Cited by 41Motor Control and AdaptationMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Motor skill learning depends on protein synthesis in the dorsal striatum after training

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Wächter, Tobias, Röhrich, Sebastian, Frank, Anita, Molina-Luna, Katiuska, Pekanovic, Ana, Hertler, Benjamin, Schubring-Giese, Maximilan, Luft, Andreas R.·2010·Experimental Brain Research

Abstract

Functional imaging studies in humans and electrophysiological data in animals suggest that corticostriatal circuits undergo plastic modifications during motor skill learning. In motor cortex and hippocampus circuit plasticity can be prevented by protein synthesis inhibition (PSI) which can interfere with certain forms learning. Here, the hypothesis was tested that inducing PSI in the dorsal striatum by bilateral intrastriatal injection of anisomycin (ANI) in rats interferes with learning a precision forelimb reaching task. Injecting ANI shortly after training on days 1 and 2 during 4 days of daily practice (n = 14) led to a significant impairment of motor skill learning as compared with vehicle-injected controls (n = 15, P = 0.033). ANI did not affect the animals' motivation as measured by intertrial latencies. Also, ANI did not affect reaching performance once learning was completed and performance reached a plateau. These findings demonstrate that PSI in the dorsal striatum after training impairs the acquisition of a novel motor skill. The results support the notion that plasticity in basal ganglia circuits, mediated by protein synthesis, contributes to motor skill learning.

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Crossref · 10.1007/s00221-009-2027-7

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Authors
Wächter, T., Röhrich, S., Frank, A., Molina-Luna, K., Pekanovic, A., Hertler, B., Schubring-Giese, M., & Luft, A. R.
Affiliations
University of Zurich (CH)
Corresponding author
Luft, Andreas R.
Venue
Experimental Brain Research
Published
2009-10-13
Volume
200
Issue
3-4
Pages
319-323
ISSN
  • 0014-4819 (ISSN-L)
  • 1432-1106
OpenAlex
W1967702876
Cited by
41
References
21
Citations by year
2025: 2 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 2
FWCI
1.62
Type
journal article
Language
en
Open access
Locations
  • Experimental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • reroDoc Digital Library (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
motor skill learning, protein synthesis inhibition, dorsal striatum, anisomycin, corticostriatal circuits, learning disabilities
MeSH terms
Animals, Anisomycin, Antidotes, Behavior, Animal, Corpus Striatum, Forelimb, Learning, Male, Motor Skills, Protein Synthesis Inhibitors, Teaching, Time Factors, Protein Biosynthesis, Rats, Long-Evans, Rats

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