Cited by 17Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity DisorderNeuroscience and Neuropharmacology Research

Effect of age on methylphenidate-induced conditioned taste avoidance and related BDNF/TrkB signaling in the insular cortex of the rat

Open access
Wetzell, B. Bradley, Muller, Mirabella M., Cobuzzi, Jennifer L., Hurwitz, Zachary E., DeCicco-Skinner, Kathleen, Riley, Anthony L.·2014·Psychopharmacology

Abstract

Rationale Drug use and abuse is thought to be a function of the balance between its rewarding and aversive effects, such that the rewarding effects increase the likelihood of use while the drug's dissociable aversive effects limit it. Adolescents exhibit a shift in this balance toward reward, which may ultimately lead to increased use. Importantly, recent work shows that adolescents are also protected from the aversive effects of many abusable drugs as measured by conditioned taste avoidance (CTA). However, such effects of methylphenidate (MPH, widely prescribed to adolescents with ADHD) have not been characterized. Objectives The effect of age on MPH-induced CTA was assessed. In addition, MPH-induced changes in brain-derived neurotrophic factor (BDNF) activity in the insular cortex (IC) and central nucleus of the amygdala (CeA), known to be important to CTA, were examined and related to CTAs in adolescents and adults. Methods CTAs induced by MPH (0, 10, 18, and 32 mg/kg) were assessed in adolescent (n = 34) and adult (n = 33) male Sprague Dawley rats. Following MPH CTA, IC and CeA tissue was probed for differences in BDNF and tropomyosin-related kinase receptor-B (TrkB) using Western blots. Results Blunted expression of MPH CTA was observed in the adolescents versus adults, which correlated with generally attenuated adolescent BDNF/TrkB activity in the IC, but the drug effects ran contrary to the expression of CTA. Conclusions Adolescents are protected from the aversive effe…

Integrity signals

Registry

Crossref · 10.1007/s00213-014-3500-y

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 60 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Wetzell, B. B., Muller, M. M., Cobuzzi, J. L., Hurwitz, Z. E., DeCicco-Skinner, K., & Riley, A. L.
Affiliations
American University (US)
Corresponding author
  • Wetzell, B. Bradley
  • Riley, Anthony L.
Venue
Psychopharmacology
Published
2014-02-22
Volume
231
Issue
8
Pages
1493-1501
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W1979601992
Cited by
17
References
60
Citations by year
2025: 1 · 2023: 1 · 2022: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 2
FWCI
1.68
Type
journal article
Language
en
Open access
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • American University Research Archive
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
methylphenidate, conditioned taste avoidance, age differences, adolescents, insula, central amygdala, brain-derived neurotrophic factor, TrkB, drug reward, attention deficit hyperactivity disorder, neuroprotection
MeSH terms
Animals, Avoidance Learning, Cerebral Cortex, Conditioning, Classical, Dose-Response Relationship, Drug, Eating, Male, Methylphenidate, Phosphorylation, Saccharin, Blotting, Western, Signal Transduction, Rats, Sprague-Dawley, Dopamine Uptake Inhibitors, Brain-Derived Neurotrophic Factor, Receptor, trkB, Taste Perception, Central Amygdaloid Nucleus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review