Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat
Abstract
Early exposure to infection is known to affect brain development and has been linked to an increased risk for schizophrenia. The present study aimed to determine whether neonatal infection produced long-term disruptions in behaviour and pathology that might provide a parallel with that observed in schizophrenia. Rats were administered lipopolysaccharide (LPS; 500 microg/kg i.p.) on postnatal day 7 and 9. Locomotor activity and object recognition memory were tested at day 35 and day 70. LPS animals were observed to be less active at adulthood as measured by locomotor activity. With regards to object recognition memory, LPS administration produced no early impairment in task performance, however, at day 70 LPS animals spent significantly less time exploring the novel object than control animals. Analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus of LPS animals with significant reductions selectively localised to the CA1-CA3 region, and not the dentate gyrus. No changes were observed in prefrontal cortex. These results show that neonatal LPS results in pathophysiological brain changes in hippocampal CA1-CA3 subregions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Early-life pro-inflammatory conditions, such as maternal and neonatal immune challenges, cause a persistent decrease in the number of prefrontal and/or hippocampal parvalbumin-immunoreactive interneurons.
“Early-life pro-inflammatory conditions, such as maternal and neonatal immune challenges, cause a persistent decrease in number of prefrontal and/or hippocampal parvalbumin-immunoreactive interneurons (Jenkins et al., 2009; Meyer et al., 2008).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Jenkins et al., 2009
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Bevins, R. A., & Besheer, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.205 · Cited by 1,278 · see citing works
Translating developmental time across mammalian species
Clancy, B., Darlington, R. B., & Finlay, B. L. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00171-3 · Cited by 1,221 · see citing works
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,198 · see citing works
Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.774 · Cited by 1,048 · see citing works
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025 · see citing works
Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region
Witter, M. P., Groenewegen, H. J., Lopes, F. H. D. S., & Lohman, A. H. M. (1989) · Progress in Neurobiology · doi:10.1016/0301-0082(89)90009-9 · Cited by 918 · see citing works
Bayer, S. A. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901900107 · Cited by 913 · see citing works
Lipska, B. K., Jaskiw, G. E., & Weinberger, D. R. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.44 · Cited by 697 · see citing works
Amaral, D. G., & Dent, J. A. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901950106 · Cited by 606 · see citing works
Prenatal Infection as a Risk Factor for Schizophrenia
Brown, A. S. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj052 · Cited by 540 · see citing works
Kosaka, T., Katsumaru, H., Hama, K., Wu, J.-Y., & Heizmann, C. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)90575-0 · Cited by 536 · see citing works
Maternal Infections and Subsequent Psychosis Among Offspring
Buka, S. L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1032 · Cited by 512 · see citing works
Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring
Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Liu, L., Babulas, V. P., & Susser, E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.767 · Cited by 490 · see citing works
On the delay-dependent involvement of the hippocampus in object recognition memory
HAMMOND, R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.005 · Cited by 476 · see citing works
Lodge, D., & Grace, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2847-07.2007 · Cited by 475 · see citing works
Zhang, Z. J., & Reynolds, G. P. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00188-8 · Cited by 460 · see citing works
Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
BEASLEY, C., & REYNOLDS, G. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00122-3 · Cited by 426 · see citing works
Urakubo, A., Jarskog, L. F., Lieberman, J. A., & Gilmore, J. H. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00032-3 · Cited by 405 · see citing works
Cognitive Dysfunction in Schizophrenia: Convergence of γ-Aminobutyric Acid and Glutamate Alterations
Lewis, D. A., & Moghaddam, B. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1372 · Cited by 404 · see citing works
Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic
O’Callaghan, E., Sham, P. C., Takei, N., Murray, R. M., & Glover, G. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)92919-s · Cited by 402 · see citing works
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356 · see citing works
Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R. (1997) · Psychopharmacology · doi:10.1007/s002130050349 · Cited by 346 · see citing works
Borrell, J. I. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00360-8 · Cited by 307 · see citing works
Neuronal differentiation factors/cytokines and synaptic plasticity
Patterson, P. H., & Nawa, H. (1993) · Cell · doi:10.1016/s0092-8674(05)80032-7 · Cited by 288 · see citing works
Hippocampal modulation of sensorimotor processes.
