Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior
Open accessAbstract
Impairments in social interaction represent a core symptom of a number of psychiatric disease states, including autism, schizophrenia, depression, and anxiety. Although the amygdala has long been linked to social interaction, little is known about the functional role of connections between the amygdala and downstream regions in noncompetitive social behavior. In the present study, we used optogenetic and pharmacological tools in mice to study the role of projections from the basolateral complex of the amygdala (BLA) to the ventral hippocampus (vHPC) in two social interaction tests: the resident-juvenile-intruder home-cage test and the three chamber sociability test. BLA pyramidal neurons were transduced using adeno-associated viral vectors (AAV5) carrying either channelrhodopsin-2 (ChR2) or halorhodopsin (NpHR), under the control of the CaMKIIα promoter to allow for optical excitation or inhibition of amygdala axon terminals. Optical fibers were chronically implanted to selectively manipulate BLA terminals in the vHPC. NpHR-mediated inhibition of BLA-vHPC projections significantly increased social interaction in the resident-juvenile intruder home-cage test as shown by increased intruder exploration. In contrast, ChR2-mediated activation of BLA-vHPC projections significantly reduced social behaviors as shown in the resident-juvenile intruder procedure as seen by decreased time exploring the intruder and in the three chamber sociability test by decreased time spent in the social zone. These results indicate that BLA inputs to the vHPC are capable of modulating social behaviors in a bidirectional manner.
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Stimulating NAc-targeting BLA PNs promotes reward-seeking.
“Recent optogenetic studies have shown that photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction, whereas photosilencing this pathway has the opposite effects, and, conversely, stimulating NAc-targeting BLA PNs promotes reward-seeking (20,22,23,39).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [39]
Photosilencing the BLA→vHPC pathway has effects opposite to photostimulation.
“Recent optogenetic studies have shown that photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction, whereas photosilencing this pathway has the opposite effects, and, conversely, stimulating NAc-targeting BLA PNs promotes reward-seeking (20,22,23,39).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [39]
Photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction.
“Recent optogenetic studies have shown that photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction, whereas photosilencing this pathway has the opposite effects, and, conversely, stimulating NAc-targeting BLA PNs promotes reward-seeking (20,22,23,39).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [39]
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- Authors
- Felix-Ortiz, A. C., & Tye, K. M.
- Affiliations
- Massachusetts Institute of Technology (US)
- ORCID
- Tye, Kay M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-01-08
- Volume
- 34
- Issue
- 2
- Pages
- 586-595
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3870937
- OpenAlex
- W1985661446
- Cited by
- 473
- References
- 41
- Citations by year
- 2026: 26 · 2025: 38 · 2024: 42 · 2023: 49 · 2022: 43 · 2021: 57 · 2020: 33 · 2019: 36 · 2018: 41 · 2017: 29 · 2016: 29 · 2015: 26 · 2014: 22 · 2012: 1
- FWCI
- 19.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
- Funders
- Simons Center for the Social Brain, Massachusetts Institute of Technology
- National Institute of Mental Health (R01MH102441)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amygdala, ventral hippocampus, basolateral amygdala, social behavior, social interaction, optogenetics, halorhodopsin, channelrhodopsin-2, bidirectional modulation
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Hippocampus, Immunohistochemistry, Male, Mice, Inbred C57BL, Neural Pathways, Social Behavior, Microscopy, Confocal, Mice
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