and related behaviors
Parvaz, M. A., Alia-Klein, N., Woicik, P. A., Volkow, N. D., & Goldstein, R. Z. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.055 · Cited by 151 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Krasnova, I. N., Justinová, Z., Ladenheim, B., Jayanthi, S., McCoy, M. T., Barnes, C., Warner, J. E., Goldberg, S. R., & Cadet, J. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008790 · Cited by 136 · see citing works
Robertson, C. L., Ishibashi, K., Chudzynski, J. E., Mooney, L. J., Rawson, R. A., Dolezal, B. A., Cooper, C. B., Brown, A. K., Mandelkern, M. A., & London, E. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.331 · Cited by 136 · see citing works
Moszczyńska, A., & Callan, S. P. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.238501 · Cited by 133 · see citing works
Neurologic Manifestations of Chronic Methamphetamine Abuse
Rusyniak, D. E. (2011) · Neurologic Clinics · doi:10.1016/j.ncl.2011.05.004 · Cited by 125 · see citing works
Simon, S. L., Dean, A. C., Cordova, X., Monterosso, J. R., & London, E. D. (2010) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2010.71.335 · Cited by 117 · see citing works
Long-term cognitive and neurochemical effects of “bath salt” designer drugs methylone and mephedrone
den Hollander, B., Rozov, S. V., Linden, A.-M., Uusi‐Oukari, M., Ojanperä, I. A., & Korpi, E. R. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.10.006 · Cited by 113 · see citing works
Iudicello, J. E., Woods, S. P., Vigil, O., Scott, J. C., Cherner, M., Heaton, R. K., Atkinson, J. H., Grant, I., & Ce, T. H. N. R. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390903512637 · Cited by 111 · see citing works
Neuropsychological Consequences of Chronic Drug Use: Relevance to Treatment Approaches
Cadet, J. L., & Bisagno, V. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00189 · Cited by 110 · see citing works
Shin, E., Dang, D., Tran, T.-V., Tran, H., Jeong, J. H., Nah, S.-Y., Jang, C., Yamada, K., Nabeshima, T., & Kim, H. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0897-y · Cited by 104 · see citing works
Pharmacotherapeutic agents in the treatment of methamphetamine dependence
Morley, K. C., Cornish, J. L., Faingold, A., Wood, K., & Haber, P. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1313229 · Cited by 108 · see citing works
van Duijvenbode, N., VanDerNagel, J., Didden, R., Engels, R. C. M. E., Buitelaar, J. K., Kiewik, M., & de Jong, C. A. J. (2015) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.12.029 · Cited by 104 · see citing works
Galloway, G., Buscemi, R., Coyle, J., Flower, K., Siegrist, J. D., Fiske, L. A., Baggott, M. J., Li, L., Polcin, D. L., Chen, C. A., et al. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.307 · Cited by 103 · see citing works
Self-citationNeurocognitive deficits are associated with unemployment in chronic methamphetamine users
Weber, E., Blackstone, K., Iudicello, J., Morgan, E. E., Grant, I., Moore, D. J., & Woods, S. P. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.04.002 · Cited by 102 · see citing works
Bertolino, A., Fazio, L., Giorgio, A. D., Blasi, G., Romano, R., Taurisano, P., Caforio, G., Sinibaldi, L., Ursini, G., Popolizio, T., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4858-08.2009 · Cited by 101 · see citing works
Fleckenstein, A. E., Volz, T. J., & Hanson, G. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.002 · Cited by 100 · see citing works
Boileau, I., Rusjan, P., Houle, S., Wilkins, D., Tong, J., Selby, P., Guttman, M., Saint-Cyr, J. A., Wilson, A. A., & Kish, S. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3008-08.2008 · Cited by 100 · see citing works
Effect of methamphetamine dependence on everyday functional ability
Henry, B. L., Minassian, A., & Perry, W. (2010) · Addictive Behaviors · doi:10.1016/j.addbeh.2010.01.013 · Cited by 96 · see citing works
Dalley, J. W., Lääne, K., Theobald, D. E. H., Peña-López, Y., Bruce, C. C., Huszar, A. C., Wojcieszek, M., Everitt, B. J., & Robbins, T. W. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301220 · Cited by 89 · see citing works
Self-citationBrain serotonin transporter in human methamphetamine users
