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Cited by 320Psychedelics and Drug StudiesPain Management and Placebo EffectSchizophrenia research and treatment

The DOI matches its Crossref record; 80 of the 81 references it cites were found in a registry or an index.

LSD enhances suggestibility in healthy volunteers

Carhart-Harris, R. L., Kaelen, M., Whalley, M. G., Bolstridge, M., Feilding, A., Nutt, D. J.·2015·Psychopharmacology
DOI 10.1007/s00213-014-3714-z
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Abstract

Rationale Lysergic acid diethylamide (LSD) has a history of use as a psychotherapeutic aid in the treatment of mood disorders and addiction, and it was also explored as an enhancer of mind control. Objectives The present study sought to test the effect of LSD on suggestibility in a modern research study. Methods Ten healthy volunteers were administered with intravenous (i.v.) LSD (40-80 μg) in a within-subject placebo-controlled design. Suggestibility and cued mental imagery were assessed using the Creative Imagination Scale (CIS) and a mental imagery test (MIT). CIS and MIT items were split into two versions (A and B), balanced for 'efficacy' (i.e. A ≈ B) and counterbalanced across conditions (i.e. 50 % completed version 'A' under LSD). The MIT and CIS were issued 110 and 140 min, respectively, post-infusion, corresponding with the peak drug effects. Results Volunteers gave significantly higher ratings for the CIS (p = 0.018), but not the MIT (p = 0.11), after LSD than placebo. The magnitude of suggestibility enhancement under LSD was positively correlated with trait conscientiousness measured at baseline (p = 0.0005). Conclusions These results imply that the influence of suggestion is enhanced by LSD. Enhanced suggestibility under LSD may have implications for its use as an adjunct to psychotherapy, where suggestibility plays a major role. That cued imagery was unaffected by LSD implies that suggestions must be of a sufficient duration and level of detail to be enhanced by…

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Research works printed but not linked: 2

  1. Grof S (1980) LSD Psychotherapy. Hunter House, US
  2. Weitzenhoffer AM, Hilgard ER (1959) Stanford hypnotic susceptibility scale, for use in research investigations in the field of hypnotic phenomena. Consulting Psychologists, Palo Alto

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Metadata

Authors
Carhart-Harris, R. L., Kaelen, M., Whalley, M. G., Bolstridge, M., Feilding, A., & Nutt, D. J.
Affiliations
  • Imperial College London (GB)
  • Royal Berkshire NHS Foundation Trust (GB)
  • Beckley Foundation (GB)
Corresponding author
Carhart-Harris, R. L.
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2014-09-23
Volume
232
Issue
4
Pages
785-794
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-014-3714-z
OpenAlex
W2037317432
Cited by
320
References
81
Citations by year
2026: 25 · 2025: 40 · 2024: 52 · 2023: 36 · 2022: 40 · 2021: 38 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 15 · 2016: 18 · 2015: 4 · 2014: 1
FWCI
14.95
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Beckley Foundation
  • National Institute for Health and Care Research
  • Medical Research Council (MR/J00460X/1)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
lysergic acid diethylamide, LSD, suggestibility, psychedelic effects, mind control, psychotherapy adjunct
MeSH terms
Adult, Affect, Dose-Response Relationship, Drug, Hallucinogens, Humans, Imagination, Infusions, Intravenous, Lysergic Acid Diethylamide, Male, Placebos, Suggestion, Single-Blind Method, Healthy Volunteers

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