Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens

Hernandez, Pepe J.; Sadeghian, Kenneth; Kelley, Ann E.

doi:10.1038/nn973

Cited by 186Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens

Hernandez, Pepe J., Sadeghian, Kenneth, Kelley, Ann E.·2002·Nature Neuroscience

DOI 10.1038/nn973

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Abstract

It is widely held that long-term memories are established by consolidation of newly acquired information into stable neural representations, a process that requires protein synthesis and synaptic plasticity. Plasticity within the nucleus accumbens (NAc), a major component of the ventral striatum, is thought to mediate instrumental learning processes and many aspects of drug addiction. Here we show that the inhibition of protein synthesis within the NAc disrupts consolidation of an appetitive instrumental learning task (lever-pressing for food) in rats. Post-trial infusions of anisomycin immediately after the first several training sessions prevented consolidation, whereas infusions delayed by 2 or 4 hours had no effect. However, if the rats were allowed to learn the task, the behavior was not sensitive to disruption by intra-accumbens anisomycin. Control infusions into the medial NAc shell or the dorsolateral striatum did not impair learning; in fact, an enhancement was observed in the latter case. These results show that de novo protein synthesis within the NAc is necessary for the consolidation, but not reconsolidation, of appetitive instrumental memories.

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The same is true when rats receive the protein synthesis inhibitor anisomycin into the core, but not the shell or dorsolateral striatum, immediately after each learning session.
“The same is true when rats receive the protein synthesis inhibitor anisomycin into the core, but not the shell or dorsolateral striatum, immediately after each learning session (Hernandez et al., 2002).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Hernandez et al., 2002

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Authors: Hernandez, P. J., Sadeghian, K., & Kelley, A. E.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Hernandez, Pepe J.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2002-11-11
Volume: 5
Issue: 12
Pages: 1327-1331
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn973
OpenAlex: W2040297259
Cited by: 186
References: 41
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 13
FWCI: 5.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA-04788)
National Institute of General Medical Sciences (GM 07507, T32GM007507)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: memory consolidation, protein synthesis, nucleus accumbens, operant conditioning, appetitive learning, anisomycin, synaptic plasticity, ventral striatum, dorsolateral striatum, memory reconsolidation, drug addiction
MeSH terms: Animals, Anisomycin, Dose-Response Relationship, Drug, Learning, Male, Memory, Nerve Tissue Proteins, Neural Pathways, Neuronal Plasticity, Neurons, Nucleus Accumbens, Protein Synthesis Inhibitors, Psychomotor Performance, Neostriatum, Rats, Sprague-Dawley, Rats

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Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens

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