Kish, S. J., Fitzmaurice, P. S., Boileau, I., Schmunk, G. A., Ang, L.-C., Furukawa, Y., Chang, L., Wickham, D. J., Sherwin, A. L., & Tong, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1346-x · Cited by 93 · see citing works
Aron, J. L., & Paulus, M. P. (2007) · Addiction · doi:10.1111/j.1360-0443.2006.01778.x · Cited by 91 · see citing works
Fitzmaurice, P. S., Tong, J., Yazdanpanah, M., Liu, P. P., Kalasinsky, K. S., & Kish, S. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.109173 · Cited by 89 · see citing works
Neuropsychiatric Adverse Effects of Amphetamine and Methamphetamine
Harro, J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.02.004 · Cited by 84 · see citing works
Hedges, D. M., Obray, J. D., Yorgason, J. T., Jang, E. Y., Weeresekara, V., Uys, J. D. K., Bellinger, F. P., & Steffensen, S. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.291 · Cited by 81 · see citing works
Melega, W. P., Jorgensen, M. J., Laćan, G., Way, B. M., Pham, J., Morton, G. G., Cho, A. K., & Fairbanks, L. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301502 · Cited by 78 · see citing works
The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans
Olive, M. F., Taylor, & Lewis (2013) · Substance Abuse and Rehabilitation · doi:10.2147/sar.s39684 · Cited by 78 · see citing works
Sambo, D. O., Lebowitz, J. J., & Khoshbouei, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.009 · Cited by 75 · see citing works
Cherner, M., Suárez, P., Casey, C. Y., Deiss, R., Letendre, S. L., Marcotte, T. D., Vaida, F., Atkinson, J. H., Grant, I., & Heaton, R. K. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.08.010 · Cited by 76 · see citing works
A placebo‐controlled trial of mirtazapine for the management of methamphetamine withdrawal
CRUICKSHANK, C. C., MONTEBELLO, M. E., DYER, K. R., QUIGLEY, A., BLASZCZYK, J., TOMKINS, S., & SHAND, D. (2008) · Drug and Alcohol Review · doi:10.1080/09595230801935672 · Cited by 74 · see citing works
Camardese, G., Giuda, D. D., Nicola, M. D., Cocciolillo, F., Giordano, A., Janiri, L., & Guglielmo, R. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.006 · Cited by 72 · see citing works
Shukla, M., & Vincent, B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.016 · Cited by 72 · see citing works
Antipsychotic Drug Responsiveness and Dopamine Receptor Signaling; Old Players and New Prospects
Rampino, A., Marakhovskaia, A., Soares-Silva, T., Torretta, S., Veneziani, F., & Beaulieu, J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00702 · Cited by 70 · see citing works
Neuropsychological deficits in adolescent methamphetamine abusers
King, G., Alicata, D., Cloak, C. C., & Chang, L. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1949-x · Cited by 70 · see citing works
Mitochondria: key players in the neurotoxic effects of amphetamines
Barbosa, D. J., Capela, J. P., Feio‐Azevedo, R., Gomes, A., Bastos, M. D. L., & Carvalho, F. D. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1478-9 · Cited by 69 · see citing works
McFadden, L. M., Hadlock, G. C., Allen, S. C., Vieira‐Brock, P. L., Stout, K. A., Ellis, J. D., Hoonakker, A. J., Andrenyak, D. M., Nielsen, S. M., Wilkins, D. G., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.188433 · Cited by 67 · see citing works
Kish, S. J., Boileau, I., Callaghan, R. C., & Tong, J. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13363 · Cited by 67 · see citing works
Narendran, R., Lopresti, B. J., Mason, N. S., Deuitch, L., Paris, J., Himes, M. L., Kodavali, C. V., & Nimgaonkar, V. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0928-14.2014 · Cited by 66 · see citing works
Newton, T. F., Reid, M. S., Garza, R. D. L., Mahoney, J. J., Abad, A., Condos, R., Palamar, J. J., Halkitis, P. N., Mojisak, J., Anderson, A., et al. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009097 · Cited by 61 · see citing works
Bisagno, V., González, B., & Urbano, F. J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.013 · Cited by 59 · see citing works
Ammonia Mediates Methamphetamine-Induced Increases in Glutamate and Excitotoxicity
Halpin, L. E., Northrop, N. A., & Yamamoto, B. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.306 · Cited by 57 · see citing works