Bast, T., & Feldon, J. (2003) · Progress in neurobiology · doi:10.1016/s0301-0082(03)00112-6 · Cited by 267 · see citing works
Ontogeny of the calcium binding protein parvalbumin in the rat nervous system
Solbach, S., & Celio, M. R. (1991) · Anatomy and Embryology · doi:10.1007/bf00942742 · Cited by 262 · see citing works
Quan, N., Stern, E. L., Whiteside, M. B., & Herkenham, M. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00193-3 · Cited by 251 · see citing works
Grayson, B., Idris, N. F., & Neill, J. C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.06.012 · Cited by 243 · see citing works
Gayle, D. A., Beloosesky, R., Desai, M., Amidi, F., Nuñez, S., & Ross, M. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00664.2003 · Cited by 221 · see citing works
Exposure to infection and brain development: cytokines in the pathogenesis of schizophrenia
GILMORE, J., & FREDRIKJARSKOG, L. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00123-5 · Cited by 209 · see citing works
Dickerson, F., Boronow, J. J., Stallings, C. R., Origoni, A. E., Ruslanova, I., & Yolken, R. H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.466 · Cited by 209 · see citing works
Abdul-Monim, Z., Neill, J. C., & Reynolds, G. P. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107067097 · Cited by 206 · see citing works
Self-citationThe organization and development of the hippocampal mossy fiber system
Gaarskjaer, F. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90004-4 · Cited by 186 · see citing works
Schizophrenic births and viral diseases in two states
Torrey, Ε. F., Rawlings, R. R., & Waldman, I. N. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90043-6 · Cited by 185 · see citing works
Nawa, H., & Takei, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.002 · Cited by 174 · see citing works
Reynolds, G. P., Abdul-Monim, Z., Neill, J. C., & Zhang, Z. (2004) · Neurotoxicity Research · doi:10.1007/bf03033297 · Cited by 150 · see citing works
Ainge, J. A., Heron-Maxwell, C., Theofilas, P., Wright, P., de Hoz, L., & Wood, E. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.09.005 · Cited by 140 · see citing works
Romero, E., Ali, C., Molina‐Holgado, E., Castellano, B., Guaza, C., & Borrell, J. I. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301292 · Cited by 138 · see citing works
Penschuck, S., Flagstad, P., Didriksen, M., Leist, M., & Michael-Titus, A. T. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04536.x · Cited by 127 · see citing works
Coyle, P. V., TRAN, N., FUNG, J., Summers, B. L., & Rofe, A. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.022 · Cited by 102 · see citing works
Brain Cytokines and Chemokines: Roles in Ischemic Injury and Pain
Minami, M., Katayama, T., & Satoh, M. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj06005x · Cited by 99 · see citing works
Bast, T., Zhang, W.-N., & Feldon, J. (2001) · Psychopharmacology · doi:10.1007/s002130100775 · Cited by 73 · see citing works
Prenatal infectious and nutritional factors and risk of adult schizophrenia
Penner, J. D., & Brown, A. S. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.7.797 · Cited by 58 · see citing works
Verdoux, H., & Sutter‐Dallay, A. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10906 · Cited by 57 · see citing works
Jenkins, T. A., Harte, M., McKibben, C. E., Elliott, J. J., & Reynolds, G. P. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.020 · Cited by 50 · see citing works
Developmental challenge and GABAergic neuronal abnormalities : their relevance to schizophrenia.
