Cited by 110Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on Behavior

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Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner

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Torres, Oscar V., Natividad, Luis A., Tejeda, Hugo A., Van Weelden, Susan A., O’Dell, Laura E.·2009·Psychopharmacology

DOI 10.1007/s00213-009-1607-3PMC PMC2746680

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Abstract

Introduction The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats.Methods Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferred side. Following four conditioning trials, rats were re-tested for their preference. To examine developmental differences, we compared the effects of various nicotine doses in female and male adolescent and adult rats. To examine whether our developmental differences are specific to nicotine, we included adolescent and adult females that were conditioned with various amphetamine doses. To examine the influence of hormones on the behavioral effects of nicotine, we compared the effects of various nicotine doses in intact females that were tested during different phases of the estrous cycle and in separate females that were ovariectomized.Results The rewarding effects of nicotine were observed at a lower nicotine dose in adolescents versus adults. Amphetamine produced similar rewarding effects across age groups in females. The shifts in preference produced by nicotine were similar across the different phases of estrous. Females lacking ovarian hormones did not display rewarding effects of nicotine at any dose. The rewarding effects of nicotine were enhanced in adult female versus male rats. An intermediate nicotine dose produced rewarding effects in adolescent male but not female rats, suggesting that developmental differences to nicotine may be enhanced in males.Conclusion In females, nicotine reward is enhanced during adolescence and is facilitated by the presence of ovarian hormones.

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Portugal, G. S., Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.003 · Cited by 79
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Authors: Torres, O. V., Natividad, L. A., Tejeda, H. A., Van Weelden, S. A., & O’Dell, L. E.
Affiliations: The University of Texas at El Paso (US)
Corresponding author: O’Dell, Laura E.
ORCID: Natividad, Luis A.
Tejeda, Hugo A.
O’Dell, Laura E.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2009-07-23
Volume: 206
Issue: 2
Pages: 303-312
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-009-1607-3
PMC: PMC2746680
OpenAlex: W2138885252
Cited by: 110
References: 36
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 2 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 4 · 2013: 9 · 2012: 3
FWCI: 3.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
National Institutes of Health
National Institute on Drug Abuse (R01DA021274, R25DA033613)
National Center for Research Resources (G12RR008124)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, nicotine reward, sex differences, age differences, adolescent development, estrous cycle, ovarian hormones, ovariectomy, amphetamine, place conditioning, female rats
MeSH terms: Age Factors, Amphetamine, Central Nervous System Stimulants, Animals, Animals, Newborn, Avoidance Learning, Conditioning, Operant, Dose-Response Relationship, Drug, Female, Hormones, Male, Nicotine, Ovariectomy, Reward, Sex Characteristics, Rats, Wistar, Nicotinic Agonists, Estrous Cycle, Rats

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Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner

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