Ru, Q., Xiong, Q., Zhou, M., Chen, L., Tian, X., Xiao, H., Li, Z., & Li, Y. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.072 · Cited by 57 · see citing works
Monoamine Transporter Inhibitors and Substrates as Treatments for Stimulant Abuse
Howell, L. L., & Negus, S. S. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00004-4 · Cited by 56 · see citing works
Jan, R. K., Lin, J. C., Miles, S. W., Kydd, R. R., & Russell, B. (2012) · Brain Sciences · doi:10.3390/brainsci2040553 · Cited by 56 · see citing works
8.3 Imaging Dopamine’s Role in Drug Abuse and Addiction
Volkow, N. D., Fowler, J. S., Wang, G., Telang, F., & Baler, R. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195373035.003.0028 · Cited by 58 · see citing works
Narendran, R., Lopresti, B. J., Martinez, D., Mason, N. S., Himes, M., May, M. A., Daley, D. C., Price, J. C., Mathis, C. A., & Frankle, W. G. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11010126 · Cited by 53 · see citing works
Churchwell, J. C., Carey, P. D., Ferrett, H. L., Stein, D. J., & Yurgelun-Todd, D. A. (2012) · Developmental Neuroscience · doi:10.1159/000337724 · Cited by 52 · see citing works
Proebstl, L., Kamp, F., Manz, K., Krause, D., Adorjan, K., Pogarell, O., Koller, G., Soyka, M., Falkai, P., & Kambeitz, J. (2019) · European psychiatry · doi:10.1016/j.eurpsy.2019.03.003 · Cited by 52 · see citing works
Role of microglia in methamphetamine-induced neurotoxicity.
Xu, E., Liu, J., Liu, H., Wang, X., & Xiong, H. (2017) · Europe PMC (PubMed Central) · Cited by 52 · see citing works
Functional and Structural Brain Changes Associated with Methamphetamine Abuse
Jan, R. K., Kydd, R. R., & Russell, B. R. (2012) · Brain Sciences · doi:10.3390/brainsci2040434 · Cited by 51 · see citing works
Compulsivity Across the Pathological Misuse of Drug and Non-Drug Rewards
Banca, P., Harrison, N. A., & Voon, V. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00154 · Cited by 52 · see citing works
Farhadian, M., Akbarfahimi, M., Hassani‐Abharian, P., Hosseini, S. G., & Shokri, S. (2017) · Basic and Clinical Neuroscience Journal · doi:10.18869/nirp.bcn.8.2.147 · Cited by 51 · see citing works
Guerin, A. A., Bonomo, Y. A., Lawrence, A. J., Baune, B. T., Nestler, E. J., Rossell, S. L., & Kim, J. H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00880 · Cited by 48 · see citing works
Sung, Y., Carey, P. D., Stein, D. J., Ferrett, H. L., Spottiswoode, B. S., Renshaw, P. F., & Yurgelun-Todd, D. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.028 · Cited by 45 · see citing works
Voon, V., & Dalley, J. W. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5013 · Cited by 46 · see citing works
Acheson, L. S., Williams, B. H., Farrell, M., McKetin, R., Ezard, N., & Siefried, K. J. (2022) · Drug and Alcohol Review · doi:10.1111/dar.13511 · Cited by 45 · see citing works
Gross, N. B., Duncker, P. C., & Marshall, J. F. (2011) · Synapse · doi:10.1002/syn.20952 · Cited by 44 · see citing works
Tong, J., Wilson, A. A., Boileau, I., Houle, S., & Kish, S. J. (2008) · Synapse · doi:10.1002/syn.20573 · Cited by 44 · see citing works
A Single Neurotoxic Dose of Methamphetamine Induces a Long-Lasting Depressive-Like Behaviour in Mice
Silva, C., Neves, A. F., Dias, A. I., de Freitas, H. J. F., Mendes, S. M., Pita, I. R., Viana, S., de Oliveira, P. A., Cunha, R. A., Ribeiro, C., et al. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9423-2 · Cited by 43 · see citing works
Grace, C. E., Schaefer, T. L., Herring, N. R., Graham, D. L., Skelton, M. R., Gudelsky, G. A., Williams, M. T., & Vorhees, C. V. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.01.006 · Cited by 42 · see citing works
Hofford, R. S., Darna, M., Wilmouth, C. E., Dwoskin, L. P., & Bardo, M. T. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.007 · Cited by 42 · see citing works
O’Dell, S. J., Feinberg, L. M., & Marshall, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.022 · Cited by 41 · see citing works
Impulsivity, Stimulant Abuse, and Dopamine Receptor Signaling
London, E. D. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.01.002 · Cited by 40 · see citing works
