Dishabituation of laser-evoked EEG responses: dissecting the effect of certain and uncertain changes in stimulus spatial location
Abstract
The repetition of nociceptive stimuli of identical modality, intensity and location at short (1 s) and constant inter-stimulus interval (ISI) determines a strong habituation of the corresponding electroencephalographic (EEG) responses. To understand what determines this response habituation, we (1) examined the effect of introducing a selective change in the spatial location of the repeated stimulus (i.e., without altering its modality, intensity and timing), and (2) dissected the relative contribution of bottom-up, stimulus-driven spatial changes and top-down, cognitive expectations of such a change. Multichannel EEG was recorded while participants received a triplet of stimuli (S1-S2-S3) delivered to the hand dorsum at 1-s ISI. S3 was delivered either to the same hand as S1 and S2 or to the other hand, and participants were either explicitly informed or not informed of the location of S3. We found that, unlike the introduction of a change in the sensory modality of the repeated stimulus (Valentini et al. in J Cogn Neurosci 23:2822-2837, 2011), introducing a change in its spatial location did not produce a significant dishabituation of the laser-evoked N1, N2 and P2 peaks, but only a small amplitude increase following the P2 peak, maximal on the hemisphere contralateral to the stimulated hand. Furthermore, the magnitude of the elicited responses was not significantly affected by cognitive expectations. Altogether, these results indicate that bottom-up, stimulus-driven novelty resulting from a change in stimulus spatial location does not revert the habituation caused by repetition suppression, but determines a small increase of neural activity over the contralateral central-parietal cortex, likely reflecting shifts in spatial attention.
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The cortical processes generating LEPs are largely related to the perception of salient changes in the sensory environment and contribute to the perception of pain.
“the cortical processes generating LEPs are largely related to the perception of salient changes in the sensory environment 59, 60, and contribute to the perception of pain 61, 62.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [59]
The P2 component has been shown to be modulated specifically by factors reflecting the salience of noxious stimuli and to reflect multimodal (rather than somatosensory-specific) processes.
“The P2 component has been shown to be modulated specifically by factors reflecting the salience of noxious stimuli (e.g. stimulus probability) 33, 59, 69 and to reflect multimodal (rather than somatosensory‐specific) processes 61.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [59]
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Self-citation
- Authors
- Torta, D. M., Liang, M., Valentini, E., Mouraux, A., & Iannetti, G. D.
- Affiliations
- University College London (GB)
- Fondazione Santa Lucia (IT)
- UCLouvain (BE)
- Corresponding author
- Iannetti, G. D.
- Venue
- Experimental Brain Research
- Published
- 2012-02-17
- Volume
- 218
- Issue
- 3
- Pages
- 361-372
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W2007093917
- Cited by
- 41
- References
- 44
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Lirias (submittedVersion)
- Funders
- Royal Society
- Biotechnology and Biological Sciences Research Council (BB/G01177X/2)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dishabituation, habituation, laser-evoked potentials, nociceptive stimuli, repetition suppression, novelty detection, top-down expectations, bottom-up processing, spatial attention
- MeSH terms
- Adult, Electroencephalography, Evoked Potentials, Somatosensory, Female, Habituation, Psychophysiologic, Humans, Lasers, Male, Middle Aged, Reaction Time, Space Perception, Uncertainty, Young Adult, Pain Perception
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