Baker, C. P. (2002) · Europe PMC (PubMed Central) · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gandal, M. J., Edgar, J. C., Klook, K., & Siegel, S. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.007 · Cited by 269 · see citing works
Steullet, P., Cabungcal, J. H., Monin, A., Dwir, D., O'Donnell, P., Cuenod, M., & Do, K. Q. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.021 · Cited by 262 · see citing works
Gut microbiota, immune development and function
Bengmark, S. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.002 · Cited by 264 · see citing works
Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., Koshimizu, H., Umemori, J., Toyama, K., Nakamura, H. K., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.38 · Cited by 173 · see citing works
Powell, S. B., Sejnowski, T. J., & Behrens, M. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.049 · Cited by 164 · see citing works
Bossù, P., Cutuli, D., Palladino, I., Caporali, P., Angelucci, F., Laricchiuta, D., Gelfo, F., Bartolo, P. D., Caltagirone, C., & Petrosini, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-101 · Cited by 168 · see citing works
Do, K. Q., Cuenod, M., & Hensch, T. K. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv065 · Cited by 158 · see citing works
Lyon, L., Saksida, L. M., & Bussey, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2536-5 · Cited by 105 · see citing works
Sominsky, L., Fuller, E. A., Bondarenko, E., Ong, L. K., Averell, L., Nalivaiko, E., Dunkley, P. R., Dickson, P. W., & Hodgson, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057700 · Cited by 90 · see citing works
Piontkewitz, Y., Bernstein, H., Dobrowolny, H., Bogerts, B., Weiner, I., & Keilhoff, G. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.004 · Cited by 93 · see citing works
Camara, M. L., Corrigan, F., Jaehne, E. J., Jawahar, M. C., Anscomb, H., & Baune, B. T. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.199 · Cited by 91 · see citing works
Jiang, Z., Cowell, R. M., & Nakazawa, K. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00116 · Cited by 89 · see citing works
Models of Neurodevelopmental Abnormalities in Schizophrenia
Powell, S. B. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_57 · Cited by 84 · see citing works
Social Origins of Developmental Risk for Mental and Physical Illness
Cameron, J. L., Eagleson, K. L., Fox, N. A., Hensch, T. K., & Levitt, P. R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1822-17.2017 · Cited by 81 · see citing works
Stolp, H. B., Neuhaus, A. A., Sundramoorthi, R., & Molnár, Z. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00050 · Cited by 85 · see citing works
Savi, F. F., de Oliveira, A. L. R., de Medeiros, G. F., Bozza, F. A., Michels, M., Sharshar, T., Dal‐Pizzol, F., & Ritter, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.005 · Cited by 79 · see citing works
Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain
Saito, M., Chakraborty, G., Hui, M., Masiello, K., & Saito, M. (2016) · Brain Sciences · doi:10.3390/brainsci6030031 · Cited by 69 · see citing works
Möller, M., Swanepoel, T., & Harvey, B. H. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn5003368 · Cited by 59 · see citing works
Feleder, C., Tseng, K. Y., Calhoon, G. G., & O'Donnell, P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.028 · Cited by 57 · see citing works
Тишкина, А. О., Stepanichev, M. Y., Kudryashova, I. V., Freiman, S. V., Onufriev, M. V., Лазарева, Н. А., & Gulyaeva, N. V. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.02.001 · Cited by 54 · see citing works
O’Donnell, P. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.07.005 · Cited by 52 · see citing works
Basta‐Kaim, A., Fijał, K., Ślusarczyk, J., Trojan, E., Głombik, K., Budziszewska, B., Leśkiewicz, M., Regulska, M., Kubera, M., Lasoń, W., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.013 · Cited by 48 · see citing works