Basterfield, C., Hester, R., & Bowden, S. C. (2019) · Neuropsychology · doi:10.1037/neu0000552 · Cited by 43 · see citing works
Cadet, J. L., Krasnova, I. N., Ladenheim, B., Cai, N.-S., McCoy, M. T., & Atianjoh, F. E. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9026-0 · Cited by 40 · see citing works
Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior
Saloner, R., Fields, J. A., Marcondes, M. C. G., Iudicello, J. E., von Känel, S., Cherner, M., Letendre, S. L., Kaul, M., & Grant, I. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09957-0 · Cited by 38 · see citing works
Biological substrates of addiction
Joffe, M. E., Grueter, C. A., & Grueter, B. A. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1273 · Cited by 39 · see citing works
Pattern and related factors of cognitive impairment among chronic methamphetamine users
Wang, T., Fan, T., Bao, Y., Li, X.-D., Liang, C., Wang, R., Ma, J., Han, Y., Meng, S., Wu, P., et al. (2017) · American Journal on Addictions · doi:10.1111/ajad.12505 · Cited by 39 · see citing works
Decreased cortical complexity in methamphetamine abusers
Yun, K., Park, H.-K., Kwon, D.-H., Kim, Y., Cho, S., Cho, H.-J., Peterson, B. S., & Jeong, J. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.07.009 · Cited by 38 · see citing works
Working Memory and Speed of Information Processing in Chronic Khat Users: Preliminary Findings
Hoffman, R., & Al’Absi, M. (2012) · European Addiction Research · doi:10.1159/000338285 · Cited by 38 · see citing works
Neurologic Complications of Psychomotor Stimulant Abuse
Sanchez‐Ramos, J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.02.003 · Cited by 39 · see citing works
Stoops, W. W. (2006) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.14.4.413 · Cited by 38 · see citing works
Brain-derived neurotrophic factor levels and depression during methamphetamine withdrawal
Ren, W., Luan, X., Zhang, J., Gutteea, P., Cai, Y., Zhao, J., Gu, Y., Wu, C., Su, H., Tao, J., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.017 · Cited by 37 · see citing works
Hall, M. G., Hauson, A. O., Wollman, S. C., Allen, K. E., Connors, E. J., Stern, M. J., Kimmel, C. L., Stephan, R. A., Sarkissians, S., Barlet, B. D., et al. (2017) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2017.1355919 · Cited by 37 · see citing works
Wang, L., Chen, C., Lin, S., Chen, Y., Xu, K., & Huang, M. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4910-z · Cited by 37 · see citing works
Graves, S. M., Schwarzschild, S. E., Tai, R., Chen, Y., & Surmeier, D. J. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105409 · Cited by 37 · see citing works
- Authors
- Johanson, C.-E., Frey, K. A., Lundahl, L. H., Keenan, P., Lockhart, N., Roll, J., Galloway, G. P., Koeppe, R. A., Kilbourn, M. R., Robbins, T., & Schuster, C. R.
- Affiliations
- Wayne State University (US)
- University of Michigan (US)
- Friends Research Institute (US)
- University of Cambridge (GB)
- Corresponding author
- Johanson, Chris-Ellyn
- ORCID
- Venue
- Psychopharmacology
- Published
- 2006-03-03
- Volume
- 185
- Issue
- 3
- Pages
- 327-338
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1973774749
- Cited by
- 233
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 30 · 2019: 8 · 2018: 9 · 2017: 12 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 19 · 2012: 21
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (5r01da012458-03, 5r21da014392-02)
- National Institute on Drug Abuse (DA14392, DA12458, R01DA010641, R01 DA10641)
- National Institute of Neurological Disorders and Stroke (NS-15655)
- National Center for Research Resources (RR00042, M01RR000042)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- methamphetamine, abstinence, cognitive function, nigrostriatal pathway, dopamine transporter, vesicular monoamine transporter 2, striatum, dopamine deficiency, monoamine transporters, executive function, learning and memory, attention, motor function
- MeSH terms
- Adolescent, Adult, Cognition, Corpus Striatum, Dopamine, Female, Humans, Male, Methamphetamine, Middle Aged, Psychological Tests, Substantia Nigra, Amphetamine-Related Disorders, Dopamine Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review