Ethanol‐induced conditioned taste aversion in male Sprague‐Dawley rats: impact of age and stress
Open accessAbstract
Background: Age‐specific characteristics may contribute to the elevation in ethanol intake commonly reported among adolescents compared to adults. This study was designed to examine age‐related differences in sensitivity to ethanol’s aversive properties using a conditioned taste aversion (CTA) procedure with sucrose serving as the conditioned stimulus (CS). Given that ontogenetic differences in responsiveness to stressors have been previously reported, the role of stressor exposure on the development of CTA was also assessed. Methods: Experiment 1 examined the influence of 5 days of prior restraint stress exposure on the expression of CTA in a 2‐bottle test following 1 pairing of a sucrose solution with ethanol. In Experiment 2, the effects of 7 days of social isolation on the development of CTA were observed using a 1‐bottle test following multiple sucrose–ethanol pairings. Results: This study revealed age‐related differences in the development of ethanol‐induced CTA. In Experiment 1, adolescents required a higher dose of ethanol than adults to demonstrate an aversion. In Experiment 2, adolescents required not only a higher ethanol dose but also more pairings of ethanol with the sucrose CS. No effects of prior stressor exposure were observed in either experiment. Conclusions: Together, these experiments demonstrate an adolescent‐specific insensitivity to the aversive properties of ethanol that elicit CTA, a pattern not influenced by repeated restraint stress or housing in social isolation. This age‐related insensitivity to the dysphoric effects of ethanol is consistent with other work from our laboratory, adding further to the evidence that adolescent rats are less susceptible to negative consequences of ethanol that may serve as cues to curb consumption.
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The effects of the deprivation of food and/or water and isolated housing environments have been found to differ between age groups and may confound age effects.
“In particular, the effects of the deprivation of food and/or water (Anderson et al., 2010) and iso lated housing environments (Smith et al., 1998) have been found to differ between age groups (Anderson et al., 2010) and may confound age”
From Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults. (2023) · cites this paper as Anderson et al., 2010
Experiment 2 Results (page unavailable) report that isolation housing reduced baseline sucrose intake in adolescents but not adults, supporting an age-dependent housing effect. The Discussion (page unavailable) suggests water deprivation might have masked additional stressor effects, but does not show that food or water deprivation affects the age groups differently; the claimed deprivation-related confound is therefore unsupported. (LLM, conf=0.85)
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- Authors
- Anderson, R. I., Varlinskaya, E. I., & Spear, L. P.
- Affiliations
- Binghamton University (US)
- Corresponding author
- Spear, Linda P.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2010-09-22
- Volume
- 34
- Issue
- 12
- Pages
- 2106-2115
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC2988942
- OpenAlex
- W1689813214
- Cited by
- 96
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 17 · 2012: 6
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01 AA16887, R37-AA12525, R01AA018026, R01AA016887, R37AA012525)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- ethanol, conditioned taste aversion, age differences, adolescents, restraint stress, social isolation, ethanol consumption
- MeSH terms
- Age Factors, Ethanol, Animals, Avoidance Learning, Conditioning, Classical, Dose-Response Relationship, Drug, Male, Stress, Psychological, Taste, Rats, Sprague-Dawley, Rats
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