Réus, G. Z., Simões, L. R., Colpo, G. D., Scaini, G., Oses, J. P., Generoso, J. S., Prossin, A. R., Kaddurah-Daouk, R. F., Quevedo, J., & Barichello, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.016 · Cited by 48 · see citing works
A potential role for glia‐derived extracellular matrix remodeling in postinjury epilepsy
Kim, S. Y., Porter, B. E., Friedman, A., & Kaufer, D. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23758 · Cited by 47 · see citing works
Wang, X., Pinto-Duarte, A., Sejnowski, T. J., & Behrens, M. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4907 · Cited by 46 · see citing works
Neonatal exposure to LPS leads to heightened exploratory activity in adolescent rats
Rico, J. L., Ferraz, D. B., Ramalho-Pinto, F. J., & Morato, S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.001 · Cited by 43 · see citing works
DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia
Ermakov, E. A., Smirnova, L. P., Parkhomenko, T. A., Dmitrenok, P. S., Михайловна, К. Н., Fattakhov, N. S., Bokhan, N. A., Semke, A. V., Ivanova, S. А., Buneva, V. N., et al. (2015) · Open Biology · doi:10.1098/rsob.150064 · Cited by 43 · see citing works
Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity
Vinogradov, S., Chafee, M. V., Lee, E. G., & Morishita, H. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01451-w · Cited by 44 · see citing works
Babri, S., Doosti, M.-H., & Salari, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.037 · Cited by 41 · see citing works
Perinatal complications and schizophrenia: involvement of the immune system
Jenkins, T. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00110 · Cited by 41 · see citing works
Parshukova, D. A., Smirnova, L. P., Ermakov, E. A., Bokhan, N. A., Semke, A. V., Ivanova, S. А., Buneva, V. N., & Nevinsky, G. A. (2018) · Journal of Molecular Recognition · doi:10.1002/jmr.2759 · Cited by 35 · see citing works
Season of birth in schizophrenia: a maternal-fetal chronobiological hypothesis.
Schwartz, P. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.019 · Cited by 32 · see citing works
Modelling the cognitive and neuropathological features of schizophrenia with phencyclidine
Reynolds, G. P., & Neill, J. C. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116667668 · Cited by 27 · see citing works
Fachim, H. A., Srisawat, U., Dalton, C. F., Harte, M. K., Marsh, S., Neill, J. C., & Reynolds, G. P. (2016) · Epigenomics · doi:10.2217/epi-2016-0050 · Cited by 22 · see citing works
Catalase activity of IgG antibodies from the sera of healthy donors and patients with schizophrenia
Ermakov, E. A., Smirnova, L. P., Bokhan, N. A., Semke, A. V., Ivanova, S. А., Buneva, V. N., & Nevinsky, G. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183867 · Cited by 20 · see citing works
Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients
Ermakov, E. A., Ivanova, S. А., Buneva, V. N., & Nevinsky, G. A. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918050048 · Cited by 17 · see citing works
The neurochemical pathology of schizophrenia: post-mortem studies from dopamine to parvalbumin
Reynolds, G. P. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02453-6 · Cited by 16 · see citing works
The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders
Palmisano, A., Pandit, S., Smeralda, C. L., Demchenko, I., Rossi, S., Battelli, L., Rivolta, D., Bhat, V., & Santarnecchi, E. (2024) · Life · doi:10.3390/life14050578 · Cited by 16 · see citing works
Nakajima, A., Ibi, D., Nagai, T., Yamada, S., Nabeshima, T., & Yamada, K. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.08.034 · Cited by 13 · see citing works
Marchese, E., Corvino, V., di Maria, V., Furno, A., Giannetti, S., Cesari, E., Lulli, P., Michetti, F., & Geloso, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00385 · Cited by 13 · see citing works
Effects of in utero endotoxemia on the ovine fetal brain A model for schizophrenia
Kramer, B. W. W. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e588 · Cited by 12 · see citing works
Shishkina, G. T., Kalinina, T. S., Lanshakov, D. A., Bulygina, V. V., Komysheva, N. P., Bannova, A. V., Drozd, U. S., & Дыгало, Н. Н. (2023) · Biomedicines · doi:10.3390/biomedicines11102595 · Cited by 10 · see citing works
