Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: impulsivity predicts autoshaping

Tomie, A.; Aguado, A. S.; Pohorecky, L. A.; Benjamin, D.

doi:10.1007/s002130050728

Cited by 108Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: impulsivity predicts autoshaping

Tomie, A., Aguado, A. S., Pohorecky, L. A., Benjamin, D.·1998·Psychopharmacology

DOI 10.1007/s002130050728

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Abstract

Autoshaping conditioned responses (CRs) are reflexive and targeted motor responses expressed as a result of experience with reward. To evaluate the hypothesis that autoshaping may be a form of impulsive responding, within-subjects correlations between performance on autoshaping and impulsivity tasks were assessed in 15 Long-Evans hooded rats. Autoshaping procedures [insertion of retractable lever conditioned stimulus (CS) followed by the response-independent delivery of food (US)] were followed by testing for impulsive-like responding in a two-choice lever-press operant delay-of-reward procedure (immediate small food reward versus delayed large food reward). Delay-of-reward functions revealed two distinct subject populations. Subjects in the Sensitive group (n=7) were more impulsive-like, increasing immediate reward choices at longer delays for large reward, while those in the Insensitive group (n=8) responded predominantly on only one lever. During the prior autoshaping phase, the Sensitive group had performed more autoshaping CRs, and correlations revealed that impulsive subjects acquired the autoshaping CR in fewer trials. In the Sensitive group, acute injections of ethanol (0, 0.25, 0.50, 1.00, 1.50 g/kg) given immediately before delay-of-reward sessions yielded an inverted U-shaped dose-response curve with increased impulsivity induced by the 0.25, 0.50, and 1.00 g/kg doses of ethanol, while choice strategy of the Insensitive group was not influenced by ethanol dose. Ethanol induced impulsive-like responding only in rats that were flexible in their response strategy (Sensitive group), and this group also performed more autoshaping CRs. Data support the hypothesis that autoshaping and impulsivity are linked.

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Effects of ethanol on Pavlovian autoshaping in rats
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Lever conditioned stimulus–directed autoshaping induced by saccharin–ethanol unconditioned stimulus solution: effects of ethanol concentration and trial spacing
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Autoshaping of ethanol drinking in rats: effects of ethanol concentration and trial spacing
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Autoshaped impulsivity: Some explorations with a neural network model
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P.1.d.021 Ethanol reduces the tolerance to delay of reinforcement and induces impulsivity in rats
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Authors: Tomie, A., Aguado, A. S., Pohorecky, L. A., & Benjamin, D.
Affiliations: Rutgers, The State University of New Jersey (US)
ORCID: Aguado, A. S.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1998-09-15
Volume: 139
Issue: 4
Pages: 376-382
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s002130050728
OpenAlex: W2072312333
Cited by: 108
References: 17
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 6 · 2012: 2
FWCI: 1.05
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r03mh052293-02)
U.S. Public Health Service (10124-02)
National Institute on Alcohol Abuse and Alcoholism
National Institute of Mental Health (MH 52293-02)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: ethanol, impulsivity, autoshaping, reward delay, operant choice, conditioned response, acute ethanol effects, dose-response relationship, response flexibility, rats
MeSH terms: Ethanol, Animals, Conditioning, Operant, Impulsive Behavior, Male, Psychomotor Performance, Reward, Rats, Long-Evans, Rats

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Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: impulsivity predicts autoshaping

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