Neuroimaging for drug addiction and related behaviors
Open accessAbstract
In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.
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Contemporary theories addressing the pathophysiology of substance-use disorders highlight altered motivational states, cognitive control, inhibitory function, and decision-making, mediated in large part by dysfunctional output of mesolimbic and mesocortical brain systems.
“Contemporary theories addressing the pathophysiology of substance-use disorders highlight altered motivational states, cognitive control, inhibitory function, and decision-making, mediated in large part by dysfunctional output of mesolimbic and mesocortical brain systems [104-107].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [107]
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- Authors
- Parvaz, M. A., Alia-Klein, N., Woicik, P. A., Volkow, N. D., & Goldstein, R. Z.
- Affiliations
- Brookhaven National Laboratory (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Goldstein, Rita Z.
- Venue
- Reviews in the Neurosciences
- Publisher
- Walter de Gruyter GmbH
- Published
- 2011-01-01
- Volume
- 22
- Issue
- 6
- Pages
- 609-24
- ISSN
- 0334-1763 (ISSN-L)
- 2191-0200
- PMC
- PMC3462350
- OpenAlex
- W1996180070
- Cited by
- 151
- References
- 249
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 31 · 2019: 13 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 10 · 2012: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Reviews in the Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA023579)
- National Center for Research Resources (M01RR010710, 5-MO1-RR-10 710)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- drug addiction, neuroimaging, reward systems, impulsivity, craving, withdrawal, bingeing, positron emission tomography, functional MRI, EEG
- MeSH terms
- Brain, Cognition Disorders, Electroencephalography, Humans, Radionuclide Imaging, Mood Disorders, Substance-Related Disorders, Neuroimaging
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