The tendency to sign-track predicts cue-induced reinstatement during nicotine self-administration, and is enhanced by nicotine but not ethanol

Versaggi, Cassandra L.; King, Christopher P.; Meyer, Paul J.

doi:10.1007/s00213-016-4341-7

Cited by 60Neurotransmitter Receptor Influence on BehaviorSmoking Behavior and CessationNicotinic Acetylcholine Receptors Study

The tendency to sign-track predicts cue-induced reinstatement during nicotine self-administration, and is enhanced by nicotine but not ethanol

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Versaggi, Cassandra L., King, Christopher P., Meyer, Paul J.·2016·Psychopharmacology

DOI 10.1007/s00213-016-4341-7PMC PMC4935618

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Abstract

Rationale Some individuals are particularly responsive to reward-associated stimuli ("cues"), including the effects of these cues on craving and relapse to drug-seeking behavior. In the cases of nicotine and alcohol, cues may acquire these abilities via the incentive-enhancing properties of the drug.Objectives To determine the interaction between cue-responsivity and nicotine reinforcement, we studied the patterns of nicotine self-administration in rats categorized based on their tendency to approach a food-predictive cue ("sign-trackers") or a reward-delivery location ("goal-trackers"). In a second experiment, we determined whether nicotine and ethanol altered the incentive value of a food cue.Methods Rats were classified as sign- or goal-trackers during a Pavlovian conditioned approach paradigm. Rats then self-administered intravenous nicotine (0.03 mg/kg infusions) followed by extinction and cue-induced reinstatement tests. We also tested the effects of nicotine (0.4 mg/kg base s.c.) or ethanol (0.7 g/kg i.p.) on the approach to, and reinforcing efficacy of, a food cue.Results Sign-trackers showed greater reinstatement in response to a nicotine cue. Further, nicotine enhanced sign-tracking but not goal-tracking to a food cue and also enhanced responding for the food cue during the conditioned reinforcement test. Conversely, ethanol reduced sign-tracking and increased goal-tracking, but had no effect on conditioned reinforcement.Conclusions Our studies demonstrate that the tendency to attribute incentive value to a food cue predicts enhanced cue-induced reinstatement. Additionally, the incentive value of food cues is differentially modulated by nicotine and ethanol, which may be related to the reinforcing effects of these drugs.

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In animals, cue attraction predicts cue-induced reinstatement of nicotine self-administration, while nicotine administration enhances cue-induced approach behavior, an effect disrupted by dopamine antagonists.
“Similarly in animals, cue attraction predicts cue-induced reinstatement of nicotine self-administration, while in converse, nicotine administration enhances cue-induced approach behavior (Palmatier, Kellicut, Brianna Sheppard, Brown, & Robinson, 2014; Versaggi, King, & Meyer, 2016), an effect which is disrupted by dopamine antagonists (Palmatier et al., 2014).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Versaggi, King, & Meyer, 2016

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Authors: Versaggi, C. L., King, C. P., & Meyer, P. J.
Affiliations: University at Buffalo, State University of New York (US)
Corresponding author: Meyer, Paul J.
ORCID: King, Christopher P.
Meyer, Paul J.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2016-06-09
Volume: 233
Issue: 15-16
Pages: 2985-2997
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-016-4341-7
PMC: PMC4935618
OpenAlex: W2415741020
Cited by: 60
References: 75
Citations by year: 2026: 5 · 2025: 9 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 2
FWCI: 3.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH Office of the Director
National Institute on Alcohol Abuse and Alcoholism (AA024112)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: sign-tracking, goal tracking, nicotine self-administration, cue-induced reinstatement, nicotine, ethanol, incentive value, Pavlovian conditioned approach, food cues, conditioned reinforcement, drug craving, relapse
MeSH terms: Ethanol, Animals, Central Nervous System Depressants, Conditioning, Classical, Cues, Food, Male, Motivation, Nicotine, Reinforcement, Psychology, Reward, Self Administration, Rats, Sprague-Dawley, Nicotinic Agonists, Rats, Drug-Seeking Behavior

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The tendency to sign-track predicts cue-induced reinstatement during nicotine self-administration, and is enhanced by nicotine but not ethanol

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