Motor skill learning depends on protein synthesis in the dorsal striatum after training
Open accessAbstract
Functional imaging studies in humans and electrophysiological data in animals suggest that corticostriatal circuits undergo plastic modifications during motor skill learning. In motor cortex and hippocampus circuit plasticity can be prevented by protein synthesis inhibition (PSI) which can interfere with certain forms learning. Here, the hypothesis was tested that inducing PSI in the dorsal striatum by bilateral intrastriatal injection of anisomycin (ANI) in rats interferes with learning a precision forelimb reaching task. Injecting ANI shortly after training on days 1 and 2 during 4 days of daily practice (n = 14) led to a significant impairment of motor skill learning as compared with vehicle-injected controls (n = 15, P = 0.033). ANI did not affect the animals' motivation as measured by intertrial latencies. Also, ANI did not affect reaching performance once learning was completed and performance reached a plateau. These findings demonstrate that PSI in the dorsal striatum after training impairs the acquisition of a novel motor skill. The results support the notion that plasticity in basal ganglia circuits, mediated by protein synthesis, contributes to motor skill learning.
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- Authors
- Wächter, T., Röhrich, S., Frank, A., Molina-Luna, K., Pekanovic, A., Hertler, B., Schubring-Giese, M., & Luft, A. R.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Luft, Andreas R.
- Venue
- Experimental Brain Research
- Published
- 2009-10-13
- Volume
- 200
- Issue
- 3-4
- Pages
- 319-323
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W1967702876
- Cited by
- 41
- References
- 21
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- motor skill learning, protein synthesis inhibition, dorsal striatum, anisomycin, corticostriatal circuits, learning disabilities
- MeSH terms
- Animals, Anisomycin, Antidotes, Behavior, Animal, Corpus Striatum, Forelimb, Learning, Male, Motor Skills, Protein Synthesis Inhibitors, Teaching, Time Factors, Protein Biosynthesis, Rats, Long-Evans, Rats
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