IgGs-Abzymes from the Sera of Patients with Multiple Sclerosis Recognize and Hydrolyze miRNAs
Ermakov, E. A., Kabirova, E. M., Buneva, V. N., & Nevinsky, G. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062812 · Cited by 10 · see citing works
Adinolfi, A., Sante, G. D., Vaccari, L. R., Tredicine, M., Ria, F., Bonvissuto, D., Corvino, V., Sette, C., & Geloso, M. C. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1073627 · Cited by 6 · see citing works
Lunardelli, A., Luft, C., Pedrazza, L., Martha, B. A., de Oliveira, J. R., & Donadio, M. V. F. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.023 · Cited by 6 · see citing works
Трофимов, А. Н., Zubareva, O. E., Simbirtsev, A. S., & Клименко, В. М. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-9918-1 · Cited by 6 · see citing works
Трофимов, А. Н., Zubareva, O. E., Шварц, А. П., Ищенко, А. М., & Клименко, В. М. (2016) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-016-0252-7 · Cited by 5 · see citing works
Prenatal exposure and fetal programming of schizophrenia
Okechukwu, C. E. (2019) · Nigerian Journal of Experimental and Clinical Biosciences · doi:10.4103/njecp.njecp_12_19 · Cited by 5 · see citing works
Miller, B., Crider, A., Aravamuthan, B. R., & Galindo, R. (2026) · Scientific Reports · doi:10.1038/s41598-026-35852-4 · Cited by 4 · see citing works
Rahman, M. F., Yuksel, C. B., & McGowan, P. O. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.03.003 · Cited by 4 · see citing works
Buneva, V. N., Ermakov, E. A., & Nevinsky, G. A. (2018) · InTech eBooks · doi:10.5772/intechopen.73194 · Cited by 3 · see citing works
Experimental Autoimmune Encephalomyelitis of Mice: IgGs from the Sera of Mice Hydrolyze miRNAs
Nevinsky, G. A., Urusov, A. E., Aulova, K. S., & Ermakov, E. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054433 · Cited by 3 · see citing works
Fetal inflammatory injury as origin of long term disease : lessons from animal models
Gantert, M. (2014) · doi:10.26481/dis.20140131mg · Cited by 3 · see citing works
Inflammation and Microbiota and Gut Reconditioning
Bengmark, S. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch64 · Cited by 2 · see citing works
Efeitos de longo prazo do estresse neonatal com lipopolissacarídeo em ratos
Lunardelli, A., Luft, C., Pedrazza, L., & Donadio, M. V. F. (2014) · Ciência & Saúde · doi:10.15448/1983-652x.2014.1.14971 · Cited by 2 · see citing works
Gen, J. J. V., Alvarado-Olivarez, M., Guzmán‐Gerónimo, R. I., González-Nieto, P. F., Gutiérrez‐García, A. G., & Oliart‐Ros, R. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125642 · Cited by 1 · see citing works
Schizophrénie et douleur : une perspective psychiatrique
Grignon, S. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0307-4_10 · Cited by 1 · see citing works
Fever and sickness behaviour during simulated Mycoplasma infection in rats
Swanepoel, T. (2013) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Lunardelli, A., Luft, C., Pedrazza, L., & Donadio, M. V. F. (2014) · DOAJ (DOAJ: Directory of Open Access Journals)
Pantera, G., & Scapigliati, G. (2013)
- Authors
- Jenkins, T. A., Harte, M. K., Stenson, G., & Reynolds, G. P.
- Affiliations
- Queen's University Belfast (GB)
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2009-12-28
- Volume
- 205
- Issue
- 2
- Pages
- 355-359
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2027266077
- Cited by
- 61
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neonatal infection, parvalbumin, hippocampus, CA1-CA3, object recognition memory, locomotor activity, schizophrenia, brain development, prefrontal cortex
- MeSH terms
- Aging, Animals, Animals, Newborn, Female, Lipopolysaccharides, Locomotion, Male, Neurons, Neuropsychological Tests, Parvalbumins, Rats, Inbred Strains, Prefrontal Cortex, Dentate Gyrus, Recognition, Psychology, Rats, CA1 Region, Hippocampal, CA3 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
